R Charles Coombes

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Epirubicin dose and sequential hormonal therapy-Mature results of the HMFEC randomised phase III trial in premenopausal patients with node positive early breast cancer
    R C Coombes
    Department of Surgery and Cancer, Imperial College London, London, UK Electronic address
    Eur J Cancer 60:146-53. 2016
  2. ncbi request reprint Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts
    Jacqueline A Shaw
    Department of Cancer Studies, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom
    Clin Cancer Res . 2016
  3. ncbi request reprint A phase I dose escalation study to determine the optimal biological dose of irosustat, an oral steroid sulfatase inhibitor, in postmenopausal women with estrogen receptor-positive breast cancer
    R Charles Coombes
    Department of Cancer and Surgery, Faculty of Medicine, ICTEM, Imperial College London, Room 145, Du Cane Road, London, W12 0NN, UK
    Breast Cancer Res Treat 140:73-82. 2013
  4. doi request reprint Drug testing in the patient: toward personalized cancer treatment
    R Charles Coombes
    Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
    Sci Transl Med 7:284ps10. 2015
  5. pmc Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
    S Rasul
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Oncology, MRC Cyclotron Building, Imperial College London, London W12 0NN, UK
    Br J Cancer 100:1879-88. 2009
  6. pmc Viable circulating tumour cell detection using multiplex RNA in situ hybridisation predicts progression-free survival in metastatic breast cancer patients
    R E Payne
    Division of Cancer, Imperial College, MRC Cyclotron Building, Hammersmith Hospitals Trust, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Br J Cancer 106:1790-7. 2012
  7. pmc The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy
    R E Payne
    Division of Cancer, Imperial College, MRC Cyclotron Building, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Br J Cancer 106:375-82. 2012
  8. pmc Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment
    M J Slade
    1Department of Oncology, Imperial College, MRC Cyclotron Building, London W12 0NN, UK
    Br J Cancer 100:160-6. 2009
  9. pmc Evaluation of limited blood sampling population input approaches for kinetic quantification of [18F]fluorothymidine PET data
    Kaiyumars B Contractor
    Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
    EJNMMI Res 2:11. 2012
  10. pmc The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
    John P Alao
    Department of Cancer Medicine, Imperial College, Hammersmith Hospital, London, W12 0NN, UK
    Mol Cancer 5:7. 2006

Collaborators

Detail Information

Publications51

  1. doi request reprint Epirubicin dose and sequential hormonal therapy-Mature results of the HMFEC randomised phase III trial in premenopausal patients with node positive early breast cancer
    R C Coombes
    Department of Surgery and Cancer, Imperial College London, London, UK Electronic address
    Eur J Cancer 60:146-53. 2016
    ....
  2. ncbi request reprint Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts
    Jacqueline A Shaw
    Department of Cancer Studies, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom
    Clin Cancer Res . 2016
    ..We aimed to determine whether cfDNA would reflect the heterogeneity observed in 40 single CTCs...
  3. ncbi request reprint A phase I dose escalation study to determine the optimal biological dose of irosustat, an oral steroid sulfatase inhibitor, in postmenopausal women with estrogen receptor-positive breast cancer
    R Charles Coombes
    Department of Cancer and Surgery, Faculty of Medicine, ICTEM, Imperial College London, Room 145, Du Cane Road, London, W12 0NN, UK
    Breast Cancer Res Treat 140:73-82. 2013
    ..A larger study is required to define an accurate response rate to irosustat as a single agent and whether co-administration with an aromatase inhibitor is needed...
  4. doi request reprint Drug testing in the patient: toward personalized cancer treatment
    R Charles Coombes
    Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
    Sci Transl Med 7:284ps10. 2015
    ..and Klinghoffer et al., this issue). ..
  5. pmc Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
    S Rasul
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Oncology, MRC Cyclotron Building, Imperial College London, London W12 0NN, UK
    Br J Cancer 100:1879-88. 2009
    ..GSI1 also inhibited proteasome activity. Thus, the gamma-secretase inhibitor GSI1 has a complex mode of action to inhibit breast cancer cell survival and may represent a novel therapy in breast cancer...
