Imperial College

Summary

Organization: Imperial College
Country: UK

Top Publications

  1. pmc A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    Robert J Snelgrove
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Lung Health Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 330:90-4. 2010
  2. doi Are rapid access cardiology clinics a valued part of a district cardiology service?
    Kevin F Fox
    Department of Cardiology, Charing Cross Hospital, London W6 8RF, UK
    Int J Cardiol 137:42-6. 2009
  3. doi HIV-1 transmission, by stage of infection
    T Deirdre Hollingsworth
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Infect Dis 198:687-93. 2008
  4. doi High-speed optical observations and simulation results of SonoVue microbubbles at low-pressure insonation
    Kevin Chetty
    Imaging Sciences Department, Imperial College, London, United Kingdom
    IEEE Trans Ultrason Ferroelectr Freq Control 55:1333-42. 2008
  5. pmc Interactions between APP secretases and inflammatory mediators
    Magdalena Sastre
    Division of Neuroscience and Mental Health, Imperial College London, The Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Neuroinflammation 5:25. 2008
  6. doi A method of controlled closure: the use of Ligaclips in the delayed primary closure of flaps
    Alexander James Hills
    Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Singapore, Singapore
    J Plast Reconstr Aesthet Surg 62:e322-4. 2009
  7. doi Dimethylamine and diet
    S C Mitchell
    Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, South Kensington, London, UK
    Food Chem Toxicol 46:1734-8. 2008
  8. ncbi Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology
    Robert Dickinson
    Blackett Laboratory, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    Anesthesiology 107:756-67. 2007
  9. ncbi Artificial neural networks: useful aid in diagnosing acute appendicitis
    S G Prabhudesai
    Department of Biosurgery and Surgical Technology, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, Room 1029, 10th Floor QEQM Building, Praed Street, London, W2 1NY, UK
    World J Surg 32:305-9; discussion 310-1. 2008
  10. ncbi Does retrograde diastolic flow in the descending aorta signify impaired systemic perfusion in preterm infants?
    Alan M Groves
    Neonatal Unit, Queen Charlotte s and Chelsea Hospital, London, W12 0HS, United Kingdom
    Pediatr Res 63:89-94. 2008

Detail Information

Publications62

  1. pmc A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    Robert J Snelgrove
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Lung Health Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 330:90-4. 2010
    ..These studies imply that therapeutic strategies inhibiting LTA(4)H to prevent LTB(4) generation may not reduce neutrophil recruitment because of elevated levels of PGP...
  2. doi Are rapid access cardiology clinics a valued part of a district cardiology service?
    Kevin F Fox
    Department of Cardiology, Charing Cross Hospital, London W6 8RF, UK
    Int J Cardiol 137:42-6. 2009
    ..Previous data have shown the effectiveness of this service in diagnosing and risk stratifying patients with suspected cardiac disease. We evaluated Primary Care and Patient views on this service...
  3. doi HIV-1 transmission, by stage of infection
    T Deirdre Hollingsworth
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Infect Dis 198:687-93. 2008
    ....
  4. doi High-speed optical observations and simulation results of SonoVue microbubbles at low-pressure insonation
    Kevin Chetty
    Imaging Sciences Department, Imperial College, London, United Kingdom
    IEEE Trans Ultrason Ferroelectr Freq Control 55:1333-42. 2008
    ..Microbubble oscillations were modeled more successfully by incorporating a varying elasticity term into the model...
  5. pmc Interactions between APP secretases and inflammatory mediators
    Magdalena Sastre
    Division of Neuroscience and Mental Health, Imperial College London, The Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Neuroinflammation 5:25. 2008
    ..In this review we will discuss some of these issues and the role of the secretases in inflammation, independent of their effect on Abeta formation...
  6. doi A method of controlled closure: the use of Ligaclips in the delayed primary closure of flaps
    Alexander James Hills
    Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Singapore, Singapore
    J Plast Reconstr Aesthet Surg 62:e322-4. 2009
    ....
