N J Sebire

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. doi request reprint Implications of placental pathology for disease mechanisms; methods, issues and future approaches
    Neil James Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, WC1N 3JH, UK Electronic address
    Placenta . 2016
  2. pmc Abnormal villous morphology mimicking a hydatidiform mole associated with paternal trisomy of chromosomes 3,7,8 and unipaternal disomy of chromosome 11
    Neil J Sebire
    Trophoblastic Tumour Screening and Treatment Centre, Imperial College London, Charing Cross Campus, Fulham Palace Road, London, W6 8RF, UK
    Diagn Pathol 11:20. 2016
  3. doi request reprint Histopathological features of biparental complete hydatidiform moles in women with NLRP7 mutations
    N J Sebire
    Trophoblastic Tumour Screening and Treatment Centre, Department of Oncology, Imperial College Healthcare NHS, UK
    Placenta 34:50-6. 2013
  4. doi request reprint Histological examination in sudden unexpected death in infancy: evidence base for histological sampling
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK and UCL Institute of Child Health, London, UK
    J Clin Pathol 65:58-63. 2012
  5. doi request reprint Intrauterine growth in multiple pregnancies in relation to fetal number, chorionicity and gestational age
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Ultrasound Obstet Gynecol 32:890-3. 2008
  6. doi request reprint Salvage chemotherapy of relapsed or high-risk gestational trophoblastic neoplasia (GTN) with paclitaxel/cisplatin alternating with paclitaxel/etoposide (TP/TE)
    J Wang
    Department of Health, Charing Cross Hospital Gestational Trophoblastic Disease Centre, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    Ann Oncol 19:1578-83. 2008
  7. doi request reprint Role of routine neuropathological examination for determining cause of death in sudden unexpected deaths in infancy (SUDI)
    J W Pryce
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    J Clin Pathol 65:257-61. 2012
  8. ncbi request reprint Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles
    F J Paradinas
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    Histopathology 39:447-54. 2001
  9. pmc Quantification of maceration changes using post mortem MRI in fetuses
    P Montaldo
    Centre for Perinatal Neuroscience, Imperial College London, Du Cane Road, London, W12 0HS, UK
    BMC Med Imaging 16:34. 2016
  10. doi request reprint The role of post-mortem investigations in determining the cause of sudden unexpected death in infancy
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, London, UK
    Arch Dis Child 93:1048-53. 2008

Detail Information

Publications86

  1. doi request reprint Implications of placental pathology for disease mechanisms; methods, issues and future approaches
    Neil James Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, WC1N 3JH, UK Electronic address
    Placenta . 2016
    ....
  2. pmc Abnormal villous morphology mimicking a hydatidiform mole associated with paternal trisomy of chromosomes 3,7,8 and unipaternal disomy of chromosome 11
    Neil J Sebire
    Trophoblastic Tumour Screening and Treatment Centre, Imperial College London, Charing Cross Campus, Fulham Palace Road, London, W6 8RF, UK
    Diagn Pathol 11:20. 2016
    ..Determination of the underlying aetiology may be difficult in such cases...
  3. doi request reprint Histopathological features of biparental complete hydatidiform moles in women with NLRP7 mutations
    N J Sebire
    Trophoblastic Tumour Screening and Treatment Centre, Department of Oncology, Imperial College Healthcare NHS, UK
    Placenta 34:50-6. 2013
    ..Our objective was to investigate whether these genetic differences might be reflected in identifiable phenotypic differences between BiCHM and AnCHM that could enable earlier diagnosis of FRHM...
  4. doi request reprint Histological examination in sudden unexpected death in infancy: evidence base for histological sampling
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK and UCL Institute of Child Health, London, UK
    J Clin Pathol 65:58-63. 2012
    ..This study establishes the frequency with which histological examination of visceral organs determines cause of death and examines associations between clinical, macroscopic and microscopic findings...
