Organization: Guy's Hospital
- Clinical ultraviolet dosimetry with a CCD monochromator array spectroradiometerAndrew Coleman
Medical Physics Department, The Rayne Institute, Guy s and St Thomas NHS Foundation Trust, London SE1 7EH, UK
Phys Med Biol 53:5239-55. 2008....
- Multiple system atrophy presenting as central sleep apnoeaL J Cormican
Dept of Respiratory Medicine, St Thomas Hospital, London, UK
Eur Respir J 24:323-5. 2004..The current authors believe that multiple system atrophy should be considered in the differential diagnosis of late onset central sleep apnoea and progressive hypoventilation...
- Guidelines on the role of the specialist nurse in supporting patients with lung cancerSally Moore
c o Guy s and St Thomas Hospital NHS Trust, Palliative Care Department, Guy s Hospital, London, UK
Eur J Cancer Care (Engl) 13:344-8. 2004..Recommendations are based on Government guidelines, evidence from recent research studies and the experience of the members of the Forum...
- Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Jeremy Sanderson
Departments of Purine Research and Gastroenterology, Guy s and St Thomas Hospitals, London SE1 7EH, UK
Ann Clin Biochem 41:294-302. 2004..This article reviews literature on the role of TPMT measurement prior to treatment with thiopurines and provides some guidance to the use of TPMT as a guide to tailoring thiopurine therapy...
- Strategies for the rapid prenatal diagnosis of chromosome aneuploidyKathy Mann
Cytogenetics Department, Guy s and St Thomas Hospital Trust, London, UK
Eur J Hum Genet 12:907-15. 2004..Maternal cell contamination and mosaicism were also detected. Our data recommend a QF-PCR approach as the current method of choice for rapid aneuploidy testing...
- Identification of potential candidates for varicella vaccination by history: questionnaire and seroprevalence studyEithne MacMahon
Department of Infection, Guy s and St Thomas Hospital NHS Trust, London SE1 7EH
BMJ 329:551-2. 2004
- An Alu-mediated 31.5-kb deletion as the cause of factor XI deficiency in 2 unrelated patientsMichael Mitchell
Centre for Haemostasis and Thrombosis, The Haemophilia Reference Centre, 1st Floor North Wing, St Thomas Hospital, London SE1 7EH United Kingdom
Blood 104:2394-6. 2004..We report here the first confirmed whole gene deletion as the causative mutation of factor XI deficiency, the result of unequal homologous recombination between flanking Alu repeat sequences...
- Clinical findings in 111 ex-Porton Down volunteersH A Lee
Baird Health Centre, Gassiot House, St Thomas Hospital, London
J R Army Med Corps 150:14-9. 2004..To determine whether the health of Porton Down volunteers (PDV) has suffered as a result of their participation in medical trials, during which they were exposed to single low dose concentrations of chemical warfare agents...
- Drug metabolism and ageingM T Kinirons
Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College London, London, UK
Br J Clin Pharmacol 57:540-4. 2004..Finally, the concept of frailty is being underpinned by studies documenting a decline in drug metabolism and changes in disposition in frail older people compared with either healthy elderly or the young...
- Type 2 diabetes mellitus: a disease of the innate immune system? An updateM Crook
Clinical Biochemistry, University Hospital Lewisham, London, UK
Diabet Med 21:203-7. 2004..This article discusses these issues...
- Validation of a quantitative SPR assay for recombinant FVIIIA N McCormick
The Haemophilia Centre, St Thomas Hospital, London, UK
Clin Lab Haematol 26:57-64. 2004..The assay was found to be unsuitable for quantitation of plasma derived FVIII product but may prove useful for monitoring of rFVIII production...
- Hyperhomocysteinemia and B-vitamin status after discontinuation of oral anticoagulation therapy in patients with a history of venous thromboembolismAgata Sobczyńska-Malefora
The Haemophilia Reference Centre, Centre for Thrombosis and Haemostasis, St Thomas Hospital, London, UK
Clin Chem Lab Med 41:1493-7. 2003..On the basis of this study we suggest that homocysteine screening should be carried out at the time that patients begin warfarin therapy...
- Essential thrombocythemiaClaire N Harrison
Department of Haematology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Hematol Oncol Clin North Am 17:1175-90, vii. 2003..This article discusses diagnostic criteria, clinical features, prognosis, and management...
