Affiliation: Guy's Hospital
- Genetic variation in myosin IXB is associated with ulcerative colitisAdriaan A van Bodegraven
Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
Gastroenterology 131:1768-74. 2006..These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease...
- Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Jeremy Sanderson
Departments of Purine Research and Gastroenterology, Guy s and St Thomas Hospitals, London SE1 7EH, UK
Ann Clin Biochem 41:294-302. 2004..This article reviews literature on the role of TPMT measurement prior to treatment with thiopurines and provides some guidance to the use of TPMT as a guide to tailoring thiopurine therapy...
- Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and CaucasiansAnthony M Marinaki
Purine Research and Department of Gastroenterology, Guy s and St Thomas Hospital, London SE1 9RT, UK
Pharmacogenetics 13:97-105. 2003..Here we present the allele frequencies of genetic modifiers of TPMT activity in a British Asian population, as well as the concordance between intermediate TPMT activity and ORF and VNTR genotypes in a predominantly Caucasian population...
- The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel diseaseAndrew P Cuthbert
Division of Medical and Molecular Genetics, Guy s, King s, and St Thomas School of Medicine, London, England, United Kingdom
Gastroenterology 122:867-74. 2002....
- Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variantsPaul R Burton
Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
Nat Genet 39:1329-37. 2007....
- A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5Natalie J Prescott
Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
Gastroenterology 132:1665-71. 2007..We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis...
- IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel diseaseMark Tremelling
IBD Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
Gastroenterology 132:1657-64. 2007..We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15...
- Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British populationAlexandra V Pearce
Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Int J Colorectal Dis 22:419-24. 2007....
- Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis studyClive M Onnie
Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, UK
Inflamm Bowel Dis 12:263-71. 2006....
- Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD15Kathy King
Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London, United Kingdom
Hum Mutat 27:44-54. 2006..The strategy developed here may have general application to the assessment of mutation pathogenicity and genetic models in other complex disorders...
- Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn diseaseMuddassar M Mirza
Division of Medical and Molecular Genetics, Guy s, King s, and Thomas s School of Medicine, King s College London, Guy s Hospital, London, United Kingdom
Am J Hum Genet 72:1018-22. 2003..0019). These findings suggest that genetic variants at the 5q31 (IBD5) locus may hasten the onset of Crohn disease and cooperate with CARD15 in disease causation...
- Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's diseaseClive M Onnie
Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, London, UK
Eur J Gastroenterol Hepatol 20:37-45. 2008..We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD...