Genomes and Genes
Organization: Imperial College
- A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammationRobert J Snelgrove
Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Lung Health Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Science 330:90-4. 2010..These studies imply that therapeutic strategies inhibiting LTA(4)H to prevent LTB(4) generation may not reduce neutrophil recruitment because of elevated levels of PGP...
- Are rapid access cardiology clinics a valued part of a district cardiology service?Kevin F Fox
Department of Cardiology, Charing Cross Hospital, London W6 8RF, UK
Int J Cardiol 137:42-6. 2009..Previous data have shown the effectiveness of this service in diagnosing and risk stratifying patients with suspected cardiac disease. We evaluated Primary Care and Patient views on this service...
- HIV-1 transmission, by stage of infectionT Deirdre Hollingsworth
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
J Infect Dis 198:687-93. 2008....
- High-speed optical observations and simulation results of SonoVue microbubbles at low-pressure insonationKevin Chetty
Imaging Sciences Department, Imperial College, London, United Kingdom
IEEE Trans Ultrason Ferroelectr Freq Control 55:1333-42. 2008..Microbubble oscillations were modeled more successfully by incorporating a varying elasticity term into the model...
- Interactions between APP secretases and inflammatory mediatorsMagdalena Sastre
Division of Neuroscience and Mental Health, Imperial College London, The Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
J Neuroinflammation 5:25. 2008..In this review we will discuss some of these issues and the role of the secretases in inflammation, independent of their effect on Abeta formation...
- A method of controlled closure: the use of Ligaclips in the delayed primary closure of flapsAlexander James Hills
Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Singapore, Singapore
J Plast Reconstr Aesthet Surg 62:e322-4. 2009....
- Dimethylamine and dietS C Mitchell
Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, South Kensington, London, UK
Food Chem Toxicol 46:1734-8. 2008..Freshwater trout, plaice and prawns gave no discernable effect. It seems that not all fish and seafoods may be treated equally with regards to human dimethylamine exposure and that the situation is more complicated than at first appears...
- Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiologyRobert Dickinson
Blackett Laboratory, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
Anesthesiology 107:756-67. 2007..However, the site of action of these agents on the NMDA receptor is unknown. The authors show that xenon and isoflurane compete for the binding of the coagonist glycine on the NMDA receptor NR1 subunit...
- Artificial neural networks: useful aid in diagnosing acute appendicitisS G Prabhudesai
Department of Biosurgery and Surgical Technology, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, Room 1029, 10th Floor QEQM Building, Praed Street, London, W2 1NY, UK
World J Surg 32:305-9; discussion 310-1. 2008....
- Does retrograde diastolic flow in the descending aorta signify impaired systemic perfusion in preterm infants?Alan M Groves
Neonatal Unit, Queen Charlotte s and Chelsea Hospital, London, W12 0HS, United Kingdom
Pediatr Res 63:89-94. 2008..Retrograde DAo flow is a marker of high-volume shunt, evidenced by increased LVO. Preterm infants with high-volume ductal shunt may have preserved upper body perfusion but reduced lower body perfusion...
- Generating new candidate genes for neonatal diabetes: functional and genetic studies of insulin secretion in type 2 diabetesGuy A Rutter
Department of Cell Biology, Division of Medicine, Imperial College London, London, UK
Endocr Dev 12:75-85. 2007..Here, I survey recent published data in this context...
- Prognostic significance of immune subset measurement in individuals with AIDS-associated Kaposi's sarcomaJustin Stebbing
Imperial College of Science, Medicine, and Technology, Department of Oncology, The Chelsea and Westminster Hospital, London, United Kingdom
J Clin Oncol 25:2230-5. 2007..Because immune subset measurement is often performed in HIV-positive individuals, we examined whether these were predictive of mortality independently of the prognostic index, or could predict time to progression of KS...
- World Transplant Congress. Boston, Massachusetts, USA, 22-27 July 2006P H Tan
John Radcliffe Hospital, Regional Vascular Unit, Nuffield Department of Surgery, Oxford University, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK
Expert Opin Biol Ther 6:1061-5. 2006..More importantly, it has highlighted the potentials of harnessing these new findings for future biological therapies in preventing rejection and inducing tolerance...
