Christopher J Hammond

Summary

Country: UK

Publications

  1. pmc A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins
    Christopher J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, and West Kent Eye Center, Princess Royal University Hospital, Orpington, United Kingdom
    Am J Hum Genet 75:294-304. 2004
  2. pmc Identification of a candidate gene for astigmatism
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:1260-7. 2013
  3. pmc Copy number variation at chromosome 5q21.2 is associated with intraocular pressure
    Abhishek Nag
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:3607-12. 2013
  4. pmc Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies
    Francis Carbonaro
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5115-9. 2009
  5. pmc The heritability of the ring-like distribution of macular pigment assessed in a twin study
    Ambreen Tariq
    Department of Ophthalmology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:2214-9. 2014
  6. pmc Cohort Profile: TwinsUK and healthy ageing twin study
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Int J Epidemiol 42:76-85. 2013
  7. pmc Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract
    Ekaterina Yonova-Doing
    Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom
    Ophthalmology 123:1237-44. 2016
  8. pmc Increasing Prevalence of Myopia in Europe and the Impact of Education
    Katie M Williams
    Department of Ophthalmology, King s College London, St Thomas Hospital, London, United Kingdom Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Ophthalmology 122:1489-97. 2015
  9. doi request reprint Common polymorphisms in the SERPINI2 gene are associated with refractive error in the 1958 British Birth Cohort
    Pirro G Hysi
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 53:440-7. 2012
  10. pmc A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25
    Pirro G Hysi
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Nat Genet 42:902-5. 2010

