Julia L Newton

Summary

Affiliation: Freeman Hospital
Country: UK

Publications

  1. doi request reprint Syncope and falls in older people: defining the size of the problem
    J Newton
    Cardiovascular Investigation Unit and Institute for Ageing and Health, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Expert Rev Pharmacoecon Outcomes Res 1:187-97. 2001
  2. ncbi request reprint Changes in upper gastrointestinal physiology with age
    J L Newton
    Institute for Ageing and Health, Department of Medicine Geriatrics, Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Mech Ageing Dev 125:867-70. 2004
  3. ncbi request reprint Prevalence of family history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives: preliminary data for the Newcastle cohort
    Julia L Newton
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Auton Res 13:22-6. 2003
  4. doi request reprint Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Liver Int 30:878-85. 2010
  5. doi request reprint Home orthostatic training in vasovagal syncope modifies autonomic tone: results of a randomized, placebo-controlled pilot study
    Maw Pin Tan
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Europace 12:240-6. 2010
  6. doi request reprint Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:541-9. 2008
  7. doi request reprint Impedance cardiography: a role in vasovagal syncope diagnosis?
    Steve W Parry
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Age Ageing 38:718-23. 2009
  8. doi request reprint Lower ambulatory blood pressure in chronic fatigue syndrome
    Julia L Newton
    Cardiovascular Investigation Unit, Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK
    Psychosom Med 71:361-5. 2009
  9. doi request reprint Level of psychosocial impairment predicts early response to treatment in vasovagal syncope
    Bev Flint
    Department of Clinical Health Psychology, Royal Victoria Infirmary, Newcastle, UK
    Europace 11:231-6. 2009
  10. ncbi request reprint The role of psychological factors in the fatigue of primary biliary cirrhosis
    Peter Blackburn
    Department of Health Psychology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Liver Int 27:654-61. 2007

Collaborators

Detail Information

Publications68

  1. doi request reprint Syncope and falls in older people: defining the size of the problem
    J Newton
    Cardiovascular Investigation Unit and Institute for Ageing and Health, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Expert Rev Pharmacoecon Outcomes Res 1:187-97. 2001
    ..Syncope and falls are common in older people and are a major cause of healthcare expenditure. Clinical interventions are available, but the cost-effectiveness of those interventions is unclear...
  2. ncbi request reprint Changes in upper gastrointestinal physiology with age
    J L Newton
    Institute for Ageing and Health, Department of Medicine Geriatrics, Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Mech Ageing Dev 125:867-70. 2004
    ..Strategies to improve the management of upper gastrointestinal diseases in older people will reduce mortality and improve quality of life...
  3. ncbi request reprint Prevalence of family history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives: preliminary data for the Newcastle cohort
    Julia L Newton
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Auton Res 13:22-6. 2003
    ..Vasovagal syncope is an exaggerated form of the common faint affecting all age groups. Aetiology is unknown but the tendency for the disease to run in families has previously been noted...
  4. doi request reprint Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Liver Int 30:878-85. 2010
    ..Cognitive impairment is recognised in the early stages of primary biliary cirrhosis (PBC)...
  5. doi request reprint Home orthostatic training in vasovagal syncope modifies autonomic tone: results of a randomized, placebo-controlled pilot study
    Maw Pin Tan
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Europace 12:240-6. 2010
    ..To detect possible autonomic changes due to home orthostatic training (HOT) and to assess the feasibility of a larger, placebo-controlled study of HOT in vasovagal syncope (VVS)...
  6. doi request reprint Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:541-9. 2008
    ..Structural brain lesions were found in PBC, the density of which correlated with degree of cognitive impairment (P = 0.01, r(2) = 0.5) and autonomic function (P = 0.03, r(2) = 0.2)...
  7. doi request reprint Impedance cardiography: a role in vasovagal syncope diagnosis?
    Steve W Parry
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Age Ageing 38:718-23. 2009
    ..Alternative methods of diagnosing vasovagal syncope would thus be useful...
  8. doi request reprint Lower ambulatory blood pressure in chronic fatigue syndrome
    Julia L Newton
    Cardiovascular Investigation Unit, Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK
    Psychosom Med 71:361-5. 2009
    ..The cause of CFS remains unknown and there are no effective treatments...
