- Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthaseA Achari
Glaxo Wellcome Research and Development, Beckenham, Kent, UK
Nat Struct Biol 4:490-7. 1997..The 7,8-dihydropterin pyrophosphate (DHPPP) substrate binds in a deep cleft in the barrel, whilst sulfanilamide binds closer to the surface. The DHPPP ligand site is highly conserved amongst prokaryotic and eukaryotic DHPSs...
- 2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogueD K Stammers
Glaxo Wellcome R and D, Medicines Research Centre, Stevenage, UK
FEBS Lett 456:49-53. 1999....
- Glucose-6-phosphate isomeraseA Achari
Philos Trans R Soc Lond B Biol Sci 293:145-57. 1981..It seems possible that glucose-6-phosphate isomerase, triose phosphate isomerase and pyruvate kinase all contain a histidine and a glutamate residue at the active site...