  7. doi Dimethylamine and diet
    S C Mitchell
    Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, South Kensington, London, UK
    Food Chem Toxicol 46:1734-8. 2008
    ..Freshwater trout, plaice and prawns gave no discernable effect. It seems that not all fish and seafoods may be treated equally with regards to human dimethylamine exposure and that the situation is more complicated than at first appears...
  8. ncbi Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology
    Robert Dickinson
    Blackett Laboratory, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    Anesthesiology 107:756-67. 2007
    ..However, the site of action of these agents on the NMDA receptor is unknown. The authors show that xenon and isoflurane compete for the binding of the coagonist glycine on the NMDA receptor NR1 subunit...
  9. ncbi Artificial neural networks: useful aid in diagnosing acute appendicitis
    S G Prabhudesai
    Department of Biosurgery and Surgical Technology, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, Room 1029, 10th Floor QEQM Building, Praed Street, London, W2 1NY, UK
    World J Surg 32:305-9; discussion 310-1. 2008
    ....
  10. ncbi Does retrograde diastolic flow in the descending aorta signify impaired systemic perfusion in preterm infants?
    Alan M Groves
    Neonatal Unit, Queen Charlotte s and Chelsea Hospital, London, W12 0HS, United Kingdom
    Pediatr Res 63:89-94. 2008
    ..Retrograde DAo flow is a marker of high-volume shunt, evidenced by increased LVO. Preterm infants with high-volume ductal shunt may have preserved upper body perfusion but reduced lower body perfusion...
  11. ncbi Generating new candidate genes for neonatal diabetes: functional and genetic studies of insulin secretion in type 2 diabetes
    Guy A Rutter
    Department of Cell Biology, Division of Medicine, Imperial College London, London, UK
    Endocr Dev 12:75-85. 2007
    ..Here, I survey recent published data in this context...
  12. ncbi Prognostic significance of immune subset measurement in individuals with AIDS-associated Kaposi's sarcoma
    Justin Stebbing
    Imperial College of Science, Medicine, and Technology, Department of Oncology, The Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 25:2230-5. 2007
    ..Because immune subset measurement is often performed in HIV-positive individuals, we examined whether these were predictive of mortality independently of the prognostic index, or could predict time to progression of KS...
  13. ncbi World Transplant Congress. Boston, Massachusetts, USA, 22-27 July 2006
    P H Tan
    John Radcliffe Hospital, Regional Vascular Unit, Nuffield Department of Surgery, Oxford University, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK
    Expert Opin Biol Ther 6:1061-5. 2006
    ..More importantly, it has highlighted the potentials of harnessing these new findings for future biological therapies in preventing rejection and inducing tolerance...
  14. ncbi Characterization of ac voltammetric reaction-diffusion dynamics: from patterns to physical parameters
    Costas A Anastassiou
    Institute of Biomedical Engineering and Department of Bioengineering, Imperial College London, Prince Consort Road, SW7 2AZ, London, UK
    Anal Chem 78:4383-9. 2006
    ....
  15. pmc Screening for tuberculosis infection prior to initiation of anti-TNF therapy
    Ajit Lalvani
    Tuberculosis Immunology Group, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Autoimmun Rev 8:147-52. 2008
    ..Therefore, a positive result to either an IGRA or TST, in addition to currently recommended clinical screening for risk factors for LTBI, should prompt consideration of preventive treatment of LTBI in this population...
  16. pmc Reverse genetics screen identifies six proteins important for malaria development in the mosquito
    Andrea Ecker
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 70:209-20. 2008
    ....
  17. doi Role of HDAC2 in the pathophysiology of COPD
    Peter J Barnes
    National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    Annu Rev Physiol 71:451-64. 2009
    ..Antioxidants and inhibitors of nitric oxide synthesis may therefore restore corticosteroid sensitivity in COPD, but this can also be achieved by low concentrations of theophylline and curcumin, which act as HDAC activators...
  18. doi A novel approach to modelling counter-current chromatography
    Hacer Guzlek
    Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Chromatogr A 1217:6230-40. 2010
    ..Overall, this model proved to be a useful tool for parameter estimation and, most significantly, separation optimisation...