- Malignant sarcoma masquerading as a pseudotumour in a patient with mild haemophiliaPhillip Connor
Haemophilia Reference Centre, St Thomas Hospital, London, UK
Br J Haematol 123:191. 2003
- Making an IMPACT on emergency department flow: improving patient processing assisted by consultant at triageJ Terris
Emergency Department, St Thomas s Hospital, Lambeth Palace Road, London SE1 7EH, UK
Emerg Med J 21:537-41. 2004..To assess whether initial patient consult by senior clinicians reduces numbers of patients waiting to be seen as an indirect measure of waiting time throughout the emergency department (ED)...
- Vascular calcification: a stiff challenge for the nephrologist: does preventing bone disease cause arterial disease?David Goldsmith
Guy s Hospital, London, United Kingdom
Kidney Int 66:1315-33. 2004....
- Tuberculosis and HIV infection: minimising transmissionDiana Rayner
Guy s and St Thomas s Hospital NHS Trust, London
Nurs Stand 19:47-53; quiz 54. 2004..Tuberculosis and human immunodeficiency virus have developed as co-infections globally and are now affecting the UK. Nurses should be aware of the need to have effective infection control policies to manage this serious condition...
- Validation of the Omron M7 (HEM-780-E) oscillometric blood pressure monitoring device according to the British Hypertension Society protocolAndrew Coleman
Medical Physics Department, Guy s and St Thomas NHS Foundation Trust, London, UK
Blood Press Monit 13:49-54. 2008..The aim of this study was to validate the accuracy of this device according to the British Hypertension Society (BHS) and the Association for the Advancement of Medical Instrumentation (AAMI) SP10 validation criteria...
- Oral intake during laborGeraldine O'Sullivan
Department of Anesthetics, St Thomas Hospital, London, UK
Int Anesthesiol Clin 45:133-47. 2007
- Quality assurance guidelines for placement of gastroduodenal stentsT Sabharwal
Guy s and St Thomas Foundation Hospital NHS Trust, London, UK
Cardiovasc Intervent Radiol 30:1-5. 2007
- Hormone dependency of breast tumours developing in the Guernsey Cohort studyI S Fentiman
Hedley Atkins Breast Unit, Guy s Hospital, London, UK
Breast Cancer Res Treat 97:205-8. 2006..In terms of 16hydroxyestrone excretion the proportions ER+ve tumours were 22% in the lowest tertile and 38% in the highest tertile. This suggests that endogenous estrogen levels do impact on the phenotype of subsequent breast cancer...
- New therapies for sickle cell diseaseIheanyi E Okpala
Hematology Department, St Thomas Hospital, University of London, London, England, UK
Hematol Oncol Clin North Am 19:975-87, ix. 2005..Deferiprone is licensed in Europe and India, and deferasirox (ICL670) holds out important promise because it has not been shown to affect blood cell counts...
- Recurrent autonomic status epilepticus in Panayiotopoulos syndrome: video/EEG studiesMichael Koutroumanidis
Department of Clinical Neurophysiology and Epilepsies, St Thomas Hospital, London SE1 7EH, UK
Epilepsy Behav 7:543-7. 2005..Two video/EEG recordings, taken a year apart, revealed prolonged autonomic seizures and other subtle behavioral changes, suggesting that episodes of nonconvulsive status epilepticus in PS may be more frequent than appreciated...
- Immediate effects of methylphenidate on cognitive attention skills of children with attention-deficit-hyperactivity disorderJane Hood
Newcomen Centre, Guy s Hospital, St Thomas Street, London SE 1 9RT, UK
Dev Med Child Neurol 47:408-14. 2005..The immediate effects of methylphenidate and the significance of measuring cognitive aspects of attention as well as behavioural measures are discussed...
- Tension-free vaginal tape (TVT) in the United KingdomJ R A Duckett
Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Windmill Road, Gillingham, Kent ME7 5NY, UK
J Obstet Gynaecol 24:794-7. 2004..The different surgical techniques have not been evaluated prospectively and complications are seen more commonly than originally reported...