- Characterization of ac voltammetric reaction-diffusion dynamics: from patterns to physical parametersCostas A Anastassiou
Institute of Biomedical Engineering and Department of Bioengineering, Imperial College London, Prince Consort Road, SW7 2AZ, London, UK
Anal Chem 78:4383-9. 2006....
- Screening for tuberculosis infection prior to initiation of anti-TNF therapyAjit Lalvani
Tuberculosis Immunology Group, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
Autoimmun Rev 8:147-52. 2008..Therefore, a positive result to either an IGRA or TST, in addition to currently recommended clinical screening for risk factors for LTBI, should prompt consideration of preventive treatment of LTBI in this population...
- Reverse genetics screen identifies six proteins important for malaria development in the mosquitoAndrea Ecker
Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
Mol Microbiol 70:209-20. 2008....
- Role of HDAC2 in the pathophysiology of COPDPeter J Barnes
National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
Annu Rev Physiol 71:451-64. 2009..Antioxidants and inhibitors of nitric oxide synthesis may therefore restore corticosteroid sensitivity in COPD, but this can also be achieved by low concentrations of theophylline and curcumin, which act as HDAC activators...
- A novel approach to modelling counter-current chromatographyHacer Guzlek
Imperial College London, South Kensington Campus, London SW7 2AZ, UK
J Chromatogr A 1217:6230-40. 2010..Overall, this model proved to be a useful tool for parameter estimation and, most significantly, separation optimisation...
- The future of imaging: developing the tools for monitoring response to therapy in oncology: the 2009 Sir James MacKenzie Davidson Memorial lectureE O Aboagye
Comprehensive Cancer Imaging Centre at Imperial College, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK
Br J Radiol 83:814-22. 2010..This could fundamentally change the way medicine is practised in the next 5-10 years...
- Sexual risk among orphaned adolescents: is country-level HIV prevalence an important factor?Laura Robertson
Department of Infectious Disease Epidemiology, Imperial College London, London, UK
AIDS Care 22:927-38. 2010..This suggests that orphaned adolescent women are an important target group for HIV prevention and that efforts should be made to integrate prevention messages into existing support programmes for orphans and vulnerable children...
- Modelling sexual transmission of HIV: testing the assumptions, validating the predictionsRebecca F Baggaley
Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
Curr Opin HIV AIDS 5:269-76. 2010..To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact...
- The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideasR L Carhart-Harris
Neuropsychopharmacology Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
Brain 133:1265-83. 2010....
- Early in-hospital mortality following trainee doctors' first day at workMin Hua Jen
Dr Foster Unit at Imperial College, Department of Primary Care and Social Medicine, Imperial College London, London, United Kingdom
PLoS ONE 4:e7103. 2009..We investigate whether in-hospital mortality is higher in the week following the first Wednesday in August than in the previous week...
- Diffraction and coherence in breast ultrasound tomography: a study with a toroidal arrayF Simonetti
Department of Mechanical Engineering, Imperial College, London SW7 2AZ, United Kingdom
Med Phys 36:2955-65. 2009..The in vivo tests demonstrate that TDT can image the complex boundary of a cancer mass and suggest that it can reveal the anatomy of milk ducts and Cooper's ligaments...
- Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosisP Beirne
Dept of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK
Eur Respir J 34:1376-82. 2009..These findings, if they are corroborated by independent studies in other centres, have potential for clinical application and may generate novel insights into the modulation of immune profiles during disease evolution...
- Fluorescence lifetime optical projection tomographyJames McGinty
Department of Physics, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2BW, UK
J Biophotonics 1:390-4. 2008....
- Life on the edge: carnivore body size variation is all over the placeShai Meiri
NERC Centre for Population Biology, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK
Proc Biol Sci 276:1469-76. 2009....
- Microglial activation and amyloid deposition in mild cognitive impairment: a PET studyA Okello
Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK
Neurology 72:56-62. 2009..They are, therefore, a potential therapeutic target in both AD and its prodrome amnestic mild cognitive impairment (MCI)...
- Engagement and retention in specialist services for people with personality disorderM J Crawford
Department of Psychological Medicine, Faculty of Medicine, Imperial College London, UK
Acta Psychiatr Scand 119:304-11. 2009..To quantify levels of engagement and retention in specialist services for people with personality disorder (PD)...
