W Jiang

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom
    J Exp Ther Oncol 6:257-64. 2007
  2. doi request reprint Tissue invasion and metastasis: Molecular, biological and clinical perspectives
    W G Jiang
    Cardiff University, Cardiff, United Kingdom Electronic address
    Semin Cancer Biol 35:S244-75. 2015
  3. pmc YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells
    Wen G Jiang
    Cardiff University Peking University Cancer Institute, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    J Transl Med 13:280. 2015
  4. ncbi request reprint Expression of Sonic Hedgehog (SHH) in human lung cancer and the impact of YangZheng XiaoJi on SHH-mediated biological function of lung cancer cells and tumor growth
    Wen G Jiang
    Cardiff University Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff, UK
    Anticancer Res 35:1321-31. 2015
  5. pmc FAP-α (Fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway
    Jun Jia
    Cardiff University Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff CF14 4XNWales, UK
    BMC Cell Biol 15:16. 2014
  6. pmc Association of Differentiation-Related Gene-1 (DRG1) with Breast Cancer Survival and in Vitro Impact of DRG1 Suppression
    Ruqia Mehmood Baig
    Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Cancers (Basel) 4:658-72. 2012
  7. pmc Impact of fibroblast activation protein on osteosarcoma cell lines in vitro
    Lixiang Ding
    Cardiff University Capital Medical University Joint Centre for Biomedical Research, Cardiff CF14 4XN, UK Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK Department of Orthopaedic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P R China
    Oncol Lett 7:699-704. 2014
  8. pmc Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    J Transl Med 11:269. 2013
  9. pmc Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways
    Astrid Escudero-Esparza
    Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK
    J Exp Clin Cancer Res 31:43. 2012
  10. pmc The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions
    Mu Hu
    Cardiff University Capital Medical University Joint Centre for Biomedical Research, Cardiff, UK
    BMC Cancer 12:588. 2012

Collaborators

Detail Information

Publications142 found, 100 shown here

  1. ncbi request reprint Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom
    J Exp Ther Oncol 6:257-64. 2007
    ....
  2. doi request reprint Tissue invasion and metastasis: Molecular, biological and clinical perspectives
    W G Jiang
    Cardiff University, Cardiff, United Kingdom Electronic address
    Semin Cancer Biol 35:S244-75. 2015
    ..Together, these strategies could represent new, inexpensive, low toxicity strategies to aid in the management of cancer metastasis as well as having holistic effects against other cancer hallmarks. ..
  3. pmc YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells
    Wen G Jiang
    Cardiff University Peking University Cancer Institute, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    J Transl Med 13:280. 2015
    ..In the present study, we investigated the effect of a traditional Chinese medicine reported in cancer therapies, namely YangZheng XiaoJi (YZXJ) on lung cancer and on HGF mediated migration and invasion of lung cancer cells...
  4. ncbi request reprint Expression of Sonic Hedgehog (SHH) in human lung cancer and the impact of YangZheng XiaoJi on SHH-mediated biological function of lung cancer cells and tumor growth
    Wen G Jiang
    Cardiff University Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff, UK
    Anticancer Res 35:1321-31. 2015
    ..Together with the aberrant expression of SHH in NSCLC tumors in the patients, it is suggested that SHH is a potential target for therapies for NSCLC. ..
  5. pmc FAP-α (Fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway
    Jun Jia
    Cardiff University Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff CF14 4XNWales, UK
    BMC Cell Biol 15:16. 2014
    ..Furthermore the potential interaction of FAP-α with other signalling pathways was investigated...
  6. pmc Association of Differentiation-Related Gene-1 (DRG1) with Breast Cancer Survival and in Vitro Impact of DRG1 Suppression
    Ruqia Mehmood Baig
    Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Cancers (Basel) 4:658-72. 2012
    ....
  7. pmc Impact of fibroblast activation protein on osteosarcoma cell lines in vitro
    Lixiang Ding
    Cardiff University Capital Medical University Joint Centre for Biomedical Research, Cardiff CF14 4XN, UK Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK Department of Orthopaedic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P R China
    Oncol Lett 7:699-704. 2014
    ..05). In conclusion, FAP influences OS cells and may play a role in OS tumor progression and metastasis...
  8. pmc Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    J Transl Med 11:269. 2013
    ..The present study aimed to investigate the influence of TGase-4 on cell-matrix adhesion and search for the candidate active domain[s] within the protein...
