Emma J Birks

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis
    Martin E Cullen
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield, Middlesex, UB9 6JH, UK
    Circulation 114:I16-20. 2006
  2. ncbi request reprint Bridge to transplantation with a left ventricular assist device for systemic ventricular failure after Mustard procedure
    Robert S George
    Department of Transplantation and Mechanical Circulatory, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, United Kingdom
    Ann Thorac Surg 83:306-8. 2007
  3. ncbi request reprint Transplantation using hearts from primary pulmonary hypertensive donors for recipients with a high pulmonary vascular resistance
    Emma J Birks
    Royal Brompton and Harefield Hospital, Harefield, Middlesex, England UK
    J Heart Lung Transplant 23:1339-44. 2004
  4. ncbi request reprint Incidence and clinical management of life-threatening left ventricular assist device failure
    E J Birks
    Department of Transplantation and Heart Science Centre, Royal Brompton and Harefield Hospital, Harefield, Middlesex, UK
    J Heart Lung Transplant 23:964-9. 2004
  5. ncbi request reprint The role of bridge to transplantation: should LVAD patients be transplanted?
    Emma J Birks
    Transplant Unit, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UK
    Curr Opin Cardiol 19:148-53. 2004
  6. ncbi request reprint Hemodynamic and echocardiographic responses to acute interruption of left ventricular assist device support: relevance to assessment of myocardial recovery
    Robert S George
    Royal Brompton and Harefield NHS Trust, Harefield Hospital, Uxbridge, Middlesex, UK
    J Heart Lung Transplant 26:967-73. 2007
  7. doi request reprint Quality of life after removal of left ventricular assist device for myocardial recovery
    Robert S George
    Royal Brompton and Harefield NHS Trust, Magdi Yacoub Institute, Harefield Hospital, Harefield, Middlesex, UK
    J Heart Lung Transplant 27:165-72. 2008
  8. ncbi request reprint Left ventricular assist device and drug therapy for the reversal of heart failure
    Emma J Birks
    Royal Brompton and Harefield National Health Service Trust, Harefield, Middlesex, United Kingdom
    N Engl J Med 355:1873-84. 2006
  9. doi request reprint Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression
    Leanne Elizabeth Felkin
    Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
    J Cardiovasc Transl Res 4:321-31. 2011
  10. ncbi request reprint Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices
    Emma J Birks
    Heart Science Centre, Royal Brompton and Harefield Hospital, Harefield, Middlesex, United Kingdom
    J Heart Lung Transplant 23:228-35. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis
    Martin E Cullen
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield, Middlesex, UB9 6JH, UK
    Circulation 114:I16-20. 2006
    ..The aim of this study was to evaluate the expression and role of AGAT expression in heart failure and recovery...
  2. ncbi request reprint Bridge to transplantation with a left ventricular assist device for systemic ventricular failure after Mustard procedure
    Robert S George
    Department of Transplantation and Mechanical Circulatory, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, United Kingdom
    Ann Thorac Surg 83:306-8. 2007
    ..The specific problems are discussed and a management scheme is proposed...
  3. ncbi request reprint Transplantation using hearts from primary pulmonary hypertensive donors for recipients with a high pulmonary vascular resistance
    Emma J Birks
    Royal Brompton and Harefield Hospital, Harefield, Middlesex, England UK
    J Heart Lung Transplant 23:1339-44. 2004
    ....
  4. ncbi request reprint Incidence and clinical management of life-threatening left ventricular assist device failure
    E J Birks
    Department of Transplantation and Heart Science Centre, Royal Brompton and Harefield Hospital, Harefield, Middlesex, UK
    J Heart Lung Transplant 23:964-9. 2004
    ..However, its incidence and clinical management have not been widely studied...
  5. ncbi request reprint The role of bridge to transplantation: should LVAD patients be transplanted?