  6. pmc Viable circulating tumour cell detection using multiplex RNA in situ hybridisation predicts progression-free survival in metastatic breast cancer patients
    R E Payne
    Division of Cancer, Imperial College, MRC Cyclotron Building, Hammersmith Hospitals Trust, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Br J Cancer 106:1790-7. 2012
    ..This method detects a multitude of tumour-specific markers at single-cell level in blood...
  7. pmc The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy
    R E Payne
    Division of Cancer, Imperial College, MRC Cyclotron Building, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Br J Cancer 106:375-82. 2012
    ..The aim of this study was to gain insight into breast cancer dormancy by examining different measures of minimal residual disease (MRD) over time in relation to known prognostic factors...
  8. pmc Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment
    M J Slade
    1Department of Oncology, Imperial College, MRC Cyclotron Building, London W12 0NN, UK
    Br J Cancer 100:160-6. 2009
    ....
  9. pmc Evaluation of limited blood sampling population input approaches for kinetic quantification of [18F]fluorothymidine PET data
    Kaiyumars B Contractor
    Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
    EJNMMI Res 2:11. 2012
    ..The aim of this study was to investigate whether a population-based input function (POP-IF) reliant on only a few individual discrete samples allows accurate estimates of tumour proliferation using [18F]fluorothymidine (FLT)...
  10. pmc The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
    John P Alao
    Department of Cancer Medicine, Imperial College, Hammersmith Hospital, London, W12 0NN, UK
    Mol Cancer 5:7. 2006
    ..Additional studies were initiated in order to further investigate the effect of TSA on cyclin D1 regulation using sub-cellular fractionation techniques...
  11. pmc Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells
    John P Alao
    Department of Cancer Medicine, Imperial College, Hammersmith Hospital, London, W12 0NN, UK
    Mol Cancer 5:8. 2006
    ..TSA treatment also resulted in accumulation of polyubiquitylated GFP-cyclin D1 species and reduced levels of the recombinant protein within the nucleus...
  12. pmc Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells
    John P Alao
    Department of Cell and Molecular Biology, Lundberg Laboratory, Gothenburg University, Gothenburg, Sweden
    Mol Cancer 5:40. 2006
    ..Our findings identify GSK3beta as an important mediator of TSA-induced cytotoxicity in MCF-7 breast cancer cells...
  13. doi request reprint Randomized, phase III trial of sequential epirubicin and docetaxel versus epirubicin alone in postmenopausal patients with node-positive breast cancer
    R Charles Coombes
    Division of Cancer, Imperial College London, London, United Kingdom
    J Clin Oncol 29:3247-54. 2011
    ..The Docetaxel Epirubicin Adjuvant (DEVA) trial evaluated the efficacy and toxicity of incorporating docetaxel after epirubicin to create a sequential anthracycline-taxane regimen in early breast cancer...
  14. ncbi request reprint High dose chemotherapy and autologous stem cell transplantation as adjuvant therapy for primary breast cancer patients with four or more lymph nodes involved: long-term results of an international randomised trial
    R C Coombes
    Cancer Research UK Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London
    Ann Oncol 16:726-34. 2005
    ....
  15. pmc Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells
    Chun Fui Lai
    Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK, Department of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands and Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
    Nucleic Acids Res 41:10228-40. 2013
    ....
  16. ncbi request reprint Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial
    R C Coombes
    Cancer Research UK Department of Cancer Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Imperial College London, Faculty of Medicine, Hammersmith Hospitals Trust, London W12 0NN, UK
    Lancet 369:559-70. 2007
    ..However, little information exists on the long-term effects of aromatase inhibitors after treatment, and whether these early improvements lead to real gains in survival...
  17. ncbi request reprint The nuclear oxysterol receptor LXRalpha is expressed in the normal human breast and in breast cancer
    D M Vigushin
    Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN
    Med Oncol 21:123-31. 2004
    ..Inhibition of breast cancer cell proliferation suggests that pharmacological LXRalpha agonists may have potential preventive and/or therapeutic antitumor activity in breast cancer...