Collaborators

Detail Information

Publications34

  1. pmc A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins
    Christopher J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, and West Kent Eye Center, Princess Royal University Hospital, Orpington, United Kingdom
    Am J Hum Genet 75:294-304. 2004
    ....
  2. pmc Identification of a candidate gene for astigmatism
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:1260-7. 2013
    ..Twin studies of astigmatism have found approximately 60% of phenotypic variance is explained by genetic factors. This study aimed to identify susceptibility loci for astigmatism...
  3. pmc Copy number variation at chromosome 5q21.2 is associated with intraocular pressure
    Abhishek Nag
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:3607-12. 2013
    ..We hypothesized that copy number variants (CNVs) might influence part of the susceptibility to glaucoma or its related quantitative endophenotypes...
  4. pmc Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies
    Francis Carbonaro
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5115-9. 2009
    ..This was a cohort study in which 344 pairs of twins, 163 monozygotic (MZ) and 181 dizygotic (DZ), were enrolled...
  5. pmc The heritability of the ring-like distribution of macular pigment assessed in a twin study
    Ambreen Tariq
    Department of Ophthalmology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:2214-9. 2014
    ..We explored relative contributions of genetic and environmental factors in macular pigment optical density (MPOD) distributions using a classic twin study...
  6. pmc Cohort Profile: TwinsUK and healthy ageing twin study
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Int J Epidemiol 42:76-85. 2013
    ..Several collaborative projects in the field of epidemiology of complex disorders are ongoing in our cohort and interested researchers are encouraged to get in contact for future collaborations...
  7. pmc Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract
    Ekaterina Yonova-Doing
    Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom
    Ophthalmology 123:1237-44. 2016
    ..To determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract...
  8. pmc Increasing Prevalence of Myopia in Europe and the Impact of Education
    Katie M Williams
    Department of Ophthalmology, King s College London, St Thomas Hospital, London, United Kingdom Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Ophthalmology 122:1489-97. 2015
    ..To investigate whether myopia is becoming more common across Europe and explore whether increasing education levels, an important environmental risk factor for myopia, might explain any temporal trend...
  9. doi request reprint Common polymorphisms in the SERPINI2 gene are associated with refractive error in the 1958 British Birth Cohort
    Pirro G Hysi
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 53:440-7. 2012
    ..To identify heritable genetic factors altering susceptibility to refractive error in the general population...
  10. pmc A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25
    Pirro G Hysi
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Nat Genet 42:902-5. 2010
    ..001). The identification of a susceptibility locus for refractive error on 15q25 will be important in characterizing the molecular mechanism responsible for the most common cause of visual impairment...
  11. doi request reprint Estimating heritability and shared environmental effects for refractive error in twin and family studies
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:126-31. 2009
    ..This large twin study aimed to explore the role of shared environment in refractive error...
  12. doi request reprint Aging Trajectories in Different Body Systems Share Common Environmental Etiology: The Healthy Aging Twin Study (HATS)
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Twin Res Hum Genet 19:27-34. 2016
    ..Confirmatory studies are needed using population-based twin cohorts and alternative methods of handling missing data...
  13. pmc Prevalence of refractive error in Europe: the European Eye Epidemiology (E(3)) Consortium
    Katie M Williams
    Department of Ophthalmology, King s College London, St Thomas Hospital, London, UK
    Eur J Epidemiol 30:305-15. 2015
    ..The greatest burden of refractive error is due to myopia, with high prevalence rates in young adults. Using the 2010 European population estimates, we estimate there are 227.2 million people with myopia across Europe...
  14. pmc The relationship between retinal arteriolar and venular calibers is genetically mediated, and each is associated with risk of cardiovascular disease
    Samantha J Fahy
    Department of Twin Research and Genetic Epidemiology, King s College London, School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:975-81. 2011
    ..59) between these two traits and to assess the shared and specific influence of established and novel cardiovascular disease risk factors on them...
  15. pmc Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping
    Toby Andrew
    Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    PLoS Genet 4:e1000220. 2008
    ..That two mitochondrial regulatory processes in the retina are implicated in the aetiology of myopia is surprising and is likely to provide novel insight into the molecular genetic basis of common myopia...
  16. doi request reprint Predictors of Discordance between Symptoms and Signs in Dry Eye Disease
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Waterloo, London, United Kingdom Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands Department of Ophthalmology, King s College London, St Thomas Hospital, Waterloo, London, United Kingdom Electronic address
    Ophthalmology . 2016
    ..To investigate predictors of discordance between symptoms and signs in dry eye disease (DED)...
  17. doi request reprint Prevalence and risk factors of dry eye disease in a British female cohort
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    Br J Ophthalmol 98:1712-7. 2014
    ..To estimate the prevalence and risk factors of dry eye disease (DED) in a female cohort in the UK...
  18. pmc The heritability of dry eye disease in a female twin cohort
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:7278-83. 2014
    ..We estimated the relative importance of genes and environment in dry eye disease (DED) using a classic twin study...
  19. doi request reprint Twin studies in inherited eye disease
    Abhishek Nag