  9. doi request reprint Level of psychosocial impairment predicts early response to treatment in vasovagal syncope
    Bev Flint
    Department of Clinical Health Psychology, Royal Victoria Infirmary, Newcastle, UK
    Europace 11:231-6. 2009
    ..To investigate whether levels of psychosocial impairment and psychological distress at diagnosis in those with vasovagal syncope (VVS) predict subsequent response to conventional treatment...
  10. ncbi request reprint The role of psychological factors in the fatigue of primary biliary cirrhosis
    Peter Blackburn
    Department of Health Psychology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Liver Int 27:654-61. 2007
    ....
  11. doi request reprint Functional capacity is significantly impaired in primary biliary cirrhosis and is related to orthostatic symptoms
    Julia L Newton
    Institute of Cellular Medicine, Newcastle University, NIHR Biomedical Research Centre in Ageing Liver Theme, Newcastle upon Tyne, UK
    Eur J Gastroenterol Hepatol 23:566-72. 2011
    ..To assess patient-reported functional ability and its relationship with symptoms in primary biliary cirrhosis (PBC)...
  12. ncbi request reprint Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 45:1496-505. 2007
    ..Autonomic dysfunction is independently associated with both fatigue and, importantly, symptoms of cognitive dysfunction, suggesting the potential for significant organic sequelae...
  13. ncbi request reprint Human pancreatic polypeptide has a marked diurnal rhythm that is affected by ageing and is associated with the gastric TFF2 circadian rhythm
    C Emma Johns
    Department of Pathology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Peptides 27:1341-8. 2006
    ..These results identify potential therapies for treatment of gastric mucosal morbidity and age-associated loss of appetite...
  14. doi request reprint Reduction in functional ability is significant postliver transplantation compared with matched liver disease and community dwelling controls
    Chris Elliott
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK
    Transpl Int 24:588-95. 2011
    ..Further study is warranted to address the mechanisms responsible for post-transplant functional impairment and to develop effective rehabilitation regimes to maximize function following liver transplantation...
  15. doi request reprint Is chronic fatigue syndrome in older patients a different disease? -- a clinical cohort study
    Ieuan Lewis
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Eur J Clin Invest 43:302-8. 2013
    ..Therefore, we performed a clinical cohort study to examine and differentiate the clinical and autonomic features in CFS patients aged over 50...
  16. doi request reprint Impaired functional status in primary Sjögren's syndrome
    Katie L Hackett
    National Institute of Health Research Biomedical Research Centre in Ageing, Newcastle University, Newcastle upon Tyne, UK
    Arthritis Care Res (Hoboken) 64:1760-4. 2012
    ....
  17. doi request reprint The relationship between carotid sinus hypersensitivity, orthostatic hypotension, and vasovagal syncope: a case-control study
    Maw Pin Tan
    Institute for Ageing and Health, Wolfson Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Europace 10:1400-5. 2008
    ..We conducted a case-control study evaluating this relationship in a large patient cohort...
  18. doi request reprint Results of carotid sinus massage in a tertiary referral unit--is carotid sinus syndrome still relevant?
    Maw Pin Tan
    Institute for Ageing and Health, Wolfson Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Age Ageing 38:680-6. 2009
    ..carotid sinus hypersensitivity (CSH) is associated with syncope, drop attacks and unexplained falls in older people. However, a recent study has also reported a prevalence of 35% in asymptomatic community-dwelling older people...
  19. doi request reprint Vasovagal syncope in the older person: differences in presentation between older and younger patients
    Gordon W Duncan
    Institute for Ageing and Health, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Age Ageing 39:465-70. 2010
    ..To address this issue, we investigated the age distribution and differences in clinical characteristics associated with age in patients diagnosed with VVS by HUTT at our tertiary referral centre...
  20. doi request reprint 'Front-loaded' head-up tilt table testing: validation of a rapid first line nitrate-provoked tilt protocol for the diagnosis of vasovagal syncope
    Steve W Parry
    Falls and Syncope Service and Institute for Ageing and Health, Newcastle University, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
    Age Ageing 37:411-5. 2008
    ..06, 27.4). The front-loaded GTN protocol provided a higher diagnostic rate than passive tilt testing, and provides a rapid alternative to conventional methods, though false positivity rates are higher...