  5. doi request reprint Intrauterine growth in multiple pregnancies in relation to fetal number, chorionicity and gestational age
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Ultrasound Obstet Gynecol 32:890-3. 2008
    ..To examine birth weight in dichorionic and monochorionic twins and trichorionic triplets, and to estimate the relative independent importance on growth of fetal number, chorionicity and gestational age...
  6. doi request reprint Salvage chemotherapy of relapsed or high-risk gestational trophoblastic neoplasia (GTN) with paclitaxel/cisplatin alternating with paclitaxel/etoposide (TP/TE)
    J Wang
    Department of Health, Charing Cross Hospital Gestational Trophoblastic Disease Centre, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    Ann Oncol 19:1578-83. 2008
    ..To evaluate the efficacy and toxicity of paclitaxel and cisplatin alternating with paclitaxel and etoposide doublet regimen (TP/TE), for salvage of patients with high-risk gestational trophoblastic neoplasia (GTN)...
  7. doi request reprint Role of routine neuropathological examination for determining cause of death in sudden unexpected deaths in infancy (SUDI)
    J W Pryce
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    J Clin Pathol 65:257-61. 2012
    ..This study examines the frequency of neuropathological findings determining cause of death at postmortem examination in SUDI in relation to clinical and macroscopic features...
  8. ncbi request reprint Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles
    F J Paradinas
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    Histopathology 39:447-54. 2001
    ....
  9. pmc Quantification of maceration changes using post mortem MRI in fetuses
    P Montaldo
    Centre for Perinatal Neuroscience, Imperial College London, Du Cane Road, London, W12 0HS, UK
    BMC Med Imaging 16:34. 2016
    ..The aim of this study was to investigate whether any changes seen on a whole body fetal post mortem magnetic resonance imaging (PMMR) correspond to maceration at conventional autopsy...
  10. doi request reprint The role of post-mortem investigations in determining the cause of sudden unexpected death in infancy
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, London, UK
    Arch Dis Child 93:1048-53. 2008
    ..The aim of this study is to provide data on the utility of such post-mortem investigations from a large paediatric autopsy series to inform future policy...
  11. pmc Changing patterns of infant death over the last 100 years: autopsy experience from a specialist children's hospital
    J W Pryce
    UCL Institute of Child Health, London, UK
    J R Soc Med 105:123-30. 2012
    ..Postmortem examinations have been performed at Great Ormond Street Hospital for over 100 years, and analysis of cases across this period has been performed to assess changing patterns of infant deaths undergoing autopsy...
  12. doi request reprint Staphylococcal toxins in sudden unexpected death in infancy: experience from a single specialist centre
    M A Weber
    Department of Paediatric Histopathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, London, UK
    Forensic Sci Med Pathol 7:141-7. 2011
    ..These data are consistent with the hypothesis that a subset of otherwise unexplained SUDI may be related to the presence of S aureus colonization/infection, but do not indicate routine testing for toxin-associated genotypes...
  13. ncbi request reprint Twin-to-twin transfusion syndrome results from dynamic asymmetrical reduction in placental anastomoses: a hypothesis
    N J Sebire
    Centre for Fetal Care, Department of Maternal-Fetal Medicine, Imperial College School of Medicine at Queen Charlotte's, Hammersmith Hospital Site, Du Cane Road, London, UK
    Placenta 22:383-91. 2001
    ....
  14. ncbi request reprint Extravillus endovascular implantation site trophoblast invasion is abnormal in complete versus partial molar pregnancies
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Surveillance Unit, Charing Ross Hospital, London, UK
    Placenta 22:725-8. 2001
    ..These findings may provide some explanation regarding the mechanism of clinical findings in molar pregnancy...
  15. doi request reprint Normal ascent of the conus medullaris: a post-mortem foetal MRI study
    O J Arthurs
    Great Ormond Street Hospital for Children, London, WC1N 3JH, UK
    J Matern Fetal Neonatal Med 26:697-702. 2013
    ..We used magnetic resonance imaging (MRI) to measure the position of the conus in post-mortem foetuses, to investigate the timing of normal ascent...