- Coronary artery changes in patients with Kawasaki diseaseR M R Tulloh
Department of Congenital Heart Disease, Guy s and St Thomas Hospitals NHS Trust, London, United Kingdom
Acta Paediatr Suppl 93:75-9. 2004..In the future, we hope to have more accurate diagnostic tests or prophylaxis against the disease, in addition to improved means of determining the susceptibility to or presence of long-term complications...
- A case-control study to investigate an association between adverse pregnancy outcome and periodontal diseaseS Moore
Periodontology and Preventive Dentistry Guy s, King s, and St Thomas Dental Institute, King s College, London, UK
J Clin Periodontol 32:1-5. 2005..The aim of this case-control study was to ascertain if women who experienced a preterm (or premature) birth had any differences in periodontal disease severity compared with women who delivered at term...
- Improved quality of life in patients with overactive bladder symptoms treated with solifenacinCon J Kelleher
Guy s and St Thomas Hospital, London, UK
BJU Int 95:81-5. 2005..To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB)...
- Comment with regard to: Outcomes of a prospective cohort study on peri-radicular infiltration for radicular pain in patients with lumbar disc herniation and spinal stenosis (L. Ng et al.)Charles Pither
St Thomas s Hospital London, SE1 7EH, UK
Eur Spine J 13:330-1. 2004
- Livedo reticularis and pregnancy morbidity in patients negative for antiphospholipid antibodiesS Sangle
Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
Ann Rheum Dis 64:147-8. 2005..Livedo may be an independent risk factor for pregnancy morbidity, additional to the known risks associated with the presence of antiphospholipid antibodies (aPL)...
- Obstetric implications of low-lying placentas diagnosed in the second trimesterO Ogueh
Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Canada
Int J Gynaecol Obstet 83:11-7. 2003..To determine the obstetrical outcome of pregnancies initially complicated by a low-lying placenta in the second trimester...
- Integrins in angiogenesis: multitalented molecules in a balancing actKairbaan M Hodivala-Dilke
Cell Adhesion and Disease Laboratory, Cancer Research UK, Richard Dimbleby Department of Cancer Research, St Thomas Hospital, Lambeth Palace Road, SE1 7EH, London, UK
Cell Tissue Res 314:131-44. 2003..Here we will clarify the varied role of integrins and aim to elucidate and simplify the combined functions of these molecules in angiogenesis...
- Coronary artery disease in uremia: Etiology, diagnosis, and therapyD J Goldsmith
Renal Unit, Guy s Hospital, London, England, United Kingdom
Kidney Int 60:2059-78. 2001..Many more randomized trials are needed. In the absence of information from such trials, we advocate aggressive control of conventional and novel cardiovascular risk factors, and early intervention for symptomatic coronary disease...
- Elective surgery on factor VIII inhibitor patients using continuous infusion of recombinant activated factor VII: plasma factor VII activity of 10 IU/ml is associated with an increased incidence of bleedingM P Smith
Haemophilia Centre, Reference Centre for Haemostatic and Thrombotic Disorders, St Thomas Hospital, London, UK
Thromb Haemost 86:949-53. 2001..In conclusion, the 16.5 microg/kg/h infusion rate reliably achieves plasma factor VII activity levels of 10 IU/ml, but this level does not provide reliable haemostasis...
- Inspiratory muscle strength in acute asthmaI M Stell
Department of Accident and Emergency Medicine, King s College Hospital, London, UK
Chest 120:757-64. 2001..CONCLUSIONS: This study did not find evidence of inspiratory muscle weakness or fatigue in patients with moderately severe acute asthma presenting to the emergency department...
- Measuring plasma paracetamol concentrations in all patients with drug overdose or altered consciousness: does it change outcome?P I Dargan
Medical Toxicology Unit, Guy s and St Thomas s Hospitals, London, UK
Emerg Med J 18:178-82. 2001..To assess whether measuring plasma paracetamol concentrations in all patients with drug overdose or collapse (altered consciousness) changes outcome...
- Abnormal liver function tests in a patient fed with total parenteral nutrition and treated with octreotideM A Crook
Department of Chemical Pathology, Guy s and St Thomas and University Hospital Lewisham, London, UK
Nutrition 17:152-4. 2001..We also review the literature regarding abnormal liver function tests in patients on total parenteral nutrition...
