Katherine L Brown
Affiliation: Great Ormond Street
- Outcome in neonates with congenital heart disease referred for respiratory extracorporeal membrane oxygenationKate L Brown
Cardiac Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
Acta Paediatr 94:1280-4. 2005....
- Delayed diagnosis of congenital heart disease worsens preoperative condition and outcome of surgery in neonatesK L Brown
Cardiac Unit, Great Ormond Street Hospital for Sick Children, London, UK
Heart 92:1298-302. 2006..To assess whether the route by which neonatal congenital heart disease (CHD) is first recognised influences outcome after surgery...
- Neonatal extra-corporeal life support: indications and limitationsKate L Brown
Cardiac Intensive Care Unit, Great Ormond Street Hospital for Sick Children, Great Ormond Street, London WC1N 3JH, UK
Early Hum Dev 84:143-8. 2008..Further research is required in order to determine the optimal methods for patient selection and to establish important predictors of outcome including the longterm neurological development of survivors...
- Cost utility evaluation of extracorporeal membrane oxygenation as a bridge to transplant for children with end-stage heart failure due to dilated cardiomyopathyKate L Brown
Cardiac Unit, Great Ormond Street Hospital for Sick Children, London, United Kingdom
J Heart Lung Transplant 28:32-8. 2009..Extracorporeal membrane oxygenation (ECMO) and cardiac transplantation are recognized to be expensive...
- Extracorporeal membrane oxygenation and term neonatal respiratory failure deaths in the United Kingdom compared with the United States: 1999 to 2005Kate L Brown
Cardiac Critical Care, Great Ormond Street Hospital for Children, London, UK
Pediatr Crit Care Med 11:60-5. 2010..To compare national neonatal extracorporeal membrane oxygenation data and deaths from primary respiratory disorders of term neonates between the United Kingdom and the United States from 1999 to 2005...
- Adverse family social circumstances and outcome in pediatric cardiac transplant recipients at a UK centerKate L Brown
Cardiac Unit, Great Ormond Street Hospital, London, UK
J Heart Lung Transplant 28:1267-72. 2009..Socioeconomic disadvantage is known to prejudice certain health-related outcomes...
- The relationship between workload and medical staffing levels in a paediatric cardiac intensive care unitKatherine L Brown
Cardiac Unit, Great Ormond Street Hospital NHS Trust, London WC1N 3JH, UK
Intensive Care Med 37:326-33. 2011..To evaluate the matching between workload in a paediatric cardiac intensive care unit (ICU) and the corresponding medical staffing levels over a 24-h period...
- ECLS for children with late (post-discharge) rejection after heart transplantationAstrid E Lammers
Department of Paediatric Cardiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Pediatr Transplant 17:336-42. 2013..ECLS thus appears to be a good rescue therapy for children with severe acute rejection post OHT, refractory to conventional treatment, leading to good medium-term outcome...
- Death and Emergency Readmission of Infants Discharged After Interventions for Congenital Heart Disease: A National Study of 7643 Infants to Inform Service ImprovementSonya Crowe
Clinical Operational Research Unit, University College London, London, UK
J Am Heart Assoc 5:. 2016..We aimed to identify risk factors for such events within 1 year of discharge after intervention in infancy and, separately, to identify subgroups that might benefit from different forms of intervention...
- Acute rejection after paediatric heart transplantation: far less common and less severeAstrid E Lammers
Department of Paediatric Cardiology, Great Ormond Street Hospital for Children, London, UK
Transpl Int 23:38-46. 2010..Sirolimus without a calcineurin inhibitor was associated with more rejection episodes, whereas tacrolimus and mycophenolate appeared to provide the best protective profile...
- Identifying improvements to complex pathways: evidence synthesis and stakeholder engagement in infant congenital heart diseaseSonya Crowe
Clinical Operational Research Unit, University College London, London, UK
BMJ Open 6:e010363. 2016..There is considerable variability in the provision of care and support in this period, and some families experience barriers to care. We aimed to identify ways to improve discharge and postdischarge care for this patient group...
- Signs of deterioration in infants discharged home following congenital heart surgery in the first year of life: a qualitative studyJenifer Tregay
Great Ormond Street Hospital NHS Foundation Trust, London, UK
Arch Dis Child 101:902-8. 2016..To describe the ways in which parents recognise and make decisions about their child's symptoms following discharge home after congenital heart interventions in the first year of life and their experiences of seeking help...