    Emma J Birks
    Transplant Unit, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UK
    Curr Opin Cardiol 19:148-53. 2004
    ..We address whether these patients should be transplanted, if so, with what priority, and when and if they are not transplanted, what are the alternatives?..
  6. ncbi request reprint Hemodynamic and echocardiographic responses to acute interruption of left ventricular assist device support: relevance to assessment of myocardial recovery
    Robert S George
    Royal Brompton and Harefield NHS Trust, Harefield Hospital, Uxbridge, Middlesex, UK
    J Heart Lung Transplant 26:967-73. 2007
    ..We developed a test involving short-term interruption of LVAD support with measurements of several hemodynamic and echocardiographic parameters at rest and, whenever possible, after exercise, to investigate inotropic reserve...
  7. doi request reprint Quality of life after removal of left ventricular assist device for myocardial recovery
    Robert S George
    Royal Brompton and Harefield NHS Trust, Magdi Yacoub Institute, Harefield Hospital, Harefield, Middlesex, UK
    J Heart Lung Transplant 27:165-72. 2008
    ..This study evaluates the QOL of those patients and compares them to bridge-to-transplant (BTT) and transplanted (Tx) patients...
  8. ncbi request reprint Left ventricular assist device and drug therapy for the reversal of heart failure
    Emma J Birks
    Royal Brompton and Harefield National Health Service Trust, Harefield, Middlesex, United Kingdom
    N Engl J Med 355:1873-84. 2006
    ..Increasing the frequency and durability of myocardial recovery could reduce or postpone the need for subsequent heart transplantation...
  9. doi request reprint Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression
    Leanne Elizabeth Felkin
    Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
    J Cardiovasc Transl Res 4:321-31. 2011
    ..Modulation of Gi╬▒2, EPAC2, RGS4 and SFRP1 indicates that inhibition of cAMP signalling may potentiate recovery prior to treatment whilst enhanced cAMP and Wnt signalling may underlie recovery during LVAD support...
  10. ncbi request reprint Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices
    Emma J Birks
    Heart Science Centre, Royal Brompton and Harefield Hospital, Harefield, Middlesex, United Kingdom
    J Heart Lung Transplant 23:228-35. 2004
    ..We hypothesized the innate immune system is activated with expression of Toll-like receptor 4 (TLR4), leading to cytokine activation in these patients...
  11. ncbi request reprint A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support
    Leanne E Felkin
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield, Middlesex
    J Heart Lung Transplant 25:1413-9. 2006
    ..Matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) play a key role in myocardial remodelling and heart failure. We hypothesized that MMP and TIMP expression would be altered in these patients...
  12. doi request reprint Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study
    Emma J Birks
    Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, UK
    Circulation 123:381-90. 2011
    ..However, this protocol has not been used with nonpulsatile devices...
  13. ncbi request reprint Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support
    Emma J Birks
    Royal Brompton and Harefield Hospital NHS Trust, Harefield, Middlesex, UB9 6JH, UK
    Circulation 112:I57-64. 2005
    ..The exact molecular mechanisms involved in myocardial recovery remain unknown. Cytoskeletal proteins are essential for the structure and function of the cardiac myocyte and might play a major role...
  14. doi request reprint Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support
    Leanne E Felkin
    Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
    J Heart Lung Transplant 28:117-22. 2009
    ....
  15. ncbi request reprint Changes in sarcomeric and non-sarcomeric cytoskeletal proteins and focal adhesion molecules during clinical myocardial recovery after left ventricular assist device support
    Najma Latif
    Imperial College London, National Heart and Lung Institute, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, UK
    J Heart Lung Transplant 26:230-5. 2007
    ..However, a detailed protein analysis of their role in recovery has not been performed previously...
  16. ncbi request reprint Midterm experience with the Jarvik 2000 axial flow left ventricular assist device
    Saleem Haj-Yahia
    Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield Hospital, London, UK
    J Thorac Cardiovasc Surg 134:199-203. 2007
    ..Rotary axial flow pumps have several potential advantages and disadvantages over pulsatile pumps. The Jarvik 2000 is distinctive in being intracardiac. We report our experience in 22 patients...