  18. ncbi request reprint Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo
    D M Vigushin
    Department of Cancer Medicine, 6th Floor MRC Cyclotron Building, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Med Oncol 21:21-30. 2004
    ..The present studies confirm that gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with pronounced antitumor activity and favorable toxicity profile against breast cancer in vitro and in vivo...
  19. ncbi request reprint Targeted histone deacetylase inhibition for cancer therapy
    D M Vigushin
    Department of Cancer Medicine, Imperial College, Hammersmith Campus, London W12 0NN, UK
    Curr Cancer Drug Targets 4:205-18. 2004
    ..This report reviews the biology and clinical development of histone deacetylase inhibitors for cancer therapy...
  20. ncbi request reprint Retroviral infection of the FGF2 gene into MCF-7 cells induces branching morphogenesis, retards cell growth and suppresses tumorigenicity in nude mice
    D Liu
    Department of Cancer Medicine, Division of Medicine, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, W12 ONN, London, UK
    Eur J Cancer 37:268-80. 2001
    ..Our results suggest that introduction of the FGF2 gene into MCF-7 cells altered the malignant tumour cells towards a more benign phenotype in vitro and in vivo...
  21. ncbi request reprint Effect of tamoxifen or anastrozole on steroid sulfatase activity and serum androgen concentrations in postmenopausal women with breast cancer
    S J Stanway
    Imperial College London, London, UK
    Anticancer Res 31:1367-72. 2011
    ..In contrast, little is known about the effects of aromatase inhibitors or anti-estrogens on STS activity or serum androgen levels...
  22. ncbi request reprint Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1beta-induced paracrine growth factor for human breast cells
    C Palmieri
    Cancer Research UK Laboratories, Department of Cancer Medicine, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Endocrinol 177:65-81. 2003
    ..In summary, our findings suggest that FGF7 is a paracrine growth factor in the breast. FGF7 is produced by the breast stromal fibroblasts and has profound proliferative and morphogenic roles on both epithelial and myoepithelial cells...
  23. ncbi request reprint Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo
    D M Vigushin
    Department of Cancer Medicine, Cancer Research Campaign Laboratories, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, United Kingdom
    Clin Cancer Res 7:971-6. 2001
    ....
  24. ncbi request reprint Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF
    L Buluwela
    Department of Cancer Medicine, Imperial College London, London, UK
    Gene Ther 12:452-60. 2005
    ..Taken together, these results show that PLZF-ERalpha is a potent repressor of estrogen-regulated gene expression and could be useful in distinguishing estrogen-regulated genes required for the growth of breast cancer cells...
  25. ncbi request reprint Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments. A splice variant of FGFR-3 localizes to the nucleus
    C L Johnston
    Department of Medical Oncology, Charing Cross and Westminster Medical School, London, United Kingdom
    J Biol Chem 270:30643-50. 1995
    ..We conclude that two forms of FGFR-3 are present in breast epithelial cells; a full-length 135-kDa receptor, which has a conventional membrane localization, and a novel soluble form of 110 kDa...
  26. doi request reprint Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth
    Robert S Tolhurst
    Division of Cancer, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Breast Cancer Res Treat 128:357-68. 2011
    ....
  27. ncbi request reprint Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer
    M J Slade
    Department of Cancer Medicine, Imperial College School of Medicine, London, United Kingdom
    J Clin Oncol 17:870-9. 1999
    ..To improve the specificity of this assay, we developed a quantitative RT-PCR methodology that enables an estimate to be made of the number of CK-19 transcripts in blood and bone marrow samples...
  28. ncbi request reprint Pulmonary lymphangioleiomyomatosis and steroid receptors. An immunocytochemical study
    U Berger
    Clinical Oncology Department, St George s Hospital Medical School, London, United Kingdom
    Am J Clin Pathol 93:609-14. 1990
    ..The authors conclude that the response to hormonal treatment seen in this disease might be optimized in the future by monitoring for the presence of steroid hormone receptors...