  19. pmc The future of imaging: developing the tools for monitoring response to therapy in oncology: the 2009 Sir James MacKenzie Davidson Memorial lecture
    E O Aboagye
    Comprehensive Cancer Imaging Centre at Imperial College, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK
    Br J Radiol 83:814-22. 2010
    ..This could fundamentally change the way medicine is practised in the next 5-10 years...
  20. pmc Sexual risk among orphaned adolescents: is country-level HIV prevalence an important factor?
    Laura Robertson
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    AIDS Care 22:927-38. 2010
    ..This suggests that orphaned adolescent women are an important target group for HIV prevention and that efforts should be made to integrate prevention messages into existing support programmes for orphans and vulnerable children...
  21. pmc Modelling sexual transmission of HIV: testing the assumptions, validating the predictions
    Rebecca F Baggaley
    Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
    Curr Opin HIV AIDS 5:269-76. 2010
    ..To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact...
  22. pmc The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas
    R L Carhart-Harris
    Neuropsychopharmacology Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
    Brain 133:1265-83. 2010
    ....
  23. pmc Early in-hospital mortality following trainee doctors' first day at work
    Min Hua Jen
    Dr Foster Unit at Imperial College, Department of Primary Care and Social Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 4:e7103. 2009
    ..We investigate whether in-hospital mortality is higher in the week following the first Wednesday in August than in the previous week...
  24. ncbi Diffraction and coherence in breast ultrasound tomography: a study with a toroidal array
    F Simonetti
    Department of Mechanical Engineering, Imperial College, London SW7 2AZ, United Kingdom
    Med Phys 36:2955-65. 2009
    ..The in vivo tests demonstrate that TDT can image the complex boundary of a cancer mass and suggest that it can reveal the anatomy of milk ducts and Cooper's ligaments...
  25. doi Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis
    P Beirne
    Dept of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK
    Eur Respir J 34:1376-82. 2009
    ..These findings, if they are corroborated by independent studies in other centres, have potential for clinical application and may generate novel insights into the modulation of immune profiles during disease evolution...
  26. doi Fluorescence lifetime optical projection tomography
    James McGinty
    Department of Physics, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2BW, UK
    J Biophotonics 1:390-4. 2008
    ....
  27. pmc Life on the edge: carnivore body size variation is all over the place
    Shai Meiri
    NERC Centre for Population Biology, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK
    Proc Biol Sci 276:1469-76. 2009
    ....
  28. pmc Microglial activation and amyloid deposition in mild cognitive impairment: a PET study
    A Okello
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK
    Neurology 72:56-62. 2009
    ..They are, therefore, a potential therapeutic target in both AD and its prodrome amnestic mild cognitive impairment (MCI)...
  29. doi Engagement and retention in specialist services for people with personality disorder
    M J Crawford
    Department of Psychological Medicine, Faculty of Medicine, Imperial College London, UK
    Acta Psychiatr Scand 119:304-11. 2009
    ..To quantify levels of engagement and retention in specialist services for people with personality disorder (PD)...
  30. doi On using T2 to assess extrinsic magnetic field inhomogeneity effects on T2* measurements in myocardial siderosis in thalassemia
    Taigang He
    National Heart and Lung Institute, Imperial College London, London, UK
    Magn Reson Med 61:501-6. 2009
    ..89) between myocardial T(2)* and T(2) measurements, which indicates that the iron deposition is the dominant factor in determining these two relaxation values in this scenario...
  31. pmc Does alpha+-thalassaemia protect against malaria?
    Geoffrey Pasvol
    Wellcome Centre for Clinical Tropical Medicine, Imperial College London, London, United Kingdom
    PLoS Med 3:e235. 2006
  32. ncbi Site-specific PEGylation of native disulfide bonds in therapeutic proteins
    Sunil Shaunak
    Faculty of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Nat Chem Biol 2:312-3. 2006
    ..The yield of PEGylated protein is high, and tertiary structure and biological activity are retained...