  9. pmc Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways
    Astrid Escudero-Esparza
    Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK
    J Exp Clin Cancer Res 31:43. 2012
    ..This study examined the level of expression and distribution of Claudin-5 in human breast cancer tissues and the effect of knockdown and forced expression of Claudin-5 in the MDA-MB-231 breast cancer cell line...
  10. pmc The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions
    Mu Hu
    Cardiff University Capital Medical University Joint Centre for Biomedical Research, Cardiff, UK
    BMC Cancer 12:588. 2012
    ....
  11. ncbi request reprint The impact of angio-associated migratory cell protein (AAMP) on breast cancer cells in vitro and its clinical significance
    Yukun Yin
    Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Anticancer Res 33:1499-509. 2013
    ..However, the cellular role of AAMP in breast cancer is still unclear. The aim of the current study was to provide new insights into the implication of AAMP in breast cancer...
  12. doi request reprint Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int J Oncol 41:1635-42. 2012
    ..In conclusion, Yangzhen Xiaoji has a marked effect on angiogenesis, in vitro and that this effect is at least partly mediated by the focal adhesion kinase (FAK) pathway...
  13. ncbi request reprint Expression of signal-induced proliferation-associated gene 1 (SIPA1), a RapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells
    Ke Ji
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff, U K
    Cancer Genomics Proteomics 9:321-7. 2012
    ..However the role of this molecule in colorectal cancer remains unknown. The current study aimed to investigate the expression of SIPA1 in colorectal tumour tissues and its impact on the function of colorectal cancer cells...
  14. pmc Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, China
    World J Surg Oncol 3:68. 2005
    ..This study examined PlGF expression at protein and message levels in non-small cell lung cancer (NSCLC), in which no reports on the significance of PlGF expression is available to date...
  15. ncbi request reprint Impact of Yangzheng Xiaoji on the adhesion and migration of human cancer cells: the role of the AKT signalling pathway
    Lin Ye
    Cardiff University Peking University School of Oncology Joint Institute, Cardiff CF14 4XN, UK
    Anticancer Res 32:2537-43. 2012
    ..In the present study, we investigated the direct effects of Yangzheng Xiaoji on a range of human cancer cell lines and investigated the possible mechanism(s) of its action...
  16. ncbi request reprint EPLIN-α expression in human oesophageal cancer and its impact on cellular aggressiveness and clinical outcome
    Yinan Liu
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    Anticancer Res 32:1283-9. 2012
    ..Our current study examined this molecule in human oesophageal tissues and investigated the cellular impact of EPLIN-α on oesophageal cancer cells...
  17. pmc The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance
    Fei Xie
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF144XN, UK
    J Transl Med 9:95. 2011
    ..Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma (ESCC) has not been reported...
  18. pmc Contribution of BRCA1 germline mutation in patients with sporadic breast cancer
    Fraz A Malik
    Cancer Genetics Lab Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Int Semin Surg Oncol 5:21. 2008
    ..Further studies involving a screening of entire coding region of BRCA1 is required to explore the merits of genetic diagnosis and counseling in breast cancer patients...
  19. pmc The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer
    Jane Lane
    Metastasis Research Group, University Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff, CF4 4XN, UK
    Int Semin Surg Oncol 5:23. 2008
    ..The purpose of this study was to investigate the expression of these GEFs, in human breast cancer and assess the affect on clinical outcome...
  20. pmc Brain-derived neurotrophic factor expression predicts adverse pathological & clinical outcomes in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, 42 52 Nottingham Place, W1U 5NY, London, England, UK
    Cancer Cell Int 11:23. 2011
    ..Expression levels were compared with normal background tissues and evaluated against established pathological parameters and clinical outcome over a 10 year follow-up period...
  21. pmc Tumour suppressor function of MDA-7/IL-24 in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, 42 52 Nottingham Place, W1U 5NY, London, UK
    Cancer Cell Int 10:29. 2010
    ..Furthermore, mRNA expression of MDA-7 is assessed in a cohort of women with BC and correlated with established pathological parameters and clinical outcome...
  22. pmc The mRNA expression of SATB1 and SATB2 in human breast cancer
    Neill Patani
    Department of Breast Surgery, St, George s University of London, London, UK
    Cancer Cell Int 9:18. 2009
    ..In this study, the level of mRNA expression of SATB1 and SATB2 were assessed in normal and malignant breast tissue in a cohort of women with breast cancer and correlated to conventional clinico-pathological parameters...