  16. doi request reprint High quality genomic DNA extraction from postmortem fetal tissue
    S Addison
    Academic Neonatology, Institute for Women s Health, University College London, London, UK
    J Matern Fetal Neonatal Med 25:2467-9. 2012
    ..We examined the yield and quality of genomic deoxyribonucleic acid (DNA) extracted from various postmortem fetal tissues...
  17. ncbi request reprint The dynamic placenta: I. Hypothetical model of a placental mechanism matching local fetal blood flow to local intervillus oxygen delivery
    D Talbert
    Institute of Reproduction and Developmental Biology, ICSM, Hammersmith Hospital, Du Cane Road, London, UK
    Med Hypotheses 62:511-9. 2004
    ..Intervillus/villus flow matching is likely in the human placenta and this study suggests probable biologically plausible mechanisms for such a phenomenon...
  18. ncbi request reprint Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy
    N J Sebire
    Trophoblastic Disease Screening and Treatment Centre, Department of Cancer Medicine, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    BJOG 110:22-6. 2003
    ..To determine pregnancy outcome, including the rate of repeat molar pregnancy, following histologically confirmed complete or partial hydatidiform mole...
  19. doi request reprint Clinicopathological features of paediatric deaths due to myocarditis: an autopsy series
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, Great Ormond Street, London, UK
    Arch Dis Child 93:594-8. 2008
    ..Myocarditis is a recognised cause of cardiac failure in childhood but the frequency of myocarditis as a cause of sudden unexpected death across the paediatric age range is uncertain...
  20. ncbi request reprint Electron microscopy of chorionic villus samples for prenatal diagnosis of lysosomal storage disorders
    D J Fowler
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Ultrastruct Pathol 31:15-21. 2007
    ..In selected cases, one-third of CVS may demonstrate distinctive ultrastructural features allowing prenatal diagnosis of a range of storage diseases...
  21. ncbi request reprint Histopathological features of testicular regression syndrome: relation to patient age and implications for management
    H Law
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 25:119-29. 2006
    ..Residual testicular tubules are found in 10% of cases regardless of the presence or absence of a macroscopically identifiable nodule...
  22. ncbi request reprint Intraplacental choriocarcinoma: experience from a tertiary referral center and relationship with infantile choriocarcinoma
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Unit, Charing Cross Hospital, London, UK
    Fetal Pediatr Pathol 24:21-9. 2005
    ....
  23. ncbi request reprint Risks of miscarriage and early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Hum Reprod 21:1912-7. 2006
    ..Triplet pregnancies are associated with a high risk of miscarriage and early preterm birth. It is uncertain if the outcome is improved by embryo reduction (ER)...
  24. ncbi request reprint Is maternal underweight really a risk factor for adverse pregnancy outcome? A population-based study in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine, St Mary s Hospital, Paddington, London, UK
    BJOG 108:61-6. 2001
    ..To determine the maternal and fetal risk of adverse outcome during pregnancy in relation to low maternal body mass index in an unselected population...
  25. ncbi request reprint Histomorphometric features of hydatidiform moles in early pregnancy: relationship to detectability by ultrasound examination
    D J Fowler
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    Ultrasound Obstet Gynecol 29:76-80. 2007
    ..We measured a microscopic parameter, average villus diameter, of evacuated PHMs and CHMs to ascertain the cause of non-detection on ultrasound...
  26. ncbi request reprint The diagnostic implications of routine ultrasound examination in histologically confirmed early molar pregnancies
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, Fulham Palace Road, London, UK
    Ultrasound Obstet Gynecol 18:662-5. 2001
    ..Early ultrasound examination is being used increasingly in the diagnosis of molar pregnancy. The aim of this study was to examine the diagnostic implications of routine ultrasound examination for histologically confirmed molar pregnancies...