  33. pmc Effects of growth factors and receptor blockade on gastrointestinal cancer
    R J Playford
    Gastroenterology Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Gut 53:1059-63. 2004
    ..Similarly, peptide and non-peptide antagonists of growth factor receptors show great potential as novel antichemotherapy agents. However, their actual place in clinical practice has yet to be established...
  34. pmc Interpreting posterior relative risk estimates in disease-mapping studies
    Sylvia Richardson
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom
    Environ Health Perspect 112:1016-25. 2004
    ..5- to 2-fold). Larger (3-fold) excess risks are detected almost certainly using this rule, even when based on small expected counts, although the mean of the posterior distribution is typically smoothed to about half the true value...
  35. pmc Treating to hypertension targets
    A McKerracher
    St Mary s Hospital, Praed Street, London W2 1NY, UK
    Heart 90:iv33-5; discussion iv39-40. 2004
    ..Some of these points might be translated into the more challenging setting of primary care...
  36. ncbi Water, water everywhere, and its remarkable chemistry
    Jim Barber
    Department of Biological Sciences, Wolfson Laboratories, Biochemistry Building, South Kensington Campus, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Biochim Biophys Acta 1655:123-32. 2004
    ..A structural basis for Jerry's model is now being revealed by X-ray crystallography...
  37. ncbi Plankton lattices and the role of chaos in plankton patchiness
    R M Hillary
    RRAG, Department of Environmental Science and Technology, Imperial College, London SW7 2BP, United Kingdom
    Phys Rev E Stat Nonlin Soft Matter Phys 69:031913. 2004
    ..It is likely that this estimate of critical length may be reduced by a more exact interpretation of coupling in turbulent flows...
  38. ncbi Steroid sulphatase inhibitors for breast cancer therapy
    A Purohit
    Endocrinology and Metabolic Medicine and Sterix Ltd, Faculty of Medicine, Imperial College, St Mary s Hospital, London W2 1NY, UK
    J Steroid Biochem Mol Biol 86:423-32. 2003
    ..Second generation inhibitors, such as 2-MeOE2bisMATE, which also inhibit the growth of ER- tumours should be active against a wide range of cancers...
  39. ncbi Drugs for the control of parasitic diseases: current status and development in schistosomiasis
    Alan Fenwick
    Schistosomiasis Control Initiative, St Mary s Campus, Imperial College, Norfolk Place, London W2 1PG, UK
    Trends Parasitol 19:509-15. 2003
  40. ncbi Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics
    Ten Feizi
    The MRC Glycosciences Laboratory, Imperial College London, Northwick Park and St Mark s Hospital campus, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Curr Opin Struct Biol 13:637-45. 2003
    ..New leads to biological pathways that involve carbohydrate-protein interactions and new therapeutic targets are among biomedically important outcomes anticipated from applications of carbohydrate microarrays...
  41. ncbi Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature
    Liisa Lauren
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 32:862-76. 2003
    ....
  42. pmc Autonomic diseases: clinical features and laboratory evaluation
    Christopher J Mathias
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 74:iii31-41. 2003
  43. ncbi Pulmonary mucus: Pediatric perspective
    Duncan F Rogers
    Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Pediatr Pulmonol 36:178-88. 2003
    ..A significant challenge to the therapeutic progression of these new compounds is effective delivery to the airways in children, with the research effort into development of new compounds matched by advances in inhaler design...
  44. ncbi Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy
    Cesare M N Terracciano
    Imperial College London, National Heart and Lung Institute, Heart Science Centre, Harefield, UK
    Eur Heart J 24:1329-39. 2003
    ..This study defines changes in Ca handling at the cellular level in failing left ventricular tissue taken at LVAD implant (LVAD core) and LVAD removal (post-LVAD)...
  45. ncbi Genomic imprinting in gestational trophoblastic disease--a review
    R A Fisher
    Division of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, UK
    Placenta 24:S111-8. 2003
    ..Investigation of these unusual BiCHM and isolation of the defective gene will lead to a greater understanding of the function of genomic imprinting in early development...