  29. ncbi request reprint Analysis of estrogen-responsive finger protein expression in benign and malignant human breast
    S D Thomson
    CRC Laboratories, Department of Cancer Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    Int J Cancer 91:152-8. 2001
    ..Increased levels of EFP in lactating breast and the reduction in malignancy suggest a role for EFP in promoting mammary gland differentiation...
  30. ncbi request reprint Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice
    L Sanderson
    Department of Cancer Medicine, 6th Floor MRC Cyclotron Building, Imperial College London Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
    Drug Metab Dispos 32:1132-8. 2004
    ..We conclude that trichostatin A is rapidly and extensively metabolized in vivo following intraperitoneal administration to mice, and N-demethylation does not compromise histone deacetylase-inhibitory activity...
  31. pmc Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer
    C Zammit
    Cancer Research UK Laboratories, Department of Cancer Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Br J Cancer 86:1097-103. 2002
    ..Fibroblast growth factor 8 appears to be expressed in several organs in man and appears to have an importance in lactation...
  32. pmc The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer
    C Horlock
    Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK
    Br J Cancer 100:1061-7. 2009
    ..The change in balance of the T(reg) : Th17 ratio appears to characterise the cancer state, and furthermore, is disrupted by trastuzumab therapy...
  33. ncbi request reprint Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression
    N Sarwar
    Department of Oncology, Imperial College London, Hammersmith Hospital Campus, UK
    Endocr Relat Cancer 13:851-61. 2006
    ....
  34. ncbi request reprint Estrogen receptor alpha in human breast cancer: occurrence and significance
    S Ali
    CRC Laboratories, Department of Cancer Medicine, Imperial College School of Medicine, Hammersmith Hospital, London
    J Mammary Gland Biol Neoplasia 5:271-81. 2000
    ....
  35. pmc Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues
    Y A Luqmani
    Department of Medical Oncology, Charing Cross Hospital Medical School, London, UK
    Br J Cancer 66:273-80. 1992
    ..ZR-75-1 cells had a marked preponderance of FGFR1 variants lacking part of the coding sequence. Aberrant receptor processing may provide clues concerning the role of FGF's and their potential involvement in malignancy...
  36. ncbi request reprint Long-term follow-up of a randomised trial designed to determine the need for irradiation following conservative surgery for the treatment of invasive breast cancer
    H T Ford
    Combined Breast Clinic, St George s Hospital, Blackshaw Road, London, UK
    Ann Oncol 17:401-8. 2006
    ..A Cox's regression analysis with local recurrence as a time-dependent variable showed a risk ratio of 5.28 (P < 0.0001). This strong relationship is dependent on the intensity of post-treatment follow-up and investigation...
  37. ncbi request reprint Randomized phase III trials of adjuvant FAMTX or FEMTX compared with surgery alone in resected gastric cancer. A combined analysis of the EORTC GI Group and the ICCG
    D Nitti
    Universita di Padova, Clinica Chirurgica II, Padova, Italy, and Laurentius Hospital, Roermond, The Netherlands
    Ann Oncol 17:262-9. 2006
    ..In patients who underwent radical resection for gastric cancer, we investigate the relative efficacy of combined 5-fluorouracil+adriamycin or epirubicin and methotrexate with leucovorin rescue (FAMTX or FEMTX) compared with a control arm...
  38. ncbi request reprint Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells
    Q Y Liu
    Deparment of Medical Oncology, Charing Cross and Westminster Medical School, London, UK
    Cancer Res 56:1155-63. 1996
    ..These are the first observations of activin and activin receptor in the normal human breast and in human breast cell lines and suggest a role for activin in mammary cell growth and morphogenesis...
  39. pmc Purified malignant mammary epithelial cells maintain hormone responsiveness in culture
    M S Kothari
    Department of Cancer Cell Biology, Imperial College, London, UK
    Br J Cancer 88:1071-6. 2003
    ....