  17. doi request reprint Bridge to decision using the Levitronix CentriMag short-term ventricular assist device
    Fabio De Robertis
    Department of Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UK
    J Heart Lung Transplant 27:474-8. 2008
    ..We report our experience with the Levitronix CentriMag short-term ventricular assist device as a potential bridge prior to deciding whether a more expensive device should be used or whether transplantation should be undertaken...
  18. ncbi request reprint C34T AMP deaminase 1 gene mutation protects cardiac function in donors
    Magdi H Yacoub
    Heart Science Centre, Imperial College at Harefield Hospital, Harefield, Middx UB9 6JH, UK
    Transplantation 77:1621-3. 2004
    ..8%) was not different from that of a control population. The presence of the C34T mutation in AMPD1 gene appears to be protective against acute heart failure in cardiac donors...
  19. ncbi request reprint In vitro endothelial cell activation and inflammatory responses in end-stage heart failure
    Ginette S Hoare
    Imperial College London, Heart Science Centre, Royal Brompton and Harefield Hospital, Harefield, Middlesex UB9 6JH, UK
    J Appl Physiol 101:1466-73. 2006
    ..Aim: to determine whether the serum from patients with heart failure possesses a net proinflammatory bioactivity to active proinflammatory pathways in cultured endothelial cells...
  20. ncbi request reprint Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure
    Paul J R Barton
    Heart Science Centre, Royal Brompton and Harefield Hospital, Harefield, Middlesex, United Kingdom
    J Heart Lung Transplant 22:738-44. 2003
    ..We hypothesized that matrix metalloproteinases (MMPs) and their endogenous inhibitors, the tissue inhibitors of MMPs (TIMPs), would be implicated in the mechanisms that underlie deteriorating heart failure...
  21. doi request reprint Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy
    Emma J Birks
    Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield Hospital, Harefield, UK
    Cardiovasc Res 79:472-80. 2008
    ..Here, we examined whether elevated expression of p53 was associated with dysregulation of ubiquitin-proteasome system (UPS) components and activation of downstream effectors of apoptosis in human dilated cardiomyopathy (DCM)...
  22. ncbi request reprint Minimally invasive technique for explantation of right ventricular assist devices
    Saleem M Haj-Yahia
    Royal Brompton and Harefield Hospital, Harefield, London, United Kingdom
    Ann Thorac Surg 82:1547-8. 2006
    ....
  23. ncbi request reprint Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema
    A J Edgar
    Department of Histochemistry, Division of Investigative Sciences, Imperial College School of Medicine, 3rd Floor Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Am J Respir Cell Mol Biol 25:119-24. 2001
    ..The human mRNA has a single 1.3-kb transcript. We suggest that the increased expression of DEXI in emphysema may either be relevant to disease progression or be indicative of glucocorticoid responsiveness in treated patients...
  24. ncbi request reprint Acinetobacter mediastinitis in a heart transplant patient
    Robert S George
    Department of Artificial Heart and Transplant, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, United Kingdom
    Ann Thorac Surg 82:715-6. 2006
    ..This was followed by a total sternectomy, pectoralis flap debridement, and vacuum-assisted dressing...
  25. ncbi request reprint Heart transplantation from live donors: "domino procedure"
    Asghar Khaghani
    Transplant Unit, Royal Brompton and Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom
    J Heart Lung Transplant 23:S257-9. 2004
  26. ncbi request reprint Levitronix as a short-term salvage treatment for primary graft failure after heart transplantation
    Gianluca Santise
    Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UK
    J Heart Lung Transplant 25:495-8. 2006
    ..In these difficult cases a ventricular assist device (VAD) as a bridge to recovery or as a bridge to re-transplantation can be used. The recently introduced Levitronix Centrimag centrifugal pump might be an ideal device for this purpose...