  27. doi request reprint Tandem mass spectrometry findings at autopsy for detection of metabolic disease in infant deaths: postmortem changes and confounding factors
    J W Pryce
    UCL Institute of Child Health, Great Ormond Street Hospital for Children, London, UK
    J Clin Pathol 64:1005-9. 2011
    ..This study investigates postmortem acylcarnitine profiles in a large cohort of infant deaths from a single centre, including those with metabolic disease...
  28. ncbi request reprint Term preeclampsia is associated with minimal histopathological placental features regardless of clinical severity
    N J Sebire
    Department of Histopathology, St Mary s Hospital Paddington, London, UK
    J Obstet Gynaecol 25:117-8. 2005
    ....
  29. ncbi request reprint Massive perivillous fibrin deposition associated with discordant fetal growth in a dichorionic twin pregnancy
    N Gupta
    Department of Histopathology, Charing Cross Hospital, London, UK
    J Obstet Gynaecol 24:579-80. 2004
  30. doi request reprint Fetal and placental malignancies: prenatal diagnosis and management
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol 33:235-44. 2009
    ..Placental malignancy is most commonly in the form of gestatational trophoblastic disease, which requires assessment and management in specialist centers...
  31. doi request reprint Minimally invasive fetal postmortem examination using magnetic resonance imaging and computerised tomography: current evidence and practical issues
    S Thayyil
    Department of Radiology, Institute of Child Health, University College London, London, UK
    Prenat Diagn 30:713-8. 2010
    ..Here, we review the case for the development of less invasive autopsy using combined investigations including imaging techniques, in particular, magnetic resonance imaging and computerised tomography...
  32. ncbi request reprint The dynamic placenta: II. Hypothetical model of a fetus driven transplacental water balance mechanism producing low apparent permeability in a highly permeable placenta
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Med Hypotheses 62:520-8. 2004
    ..This may shed new light on disorders such as polyhydramnios and fetal hydrops...
  33. ncbi request reprint Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review
    P Jindal
    Recurrent Miscarriage Unit, Department of Obstetrics and Gynaecology, St Mary s Hospital, Imperial College School of Medicine, London, UK
    Hum Reprod 22:313-6. 2007
    ..The extent of additional clinically relevant information provided by this investigation in the setting of recurrent spontaneous abortion remains uncertain...
  34. ncbi request reprint 'Cor placentale': placental intervillus/intravillus blood flow mismatch is the pathophysiological mechanism in severe intrauterine growth restriction due to uteroplacental disease
    N J Sebire
    Department of Pathology, St Mary's Hospital, Paddington, London, UK
    Med Hypotheses 57:354-7. 2001
    ....
  35. ncbi request reprint Placental site trophoblastic tumour derived from an oocyte donation pregnancy
    S Khan
    Department of Health Gestational Trophoblastic Disease Centre, Charing Cross Hospital, London, UK
    BJOG 113:344-6. 2006
  36. ncbi request reprint p57(KIP2) immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy
    N J Sebire
    Department of Histopathology, Charing Cross Hospital, London, UK
    Histopathology 45:135-41. 2004
    ....
  37. ncbi request reprint Megacystis at 10-14 weeks of gestation: chromosomal defects and outcome according to bladder length
    A W Liao
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 21:338-41. 2003
    ..To examine the prevalence of chromosomal defects and outcome of fetuses with megacystis at 10-14 weeks of gestation...
  38. pmc Blood film examination for vacuolated lymphocytes in the diagnosis of metabolic disorders; retrospective experience of more than 2,500 cases from a single centre
    G Anderson
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    J Clin Pathol 58:1305-10. 2005
    ..A range of metabolic diseases can result in abnormal accumulation of metabolic byproducts, resulting in abnormal lymphocyte cytoplasmic vacuolation, identifiable on routine blood film examination...
  39. doi request reprint Effects of intrauterine retention and postmortem interval on body weight following intrauterine death: implications for assessment of fetal growth restriction at autopsy
    J Man
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol . 2016
    ..This study uses data from a large, well-characterized series of intrauterine death autopsies to investigate the effects of secondary changes such as fetal maceration, intrauterine retention and postmortem interval on body weight...