  23. pmc iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway
    Jinfeng Chen
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Thoracic Surgery, Peking University School of Oncology and Beijing Cancer Hospital and Institute Beijing, 100142 PR China
    BMC Cancer 10:694. 2010
    ..The present study investigated the expression of iASPP in clinical lung cancer, a leading cancer type in the world, and the biological impact of this molecule on lung cancer cells...
  24. ncbi request reprint Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells
    W G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Prostaglandins Leukot Essent Fatty Acids 56:307-16. 1997
    ..It is concluded that GLA reduces tumour-endothelium adhesion, partly by improved gap junction communications of the endothelium...
  25. ncbi request reprint Gamma linolenic acid regulates expression of maspin and the motility of cancer cells
    W G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Biochem Biophys Res Commun 237:639-44. 1997
    ..This reduction was reversed with anti-maspin antibody. It is concluded that GLA, a member of then-6 series of EFAs, up-regulates the expression of maspin which is associated with a reduction in the motility of cancer cells...
  26. ncbi request reprint Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids
    W G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Clin Exp Metastasis 15:593-602. 1997
    ..Other fatty acids increased Dsg expression, but to a lesser extent. It is concluded that GLA regulates desmosome-mediated cell-cell adhesion in human cancer cells, particularly in cells without E-cadherin...
  27. ncbi request reprint Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin
    S Hiscox
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    J Cell Sci 112:3081-90. 1999
    ....
  28. ncbi request reprint Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells
    W G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    J Cell Physiol 181:319-29. 1999
    ..It is concluded that HGF/SF decreases the expression of occludin, resulting in the functional change of tight junction...
  29. ncbi request reprint Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells
    W G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 5:3695-703. 1999
    ..It inhibits HGF-induced endothelial movement and tubule formation. Thus, NK4 may have an important bearing on the control of cancer progression through its role in angiogenesis. Additional in vivo studies are warranted...
  30. ncbi request reprint Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells
    W G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Prostaglandins Leukot Essent Fatty Acids 62:119-27. 2000
    ..Thus, PPAR gamma serves as the receptor for GLA in the regulation of gene expression in breast cancer cells...
  31. ncbi request reprint The pathology of essential fatty acid deficiency: is it cell adhesion mediated?
    W G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Med Hypotheses 55:257-62. 2000
    ..These findings may provide molecular explanations for those phenomena seen in EFAD and this paper aims to discuss these relationships and raise points for further discussion...
  32. ncbi request reprint E-cadherin complex and its abnormalities in human breast cancer
    W G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    Surg Oncol 9:151-71. 2000
    ..The current article summarises recent progresses in the molecular/cellular biology of E-cadherin and its complex and the clinical, diagnostic, prognostic, and therapeutic value of this complex in breast cancer...
  33. ncbi request reprint A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells
    W G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, United Kingdom
    Clin Cancer Res 7:2555-62. 2001
    ..This study examined a transgene-consisting of a combination of U1snRNA, hammerhead ribozyme, and antisense, designed to inhibit c-met expression-and its impact on the migration and in vitro invasion of breast cancer cells...
  34. ncbi request reprint Molecular detection of micro-metastasis in breast cancer
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Crit Rev Oncol Hematol 43:13-31. 2002
    ..The current article discusses recent developments, in the detection of micro-metastasis using molecular biology techniques...
  35. ncbi request reprint Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes
    Wen G Jiang
    Metastasis Research Group, University of Wales College of Medicine, Cardiff, United Kingdom
    Int J Cancer 106:752-7. 2003
    ..We conclude that there is aberrant expression of PPARgamma and its co-activator, PGC-1, in human breast cancer and low levels of these molecules in cancer tissues are associated with poor clinical outcomes...
  36. ncbi request reprint Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 69:275-81. 2003
    ....
  37. ncbi request reprint Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Clin Cancer Res 9:4274-81. 2003
    ..This study examined if inhibition of HGF/SF receptor expression by cancer cells and HGF/SF expression by stromal fibroblasts affects the growth of mammary cancer...