  21. doi request reprint The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort
    Greta Pells
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 59:67-73. 2013
    ..The aim of this study was to utilise the comprehensive UK-PBC Research Cohort, including 380 post-transplant patients and 2300 non-transplanted patients, to answer key questions regarding transplantation for PBC...
  22. pmc Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome
    Julia L Newton
    Institute of Ageing and Health and NIHR Biomedical Research Centre for Ageing, Newcastle University, Newcastle upon Tyne, UK
    Ann Rheum Dis 71:1973-9. 2012
    ..To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS...
  23. pmc The personal and health service impact of falls in 85 year olds: cross-sectional findings from the Newcastle 85+ cohort study
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e33078. 2012
    ..We investigated the prevalence and impact of falls, and the overlap between falls, dizziness and blackouts, in a population-based sample of 85 year olds...
  24. doi request reprint Impaired cardiovascular response to standing in chronic fatigue syndrome
    Kieren G Hollingsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Eur J Clin Invest 40:608-15. 2010
    ..This study examined the relationship between skeletal and cardiac muscle function and symptoms on standing in CFS using magnetic resonance spectroscopy (MRS) and impedance cardiography...
  25. ncbi request reprint Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity
    Julia L Newton
    Cardiovascular Investigation Unit, University of Newcastle, Care of the Elderly Offices, Royal Victoria Infirmary, UK
    Eur J Gastroenterol Hepatol 19:125-32. 2007
    ..Here, we investigate the prevalence of autonomic dysfunction using highly sensitive detection modalities and its relationship with fatigue in both noncirrhotic and cirrhotic primary biliary cirrhosis patients...
  26. doi request reprint Cognitive symptoms are common in immune thrombocytopenia and associate with autonomic symptom burden
    James Frith
    Institute for Ageing and Health and UK NIHR Biomedical Research Centre in Ageing, Newcastle University, Newcastle upon Tyne, UK
    Eur J Haematol 88:224-8. 2012
    ..Cognitive impairment commonly associates with autonomic dysfunction. Here, we quantified cognitive symptoms in a large cohort of patients with ITP compared with controls and explored the relationship with autonomic symptoms...
  27. pmc Single centre experience of ivabradine in postural orthostatic tachycardia syndrome
    Claire McDonald
    Institute for Ageing and Health, UK NIHR Biomedical Research Centre in Ageing and Age related Diseases Cardiovascular theme and Falls and Syncope Service, Newcastle University, Newcastle, UK
    Europace 13:427-30. 2011
    ..Conventional therapy is effective in less than 60%. Case reports suggest ivabradine (a selective sinus node blocker, with no effect on blood pressure) may alleviate POTS-related symptoms. This is a retrospective case-series...
  28. doi request reprint Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance
    J L Newton
    Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle NE1 4LP, UK
    Gut 57:807-13. 2008
    ..To quantify fatigue in non-alcoholic fatty liver disease (NAFLD), to determine whether perceived fatigue reflects impairment of physical function and to explore potential causes...
  29. ncbi request reprint Calcaneal bone mineral density in older patients who have fallen
    J L Newton
    Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    QJM 99:231-6. 2006
    ..Annually, 35-40% of those aged >65 years fall; up to 5% of such falls result in fracture. Fracture is determined both by propensity to fall and by bone fragility...
  30. pmc The costs of falls in the community to the North East Ambulance Service
    J L Newton
    Falls and Syncope Service, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Emerg Med J 23:479-81. 2006
    ..This study set out to quantify the immediate costs to the North East Ambulance Service (NEAS) of attending to fallers...
  31. doi request reprint Modified criteria for carotid sinus hypersensitivity are associated with increased mortality in a population-based study
    Claire McDonald
    Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Clinical Academic Office, M3 100, 3rd Floor Leech Building, Newcastle upon Tyne NE2 4HH, UK Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
    Europace 18:1101-7. 2016
    ..This population-based study aimed to compare the prevalence of CSH defined according to standard, Krediet and Kerr criteria, and to establish if CSH defined according these criteria is associated with all-cause mortality...