  40. doi request reprint Prospective parental consent for autopsy research following sudden unexpected childhood deaths: a successful model
    S Thayyil
    UCL Institute of Child Health, London, UK
    Arch Dis Child 94:354-8. 2009
    ..Organ retention issues, recent changes in the Coroners' (Amendment) Rules 2005 and the Human Tissue Act have resulted in pessimism regarding prospective consent for paediatric autopsy research in the UK...
  41. doi request reprint Capillary apposition and density in the diagnosis of alveolar capillary dysplasia
    L Melly
    Department of Histopathology, Royal Free Hospital, London, UK
    Histopathology 53:450-7. 2008
    ..The aim was to characterise further the histological features of patients suspected of having ACD and to correlate histopathological features with outcome...
  42. doi request reprint Stillbirth and intrauterine fetal death: contemporary demographic features of >1000 cases from an urban population
    J Man
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol . 2016
    ..The aim of this study was to document contemporary demographic findings in a large series of > 1000 deaths in utero in London and compare these with national datasets...
  43. doi request reprint Organ weights and ratios for postmortem identification of fetal growth restriction: utility and confounding factors
    J Man
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol . 2016
    ....
  44. ncbi request reprint Challenges to implementation of the new Coroners' (Amendment) Rules 2005: experience from a tertiary paediatric pathology centre
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital, London
    Med Sci Law 47:293-8. 2007
    ....
  45. ncbi request reprint Histopathological features of open lung biopsies in children treated with extracorporeal membrane oxygenation (ECMO)
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, Great Ormond Street, London WC1N 3JH, United Kingdom
    Early Hum Dev 81:455-60. 2005
    ..This study describes the histopathological features in a series of 22 children receiving ECMO therapy in whom open lung biopsy was carried out...
  46. ncbi request reprint Ultrastructural features of gaucher disease treated with enzyme replacement therapy presenting as mesenteric mass lesions
    D J Fowler
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, United Kingdom
    Fetal Pediatr Pathol 25:241-8. 2006
    ..These probably represent incomplete clearance, incomplete/partial enzyme replacement, or possibly an unusual response to a relatively small amount of storage material...
  47. ncbi request reprint Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features
    D J Fowler
    Department of Pediatric Histopathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 25:59-72. 2006
    ..At present, the optimal management includes complete surgical excision with clear margins, but there are no reliable histopathological or molecular features to predict the biological behavior in individual cases...
  48. ncbi request reprint Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center
    D J Fowler
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    Ultrasound Obstet Gynecol 27:56-60. 2006
    ....
  49. doi request reprint Correlation of placental pathology with prenatal ultrasound findings
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital Institute of Child Health, London, UK
    J Clin Pathol 61:1276-84. 2008
    ....
  50. ncbi request reprint Shortened duration of human chorionic gonadotrophin surveillance following complete or partial hydatidiform mole: evidence for revised protocol of a UK regional trophoblastic disease unit
    N J Sebire
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    BJOG 114:760-2. 2007
    ..Therefore, the current revised protocol comprises hCG follow up for 6 months after spontaneous return of hCG levels to normal for all women...
  51. doi request reprint Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region
    C M Wang
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK
    J Med Genet 46:569-75. 2009
    ..Our objectives were to investigate the diversity of mutations and their localisation to one or both isoforms of NLRP7, by screening a large series of women with FRHM and to examine the normal expression of NLRP7 in ovarian tissue...
  52. doi request reprint Enteropathic histopathological features may be associated with Shwachman-Diamond syndrome
    N Shah
    Department of Gastroenterology and Haematology, Great Ormond Street Hospital and Institute of Child Health, London, UK
    J Clin Pathol 63:592-4. 2010
    ..To review the gastrointestinal mucosal histological features of biopsies from children with Shwachman-Diamond syndrome (SDS) examined at a single specialist centre...
