F H Marshall
Affiliation: Gunnels Wood Road
- Molecular insight develops our understanding of the GABA(B) receptorF H Marshall
Molecular Pharmacology Department, Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK
Curr Opin Drug Discov Devel 3:597-604. 2000..As yet, no molecular subtypes of the receptor have been identified and the challenge for drug development remains the identification of compounds with desired therapeutic benefit combined with a low side effect profile...
- Heterodimerization of G-protein-coupled receptors in the CNSF H Marshall
Molecular Pharmacology Department, GlaxoWellcome Research and Development, Stevenage, Hertfordshire, UK
Curr Opin Pharmacol 1:40-4. 2001..Crosstalk at the level of the receptors might explain some of the known physiological interactions of these neurotransmitter systems and also provide new approaches for therapeutic intervention...
- Heterodimerization is required for the formation of a functional GABA(B) receptorJ H White
Receptor Systems, Molecular Pharmacology Unit, GlaxoWellcome, Medicines Research Centre, Stevenage, Hertfordshire, UK
Nature 396:679-82. 1998..These results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2...
- Calcium sensing properties of the GABA(B) receptorA Wise
Receptor Systems, Molecular Pharmacology Unit, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
Neuropharmacology 38:1647-56. 1999..Calcium appears to act allosterically to enhance GABA responses at the GABA(B) receptor, however, unlike the Ca2+-sensing receptor and some of the mGluR family, Ca2+ does not act as a ligand in its own right...
- The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFxJ H White
Receptor Systems, Molecular Pharmacology Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
Proc Natl Acad Sci U S A 97:13967-72. 2000..Such a signaling mechanism is unique among Family C G protein-coupled receptors and, in the case of the GABA(B) receptor and CREB2, may play a role in long-term changes in the nervous system...
- Advances in the molecular understanding of GABA(B) receptorsA Billinton
Dept of Neurobiology, Babraham Institute, Babraham, Cambridge, UK, CB2 4AT
Trends Neurosci 24:277-82. 2001....