  32. pmc Brain oxygenation responses to an autonomic challenge: a quantitative fMRI investigation of the Valsalva manoeuvre
    Iwo Bohr
    Institute of Cellular Medicine and Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Age (Dordr) 37:91. 2015
    ..This could suggest other than recurrent transient hypoxia mechanisms causing/contributing to the formation of WMH...
  33. pmc Developing a service user informed intervention to improve participation and ability to perform daily activities in primary Sjögren's syndrome: a mixed-methods study protocol
    Katie L Hackett
    Musculoskeletal Research Group, Institute of Cellular Medicine and NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Newcastle upon Tyne, UK Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
    BMJ Open 4:e006264. 2014
    ..This paper describes a research protocol for a mixed-methods study to develop an intervention to improve these outcomes. The protocol follows the Medical Research Council framework for complex interventions...
  34. pmc Fatigue in primary sclerosing cholangitis is associated with sympathetic over-activity and increased cardiac output
    Jessica K Dyson
    The Liver Unit, Freeman Hospital, Newcastle upon Tyne, UK
    Liver Int 35:1633-41. 2015
    ..The study aims were to evaluate fatigue and its associations in PSC and investigate whether overt autonomic dysfunction contributes to the expression of fatigue...
  35. pmc Reduced thoracic fluid content in early-stage primary biliary cirrhosis that associates with impaired cardiac inotropy
    Pawel Zalewski
    Institute for Ageing and Health, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Am J Physiol Gastrointest Liver Physiol 305:G393-7. 2013
    ..037; β 0.5). This study has confirmed that TFC is reduced in those with PBC, that this is specific to PBC, and that it associates independently with markers of cardiac inotropy...
  36. ncbi request reprint Effect of age-related changes in gastric physiology on tolerability of medications for older people
    Julia L Newton
    Institute for Ageing and Health, University of Newcastle, Newcastle, UK
    Drugs Aging 22:655-61. 2005
    ..This review emphasises how the stomach changes with age, and how understanding this will aid clinicians when prescribing medications with potential gastrointestinal adverse effects to older people...
  37. pmc A concept mapping study evaluating the UK's first NHS generic fatigue clinic
    Katie L Hackett
    CRESTA Fatigue Clinic, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
    Health Expect 19:1138-49. 2016
    ..The CRESTA Fatigue interdisciplinary clinic was established in 2013 in response to this unmet need...
  38. pmc Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study
    Julia L Newton
    Institute of Cellular Medicine, Newcastle upon Tyne, UK Newcastle University, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
    Open Heart 3:e000381. 2016
    ..To explore potential mechanisms that underpin the cardiac abnormalities seen in chronic fatigue syndrome (CFS) using non-invasive cardiac impedance, red cell mass and plasma volume measurements...
  39. doi request reprint Managing fatigue in the syncope unit
    Julia L Newton
    UK NIHR Biomedical Centre in Ageing, Institute of Cellular Medicine, Institute for Ageing and Health, Medical School, Newcastle University, Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Europace 14:1696-9. 2012
    ..Managing this debilitating symptom can often be challenging but, with a structured approach, immensely rewarding, and as a result improve how patients cope with their disease...
  40. doi request reprint Fatigue in adult patients with primary immune thrombocytopenia
    Julia L Newton
    Institute for Ageing and Health and UK NIHR Biomedical Research Centre in Ageing, Newcastle University, Newcastle upon Tyne, UK
    Eur J Haematol 86:420-9. 2011
    ..Patients with primary immune thrombocytopenia (ITP) commonly describe symptoms of fatigue. However, hematologists rarely consider fatigue a manifestation of ITP...
  41. doi request reprint The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: results of a 9 year follow-up
    David E Jones
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 53:911-7. 2010
    ..The aim of this study was to explore the inter-relationship between UDCA use, response, and fatigue in determining outcome over 9 years in a unique, comprehensive patient cohort...
  42. ncbi request reprint Evidence-based algorithms and the management of falls and syncope presenting to acute medical services
    Steve W Parry
    Falls and Syncope Service and Institute for Ageing and Health, Royal Victoria Infirmary, Newcastle upon Tyne
    Clin Med (Lond) 8:157-62. 2008
    ..Easy-to-use algorithms can help reduce the number of patients admitted to acute medical services with falls and syncope while optimising the care of those managed as inpatients. The algorithms are provided for use by interested parties...