  53. doi request reprint Infection and sudden unexpected death in infancy: a systematic retrospective case review
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children and the Institute of Child Health, University College London, London, UK
    Lancet 371:1848-53. 2008
    ..The cause and mechanism of most cases of sudden unexpected death in infancy (SUDI) remain unknown, despite specialist autopsy examination. We reviewed autopsy results to determine whether infection was a cause of SUDI...
  54. doi request reprint Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma
    N Himoudi
    Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London, UK
    Clin Transl Oncol 14:271-9. 2012
    ..We therefore conducted a phase I trial to assess feasibility, safety and tumour-specific immune responses in patients with relapsed disease...
  55. doi request reprint Stillbirth and intrauterine fetal death: role of routine histological organ sampling to determine cause of death
    J Man
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol . 2016
    ..Our aim was to evaluate the use of macroscopic and microscopic assessment of internal organs to determine cause of intrauterine death...
  56. doi request reprint Body weight lower limits of fetal postmortem MRI at 1.5‚ÄČT
    N Jawad
    Department of Radiology, Great Ormond Street Hospital for Children, London, UK
    Ultrasound Obstet Gynecol 48:92-7. 2016
    ..To evaluate the diagnostic yield of postmortem magnetic resonance imaging (PM-MRI) compared with conventional autopsy in fetuses of early gestational age and low body weight...
  57. doi request reprint Histopathological features of Proteus syndrome
    S E H Hoey
    Department of Dermatology, Great Ormond Street Hospital for Children, London, UK
    Clin Exp Dermatol 33:234-8. 2008
    ..Proteus syndrome is a rare, sporadic overgrowth disorder for which the underlying genetic defect remains unknown. Although the clinical course is well-described there is no systematic histopathological description of the lesional pathology...
  58. ncbi request reprint Biology and pathology of the placenta in relation to antiphospholipid antibody-associated pregnancy failure
    N J Sebire
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Imperial College School of Medicine, St Mary s Hospital, London, UK
    Lupus 11:641-3. 2002
    ....
  59. pmc Funisitis is associated with adverse neonatal outcome in low-risk unselected deliveries at or near term
    F A Jessop
    Department of Paediatric Pathology, Addenbrooke s Hospital, Cambridge, UK
    Virchows Arch 468:503-7. 2016
    ..Funisitis and extensive inflammation are associated with adverse clinical outcomes, but the precise mechanism underlying these remains to be elucidated...
  60. doi request reprint Stillbirth and intrauterine fetal death: factors affecting determination of cause of death at autopsy
    J Man
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol . 2016
    ....
  61. pmc Light microscopic examination of scalp hair samples as an aid in the diagnosis of paediatric disorders: retrospective review of more than 300 cases from a single centre
    V V Smith
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    J Clin Pathol 58:1294-8. 2005
    ..Microscopic examination of scalp hair can provide important diagnostic information in a range of paediatric conditions. It is a non-invasive and cost effective investigation, which is not widely performed...
  62. doi request reprint Stillbirth and intrauterine fetal death: role of routine histopathological placental findings to determine cause of death
    J Man
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol . 2016
    ..Our aim was to examine objectively classified placental findings from a series of > 1000 autopsies following intrauterine death in order to evaluate the role of placental histological examination in determining the cause of death...
  63. ncbi request reprint Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's Hospital, London, UK
    Int J Obes Relat Metab Disord 25:1175-82. 2001
    ..The basis of many of the complications is likely to be related to the altered metabolic state associated with morbid obesity...
  64. pmc Uterine artery pulsatility index: a predictor of methotrexate resistance in gestational trophoblastic neoplasia
    R Agarwal
    Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK
    Br J Cancer 106:1089-94. 2012
    ....
  65. pmc Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem-cell phenotype
    V A Kinsler
    Paediatric Dermatology, Great Ormond Street Hospital for Children, London, WC1N 3JH, UK
    Br J Dermatol 169:374-83. 2013
    ..Multiple congenital melanocytic naevi (CMN) in one individual are caused by somatic mosaicism for NRAS mutations; however, the lineage of the mutated cells remains uncertain...
