C J Bulpitt
Affiliation: Imperial College
- Prognostic significance of electrocardiographic voltages and their serial changes in elderly with systolic hypertensionRobert H Fagard
Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, Leuven, Belgium
Hypertension 44:459-64. 2004..86; P< or =0.05), but not of stroke or mortality. In conclusion, electrocardiographic voltages at baseline and their serial changes during follow-up predict subsequent events in older patients with systolic hypertension...
- The MRC trial of assessment and management of older people in the community: objectives, design and interventions [ISRCTN23494848]A E Fletcher
Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
BMC Health Serv Res 2:21. 2002..Despite the lack of a firm evidence base, UK primary care practitioners (general practitioners) are required to offer an annual health check to patients aged 75 years and over...
- Results of the pilot study for the Hypertension in the Very Elderly TrialChristopher J Bulpitt
Faculty of Medicine, Imperial College London, UK
J Hypertens 21:2409-17. 2003..The risks and benefits of treating hypertension in individuals older than 80 years are uncertain. A meta-analysis has suggested that a reduction in stroke events of 36% may have to be balanced against a 14% increase in total mortality...
- Why do some people look older than they should?C J Bulpitt
Section of Care of the Elderly, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Postgrad Med J 77:578-81. 2001..As a component of studies on biological age, the age of subjects from their appearance (perceived age) was estimated...
- Withdrawal from treatment in the Syst-Eur TrialChristopher J Bulpitt
Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
J Hypertens 20:339-46. 2002..To investigate the reasons for withdrawal from double-blind randomized trials, and the reasons for changing treatment within a randomized therapeutic group...
- Left ventricular hypertrophy by Sokolow-Lyon voltage criterion predicts mortality in overweight hypertensive subjectsR L Antikainen
Care of the Elderly, Division of Medicine, Imperial College, London, UK
J Hum Hypertens 23:20-6. 2009..The excess high risk of dying was evident especially in women with LVH in the highest BMI quartiles. When ECG detects LVH in overweight subjects, it is a good predictor of mortality despite the lower sensitivity in this group...
- Left ventricular hypertrophy determined by Sokolow-Lyon criteria: a different predictor in women than in men?R L Antikainen
Imperial College Faculty of Medicine, London, UK
J Hum Hypertens 20:451-9. 2006..8 and 8.5% in men, respectively. In conclusion, the greater the baseline ECG voltage sum, the greater the associated CVD mortality risk. Women tended to have a high risk of stroke mortality owing to LVH despite adjustments...
- Androgen deprivation in males is associated with decreased central arterial compliance and reduced central systolic blood pressureF Dockery
Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
J Hum Hypertens 14:395-7. 2000..It is unlikely that the presence of normal concentrations of androgens can explain the sex difference in mortality rates. Longitudinal studies are needed for further evaluation. Journal of Human Hypertension (2000) 14, 395-397..
- Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trialRuth Peters
Care of the Elderly, Imperial College London, London, UK
Lancet Neurol 7:683-9. 2008..The Hypertension in the Very Elderly trial (HYVET) was designed to assess the risks and benefits of treatment of hypertension in elderly patients and included an assessment of cognitive function...
- Transiently elevated diastolic blood pressure is associated with a gender-dependent effect on cardiovascular riskD Wingfield
Brook Green Medical Centre, Bute Gardens, London, UK
J Hum Hypertens 19:347-54. 2005..Women with this condition have a significantly lower cardiovascular mortality...
- Blood pressure control in the Hypertension in the Very Elderly Trial (HYVET)C J Bulpitt
Imperial College London, Hammersmith Campus, Care of the Elderly, London, UK
J Hum Hypertens 26:157-63. 2012..The fall in SBP accounted for the observed 30% reduction in strokes, but the 21% reduction in total mortality and 64% reduction in heart failure were greater than predicted...
- The determinants of left ventricular hypertrophy defined by Sokolow-Lyon criteria in untreated hypertensive patientsR Antikainen
Imperial College School of Medicine, London, UK
J Hum Hypertens 17:159-64. 2003..This study confirms the adverse association between ECG LVH and SBP and DBP, male gender, black race and decreased BMI. It also addresses the less well-known associations of blood glucose, cholesterol, smoking and alcohol consumption...
- The effect of low dose lofepramine in depressed elderly patients in general medical wardsR S Tan
Division of Geriatric Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London
Br J Clin Pharmacol 37:321-4. 1994..Low dose lofepramine may prove useful in moderately or severely depressed patients treated for only 4 weeks. However, low dose lofepramine is not indicated for mild (GDS 15-18) depression...
- Differences in the association between type 2 diabetes and impaired microvascular function among Europeans and African CaribbeansW D Strain
International Centre for Circulatory Health, Faculty of Medicine, Imperial College London at St Mary s, Norfolk Place, London, UK
Diabetologia 48:2269-77. 2005..We investigated whether this may be due to differences in the microvasculature...