  43. doi request reprint Orthostatic hypotension and cognitive impairment in Parkinson's disease: Causation or association?
    Claire McDonald
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Mov Disord 31:937-46. 2016
    ..Finally, we explore how modulation of blood pressure and the noradrenergic nervous system may improve cognition in PD. © 2016 International Parkinson and Movement Disorder Society. ..
  44. doi request reprint Validation of a questionnaire for orthostatic hypotension for routine clinical use
    James Frith
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Geriatr Gerontol Int 16:785-90. 2016
    ..To validate a new patient-reported outcome measure for routine clinical use...
  45. ncbi request reprint Blood pressure variability and cognitive decline in older people: a 5-year longitudinal study
    Claire McDonald
    aInstitute of Cellular Medicine, Newcastle University bNewcastle upon Tyne Hospitals NHS Foundation Trust cInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    J Hypertens 35:140-147. 2017
    ..However, research examining the association between BP variability and cognitive function in the general older population is scarce...
  46. doi request reprint The experience of sleep in chronic fatigue syndrome: A qualitative interview study with patients
    Zoe M Gotts
    Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK
    Br J Health Psychol 21:71-92. 2016
    ..The aim was to explore the specific role of sleep in patients' experience of their illness...
  47. doi request reprint Public and patient research priorities for orthostatic hypotension
    James Frith
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Age Ageing 43:865-8. 2014
    ..This report offers guidance for academics that are undertaking OH-related research and how they can improve its relevance and increase its translation into clinical practice. ..
  48. pmc Postural tachycardia syndrome is associated with significant symptoms and functional impairment predominantly affecting young women: a UK perspective
    Claire McDonald
    Institute for Ageing and Health, Campus for Ageing and Vitality, Medical School, Newcastle University, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
    BMJ Open 4:e004127. 2014
    ....
  49. ncbi request reprint Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence
    Julia L Newton
    Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Hepatology 44:91-8. 2006
    ..Existing agents effective at reducing daytime somnolence (such as modafinil) hold potential for the treatment of fatigue in PBC...
  50. ncbi request reprint Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope
    Julia L Newton
    Cardiovascular Investigation Unit Institute for Ageing and Health, Care of the Elderly Offices, Royal Victoria Infirmary, University of Newcastle, Newcastle NE1 4LP, United Kingdom
    Europace 7:396-9. 2005
    ..Here we present the first study examining a potential genetic abnormality in VVS...
  51. doi request reprint Development of an evidence-based patient information medium: empowering newly diagnosed patients with primary biliary cirrhosis
    Ruth M Pearce
    UK NIHR Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle upon Tyne, UK
    J Vis Commun Med 34:4-13. 2011
    ..We believe that introducing such a DVD into clinical practice, following diagnosis, will make a real difference to the quality of life of newly-diagnosed PBC patients...
  52. ncbi request reprint The diurnal rhythm of the cytoprotective human trefoil protein TFF2 is reduced by factors associated with gastric mucosal damage: ageing, Helicobacter pylori infection, and sleep deprivation
    C Emma Johns
    Department of Pathology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK
    Am J Gastroenterol 100:1491-7. 2005
    ..TFF2 is considered the major cytoprotective gastric trefoil protein. There is a marked circadian variation in gastric luminal TFF2 in young healthy volunteers with peak levels present during the night...
  53. ncbi request reprint The role of psychological factors in response to treatment in neurocardiogenic (vasovagal) syncope
    Jennifer Gracie
    Department of Psychology, Royal Victoria Infirmary, Newcastle NE1 4LP, UK
    Europace 8:636-43. 2006
    ..This study examines the prevalence of psychological problems in patients with VVS and whether non-responders are psychologically different from those whose symptoms respond to conservative treatment...
  54. ncbi request reprint Reduced heart rate variability and baroreflex sensitivity in primary biliary cirrhosis
    Julia L Newton
    Cardiovascular Investigation Unit, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Liver Int 26:197-202. 2006
    ..We have assessed heart rate variability (HRV) and baroreflex sensitivity (BRS) risk factors associated with cardiovascular mortality, in 57 PBC patients and age- and sex-matched normal controls...