  66. doi request reprint Risk of recurrent molar pregnancies following complete and partial hydatidiform moles
    N Eagles
    Trophoblastic Tumour Screening and Treatment Centre, Imperial College Healthcare NHS Trust, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Hum Reprod 30:2055-63. 2015
    ..What is the risk of further molar pregnancies for women with one or more hydatidiform moles (HM) in relation to molar subtype...
  67. ncbi request reprint Outcome for children born after in utero laser ablation therapy for severe twin-to-twin transfusion syndrome
    A G Sutcliffe
    Royal Free and University College Medical School, Department of Paediatrics of Child Health, London, UK
    BJOG 108:1246-50. 2001
    ..3% in the twin survivors group. This pilot data highlights the need for careful long term follow up of children affected by twin-to-twin transfusion syndrome...
  68. doi request reprint Acceptability of a minimally invasive perinatal/paediatric autopsy: healthcare professionals' views and implications for practice
    K Ben-Sasi
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Prenat Diagn 33:307-12. 2013
    ..Technology now enables less invasive alternatives to traditional autopsy and may increase the acceptability of post-mortem examination...
  69. doi request reprint Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children
    O J Arthurs
    Paediatric Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK UCL Institute of Child Health, London, UK Electronic address
    Clin Radiol 70:872-80. 2015
    ..To compare the diagnostic accuracy of non-invasive cerebral post-mortem magnetic resonance imaging (PMMRI) specifically for cerebral and neurological abnormalities in a series of fetuses and children, compared to conventional autopsy...
  70. ncbi request reprint Overdiagnosis of complete and partial hydatidiform mole in tubal ectopic pregnancies
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Unit, Charing Cross Hospital, London, UK
    Int J Gynecol Pathol 24:260-4. 2005
    ..Molar pregnancy should only be diagnosed when strict criteria regarding morphologic abnormalities previously described in uterine evacuation material are applied...
  71. ncbi request reprint Increased first-trimester fetal nuchal translucency thickness in association with chondroectodermal dysplasia (Ellis-Van Creveld syndrome)
    N Venkat-Raman
    Fetal Medicine Unit, St Mary s Hospital, Praed Street, London, UK
    Ultrasound Obstet Gynecol 25:412-4. 2005
    ..The acetabular roofs were horizontal with medial and lateral spurs. This case adds a further type of severe skeletal dysplasia to the list of genetic syndromes which may present as increased fetal NT in the late first trimester...
  72. doi request reprint Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature
    D A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
    Pathol Oncol Res 14:233-8. 2008
    ..0001). This data is consistent with previously published studies identifying strong nuclear myogenin staining in a high proportion of cells as a marker of alveolar histology...
  73. ncbi request reprint Platelet-derived growth factor receptors and ligands are up-regulated in paediatric fibromatoses
    S Gibson
    Department of Histopathology, Great Ormond Street Hospital for Children, London, UK
    Histopathology 51:752-7. 2007
    ..Overexpression of PDGF/R is reported in a wide range of solid tumours. The aim was to determine levels of PDGF/R expression in paediatric fibromatoses and myofibromatosis...
  74. ncbi request reprint Maternal serum concentrations of pregnancy associated placental protein A and pregnancy specific beta-1-glycoprotein in multifetal pregnancies before and after fetal reduction
    A Abbas
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Hum Reprod 11:900-2. 1996
    ....
  75. doi request reprint Immunohistochemical expression of inflammatory markers in sudden infant death; ancillary tests for identification of infection
    J W Pryce
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children NHS Trust, London, UK UCL Institute of Child Health, London, UK
    J Clin Pathol 67:1044-51. 2014
    ..This study investigates the role of inflammatory markers in SUDI autopsies for determining cause of death...