  46. ncbi Hemostatic risk factors and insulin sensitivity, regional body fat distribution, and the metabolic syndrome
    I F Godsland
    Endocrinology, and Metabolic Medicine, Faculty of Medicine, Wynn Department of Metabolic Medicine, Division of Medicine, Imperial College London, London, United Kingdom W2 1NY
    J Clin Endocrinol Metab 90:190-7. 2005
    ..Associations with adiposity and liver enzyme activity suggest the involvement of hepatic fat deposition...
  47. pmc Novel human in vitro system for evaluating antimycobacterial vaccines
    Beate Kampmann
    School of Child and Adolescent Health, Red Cross Children s Hospital, University of Cape Town, Republic of South Africa
    Infect Immun 72:6401-7. 2004
    ..It is therefore a useful new tool in studying the immunogenicity of newly developed vaccine candidates prior to large field trials assessing efficacy...
  48. ncbi Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 alleles
    J C Davies
    Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney St, London, SW3 6NP, UK
    Eur Respir J 24:798-804. 2004
    ....
  49. ncbi Mathematical models and lymphatic filariasis control: endpoints and optimal interventions
    Edwin Michael
    Department of Infectious Disease Epidemiology, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
    Trends Parasitol 22:226-33. 2006
    ....
  50. ncbi Heritability of left ventricular mass in a large cohort of twins
    Pankaj Sharma
    Department of Clinical Neuroscience, Hammersmith Hospitals and Imperial College, London, UK
    J Hypertens 24:321-4. 2006
    ..We used a large prospective twin database in order to establish the heritability of left ventricular mass (LVM)...
  51. ncbi Melanopsin: another way of signaling light
    Stuart Peirson
    Division of Neuroscience and Mental Health, Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Charing Cross Hospital, Imperial College London, London W6 8RF, United Kingdom
    Neuron 49:331-9. 2006
    ..This review discusses the signaling pathways that may underlie melanopsin-dependent phototransduction in native pRGCs, as well as the many exciting challenges ahead...
  52. ncbi The epidemiology of preterm labor--a global perspective
    Philip Steer
    Department of Obstetrics and Gynecology, Faculty of Medicine, Imperial College London, UK
    J Perinat Med 33:273-6. 2005
    ..Without this, medical intervention tends to increase the rate of preterm birth without corresponding improvement in outcomes...
  53. ncbi Corticospinal excitability in patients with chronic low back pain
    Paul H Strutton
    Department of Musculoskeletal Surgery, Division of Surgery, Anaesthetics, and Intensive Care, Faculty of Medicine, Imperial College London, Charing Cross Campus, London, UK
    J Spinal Disord Tech 18:420-4. 2005
    ..This study was designed to investigate corticospinal excitability of lumbar muscles using transcranial magnetic stimulation (TMS) in patients with chronic low back pain and correlate this with self-rated measures of disability and pain...
  54. ncbi Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy
    Paul J R Barton
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, London, UK
    Circulation 112:I46-50. 2005
    ..We recently found that clenbuterol induces insulin-like growth factor I (IGF-I) in cardiac myocytes in vitro. The purpose of this study is to examine IGF-I expression in recovery patients after combination therapy...
  55. ncbi Positron emission tomography in the quantification of cellular and biochemical responses to intrapulmonary particulates
    Hazel A Jones
    Experimental Medicine and Toxicology, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Toxicol Appl Pharmacol 207:230-6. 2005
    ..The use of PET to monitor different inflammatory processes by repeated scanning of the same animal or individual is helping to identify key events in the fibrotic process...
  56. ncbi Positron emission tomography imaging of small animals in anticancer drug development
    Eric O Aboagye
    Molecular Therapy and PET Oncology Research Group, The Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Rm 242 MRC Cyclotron Building, London, W12 0NN, UK
    Mol Imaging Biol 7:53-8. 2005
    ..The potential and challenge of this technology as applied to anticancer drug development is discussed here...
  57. ncbi Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma
    Maria G Belvisi
    Respiratory Pharmacology, Department of Cardiothoracic Surgery, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    J Pharmacol Exp Ther 314:568-74. 2005
    ..Furthermore, ciclesonide possesses equivalent anti-inflammatory efficacy through pulmonary activation with a significantly improved safety profile in preclinical animal models compared with fluticasone...
