G Kirov

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint The molecular genetics of schizophrenia: progress so far
    G Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff
    Mol Med Today 3:124-30. 1997
  2. doi request reprint Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha
    L S Carroll
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 15:1101-11. 2010
  3. pmc Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
    M C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:30-6. 2009
  4. doi request reprint A genome-wide association study in 574 schizophrenia trios using DNA pooling
    G Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Cardiff, UK
    Mol Psychiatry 14:796-803. 2009
  5. ncbi request reprint Screening the human protocadherin 8 (PCDH8) gene in schizophrenia
    N J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Genes Brain Behav 1:187-91. 2002
  6. ncbi request reprint Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic study
    D Ivanov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 183:409-13. 2003
  7. ncbi request reprint Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 6:671-7. 2001
  8. pmc Pooled genotyping of microsatellite markers in parent-offspring trios
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Genome Res 10:105-15. 2000
  9. ncbi request reprint Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
    H J Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003
  10. pmc Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype
    N Craddock
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:146-53. 2010

Detail Information

Publications31

  1. ncbi request reprint The molecular genetics of schizophrenia: progress so far
    G Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff
    Mol Med Today 3:124-30. 1997
    ..Here, we review the evidence for these linkages, as well as findings from association studies that have not yet received as much independent confirmation...
  2. doi request reprint Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha
    L S Carroll
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 15:1101-11. 2010
    ..However, the evidence across all approaches suggests that further study of this locus is warranted...
  3. pmc Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
    M C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:30-6. 2009
    ..17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia...
  4. doi request reprint A genome-wide association study in 574 schizophrenia trios using DNA pooling
    G Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Cardiff, UK
    Mol Psychiatry 14:796-803. 2009
    ..05, with the best result at P=1.2 x 10(-6) for rs11064768. This SNP is within the gene CCDC60, a coiled-coil domain gene. The third best SNP (P=0.00016) is rs893703, within RBP1, a candidate gene for schizophrenia...
  5. ncbi request reprint Screening the human protocadherin 8 (PCDH8) gene in schizophrenia
    N J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Genes Brain Behav 1:187-91. 2002
    ..These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded...
  6. ncbi request reprint Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic study
    D Ivanov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 183:409-13. 2003
    ..About 30% of patients with VCFS have psychosis, and the rate of these deletions in schizophrenia has been reported to be about 1%. Even higher rates of VCFS deletions have been reported for childhood-onset schizophrenia...
  7. ncbi request reprint Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 6:671-7. 2001
    ..The polymorphisms identified in this study will be useful in examining the role of this gene in other neuropsychiatric disorders and behavioural traits...
  8. pmc Pooled genotyping of microsatellite markers in parent-offspring trios
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Genome Res 10:105-15. 2000
    ..The use of trios will confirm or reject any suggested differences, thus reducing the false-positive rate that can be created by hidden population stratification...
  9. ncbi request reprint Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
    H J Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003
    ..05 level. These results do not suggest that PRODH or PsPRODH contribute to the aetiology of schizophrenia, and that the putative schizophrenia susceptibility gene in 22q11 remains unknown...
  10. pmc Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype
    N Craddock
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:146-53. 2010
    ..Our method of phenotype refinement may be useful in studies of other complex psychiatric and non-psychiatric disorders...
  11. ncbi request reprint Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:342-5. 1998
    ..84, d.f. = 1, P = 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder...
  12. ncbi request reprint Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1)
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Arch Gen Psychiatry 61:336-44. 2004
    ..Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been identified in more than 1 study...
  13. pmc Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample
    E K Green
    Department of Psychological Medicine, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 18:1302-7. 2013
    ..Second, rs3818253 (P=3.88 × 10(-8), OR=1.16), an intronic SNP on chromosome 20q11.2 in the gene TRPC4AP, which lies in a high linkage disequilibrium region along with the genes GSS and MYH7B. ..
  14. ncbi request reprint Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5
    G Kirov
    Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK
    Mol Psychiatry 4:558-65. 1999
    ..No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied...
  15. ncbi request reprint Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004
    ..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD...
  16. ncbi request reprint Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4
    B Glaser
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, UK
    Mol Psychiatry 10:920-7. 2005
    ..001), where some of the variance was accounted for by the genotype at ss24735177. Our findings thus indicate the potential functional relevance of the associated haplotype and now require replication in independent samples...
  17. ncbi request reprint Religious faith after psychotic illness
    G Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychopathology 31:234-45. 1998
    ..We conclude that the experience of a psychotic illness is likely to lead to an increase in religious beliefs. Such beliefs are commonly used for coping with the illness and some patients attach a great importance to them...
  18. ncbi request reprint Thyroid disorders in lithium-treated patients
    G Kirov
    Division of Psychological Medicine, Heath Park, Cardiff, UK
    J Affect Disord 50:33-40. 1998
    ..Little is known about the rate of thyroid disorders prior to lithium treatment, and which patients have a higher risk for developing such disorders during such treatment...
  19. pmc Polygenic dissection of the bipolar phenotype
    M L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Br J Psychiatry 198:284-8. 2011
    ..Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder...
  20. ncbi request reprint Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 7:1092-100. 2002
    ..35, P = 0.006, P = 0.078 corrected for 13 alleles)...
  21. ncbi request reprint Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele
    I P Blair
    Neurobiology Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Mol Psychiatry 11:372-83. 2006
    ..004). Together, these data provide convergent evidence that FAT and its protein partners may be components of a molecular pathway involved in susceptibility to bipolar disorder...
  22. ncbi request reprint Association between PRODH and schizophrenia is not confirmed
    H J Williams
    Mol Psychiatry 8:644-5. 2003
  23. ncbi request reprint The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report
    P Bennett
    Molecular Psychiatry Group, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Edgbaston, Birmingham, B15 2QZ, UK
    Mol Psychiatry 7:189-200. 2002
    ..54). Overall the highest MLS was 1.70 on chromosome 2 at marker D2S125, under the broadest diagnostic model...
  24. ncbi request reprint Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population
    L Georgieva
    Department of Medical Genetics, Medical University Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria
    Acta Psychiatr Scand 105:396-9. 2002
    ..No significant results have been found. We used a new collection of parent-offspring trios to test for association with schizophrenia (SZ), bipolar 1 disorder (BPI) and schizoaffective (SA) disorder...
  25. ncbi request reprint Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder
    A D Børglum
    Institute of Human Genetics, University of Aarhus, Denmark
    Am J Med Genet B Neuropsychiatr Genet 117:18-22. 2003
    ..Increased transmission of paternal DDC alleles has also been suggested in attention deficit hyperactivity disorder. We suggest that DDC might confer susceptibility to BPAD predominantly when paternally transmitted...
  26. ncbi request reprint Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls
    P Sklar
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 28:126-8. 2001
    ..These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia...
  27. ncbi request reprint Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22
    D Lambert
    Department of Genetics, Trinity College Dublin, Dublin, Republic of Ireland
    Mol Psychiatry 10:831-41. 2005
    ..Our scan also provides support for linkage (MLS> or =1.5) at several other regions that have been implicated in meta-analyses of bipolar disorder and/or schizophrenia including 9p21, 10p14-p12 and 18q22...
  28. ncbi request reprint IGF1, growth pathway polymorphisms and schizophrenia: a pooling study
    D Gunnell
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Am J Med Genet B Neuropsychiatr Genet 144:117-20. 2007
    ..SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF-I in the aetiology of schizophrenia...
  29. ncbi request reprint Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation
    E K Green
    Mol Psychiatry 11:798-9. 2006
  30. ncbi request reprint A new form of familial multi-nodular goitre with progression to differentiated thyroid cancer
    A Bakhsh
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Endocr Relat Cancer 13:475-83. 2006
    ..From these findings and from the absence of any linkage to any of the known loci associated with MNG or FNMTC, we suggest that this represents a new form of inherited MNG with a significant risk of progression to papillary carcinoma...
  31. ncbi request reprint Association study of myo-inositol monophosphatase 2 (IMPA2) polymorphisms with bipolar affective disorder and response to lithium treatment
    A Dimitrova
    Department of Medical Genetics, Medical University Sofia, Sofia, Bulgaria
    Pharmacogenomics J 5:35-41. 2005
    ....