  40. ncbi request reprint Estrogen-receptor-directed neoadjuvant therapy for breast cancer: results of a randomised trial using formestane and methotrexate, mitozantrone and mitomycin C (MMM) chemotherapy
    J C Gazet
    Combined Breast Clinic, St. George's Hospital, London, UK
    Ann Oncol 12:685-91. 2001
    ..Also, the patients whose tumours respond to neoadjuvant systemic therapy have a lower incidence of distant metastases after five year follow-up compared to those whose tumours fail to respond...
  41. ncbi request reprint Tamoxifen is not detrimental to endothelial function in postmenopausal women with breast cancer
    P J Ong
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am Heart J 142:E6. 2001
    ..17% +/- 1.05% vs 3.16% +/- 0.91%, respectively, mean +/- SEM, P =.995). CONCLUSIONS: Tamoxifen does not appear to affect endothelial function in the short term in postmenopausal women with breast cancer...
  42. pmc TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model
    A M Waterston
    Department of Cancer Medicine, Faculty of Medicine, Chelsea and Westminster Hospital, 369 Fulham Rd, Imperial College School of Medicine, London SW10 9NH, UK
    Br J Cancer 90:1279-84. 2004
    ..This study suggests that TNF autovaccination is a cheaper and highly efficient alternative that can block TNF and reduce metastasis in vivo and trials with TNF autovaccination are already underway in patients with metastatic cancer...
  43. ncbi request reprint Letter 1: Bone marrow micrometastasis in breast cancer (Br J Surg 2003; 90: 290-301)
    A Singh
    Br J Surg 90:761. 2003
  44. ncbi request reprint Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer
    A M Waterston
    Department of Cancer Medicine, Faculty of Medicine, Imperial College School of Medicine, London, W12 0HS, UK
    Cancer Immunol Immunother 54:848-57. 2005
    ..However, since the antibodies were only able to cross-react with partly denatured TNFalpha, evaluation of safety and tumour responses to the TNFalpha vaccine was compromised...
  45. ncbi request reprint Tamoxifen-related porphyria cutanea tarda
    R Agarwal
    Section of Medicine, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Med Oncol 19:121-3. 2002
    ..Tamoxifen is known to be hepatotoxic; however, its association with PCT is unclear. In this report, we discuss the porphyrinogenicity of tamoxifen and potential mechanisms...
  46. ncbi request reprint A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen
    S R D Johnston
    Cancer Research UK, Lincoln s Inn Fields, London, WC2A 3PX, UK
    Cancer Chemother Pharmacol 53:341-8. 2004
    ....
  47. ncbi request reprint Ultrastructural localization of laminin and type IV collagen in normal human breast
    H L Fu
    College of Life Science, Peking University, Beijing, China
    Ultrastruct Pathol 26:77-80. 2002
    ..This study provides a basis for further ultrastructural investigations of extracellular matrix components in normal and neoplastic breast tissue...
  48. ncbi request reprint Neoadjuvant 5-fluorouracil, epirubicin and cyclophosphamide chemotherapy followed by docetaxel in refractory patients with locally advanced breast cancer
    W Heller
    Department of Medical Oncology, Cancer Research UK Laboratories, Faculty of Medicine, Imperial College London, London W6 8RF, UK
    Oncol Rep 17:253-9. 2007
    ....
  49. ncbi request reprint Estrogen receptor beta in breast cancer
    C Palmieri
    Department of Cancer Medicine, Cancer Cell Biology Group, Cancer Research Campaign Laboratories, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Endocr Relat Cancer 9:1-13. 2002
    ....
  50. pmc Estrogen receptors and proliferation markers in primary and recurrent breast cancer
    E V Jensen
    Departments of Medical Nutrition and Biosciences, Karolinska Institute, Novum, S-141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 98:15197-202. 2001
    ..Thus, appropriate ERbeta-specific ligands, perhaps in combination with tamoxifen, may be useful in improving the treatment of breast cancers...
  51. ncbi request reprint Resolution of late-onset asthma following high-dose chemotherapy
    C Palmieri
    Department of Medical Oncology, Charing Cross Hospital, Fulham Palace Road, London, UK
    Bone Marrow Transplant 32:847-8. 2003
    ..As far as the authors are aware this is the first reported case...