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Clin Experiment Ophthalmol 42:84-93. 2014
    ..Finally, we suggest other novel approaches that can be utilized to tap the potential of twin studies to provide a more complete understanding of genetic factors underlying ocular diseases...
  20. doi request reprint Relationship between dry eye symptoms and pain sensitivity
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Waterloo, London, England2Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    JAMA Ophthalmol 131:1304-8. 2013
    ..Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these symptoms and objective signs at the ocular surface...
  21. pmc The correlation between cognitive performance and retinal nerve fibre layer thickness is largely explained by genetic factors
    Eneh Jones-Odeh
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    Sci Rep 6:34116. 2016
    ..This sharing, however, was mostly due to additive genetic effects (67% and 92% of the shared variance respectively)...
  22. doi request reprint Changes in quality of life shortly after routine cataract surgery
    B Sanjeev Heemraz
    Department of Ophthalmology, St Thomas Hospital, London, United Kingdom
    Can J Ophthalmol 51:282-7. 2016
    ..Secondary analysis explored effects of gender and ethnicity...
  23. doi request reprint Evaluation of the Myocilin Mutation Gln368Stop Demonstrates Reduced Penetrance for Glaucoma in European Populations
    Abhishek Nag
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Ophthalmology . 2016
    ..The objective of this study was to evaluate the effect of this MYOC mutation on IOP using data from large-scale European population panels (directly sequenced and imputation based)...
  24. pmc Frequency and Distribution of Refractive Error in Adult Life: Methodology and Findings of the UK Biobank Study
    Phillippa M Cumberland
    Life Course Epidemiology and Biostatistics Section, University College London UCL Institute of Child Health, London, United Kingdom Ulverscroft Vision Research Group, UCL Institute of Child Health, London, United Kingdom
    PLoS ONE 10:e0139780. 2015
    ..To report the methodology and findings of a large scale investigation of burden and distribution of refractive error, from a contemporary and ethnically diverse study of health and disease in adults, in the UK...
  25. doi request reprint Clinical Characteristics of Dry Eye Patients With Chronic Pain Syndromes
    Jelle Vehof
    Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom Electronic address
    Am J Ophthalmol 162:59-65.e2. 2016
    ..To investigate clinical characteristics of dry eye disease (DED) patients with a chronic pain syndrome...
  26. doi request reprint High heritability of posterior corneal tomography, as measured by Scheimpflug imaging, in a twin study
    Omar A Mahroo
    Ophthalmology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:8359-64. 2014
    ..Anterior corneal curvature shows significant heritability. Scheimpflug imaging also permits assessment of posterior tomography. We estimated heritability of posterior and anterior tomographic parameters...
  27. pmc The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study
    Christopher J Hammond
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 53:4963-8. 2012
    ..This classic twin study was designed to determine the heritability of macular pigment (MP) augmentation in response to supplemental lutein (L) and zeaxanthin (Z)...
  28. doi request reprint Association Between Myopia, Ultraviolet B Radiation Exposure, Serum Vitamin D Concentrations, and Genetic Polymorphisms in Vitamin D Metabolic Pathways in a Multicountry European Study
    Katie M Williams
    Department of Ophthalmology, King s College London, London, United Kingdom2Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    JAMA Ophthalmol . 2016
    ..Myopia is becoming increasingly common globally and is associated with potentially sight-threatening complications. Spending time outdoors is protective, but the mechanism underlying this association is poorly understood...
  29. doi request reprint Cilioretinal Artery Territory Infarction Associated With Papilledema in a Patient With Neurofibromatosis Type 2
    Omar A Mahroo
    Department of Ophthalmology OAM, MDM, EMG, SM, GTP, CJH, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom Department of Ophthalmology OAM, CJH, King s College London, London, United Kingdom and Department of Neurology SA, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    J Neuroophthalmol 36:58-60. 2016
    ..Our case, together with one previous report, suggests that cilioretinal artery territory infarction in the context of papilledema, although rare, is a real entity. ..
  30. pmc Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhäuser syndrome and central corneal thickness
    Alice E Davidson
    UCL Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 9:e104163. 2014
    ..This study highlights the importance of including X-chromosome SNP data in GWAS to identify potential loci associated with quantitative traits or disease risk...
  31. doi request reprint Shared genetic factors underlie chronic pain syndromes
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    Pain 155:1562-8. 2014
    ..These results are evidence of shared genetic factors in conditions manifesting chronic pain and justify the search for underlying genetic variants. ..
  32. pmc The UK Adult Twin Registry (TwinsUK Resource)
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Twin Res Hum Genet 16:144-9. 2013
    ..The scientific community now can freely access parts of the phenotype data from the 'TwinsUK', and interested researchers are encouraged to contact us via our Web site (www.twinsuk.ac.uk) for future collaborations...
  33. ncbi request reprint Genetic dissection of myopia: evidence for linkage of ocular axial length to chromosome 5q
    Gu Zhu
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Ophthalmology 115:1053-1057.e2. 2008
    ..To estimate heritability and locate quantitative trait loci influencing axial length...
  34. ncbi request reprint Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia
    Marja Majava
    Collagen Research Unit, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
    Hum Mutat 28:336-44. 2007
    ..This study provides new insight into the genetics of high myopia, suggesting that sequence variations in the SLRP genes expressed in the eye may be among the genetic risk factors underlying the pathogenesis of high myopia...