- Testosterone suppression in men with prostate cancer is associated with increased arterial stiffnessF Dockery
Section of Geriatric Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Aging Male 5:216-22. 2002..In conclusion, testosterone suppression is associated with increased aortic stiffness, only partly explained by age and blood pressure. Loss of androgens in men might therefore adversely affect cardiovascular risk...
- The uses and misuses of orchids in medicineC J Bulpitt
Experimental Medicine Care of the Elderly, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
QJM 98:625-31. 2005
- Measuring costs and financial benefits in randomized controlled trialsC J Bulpitt
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England
Am Heart J 119:766-70; discussion 770-1. 1990..Economic evaluation is seen to be justified whenever a more expensive treatment is expected to produce greater benefit. Such analyses should consider quality of life and health status, as well as the more easily identifiable outcomes...
- Selective recording in blood pressure readings may increase subsequent mortalityD Wingfield
Department of Primary Health Care and General Practice and Section of Care of the Elderly, Imperial College, Faculty of Medicine, London, UK
QJM 95:571-7. 2002..Both reduce measurement accuracy, and may have consequences for treatment and survival...
- Prevalence of visual impairment in people aged 75 years and older in Britain: results from the MRC trial of assessment and management of older people in the communityJ R Evans
Department of Epidemiology and International Eye Health, Institute of Ophthalmology, London, UK
Br J Ophthalmol 86:795-800. 2002..To measure the prevalence of visual impairment in a large representative sample of people aged 75 years and over participating in the MRC trial of assessment and management of older people in the community...
- Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemiaFrances Dockery
Section of Geriatric Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, UK
Clin Sci (Lond) 104:195-201. 2003..Our results indicate that loss of androgens in men leads to an increase in aortic stiffness and serum insulin levels, and may therefore adversely affect cardiovascular risk...
- Ambulatory pulse pressure as predictor of outcome in older patients with systolic hypertensionJan A Staessen
Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
Am J Hypertens 15:835-43. 2002....
- Quality of life on randomized treatment for isolated systolic hypertension: results from the Syst-Eur TrialAstrid E Fletcher
Centre for Ageing and Public Health, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
J Hypertens 20:2069-79. 2002..To compare quality of life in elderly patients with isolated systolic hypertension allocated randomly to groups to receive placebo or active treatment in the Systolic Hypertension in the Elderly Trial...
- How many alcoholic drinks might benefit an older person with hypertension?Christopher J Bulpitt
Faculty of Medicine, Imperial College London, UK
J Hypertens 23:1947-51. 2005..It is not suggested that the non-drinker should start drinking, but most hypertensives are over the age of 60 when community studies suggest that drinking alcohol does more good than harm...
- Quality of life and antihypertensive effect with nebivolol and losartanLuc M Van Bortel
Am J Hypertens 18:1060-6. 2005..Quality of life and antihypertensive effect, two important therapeutic goals, were determined with the third generation beta-blocker nebivolol and the angiotensin receptor blocker losartan are compared...
- Increased arterial stiffness in Europeans and African Caribbeans with type 2 diabetes cannot be accounted for by conventional cardiovascular risk factorsW David Strain
International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College London at St Mary s, Hammersmith Hospital, London, UK
Am J Hypertens 19:889-96. 2006..We hypothesized that arterial stiffness, an independent cardiovascular risk factor, would be more prevalent with diabetes and in African Caribbeans with diabetes than Europeans...
- Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trialMary Hickson
Nutrition and Dietetic Research Group, Faculty of Medicine, Imperial College, London W12 0HS
BMJ 335:80. 2007..To determine the efficacy of a probiotic drink containing Lactobacillus for the prevention of any diarrhoea associated with antibiotic use and that caused by Clostridium difficile...
- On-treatment diastolic blood pressure and prognosis in systolic hypertensionRobert H Fagard
Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, B 3000 Leuven, Belgium
Arch Intern Med 167:1884-91. 2007..We examined the association between on-treatment diastolic BP, mortality, and cardiovascular events in the prospective placebo-controlled Systolic Hypertension in Europe Trial...
- Treatment of hypertension in patients 80 years of age or olderNigel S Beckett
Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
N Engl J Med 358:1887-98. 2008..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
- Secondary prevention of coronary heart disease in the elderlyChristopher J Bulpitt
Care of the Elderly, Division of Medicine, Imperial College School of Medicine, Du Cane Road, London W12 0HS, UK
Heart 91:396-400. 2005
- Is augmentation index a good measure of vascular stiffness in the elderly?Francesco Fantin
Section of Geriatric Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Age Ageing 36:43-8. 2007..we investigated the exact relationship between age and gender on augmentation pressure (AG) and augmentation index (AI) measured over the radial (muscular) and carotid (elastic) arteries...
- Relationship between ambulatory blood pressure and follow-up clinic blood pressure in elderly patients with systolic hypertensionRobert H Fagard
Hypertension and Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Leuven, Belgium
J Hypertens 22:81-7. 2004..On the contrary, current guidelines emphasize repeated clinic blood pressure measurements for the initiation of antihypertensive therapy...
- Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe TrialJan A Staessen
J Hypertens 22:847-57. 2004....
- Probiotics in prevention of antibiotic associated diarrhoea: meta-analysisAloysius L D'Souza
Care of the Elderly Section, Faculty of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN
BMJ 324:1361. 2002..To evaluate efficacy of probiotics in prevention and treatment of diarrhoea associated with the use of antibiotics...
- Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertensionPaolo Palatini
Clinica Medica 4, University of Padova, Via Giustiniani 2, 35128 Padua, Italy
Arch Intern Med 162:2313-21. 2002..To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial...
- Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive populationEdward Pringle
Royal Sussex County Hospital, Brighton, UK
J Hypertens 21:2251-7. 2003..To investigate whether baseline systolic blood pressure variability was a risk factor for stroke, cardiovascular mortality or cardiac events during the Syst-Eur trial...
- Ethnic differences in vascular stiffness and relations to hypertensive target organ damageNish Chaturvedi
Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London at St Mary s, Norfolk Place, London, UK
J Hypertens 22:1731-7. 2004..People of Black African descent have greater risks of hypertensive target organ damage than would be anticipated for given levels of blood pressure. Arterial stiffness may further account for ethnic differences in risk...
- The relationship between androgens and arterial stiffness in older menFrances Dockery
Section of Geriatric Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
J Am Geriatr Soc 51:1627-32. 2003..To assess the relationship between endogenous androgen levels and arterial stiffness in older men...
- Estimation of central aortic pressure by SphygmoCor requires intra-arterial peripheral pressuresGeoffrey C Cloud
Section of Geriatric Medicine, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London W12 ONN, UK
Clin Sci (Lond) 105:219-25. 2003..However, age, drugs and arterial disease would also be expected to play a role...
- Geriatric Depression Scale Scores in a representative sample of 14 545 people aged 75 and over in the United Kingdom: results from the MRC Trial of Assessment and Management of Older People in the CommunityDavid P J Osborn
Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
Int J Geriatr Psychiatry 17:375-82. 2002..We describe the age and sex distribution of GDS-15 scores in the largest ever UK sample of people aged 75 and over...
- The aging of elastic and muscular arteries: a comparison of diabetic and nondiabetic subjectsJames D Cameron
Department of Vascular Sciences, Dandenong Hospital Southern Health Network and Monash University, Melbourne, Australia
Diabetes Care 26:2133-8. 2003..To compare age-related changes in the mechanical properties of different arterial segments in normal volunteers and subjects with type 2 diabetes...
- Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of deathGill M Price
Centre for Ageing and Public Health and the Nutrition and Public Health Interventions Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
Am J Clin Nutr 84:449-60. 2006..Guidelines for optimal weight in older persons are limited by uncertainty about the ideal body mass index (BMI) or the usefulness of alternative anthropometric measures...
- Terminal digit preference and single-number preference in the Syst-Eur trial: influence of quality controlDavid Wingfield
Department of Primary Health Care and General Practice, Charing Cross Campus, Imperial College, Faculty of Medicine, London, UK
Blood Press Monit 7:169-77. 2002..We describe these preferences in the Syst-Eur randomized placebo-controlled trial of the treatment of isolated systolic hypertension and describe how we sought to eliminate these problems...
- Validity of the Clock-Drawing Test as a screening tool for cognitive impairment in the elderlyYuji Nishiwaki
Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
Am J Epidemiol 160:797-807. 2004..The authors conclude that the CDT may have value as a brief face-to-face screening tool for moderate/severe cognitive impairment in an older community population but is relatively poor at detecting milder cognitive impairment...
- Population-based multidimensional assessment of older people in UK general practice: a cluster-randomised factorial trialAstrid E Fletcher
Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, London, UK
Lancet 364:1667-77. 2004..Most trials have been too small to produce adequate evidence to inform policy. We aimed to measure the effects of different approaches to assessment and management of older people...
- Peripheral arterial compliance differs between races: comparison among Asian, Afro-Caribbeans, and white Caucasians with type 2 diabetesElisabete S Pinto
Diabetes Care 28:496. 2005
- Repeatability of non-invasive measurement of intracerebral pulse wave velocity using transcranial DopplerSarah Gladdish
Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Clin Sci (Lond) 108:433-9. 2005..The between-observer repeatability of all measures was satisfactory. Owing to the less good repeatability on different occasions, the use of PWV-brain and PWV-ear will depend on the magnitude of differences to be expected...
- Ethnic differences in skin microvascular function and their relation to cardiac target-organ damageWilliam D Strain
International Centre for Circulatory Health, Faculty of Medicine, Imperial College London at St Mary s, London, UK
J Hypertens 23:133-40. 2005..People of Black African descent have increased risks of vascular target-organ damage not explained by greater blood pressures...
- Enhanced external counterpulsation does not alter arterial stiffness in patients with anginaFrances Dockery
Section of Geriatric Medicine, Imperial College, Hammersmith Hospital, London, UK
Clin Cardiol 27:689-92. 2004..However, the mechanism of the sustained clinical benefit seen with this therapy is not known...