Genomes and Genes
Dilys J Freeman
- Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimesterBarbara J Meyer
Metabolic Research Centre, School of Health Sciences, University of Wollongong, Wollongong, New South Wales 2500, Australia
J Clin Endocrinol Metab 98:643-52. 2013..In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL)...
- Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)Dilys J Freeman
Centre of Population and Health Sciences, University of Glasgow, Glasgow, UK
BMC Geriatr 11:8. 2011..We aimed to determine the effect of pravastatin on incident VTE in older people; we also studied the impact of clinical and plasma risk variables...
- Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetesScott M Nelson
Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, UK
Diabetes 56:2697-704. 2007..We examined whether these biomarkers were elevated at birth in offspring of type 1 diabetic mothers (OT1DM)...
- Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetesScott M Nelson
Faculty of Medicine, University of Glasgow, Glasgow, UK
Diabetes Care 31:1123-5. 2008..To assess the association of fetal hormones with placental growth and fetal weight-to-placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes...
- Short- and long-term changes in plasma inflammatory markers associated with preeclampsiaDilys J Freeman
Division of Developmental Medicine, University of Glasgow, Glasgow, United Kingdom
Hypertension 44:708-14. 2004..In conclusion, preeclampsia is associated with short- and long-term changes in inflammatory status...
- Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trialsNaveed Sattar
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Lancet 375:735-42. 2010..We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes...
- Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothersFrances M Stewart
Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Royal Infirmary Glasgow, United Kingdom
J Clin Endocrinol Metab 92:969-75. 2007..Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. In the nonpregnant, obesity is associated with dyslipidemia, vascular dysfunction, and low-grade chronic inflammation...
- Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post partumFrances Stewart
Division of Developmental Medicine, University of Glasgow, Royal Infirmary, Glasgow, G31 2ER, UK
Lipids 42:335-44. 2007..The correlation between maternal 22:6n3 and 24:1n9 suggests that mobilisation of these fatty acids may be coordinated. The inverse relationship between 16:1n7 and maternal central obesity warrants further investigation...
- Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspringEleanor Jarvie
Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, U K
Clin Sci (Lond) 119:123-9. 2010..The combination of excess/altered lipid nutrient supply, suboptimal in utero metabolic environment and alterations in placental gene expression, inflammation and metabolism may also induce obesity in the offspring...
- Early pregnancy soluble E-selectin concentrations and risk of preeclampsiaDavid M Carty
Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK
J Hypertens 30:954-9. 2012..We examined plasma levels of inflammatory cytokines and adhesion molecules in early pregnancy, to assess their ability to predict preeclampsia...
- Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy?Vanessa A Rodie
Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, UK
Atherosclerosis 175:189-202. 2004..These women may be an appropriate cohort for CVD risk screening and for possible intervention...
- Effects of maternal obesity on fetal growth and body composition: implications for programming and future healthDilys J Freeman
Developmental Medicine, Faculty of Medicine, University of Glasgow, 2nd Floor McGregor Building, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
Semin Fetal Neonatal Med 15:113-8. 2010....
- IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetesScott M Nelson
Department of Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 ER, UK
Diabetes 56:2705-9. 2007..We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures...
- Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipientsJudith Madigan
Division of Immunology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom
J Immunol 184:3202-12. 2010..These data support the view that trophoblast D6 scavenges maternal chemokines at the fetomaternal interface and that, in some circumstances, this can help to ensure fetal survival...
- Preeclampsia is associated with compromised maternal synthesis of long-chain polyunsaturated fatty acids, leading to offspring deficiencyVanessa A Mackay
School of Medicine, Institute of Cardiovascular and Medical Sciences, McGregor Building Level 2, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
Hypertension 60:1078-85. 2012..001; 0.40 [0.81] versus 0.00 [0.00], P=0.038 expression relative to control gene [square root]). Low maternal and fetal long-chain polyunsaturated fatty acid concentrations in PE may be the result of decreased maternal synthesis...
- Longitudinal assessment of antimüllerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectinScott M Nelson
Reproductive and Maternal Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, United Kingdom
Fertil Steril 93:1356-8. 2010....
- Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspringMalini G Kanagalingam
Reproductive and Maternal Medicine, University of Glasgow, Glasgow, United Kingdom
Atherosclerosis 205:244-50. 2009..However, whether established or putative novel cardiovascular risk factors including vascular and metabolic function are disrupted in women who delivered small for gestational age (SGA) offspring is unknown...
- Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studiesNaveed Sattar
Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Lancet 371:1927-35. 2008..We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations...
- Short- and long-term strategies for the management of hypertensive disorders of pregnancyShahzya S Huda
Clinical Lecturer, Section of Reproductive and Maternal Medicine, University of Glasgow, Level 2 McGregor Building, Western Infirmary, Glasgow G11 6NT, UK
Expert Rev Cardiovasc Ther 7:1581-94. 2009..We also explore the evidence relating adverse pregnancy outcome to an increased future risk of cardiovascular disease and potential strategies to minimize this risk...
- C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention StudyDilys J Freeman
Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
Diabetes 51:1596-600. 2002..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes...
- The G-to-T point mutation in codon 34 of the factor XIII gene and the risk of pre-eclampsiaPeter Clark
Department of Transfusion Medicine, Ninewells Hospital Dundee, Glasgow, UK
Blood Coagul Fibrinolysis 14:155-7. 2003..7 (CI95 0.4-1.1). We conclude that the presence of leucine at this site is not associated with a protection against pre-eclampsia to the magnitude of that reported in other thrombotic disease...