- Biallelic discrimination assays for the three common Ashkenazi Jewish mutations and a common non-Jewish mutation, in Tay-Sachs disease, using fluorogenic TaqMan probesC P Ward
Division of Medical and Molecular Genetics, Guy s Hospital, Guy s, King s and St Thomas School of Medicine, London, UK
Genet Test 4:351-8. 2000..There were no discrepancies noted between previously assigned genotypes and the results obtained by application of this methodology...
- Antiphospholipid antibodies and the endotheliumB J Hunt
Departments of Hematology and Lupus Unit, Guy s and St Thomas Trust, London SE1 7EH, England
Curr Rheumatol Rep 2:252-5. 2000..In vitro antiphospholipid antibodies produce endothelial cell activation. Clinical data in this area are scanty and worthy of future research, which could lead to new therapies in the management of antiphospholipid syndrome...
- Investigating the relationship between intrathoracic blood volume index and cardiac indexA McLuckie
Department of Intensive Care, Guy s and St Thomas NHS Trust, St Thomas Hospital, London, UK
Intensive Care Med 26:1376-8. 2000..To determine whether cardiac index and intrathoracic blood volume index are "mathematically coupled" under euvolaemic conditions with increasing levels of inotropic support...
- A case of lead poisoning due to snooker chalkP I Dargan
Medical Toxicology Unit, Guy s and St Thomas s NHS Trust, Avonley Road, London SE14 5ER, UK
Arch Dis Child 83:519-20. 2000..Thirty months later her blood lead was 0.39 micromol/l (80 microg/l). This case illustrates the need to be vigilant for more unusual causes of lead poisoning in the home...
- Lipid clearance and total parenteral nutrition: the importance of monitoring plasma lipidsM A Crook
Department of Chemical Pathology, Guy s and St Thomas Hospital, London, UK
Nutrition 16:774-5. 2000..This is particularly important in patients who are at high risk of impaired fat clearance, such as those who are hyperlipidemic, diabetic, septic, or with impaired renal or hepatic function, or those who are critically ill...
- Identifying patients with ischaemic heart disease in general practice: cross sectional study of paper and computerised medical recordsJ Gray
Battersea Research Group, Lavender Hill Group Practice, London SW11 5TU
BMJ 321:548-50. 2000..To identify patients with ischaemic heart disease by using a practice computer and to estimate the work required to do so...
- Benign childhood epileptic syndromes with occipital spikes: new classification proposed by the International League Against EpilepsyC P Panayiotopoulos
Department of Clinical Neurophysiology, St Thomas Hospital, London, UK
J Child Neurol 15:548-52. 2000..Panayiotopoulos syndrome, like rolandic epilepsy, needs recognition by the general pediatrician because of the invariably excellent prognosis and also because it can be misdiagnosed as an acute cerebral insult...
- Nasogastric feeding enhances nutritional status in paediatric liver disease but does not alter circulating levels of IGF-I and IGF binding proteinsR I Holt
Department of Medicine, Child Health, King s College School of Medicine and Dentistry, London, UK
Clin Endocrinol (Oxf) 52:217-24. 2000..The aim was to ascertain whether nasogastric feeding improves nutritional status in clinical practice and to assess the effect of feeding on serum IGF-I and IGFBPs...
- Mass casualty chemical incidents--towards guidance for public health managementV Murray
Chemical Incident Response Service, Guy s and St Thomas Hospital, London, UK
Public Health 116:2-14. 2002..There is therefore a need to fill this obvious gap and to develop a procedural guide for the emergency management of chemical incidents by public health professionals. This work is now under way...
- Is it time to abandon functional imaging in the study of neuroprotection?Paul Morrish
Hurstwood Park Neurological Centre, Princess Royal Hospital, West Sussex, United Kingdom
Mov Disord 17:229-32. 2002
- Presentation and prognosis of the shrinking lung syndrome in systemic lupus erythematosusMohammed Y Karim
Lupus Research Unit, The Rayne Institute, Immunology Department, St Thomas Hospital, London, UK
Semin Arthritis Rheum 31:289-98. 2002..The shrinking lung syndrome (SLS) is a rare complication of SLE. This study describes the presenting features, investigation findings, treatment measures, and outcome of 7 patients with SLE and SLS...
