John J Miles

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi request reprint Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination
    John J Miles
    T Cell Modulation Laboratory, Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK
    Immunol Cell Biol 89:375-87. 2011
  2. pmc Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection
    John J Miles
    Department of Infection, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    PLoS Pathog 6:e1001198. 2010
  3. pmc T-cell receptor specificity maintained by altered thermodynamics
    Florian Madura
    Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 288:18766-75. 2013
  4. pmc Peptide length determines the outcome of TCR/peptide-MHCI engagement
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
    Blood 121:1112-23. 2013
  5. pmc T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom
    J Biol Chem 287:37269-81. 2012
  6. pmc Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
    David K Cole
    Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Immunol 185:2600-10. 2010
  7. pmc Structural and biophysical determinants of αβ T-cell antigen recognition
    John S Bridgeman
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, UK
    Immunology 135:9-18. 2012
  8. pmc A single autoimmune T cell receptor recognizes more than a million different peptides
    Linda Wooldridge
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 287:1168-77. 2012
  9. pmc Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes
    Anna M Bulek
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Nat Immunol 13:283-9. 2012
  10. pmc Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability
    Kim M Miles
    Cardiff University, School of Medicine, Heath Park, Cardiff, UK
    Mol Immunol 48:728-32. 2011

Collaborators

Detail Information

Publications16

  1. doi request reprint Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination
    John J Miles
    T Cell Modulation Laboratory, Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK
    Immunol Cell Biol 89:375-87. 2011
    ..This review provides a catalog of αβ TCR bias by disease and by species, and discusses the mechanisms that govern this inherent and widespread phenomenon...
  2. pmc Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection
    John J Miles
    Department of Infection, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    PLoS Pathog 6:e1001198. 2010
    ..Such pattern recognition receptor-like traits within the αβ TCR system further blur the boundaries between the adaptive and innate immune systems...
  3. pmc T-cell receptor specificity maintained by altered thermodynamics
    Florian Madura
    Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 288:18766-75. 2013
    ..These findings advance our understanding of the molecular mechanisms that can govern the exquisite peptide specificity characteristic of TCR recognition...
  4. pmc Peptide length determines the outcome of TCR/peptide-MHCI engagement
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
    Blood 121:1112-23. 2013
    ..Accordingly, the effective recognition of pMHCI Ag, which is a prerequisite for successful CD8(+) T-cell immunity and protective vaccination, can only be achieved by length-matched Ag-specific CD8(+) T-cell clonotypes...
  5. pmc T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom
    J Biol Chem 287:37269-81. 2012
    ..This proof-of-concept study demonstrates that it is possible to design altered peptide antigens for the selection of superior T-cell clonotypes with enhanced antigen recognition properties...
  6. pmc Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
    David K Cole
    Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Immunol 185:2600-10. 2010
    ..Heteroclitic peptide-based immune interventions therefore require careful evaluation to ensure efficacy in the clinic...
  7. pmc Structural and biophysical determinants of αβ T-cell antigen recognition
    John S Bridgeman
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, UK
    Immunology 135:9-18. 2012
    ..Understanding the principles that govern pMHC recognition by T-cells will unlock pathways to the rational development of immunotherapeutic approaches for the treatment of infectious disease, cancer and autoimmunity...
  8. pmc A single autoimmune T cell receptor recognizes more than a million different peptides
    Linda Wooldridge
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 287:1168-77. 2012
    ....
  9. pmc Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes
    Anna M Bulek
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Nat Immunol 13:283-9. 2012
    ..Thus, highly focused peptide-centric interactions associated with suboptimal TCR-pMHCI binding affinities might lead to thymic escape and potential CD8(+) T cell-mediated autoreactivity...
  10. pmc Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability
    Kim M Miles
    Cardiff University, School of Medicine, Heath Park, Cardiff, UK
    Mol Immunol 48:728-32. 2011
    ..Our results further highlight the fact that heteroclitic peptide-based immune interventions require careful evaluation to ensure that wildtype antigen specificity is maintained in vivo...
  11. pmc Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells
    Bruno Laugel
    Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Immunol . 2016
    ..This system represents a robust and efficient method to disrupt the expression of MR1 and should facilitate investigations into the processing and presentation of MR1 Ags as well as into the biology of MAIT cells...
  12. pmc T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones
    Sarah M Theaker
    Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK
    J Immunol Methods 430:43-50. 2016
    ....
  13. pmc CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope
    Chihiro Motozono
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    PLoS ONE 8:e66152. 2013
    ..These findings explain the preferential selection of Phe at the C-terminus of VY8 in HLA-B(*)35∶01(+) individuals and demonstrate that HIV-1 can exploit the limitations of T cell recognition in vivo. ..
  14. pmc Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor
    David K Cole
    Department of Infection, Immunity, and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 284:27281-9. 2009
    ..This "innate" pattern of antigen recognition probably explains the unique characteristics and extraordinary frequencies of CD8(+) T-cell responses to this epitope...
  15. pmc MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs
    Linda Wooldridge
    Department of Infection, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:3357-66. 2010
    ..Thus, the low solution binding affinity of the pMHCI/CD8 interaction is essential for the maintenance of CTL Ag specificity...
  16. doi request reprint Understanding the complexity and malleability of T-cell recognition
    John J Miles
    1 QIMR Berghofer Medical Research Institute and QIMR Berghofer Centre for Immunotherapy and Vaccine Development, Brisbane, Queensland, Australia 2 School of Medicine, The University of Queensland, Brisbane, Queensland, Australia 3 Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK
    Immunol Cell Biol 93:433-41. 2015
    ..Here, we review some examples of the precision and flexibility intrinsic to the TCR/p/MHCI axis. ..