Pankaj K Bhavsar

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Impaired macrophage phagocytosis of bacteria in severe asthma
    Zhike Liang
    Airway Disease, National Heart and Lung Institute, Imperial College London, and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London SW3, UK
    Respir Res 15:72. 2014
  2. doi request reprint Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB
    Pankaj K Bhavsar
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, UK
    FASEB J 22:1807-16. 2008
  3. pmc Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma
    Po Jui Chang
    Airway Disease, National Heart and Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton NHS Foundation Trust, London, United Kingdom
    J Allergy Clin Immunol 130:877-85.e5. 2012
  4. doi request reprint Sputum-to-serum hydrogen sulfide ratio in COPD
    Junpei Saito
    Section of Experimental Studies, National Heart and Lung Institute, Imperial College London, London, UK NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, UK Department of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan
    Thorax 69:903-9. 2014
  5. doi request reprint Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control
    Junpei Saito
    National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Eur Respir J 43:474-84. 2014
  6. pmc Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, London SW3 6LY, United Kingdom
    J Immunol 192:4913-20. 2014
  7. doi request reprint EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD
    Stephane Jouneau
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London Royal Brompton Hospital, London, UK
    Respirology 16:705-12. 2011
  8. doi request reprint Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma
    Chun Yu Lo
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom NIHR Respiratory Biomedical Research Unit, Royal Brompton NHS Foundation Trust, London, United Kingdom Department of Thoracic Medicine, Chang Gung Medical Foundation, Chang Gung University College of Medicine, Taipei, Taiwan
    J Allergy Clin Immunol 135:1186-95.e1-6. 2015
  9. pmc Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD
    Nadia Khorasani
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust Hospital, London, UK
    Int J Chron Obstruct Pulmon Dis 10:283-91. 2015
  10. pmc TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 300:L295-304. 2011

Collaborators

Detail Information

Publications13

  1. pmc Impaired macrophage phagocytosis of bacteria in severe asthma
    Zhike Liang
    Airway Disease, National Heart and Lung Institute, Imperial College London, and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London SW3, UK
    Respir Res 15:72. 2014
    ..Bacteria are frequently cultured from sputum samples of severe asthma patients suggesting a defect in bacterial clearance from the airway. We measured the capacity of macrophages from patients with asthma to phagocytose bacteria...
  2. doi request reprint Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB
    Pankaj K Bhavsar
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, UK
    FASEB J 22:1807-16. 2008
    ..This study also provides support for the action of glucocorticoids mediating their suppressive effects on expression by interfering with the binding of transcriptional activators at native gene promoters...
  3. pmc Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma
    Po Jui Chang
    Airway Disease, National Heart and Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton NHS Foundation Trust, London, United Kingdom
    J Allergy Clin Immunol 130:877-85.e5. 2012
    ..Patients with severe asthma are less responsive to the beneficial effects of corticosteroid therapy...
  4. doi request reprint Sputum-to-serum hydrogen sulfide ratio in COPD
    Junpei Saito
    Section of Experimental Studies, National Heart and Lung Institute, Imperial College London, London, UK NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, UK Department of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan
    Thorax 69:903-9. 2014
    ..We evaluated whether H₂S levels in serum or sputum could represent a new biomarker of COPD in a cross-sectional study...
  5. doi request reprint Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control
    Junpei Saito
    National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Eur Respir J 43:474-84. 2014
    ..91, 95% CI 0.86-0.97; p<0.001). Diurnal variation in FeNO can be used as a biomarker of asthma control and as a predictor of the risk of future exacerbation. Prospective studies are warranted...
  6. pmc Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, London SW3 6LY, United Kingdom
    J Immunol 192:4913-20. 2014
    ....
  7. doi request reprint EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD
    Stephane Jouneau
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London Royal Brompton Hospital, London, UK
    Respirology 16:705-12. 2011
    ..We determined its cellular origin and role in MMP-9 production in COPD...
  8. doi request reprint Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma
    Chun Yu Lo
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom NIHR Respiratory Biomedical Research Unit, Royal Brompton NHS Foundation Trust, London, United Kingdom Department of Thoracic Medicine, Chang Gung Medical Foundation, Chang Gung University College of Medicine, Taipei, Taiwan
    J Allergy Clin Immunol 135:1186-95.e1-6. 2015
    ..The mesenchymal progenitors, fibrocytes, may be involved in the remodeling of asthmatic airways. We propose that fibrocytes in severe asthma are different from those in nonsevere asthma...
  9. pmc Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD
    Nadia Khorasani
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust Hospital, London, UK
    Int J Chron Obstruct Pulmon Dis 10:283-91. 2015
    ..We investigated whether p38 MAPK inhibition can modulate CS insensitivity of peripheral blood mononuclear cells (PBMCs) from patients with COPD...
  10. pmc TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 300:L295-304. 2011
    ..Knockdown of Nox4 using small interfering RNA partially prevented the inhibition of MnSOD but had no effect on catalase and IL-6 expression. These findings provide novel insights into redox regulation of ASM function by TGF-β...
  11. pmc A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children
    Aristea Binia
    Molecular Genetics and Genomics Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Hum Mutat 34:1131-9. 2013
    ..Our association between a variant MYB binding site in PDCD4 and the severest form of childhood asthma therefore suggests that PDCD4 is a novel molecule of importance to asthmatic inflammatory responses. ..
  12. pmc Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma
    Pankaj K Bhavsar
    Experimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London and Royal Brompton NHS Trust, London, UK
    Respir Res 11:71. 2010
    ..We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids...
  13. pmc Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells
    Shaoping Xie
    Experimental Studies, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 6:148. 2005
    ..We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases...