M Paula Longhi

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner
    M Paula Longhi
    Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Wales, United Kingdom
    J Immunol 175:7098-102. 2005
  2. ncbi request reprint CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens
    Baalasubramanian Sivasankar
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mol Immunol 44:2978-87. 2007
  3. pmc CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy?
    Baalasubramanian Sivasankar
    Department of Medical Biochemistry and Immunology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Immunol 182:5203-7. 2009
  4. ncbi request reprint Holding T cells in check--a new role for complement regulators?
    M Paula Longhi
    Medical Biochemistry and Immunology, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Trends Immunol 27:102-8. 2006
  5. pmc CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and -independent mechanisms
    M Paula Longhi
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Eur J Immunol 37:1266-74. 2007
  6. pmc Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity
    Nader Omidvar
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 176:2915-23. 2006
  7. ncbi request reprint CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity
    Hannah Richards
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Immunol 180:198-206. 2008
  8. ncbi request reprint Complement: central to innate immunity and bridging to adaptive responses
    B Paul Morgan
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Immunol Lett 97:171-9. 2005

Collaborators

Detail Information

Publications8

  1. pmc Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner
    M Paula Longhi
    Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Wales, United Kingdom
    J Immunol 175:7098-102. 2005
    ..Collectively, these results demonstrate that CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation...
  2. ncbi request reprint CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens
    Baalasubramanian Sivasankar
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mol Immunol 44:2978-87. 2007
    ..Furthermore, a CD59a fusion protein bound specifically to mouse B cells, and enhanced B cell proliferation in a MLR, demonstrating that B cells express an as yet unidentified ligand for CD59a that aids in B cell activation...
  3. pmc CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy?
    Baalasubramanian Sivasankar
    Department of Medical Biochemistry and Immunology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Immunol 182:5203-7. 2009
    ..These data highlight the potential for manipulating CD59 expression on T cells for boosting weak immune responses, such as those found in individuals with cancer...
  4. ncbi request reprint Holding T cells in check--a new role for complement regulators?
    M Paula Longhi
    Medical Biochemistry and Immunology, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Trends Immunol 27:102-8. 2006
    ..Here we review these studies, which reveal another important link between the innate and the adaptive immune system...
  5. pmc CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and -independent mechanisms
    M Paula Longhi
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Eur J Immunol 37:1266-74. 2007
    ..These results demonstrate that CD59a, previously defined as a complement regulator, modulates both the innate and adaptive immune response to influenza virus by both complement-dependent and -independent mechanisms...
  6. pmc Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity
    Nader Omidvar
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 176:2915-23. 2006
    ..The data show that the increased susceptibility of target cells expressing CD59 to NK cytotoxicity requires GPI anchor-mediating signaling events, likely mediated by interactions between GPI-anchored CD59 on targets and NK receptors...
  7. ncbi request reprint CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity
    Hannah Richards
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Immunol 180:198-206. 2008
    ..These results demonstrate that CD62L down-regulation is not required for CD8 memory cells to home to sites of infection. However, their ability to clear virus is significantly compromised if CD62L shedding is abrogated...
  8. ncbi request reprint Complement: central to innate immunity and bridging to adaptive responses
    B Paul Morgan
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Immunol Lett 97:171-9. 2005
    ..This review will describe the current state of knowledge in this swiftly moving field. It is hoped that the recognition of these properties will help to establish complement in the role it richly deserves as the lynchpin of immunity...