  76. ncbi request reprint Risk of germ cell malignancy in children with XY intersex versus isolated cryptorchidism by immunohistochemistry
    H Law
    Department of Pediatric Pathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 25:95-105. 2006
    ..The extent of increased risk of malignancy in XY INT is not simply related to increased numbers of immature PLAP+/CD117+ germ cells present; additional factors play a pathogenic role...
  77. ncbi request reprint Absent/reduced glucose transporter-1 protein expression in infantile subglottic haemangiomas
    D J Purvis
    Department of Dermatology, Great Ormond Street Hospital for Children, London, UK
    Br J Dermatol 155:1041-4. 2006
    ..Positive immunohistochemical staining for glucose transporter-1 protein (GLUT1) is a characteristic of cutaneous infantile haemangiomas...
  78. ncbi request reprint Updated diagnostic criteria for partial and complete hydatidiform moles in early pregnancy
    N J Sebire
    Trophoblastic Disease Unit, Department of Histopathology, Charing Cross Hospital, Fulham Palace Road, London, U K
    Anticancer Res 23:1723-8. 2003
    ..Diagnosis of both complete and partial hydatidiform mole at this early stage of pregnancy requires the use of appropriate, updated histopathological features which are different from those described in later pregnancy...
  79. doi request reprint Placental site trophoblastic tumours and the concept of fertility preservation
    S Saso
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    BJOG 119:369-74; discussion 374. 2012
    ..This treatment should only be offered after extensive counselling. We intend to investigate the use of intraoperative frozen section analysis with cold-knife dissection in future...
  80. ncbi request reprint Choriodecidual inflammatory syndrome (CoDIS) is the leading, and under recognised, cause of early preterm delivery and second trimester miscarriage
    N J Sebire
    Department of Histopathology, St Mary's Hospital, Paddington, London, UK
    Med Hypotheses 56:497-500. 2001
    ....
  81. doi request reprint Histopathological diagnosis of hydatidiform mole: contemporary features and clinical implications
    N J Sebire
    Trophoblastic Disease Unit, Department of Medical Oncology, Charing Cross Hospital, London, UK
    Fetal Pediatr Pathol 29:1-16. 2010
    ....
  82. doi request reprint EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A
    D M Gascoyne
    Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health, London, UK
    Oncogene 29:3134-45. 2010
    ..These results extend the hypothesis that EWS/ETS proteins induce expression of neuronal markers such as BRN3A in EFT by showing that the function of those same markers may be restricted or controlled in an EWS/ETS-dependent manner...
  83. ncbi request reprint Histomorphometric characterisation of shared and non-shared cotyledonary villus territories of monochorionic placentae in relation to pregnancy complications
    L Y Wee
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Placenta 27:475-82. 2006
    ....
  84. doi request reprint Clinical utility of postmortem microcomputed tomography of the fetal heart: diagnostic imaging vs macroscopic dissection
    J C Hutchinson
    Institute of Child Health, UCL, London, UK
    Ultrasound Obstet Gynecol 47:58-64. 2016
    ..Our objective was to examine fetal complex congenital heart disease by microcomputed tomography (micro-CT), using standard autopsy as the gold standard...
  85. ncbi request reprint Diagnosis of neuronal ceroid lipofuscinosis (Batten disease) by electron microscopy in peripheral blood specimens
    G W Anderson
    Department of Paediatric Histopathology, Great Ormond Street Hospital, London, UK
    Ultrastruct Pathol 30:373-8. 2006
    ..Ultrastructual examination of peripheral blood allows reliable and specific diagnosis of subtypes of Batten disease, including variants, and is a useful, minimally invasive test for the diagnosis of NCL in childhood...
  86. ncbi request reprint Previously unidentified complex cytogenetic changes found in a pediatric case of solid-pseudopapillary neoplasm of the pancreas
    H M Kempski
    Paediatric Malignancy Cytogenetics Unit, Great Ormond Street Hospital for Children, London, UK
    Cancer Genet Cytogenet 164:54-60. 2006
    ..These cumulative changes seem insufficient for activation of cell transformation, but could possibly play a role in priming the cell for future mutagenic events...