- On using T2 to assess extrinsic magnetic field inhomogeneity effects on T2* measurements in myocardial siderosis in thalassemiaTaigang He
National Heart and Lung Institute, Imperial College London, London, UK
Magn Reson Med 61:501-6. 2009..89) between myocardial T(2)* and T(2) measurements, which indicates that the iron deposition is the dominant factor in determining these two relaxation values in this scenario...
- Does alpha+-thalassaemia protect against malaria?Geoffrey Pasvol
Wellcome Centre for Clinical Tropical Medicine, Imperial College London, London, United Kingdom
PLoS Med 3:e235. 2006
- Site-specific PEGylation of native disulfide bonds in therapeutic proteinsSunil Shaunak
Faculty of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
Nat Chem Biol 2:312-3. 2006..The yield of PEGylated protein is high, and tertiary structure and biological activity are retained...
- Effects of growth factors and receptor blockade on gastrointestinal cancerR J Playford
Gastroenterology Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, UK
Gut 53:1059-63. 2004..Similarly, peptide and non-peptide antagonists of growth factor receptors show great potential as novel antichemotherapy agents. However, their actual place in clinical practice has yet to be established...
- Interpreting posterior relative risk estimates in disease-mapping studiesSylvia Richardson
Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom
Environ Health Perspect 112:1016-25. 2004..5- to 2-fold). Larger (3-fold) excess risks are detected almost certainly using this rule, even when based on small expected counts, although the mean of the posterior distribution is typically smoothed to about half the true value...
- Treating to hypertension targetsA McKerracher
St Mary s Hospital, Praed Street, London W2 1NY, UK
Heart 90:iv33-5; discussion iv39-40. 2004..Some of these points might be translated into the more challenging setting of primary care...
- Water, water everywhere, and its remarkable chemistryJim Barber
Department of Biological Sciences, Wolfson Laboratories, Biochemistry Building, South Kensington Campus, Imperial College London, Exhibition Road, London SW7 2AZ, UK
Biochim Biophys Acta 1655:123-32. 2004..A structural basis for Jerry's model is now being revealed by X-ray crystallography...
- Plankton lattices and the role of chaos in plankton patchinessR M Hillary
RRAG, Department of Environmental Science and Technology, Imperial College, London SW7 2BP, United Kingdom
Phys Rev E Stat Nonlin Soft Matter Phys 69:031913. 2004..It is likely that this estimate of critical length may be reduced by a more exact interpretation of coupling in turbulent flows...
- Steroid sulphatase inhibitors for breast cancer therapyA Purohit
Endocrinology and Metabolic Medicine and Sterix Ltd, Faculty of Medicine, Imperial College, St Mary s Hospital, London W2 1NY, UK
J Steroid Biochem Mol Biol 86:423-32. 2003..Second generation inhibitors, such as 2-MeOE2bisMATE, which also inhibit the growth of ER- tumours should be active against a wide range of cancers...
- Drugs for the control of parasitic diseases: current status and development in schistosomiasisAlan Fenwick
Schistosomiasis Control Initiative, St Mary s Campus, Imperial College, Norfolk Place, London W2 1PG, UK
Trends Parasitol 19:509-15. 2003
- Carbohydrate microarrays - a new set of technologies at the frontiers of glycomicsTen Feizi
The MRC Glycosciences Laboratory, Imperial College London, Northwick Park and St Mark s Hospital campus, Watford Road, Harrow, Middlesex HA1 3UJ, UK
Curr Opin Struct Biol 13:637-45. 2003..New leads to biological pathways that involve carbohydrate-protein interactions and new therapeutic targets are among biomedically important outcomes anticipated from applications of carbohydrate microarrays...
- Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literatureLiisa Lauren
Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
Int J Epidemiol 32:862-76. 2003....
- Autonomic diseases: clinical features and laboratory evaluationChristopher J Mathias
Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
J Neurol Neurosurg Psychiatry 74:iii31-41. 2003
- Pulmonary mucus: Pediatric perspectiveDuncan F Rogers
Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, UK
Pediatr Pulmonol 36:178-88. 2003..A significant challenge to the therapeutic progression of these new compounds is effective delivery to the airways in children, with the research effort into development of new compounds matched by advances in inhaler design...
- Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapyCesare M N Terracciano
Imperial College London, National Heart and Lung Institute, Heart Science Centre, Harefield, UK
Eur Heart J 24:1329-39. 2003..This study defines changes in Ca handling at the cellular level in failing left ventricular tissue taken at LVAD implant (LVAD core) and LVAD removal (post-LVAD)...
- Genomic imprinting in gestational trophoblastic disease--a reviewR A Fisher
Division of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, UK
Placenta 24:S111-8. 2003..Investigation of these unusual BiCHM and isolation of the defective gene will lead to a greater understanding of the function of genomic imprinting in early development...
- Hemostatic risk factors and insulin sensitivity, regional body fat distribution, and the metabolic syndromeI F Godsland
Endocrinology, and Metabolic Medicine, Faculty of Medicine, Wynn Department of Metabolic Medicine, Division of Medicine, Imperial College London, London, United Kingdom W2 1NY
J Clin Endocrinol Metab 90:190-7. 2005..Associations with adiposity and liver enzyme activity suggest the involvement of hepatic fat deposition...
- Novel human in vitro system for evaluating antimycobacterial vaccinesBeate Kampmann
School of Child and Adolescent Health, Red Cross Children s Hospital, University of Cape Town, Republic of South Africa
Infect Immun 72:6401-7. 2004..It is therefore a useful new tool in studying the immunogenicity of newly developed vaccine candidates prior to large field trials assessing efficacy...
- Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 allelesJ C Davies
Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney St, London, SW3 6NP, UK
Eur Respir J 24:798-804. 2004....
- Mathematical models and lymphatic filariasis control: endpoints and optimal interventionsEdwin Michael
Department of Infectious Disease Epidemiology, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
Trends Parasitol 22:226-33. 2006....
- Heritability of left ventricular mass in a large cohort of twinsPankaj Sharma
Department of Clinical Neuroscience, Hammersmith Hospitals and Imperial College, London, UK
J Hypertens 24:321-4. 2006..We used a large prospective twin database in order to establish the heritability of left ventricular mass (LVM)...
- Melanopsin: another way of signaling lightStuart Peirson
Division of Neuroscience and Mental Health, Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Charing Cross Hospital, Imperial College London, London W6 8RF, United Kingdom
Neuron 49:331-9. 2006..This review discusses the signaling pathways that may underlie melanopsin-dependent phototransduction in native pRGCs, as well as the many exciting challenges ahead...
- The epidemiology of preterm labor--a global perspectivePhilip Steer
Department of Obstetrics and Gynecology, Faculty of Medicine, Imperial College London, UK
J Perinat Med 33:273-6. 2005..Without this, medical intervention tends to increase the rate of preterm birth without corresponding improvement in outcomes...
- Corticospinal excitability in patients with chronic low back painPaul H Strutton
Department of Musculoskeletal Surgery, Division of Surgery, Anaesthetics, and Intensive Care, Faculty of Medicine, Imperial College London, Charing Cross Campus, London, UK
J Spinal Disord Tech 18:420-4. 2005..This study was designed to investigate corticospinal excitability of lumbar muscles using transcranial magnetic stimulation (TMS) in patients with chronic low back pain and correlate this with self-rated measures of disability and pain...
- Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapyPaul J R Barton
National Heart and Lung Institute, Imperial College London, Heart Science Centre, London, UK
Circulation 112:I46-50. 2005..We recently found that clenbuterol induces insulin-like growth factor I (IGF-I) in cardiac myocytes in vitro. The purpose of this study is to examine IGF-I expression in recovery patients after combination therapy...
- Positron emission tomography in the quantification of cellular and biochemical responses to intrapulmonary particulatesHazel A Jones
Experimental Medicine and Toxicology, Imperial College London, Hammersmith Campus, London W12 0NN, UK
Toxicol Appl Pharmacol 207:230-6. 2005..The use of PET to monitor different inflammatory processes by repeated scanning of the same animal or individual is helping to identify key events in the fibrotic process...
- Positron emission tomography imaging of small animals in anticancer drug developmentEric O Aboagye
Molecular Therapy and PET Oncology Research Group, The Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Rm 242 MRC Cyclotron Building, London, W12 0NN, UK
Mol Imaging Biol 7:53-8. 2005..The potential and challenge of this technology as applied to anticancer drug development is discussed here...
- Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthmaMaria G Belvisi
Respiratory Pharmacology, Department of Cardiothoracic Surgery, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
J Pharmacol Exp Ther 314:568-74. 2005..Furthermore, ciclesonide possesses equivalent anti-inflammatory efficacy through pulmonary activation with a significantly improved safety profile in preclinical animal models compared with fluticasone...
- Trimethylaminuria (fish-odour syndrome) and oral malodourS C Mitchell
Biological Chemistry, Biomedical Sciences, Faculty of Medicine, Imperial College London, South Kensington, London, UK
Oral Dis 11:10-3. 2005..This article highlights this condition and draws attention to its potential role in the causation of recalcitrant oral malodour...
- NMR-based metabonomic approaches for evaluating physiological influences on biofluid compositionMary E Bollard
Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK
NMR Biomed 18:143-62. 2005..Thus metabonomic approaches based on information-rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues...
- Phenotypic variability in siblings with type III spinal muscular atrophyM M K Muqit
Division of Clinical Neurosciences and Psychological Medicine, Imperial College at Charing Cross Hospital, London, UK
J Neurol Neurosurg Psychiatry 75:1762-4. 2004..The findings are discussed in the light of recent observations in a mouse model of SMA...
- Endocrine cell lines from the placentaM H F Sullivan
Faculty of Medicine, Wolfson and Weston Research Centre for Family Health, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Mol Cell Endocrinol 228:103-19. 2004..Despite these difficulties, useful information has been obtained from the available cell-lines, regardless of whether they have arisen spontaneously, been transformed in vitro, or derived from cancers in vivo...
- Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38Andrew R Clark
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
FEBS Lett 546:37-44. 2003..This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38...
- INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMAKIAN CHUNG; Fiscal Year: 2005..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
- Modeling lymphatic filariasis transmission and eradication in Papua New GuineaEdwin Michael; Fiscal Year: 2010....
- Modeling lymphatic filariasis transmission and eradication in Papua New GuineaEdwin Michael; Fiscal Year: 2007....
- Gut Hormones/Other Circulatory Regulators of AppetiteStephen Bloom; Fiscal Year: 2006..Obesity produces over 6,000 excess deaths a week in the USA alone, yet there is no really effective treatment. This meeting is to advance the most promising approach to a safe practical therapy seen in the last 50 years. ..
- Allergies, Genetic Susceptibility and Adult Glioma RiskDominique Michaud; Fiscal Year: 2009..Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer. ..
- Allergies, Genetic Susceptibility and Adult Glioma RiskDominique Michaud; Fiscal Year: 2006..Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer. ..
- Dendrimer aminosaccharide drug to modulate inflammatory responses in shigellosisSunil Shaunak; Fiscal Year: 2007..This new drug will enable the effective combination of existing antimicrobial drug therapy with a new immuno-modulatory drug to substantially improve the treatment of this infection of global importance. ..
- METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWNHideaki Nagase; Fiscal Year: 1992....
- METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWNHideaki Nagase; Fiscal Year: 2002..The principal investigator also proposes to examine the role of cell surface TIMP-2 in this activation process. ..
- METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWNHideaki Nagase; Fiscal Year: 1993....
- MR of Heart Iron: T2*/T2 Calibration & ApplicationDudley Pennell; Fiscal Year: 2006..These centers are Philadelphia (USA), Cagliari (Italy), Athens (Greece), Nicosia (Cyprus), Mumbai (India) and Singapore. ..
- DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTESPhilip Ashton Rickardt; Fiscal Year: 2009..The research proposed will lead to improved in vaccination through the induction of potent T cell memory, a goal that up until now has remained elusive for many viruses and cancers. ..
- DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTESPhilip Ashton Rickardt; Fiscal Year: 2004..This application will help determine whether self-reactivity, that can sometimes lead to autoimmune disease, is an intrinsic property of the immune system which ensures immunological memory. ..
- 'ROLE OF SELF-PEPTIDES IN THE SELECTION OF T LYMPHOCYTESPhilip Ashton Rickardt; Fiscal Year: 2005..It is hoped that this study lead to a better understanding of how autoimmune disease can be prevented as well as facilitate our understanding of how antiviral immunity develops. ..