- MRSA: an infection control overviewDiana Rayner
Guy s and St Thomas Hospital NHS Trust
Nurs Stand 17:47-53; quiz 54, 56. 2003..MRSA is challenging nursing and medical professionals in hospitals and the community. Effective antibiotic therapy and risk assessment are needed together with good infection control practice to reduce its transmission...
- A career in paediatric cardiologyShakeel A Qureshi
Guy s and St Thomas s Hospital NHS Trust, London SE1 9RT
BMJ 327:S3-4. 2003
- Renal transplantation from non-heart- beating donors: a review of the European experienceGeoff Koffman
Renal Transplant Unit, Department of Renal Medicine, Guy s Hospital, London, UK
J Nephrol 16:334-41. 2003..Indeed, in the experiences analysed here it appears that NHBD consistently increased the number of available kidneys and has no effect on HB donations...
- Monitoring the death rates of general practitioners' patients in a single health authorityDavid C Pinder
West Surrey Health Authority, The Ridgewood Centre, Old Bisley Road, Camberley GU16 5QE
J Public Health Med 24:230-1. 2002
- Antibodies to factor XII: a possible predictive marker for recurrent foetal lossDavid Wynne Jones
Kent Haemophilia Centre, Kent and Canterbury Hospital, Kent, UK
Immunobiology 207:43-6. 2003..While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with foetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5.4, p = 0.025)...
- Long-term effects of chemical weaponsGlyn N Volans
Medical Toxicology Unit, Guy s and St Thomas Hospital Trust, London, UK
Lancet 360:s35-6. 2002
- Monitoring cardiac function in intensive careS M Tibby
Department of Paediatric Intensive Care, Guy s Hospital, London SE1 9RT, UK
Arch Dis Child 88:46-52. 2003..This review summarises cardiac function and cardiac output measurement in terms of methodology, interpretation, and their contribution to the concepts of oxygen delivery and consumption in the critically ill child...
- Repeatability of echocardiographic measurements in the human fetusJ M Simpson
Fetal Cardiology Unit, Department of Congenital Heart Disease, Guy s Hospital, London, UK
Ultrasound Obstet Gynecol 20:332-9. 2002..To determine the repeatability of cross-sectional, M-mode and Doppler echocardiographic measurements in the human fetus...
- Interventional radiology in the treatment of hepatic metastasesA Adam
Department of Interventional Radiology, Guy s and St Thomas Hospital, St Thomas Street, London SE1 9RT, UK
Cancer Treat Rev 28:93-9. 2002..Randomised trials to accurately define the place of these innovative techniques are needed...
- Catheter closure of coronary artery fistulasS A Qureshi
Department of Congenital Heart Disease, Guy s Hospital, St Thomas Street, London SE1 9RT, United Kingdom
J Interv Cardiol 14:299-307. 2001..Controlled-release coils have made an important contribution to the technique of catheter closure of coronary artery fistulas. Catheter closure of these fistulas is an acceptable alternative to the standard surgical treatment...
- The NHS plan and cliniciansDeirdre Cunningham
Public Health and Health Systems, Lambeth, Southwark and Lewisham Health Authority, London
Clin Med 2:134-8. 2002..There may be a tension between achieving safe standards and increased activity levels if shortfalls of staffing are not addressed, but ultimately clinicians will need to safeguard their standards...
- Obstetric medicine training: picking up where the licentiate in midwifery left offCatherine Nelson-Piercy
Directorate Office, Guy s Hospital Trust, London
Clin Med 2:119-21. 2002..The practical training will take place in centres with established medical obstetric clinics and will be tailored (with appropriate modules) to the amount of previous experience in medicine or obstetrics...
- Acetaminophen poisoning: an update for the intensivistPaul I Dargan
Specialist Registrar in Medicine and Clinical Toxicology, National Poisons Information Service, Guy s and St Thomas NHS Trust, London, UK
Crit Care 6:108-10. 2002..The modified King's College Hospital criteria (incorporating lactate into the traditional criteria) represent the best tool for identifying patients who require transplantation...
- Immunonutrition in the critically ill: a systematic review of clinical outcomeR J Beale
Department of Intensive Care, Guy s and St Thomas Hospital Trust, London, United Kingdom
Crit Care Med 27:2799-805. 1999..To perform a meta-analysis addressing whether enteral nutrition with immune-enhancing feeds benefits critically ill patients after trauma, sepsis, or major surgery...