  27. ncbi request reprint Decreased cardiac activity of AMP deaminase in subjects with the AMPD1 mutation--a potential mechanism of protection in heart failure
    Kameljit K Kalsi
    Heart Science Centre, Imperial College at Harefield Hospital, Harefield, Middlesex UB9 6JH, UK
    Cardiovasc Res 59:678-84. 2003
    ..In the present study we evaluated the effect of the C34T mutation on cardiac AMP-deaminase activity and on the systemic changes in adenosine production...
  28. ncbi request reprint Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy
    Cesare M N Terracciano
    Imperial College London, National Heart and Lung Institute, Heart Science Centre, Harefield, UK
    Eur Heart J 24:1329-39. 2003
    ..This study defines changes in Ca handling at the cellular level in failing left ventricular tissue taken at LVAD implant (LVAD core) and LVAD removal (post-LVAD)...
  29. ncbi request reprint Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy
    C M N Terracciano
    Cellular Electrophysiology, Imperial College London, NHLI, Harefield Heart Science Centre, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK
    Circulation 109:2263-5. 2004
    ..Left ventricular assist device (LVAD) treatment is known to lead to structural and functional cellular modifications in the heart. The relevance of these changes for clinical recovery is unknown...
  30. ncbi request reprint Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices
    E J Birks
    National Heart and Lung Institute at Imperial College School of Medicine, Royal Brompton and Harefield Hospital, Harefield, Middlesex
    Circulation 104:I233-40. 2001
    ..These occurrences may have therapeutic implications and influence the timing of LVAD insertion...
  31. doi request reprint Left ventricular assist devices
    E J Birks
    Royal Brompton and Harefield NHS Trust, Harefield, Middlesex UB9 6JH, UK
    Heart 96:63-71. 2010
    ..LVAD technology is evolving quickly, survival is improving, the incidence of complications is decreasing and durability of the devices is improving...
  32. ncbi request reprint Clinical performance with the Levitronix Centrimag short-term ventricular assist device
    F De Robertis
    Department of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UK
    J Heart Lung Transplant 25:181-6. 2006
    ..The aim of this study is to report our early results with the Levitronix Centrimag device...
  33. ncbi request reprint Evaluation of the clinical effectiveness of the Ventricular Assist Device Program in the United Kingdom (EVAD UK)
    Linda D Sharples
    Papworth Hospital NHS Trust, Research and Development, Cambridge, UK
    J Heart Lung Transplant 26:9-15. 2007
    ..The UK Government funds ventricular assist device (VAD) implantation as bridge to transplantation (BTT) at three centers. Results from this program have not been published...
  34. ncbi request reprint Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy
    Paul J R Barton
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, London, UK
    Circulation 112:I46-50. 2005
    ..We recently found that clenbuterol induces insulin-like growth factor I (IGF-I) in cardiac myocytes in vitro. The purpose of this study is to examine IGF-I expression in recovery patients after combination therapy...
  35. ncbi request reprint Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure
    Pamela M Taylor-Harris
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London SE1 1UL, UK
    Mamm Genome 16:137-51. 2005
    ..We speculate that over the repetitive cycles of heart muscle contraction and relaxation, 4.1s are likely to locate, support, and coordinate functioning of key membrane-bound macromolecular assemblies...
  36. ncbi request reprint Images in cardiovascular medicine. Temporal and spatial changes in left ventricular pattern of flow during continuous assist device "HeartMate II"
    Michael Henein
    Royal Brompton and Harefield Trust and Imperial College School of Science, Technology and Medicine, London, UK
    Circulation 105:2324-5. 2002
  37. ncbi request reprint Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy
    Jennifer L Hall
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Mayo Mail Code 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Eur Heart J 28:613-27. 2007
    ..The aim of this study was to identify common genes and signalling pathways whose expression was associated with reversal of heart failure and restoration of ventricular function...