Christopher S Potten
Affiliation: Christie Hospital NHS Trust
- Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestineChristopher S Potten
EpiStem Ltd, Manchester M13 9XX, United Kingdom
Radiat Res 161:123-36. 2004..Such studies have allowed the cell lineages and genome protection mechanisms operating the small intestinal crypts to be defined...
- The small intestine as a model for evaluating adult tissue stem cell drug targetsChristopher S Potten
EpiStem Limited, Manchester, UK
Cell Prolif 36:115-29. 2003..Some of the regulatory networks governing stem and transit cell behaviour are beginning to be understood and it is postulated that p53 plays a crucial role in these processes...
- Adult small intestinal stem cells: identification, location, characteristics, and clinical applicationsC S Potten
EpiStem Limited, Manchester, UK
Ernst Schering Res Found Workshop . 2006..This provides a new explanation for the low cancer risk in the small intestine...
- The stem cells of small intestinal crypts: where are they?C S Potten
EpiStem Ltd, Manchester, UK
Cell Prolif 42:731-50. 2009..There could be a distinct and as yet undiscovered relationship between these observed traits, with stem cell properties both in cells of the crypt base and those at cell position 4...
- Identification of a putative intestinal stem cell and early lineage marker; musashi-1Christopher S Potten
Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
Differentiation 71:28-41. 2003..These observations suggest that Musashi-1 is a marker of stem and early lineage progenitor cells in murine intestinal tissue...
- Keratinocyte stem cells: a commentaryChristopher S Potten
Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U K
J Invest Dermatol 119:888-99. 2002..This commentary assesses the data generated to date and critically discusses the conclusions that have been drawn. Our current level of understanding, or lack of understanding, of the keratinocyte stem cell is reviewed...
- Keratinocyte stem cells, label-retaining cells and possible genome protection mechanismsChristopher S Potten
EpiStem Ltd, Incubator Building, Manchester, UK
J Investig Dermatol Symp Proc 9:183-95. 2004..Experiments in the small intestine indicate that the stem cells here are selectively sorting their DNA and becoming LRCs. A possible role for p53 in stem cell biology is presented...
- A putative human breast stem cell population is enriched for steroid receptor-positive cellsRobert B Clarke
Breast Biology Group, Cancer Research UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK
Dev Biol 277:443-56. 2005..The data suggest a model where scattered steroid receptor-positive cells are stem cells that self-renew through asymmetric cell division and generate patches of transit amplifying and differentiated cells...
- Intestinal stem cells protect their genome by selective segregation of template DNA strandsChristopher S Potten
Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M9 4BX, UK
J Cell Sci 115:2381-8. 2002..The presence of these protective mechanisms ensures that the small intestine rarely develops cancer and that stem cells can sustain the extensive cell proliferation needed during life...
- The intestinal epithelial stem cellEmma Marshman
School of Biological Sciences, University of Manchester, Manchester, UK
Bioessays 24:91-8. 2002....
- Regulation of human breast epithelial stem cellsRobert B Clarke
Breast Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK
Cell Prolif 36:45-58. 2003..ERalpha/PR+ breast cancers exhibit loss of the two key regulators of asymmetric cell division, Musashi-1 and Notch-1 and thus may arise from symmetric division of the ERalpha/PR+ stem cell...
- HIV enteropathy: crypt stem and transit cell hyperproliferation induces villous atrophy in HIV/Microsporidia-infected jejunal mucosaPhilip A Batman
Department of Histopathology, Bradford Teaching Hospitals Foundation Trust, Bradford, UK
AIDS 21:433-9. 2007..The study aim was to analyse the kinetics of stem and transit cells in the crypts of jejunal mucosa infected with HIV and Microsporidia...
- Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivoSatoshi Ishizuka
School of Clinical Medical Sciences Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
Nucleic Acids Res 31:6198-205. 2003..Our results thus establish that PARP-1 acts as a survival factor for intestinal stem cells in vivo and suggest a functional link with early p53 and p21(CIP1/WAF1) responses...
- Helicobacter pylori regulates the expression of inhibitors of DNA binding (Id) proteins by gastric epithelial cellsBarbara Ada Manzo
Research Centre for Gastroenterology, Institute of Cell and Molecular Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, UK
Microbes Infect 8:1064-74. 2006..In conclusion, H. pylori alters the expression of Id proteins, in vitro and in vivo; it is hypothesised that these changes contribute to H. pylori-associated pathologies...
- Crowd control in the cryptCatherine Booth
Nat Med 8:1360-1. 2002
- An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infectionLaura J Cliffe
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M139PT, United Kingdom
Infect Immun 75:1556-64. 2007..It is proposed that the generation of proinflammatory cytokines during chronic T. muris infection may play a positive role, by promoting intestinal epithelial cell apoptosis, to counter infection-induced epithelial hyperplasia...
- Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IVJohn M Sheehan
Department of Environmental Dermatology, St John s Institute of Dermatology, Guy s, King s, and St Thomas School of Medicine, King s College London, St Thomas Hospital, UK
J Invest Dermatol 118:825-9. 2002..This provides further indirect evidence that DNA is a chromophore for erythema, but also suggests that a tan may not be the major factor in natural photoprotection...
- Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breastKai C Chan
Department of Surgery, University Hospital of South Manchester, United Kingdom
Cancer Res 62:122-8. 2002..3; P = 0.0005]. EGFR-TK inhibition with ZD1839 offers a novel approach to the treatment of EGFR-positive DCIS, regardless of ER status, and provides a potential new chemopreventative approach in patients at high risk of breast cancer...