  58. ncbi Trimethylaminuria (fish-odour syndrome) and oral malodour
    S C Mitchell
    Biological Chemistry, Biomedical Sciences, Faculty of Medicine, Imperial College London, South Kensington, London, UK
    Oral Dis 11:10-3. 2005
    ..This article highlights this condition and draws attention to its potential role in the causation of recalcitrant oral malodour...
  59. ncbi NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
    Mary E Bollard
    Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK
    NMR Biomed 18:143-62. 2005
    ..Thus metabonomic approaches based on information-rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues...
  60. pmc Phenotypic variability in siblings with type III spinal muscular atrophy
    M M K Muqit
    Division of Clinical Neurosciences and Psychological Medicine, Imperial College at Charing Cross Hospital, London, UK
    J Neurol Neurosurg Psychiatry 75:1762-4. 2004
    ..The findings are discussed in the light of recent observations in a mouse model of SMA...
  61. ncbi Endocrine cell lines from the placenta
    M H F Sullivan
    Faculty of Medicine, Wolfson and Weston Research Centre for Family Health, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Mol Cell Endocrinol 228:103-19. 2004
    ..Despite these difficulties, useful information has been obtained from the available cell-lines, regardless of whether they have arisen spontaneously, been transformed in vitro, or derived from cancers in vivo...
  62. ncbi Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38
    Andrew R Clark
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    FEBS Lett 546:37-44. 2003
    ..This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38...

Research Grants52

  1. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  2. Modeling lymphatic filariasis transmission and eradication in Papua New Guinea
    Edwin Michael; Fiscal Year: 2010
    ....
  3. Modeling lymphatic filariasis transmission and eradication in Papua New Guinea
    Edwin Michael; Fiscal Year: 2007
    ....
  4. Gut Hormones/Other Circulatory Regulators of Appetite
    Stephen Bloom; Fiscal Year: 2006
    ..Obesity produces over 6,000 excess deaths a week in the USA alone, yet there is no really effective treatment. This meeting is to advance the most promising approach to a safe practical therapy seen in the last 50 years. ..
  5. Allergies, Genetic Susceptibility and Adult Glioma Risk
    Dominique Michaud; Fiscal Year: 2009
    ..Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer. ..
  6. Allergies, Genetic Susceptibility and Adult Glioma Risk
    Dominique Michaud; Fiscal Year: 2006
    ..Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer. ..
  7. Dendrimer aminosaccharide drug to modulate inflammatory responses in shigellosis
    Sunil Shaunak; Fiscal Year: 2007
    ..This new drug will enable the effective combination of existing antimicrobial drug therapy with a new immuno-modulatory drug to substantially improve the treatment of this infection of global importance. ..
  8. METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWN
    Hideaki Nagase; Fiscal Year: 1992
    ....
  9. METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWN
    Hideaki Nagase; Fiscal Year: 2002
    ..The principal investigator also proposes to examine the role of cell surface TIMP-2 in this activation process. ..
  10. METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWN
    Hideaki Nagase; Fiscal Year: 1993
    ....
  11. MR of Heart Iron: T2*/T2 Calibration & Application
    Dudley Pennell; Fiscal Year: 2006
    ..These centers are Philadelphia (USA), Cagliari (Italy), Athens (Greece), Nicosia (Cyprus), Mumbai (India) and Singapore. ..
  12. DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2009
    ..The research proposed will lead to improved in vaccination through the induction of potent T cell memory, a goal that up until now has remained elusive for many viruses and cancers. ..
  13. DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2004
    ..This application will help determine whether self-reactivity, that can sometimes lead to autoimmune disease, is an intrinsic property of the immune system which ensures immunological memory. ..
  14. 'ROLE OF SELF-PEPTIDES IN THE SELECTION OF T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2005
    ..It is hoped that this study lead to a better understanding of how autoimmune disease can be prevented as well as facilitate our understanding of how antiviral immunity develops. ..