- Definition of important early morbidities related to paediatric cardiac surgeryKatherine L Brown
1Cardiac, Critical Care and Respiratory Division, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom
Cardiol Young . 2016....
- Predictors of outcome for children requiring respiratory extra-corporeal life support: implications for inclusion and exclusion criteriaNazima Pathan
Cardiac Critical Care Unit, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
Intensive Care Med 34:2256-63. 2008..Our aims were: (1) to analyse predictors of outcome and (2) comment on inclusion and exclusion criteria...
- Monitoring risk-adjusted outcomes in congenital heart surgery: does the appropriateness of a risk model change with time?Victor T Tsang
Cardiac Unit, Great Ormond Street Hospital, London, United Kingdom
Ann Thorac Surg 87:584-7. 2009..A question arises as to whether the risk model used remains appropriate over time...
- Ethnic and socioeconomic variation in incidence of congenital heart defectsRachel L Knowles
Population Policy and Practice Programme, UCL Great Ormond St Institute of Child Health, University College London, London, UK
Arch Dis Child . 2016..We investigated ethnic variations in incidence of serious CHDs requiring cardiac intervention before 1 year of age...
- Role of immunoglobulin supplementation for secondary immunodeficiency associated with chylothorax after pediatric cardiothoracic surgeryAparna U Hoskote
Cardiac Critical Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
Pediatr Crit Care Med 13:535-41. 2012..To evaluate whether intravenous immunoglobulin was linked to a reduction in sepsis in patients with prolonged chylothoraces postpediatric cardiothoracic surgery...
- The impact of mechanical ventilation time before initiation of extracorporeal life support on survival in pediatric respiratory failure: a review of the Extracorporeal Life Support RegistryMichele B Domico
Department of Pediatrics, Division of Critical Care, Children s Hospital of Orange County, Orange, CA, USA
Pediatr Crit Care Med 13:16-21. 2012..Previous studies suggest patients who received >7-10 days of mechanical ventilation were not acceptable extracorporeal life support candidates as a result of irreversible lung damage...
- Mortality as a measure of quality of care in infants with congenital cardiovascular malformations following surgeryHanna A Jensen
Cardiac Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
Br Med Bull 111:5-15. 2014..In the rapidly developing arena of paediatric cardiac surgery, the insightful analysis of mortality figures is challenging...
- Cardiac ECMO for biventricular hearts after paediatric open heart surgeryR R Chaturvedi
Randall Centre, King s College, London, UK
Heart 90:545-51. 2004..To delineate predictors of hospital survival in a large series of children with biventricular physiology supported with extracorporeal membrane oxygenation (ECMO) after open heart surgery...
- Healthcare-associated infection in pediatric patients on extracorporeal life support: The role of multidisciplinary surveillanceKate L Brown
Cardiac Intensive Care Unit, Great Ormond Street Hospital for Sick Children, Institute of Child Health, London, UK
Pediatr Crit Care Med 7:546-50. 2006..To describe the use of a multidisciplinary approach to sepsis surveillance and evaluate impact on outcome...
- Percutaneous left ventricular "vent" insertion for left heart decompression during extracorporeal membrane oxygenationMichael M H Cheung
Cardiothoracic Unit, Great Ormond Street Hospital, London, UK
Pediatr Crit Care Med 4:447-9. 2003..Description of a novel method of left ventricular decompression by a percutaneous technique under transthoracic echocardiographic guidance...
- Risk factors for long intensive care unit stay after cardiopulmonary bypass in childrenKate L Brown
Cardiac Intensive Care Unit, Great Ormond Street Hospital for Sick Children, London, UK
Crit Care Med 31:28-33. 2003..To identify factors associated with longer ICU stays that are potential targets for quality improvement...
- Transcatheter closure of a patent arterial duct in a patient on veno-arterial extracorporeal membrane oxygenationKate L Brown
Cardiac Intensive Care Unit, Great Ormond Street Hospital, London, UK
Intensive Care Med 28:501-3. 2002..This is the first report of transcatheter occlusion of a patent arterial duct in an infant on ECMO support...