  55. ncbi request reprint Heart Rate and Blood Pressure Changes during Gastroscopy in Healthy Older Subjects
    Ruth Ross
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Gerontology 50:182-6. 2004
    ..One previous study of selected younger patients suggested that changes in blood pressure were more pronounced in non-premedicated patients...
  56. ncbi request reprint Abnormalities of sympathetic and parasympathetic autonomic function in subjects with defaecation syncope
    Louise Allan
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Europace 6:192-8. 2004
    ..It is associated with increased mortality; however, patients rarely voluntarily report symptoms. We have examined autonomic function in a cohort of patients with defaecation syncope...
  57. doi request reprint Self-reported symptom burden; outcome in 418 patients from the Newcastle Vasovagal (Neurocardiogenic) cohort
    R Ross
    Falls and Syncope Service, University of Newcastle, Royal Victoria Infirmary, Newcastle NE1 4LP, UK
    QJM 101:127-35. 2008
    ..Natural history of Vasovagal syndrome (Neurocardiogenic; NCS) is unclear...
  58. ncbi request reprint An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis
    D E J Jones
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Aliment Pharmacol Ther 25:471-6. 2007
    ..The CNS-acting drug modafinil has an established role in the treatment of excessive daytime somnolence in non-liver disease states...
  59. ncbi request reprint A functional polymorphism in the interleukin-1 receptor-1 gene is associated with increased risk of Helicobacter pylori infection but not with gastric cancer
    Steve Hartland
    School of Clinical Medical Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Dig Dis Sci 49:1545-50. 2004
    ..27 vs 0.156; P = 0.009; OR = 2.01). Our results suggest that the relationship among IL-1 gene polymorphism, H. pylori, and disease is more complex than initially proposed. More detailed studies of the IL-1 gene cluster are needed...
  60. pmc The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach
    J L Newton
    Department of Pathology, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Gut 46:312-20. 2000
    ..TFF1 is a 6.5 kDa secreted protein that is expressed predominantly in normal gastric mucosa. It is coexpressed with mucins and it can form dimers via a free carboxy terminal cysteine residue...
  61. ncbi request reprint Benign paroxysmal positional vertigo: clinical characteristics of dizzy patients referred to a Falls and Syncope Unit
    J Lawson
    Falls and Syncope Service, Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle
    QJM 98:357-64. 2005
    ..Benign paroxysmal positional vertigo (BPPV) is a common cause of dizziness that increases in prevalence with age, and is potentially curable...
  62. ncbi request reprint The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori
    J L Newton
    Department of Medicine Geriatrics, Medical School, University of Newcastle upon Tyne, UK
    Gerontology 46:153-7. 2000
    ..Peptic ulceration and Helicobacter pylori infection increase with advancing age. In the upper gastro-intestinal tract the first line of mucosal defence is the adherent mucus gel layer...
  63. ncbi request reprint Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: a review of 10 years' experience
    Zbigniew J Gieroba
    Flinders University Department of Rehabilitation and Aged Care, Repatriation General Hospital, Daw Park, South Australia
    J Am Geriatr Soc 52:1913-5. 2004
    ..To test the safety of the head-up tilt test (HUT) in older adults...
  64. doi request reprint Fatigue is significant in vasovagal syncope and is associated with autonomic symptoms
    Henrietta Legge
    Falls and Syncope Service, Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    Europace 10:1095-101. 2008
    ..To quantify the prevalence of fatigue and its severity in vasovagal syncope (VVS) and to examine whether fatigue severity associates with symptoms of autonomic dysfunction...
  65. ncbi request reprint The v-MFG test: investigating maternal, offspring and maternal-fetal genetic incompatibility effects on disease and viability
    Hsin Ju Hsieh
    Biostatistics, University of California, Los Angeles, CA, USA
    Genet Epidemiol 30:333-47. 2006
    ....
  66. ncbi request reprint Familial neurocardiogenic (vasovagal) syncope
    Julia L Newton
    Cardiovascular Investigation Unit Institute for Ageing and Health, School of Clinical Medical Sciences, Newcastle, United Kingdom
    Am J Med Genet A 133:176-9. 2005
    ..Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members...
  67. ncbi request reprint Upper gastrointestinal alarms in older people
    Neeraj Bhala
    Lancet 366:982-3. 2005