  38. ncbi request reprint Expression of transglutaminases in human breast cancer and their possible clinical significance
    Wen G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Oncol Rep 10:2039-44. 2003
    ..Higher levels of TGases-4 and 5 were noted in patients with local recurrence. Breast cancer displays an aberrant expression of TGases, wherein the levels of TGases-2, 3 and 7 have a relationship with node involvement and patient outcome...
  39. ncbi request reprint Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers
    Wen G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 9:6432-40. 2003
    ..This study determined the levels of expression and the distribution of Rho-A, -B, -C, and -G, and Rho-6, -7, and -8, as well as Rho-GDI-beta, and Rho-GDI-gamma, in breast cancer and assessed their prognostic value...
  40. ncbi request reprint Psoriasin is aberrantly expressed in human breast cancer and is related to clinical outcomes
    Wen G Jiang
    Metastasis Research Group, University of Wales College of Medicine, Cardiff, UK
    Int J Oncol 25:81-5. 2004
    ..02 and p<0.001, vs disease-free, respectively). It is concluded that aberrant expression of psoriasin is commonly seen in human breast cancer and that excessively high levels are correlated with the clinical outcomes...
  41. ncbi request reprint Hepatocyte growth factor, its receptor, and their potential value in cancer therapies
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Crit Rev Oncol Hematol 53:35-69. 2005
    ..The current article discusses the potential value of HGF and its receptor as targets in cancer therapies, the current development in anti-HGF research, and the clinical value of HGF in prognosis and treatment...
  42. ncbi request reprint Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University of Wales College of Medicine, Cardiff University, Cardiff, UK
    Endocr Relat Cancer 11:781-91. 2004
    ..While Cyr61 appears to act as a factor stimulating aggressiveness, CTGF and Nov may act as tumour suppressors...
  43. ncbi request reprint Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff CF4 4XN, UK
    Biochem Biophys Res Commun 330:253-62. 2005
    ..The current study investigated the impact of Com-1 on oestrogen regulated cell growth of breast cancer cells and explored the potential link between Com-1 and ER-beta...
  44. ncbi request reprint Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, UK
    Eur J Cancer 41:1628-36. 2005
    ..However, the TSC genes have not been studied in breast cancer. The current study investigated the expression of the TSC gene products and the potential mechanisms of their aberrancy in human breast cancer cells and tissues...
  45. ncbi request reprint Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Int J Cancer 117:730-7. 2005
    ..The expression levels of Com-1 in breast tumours are correlated with the prognosis of the patients and with the long term overall survival in association with ER status...
  46. ncbi request reprint Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 11:6012-9. 2005
    ..The current study examined if targeting matrilysin using retroviral ribozyme transgenes may have an impact on breast cancer cells and may have clinical implications...
  47. ncbi request reprint The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivo
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, UK
    Int J Mol Med 16:723-8. 2005
    ..Hepatocyte growth factor has potential lymphangiogenic activities, and this may have important implications in the nodal spread of cancer cells...
  48. ncbi request reprint Expression of autocrine motility factor (AMF) and its receptor, AMFR, in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    J Histochem Cytochem 54:231-41. 2006
    ..This strongly indicates that the AMF-AMFR complex plays an important role in the progression of breast cancer, as well as having a prognostic role...
  49. ncbi request reprint Aberrant expression of 5-lipoxygenase-activating protein (5-LOXAP) has prognostic and survival significance in patients with breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, School of Medicine Cardiff University, Heath Park, Cardiff, CF1A 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 74:125-34. 2006
    ..Furthermore, 5-LOXAP had a significant prognostic value in patients with breast cancer. This identifies 5-LOXAP as a potential therapeutic target in breast cancer...
  50. pmc Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, UK
    BMC Cancer 6:16. 2006
    ..This study examined the expression of angiomotin and its analogues, angiomotin-like 1 (L1) and -like 2 (L2) in breast tumour tissues, and analysed their correlation with angiogenesis and clinical outcomes...
  51. ncbi request reprint Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Int J Mol Med 17:583-90. 2006
    ..It is highly expressed in aggressive breast tumours and is associated with clinical outcome. The enzyme is a potential therapeutic target in breast cancer...
  52. ncbi request reprint Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 74:235-45. 2006
    ..The study has also reported a link between 15-LOX-2 and oestrogen receptor status in breast tumours. Both isoforms of 15-lipoxygenase have a tumour suppressing role in breast cancer...
  53. ncbi request reprint Com-1/p8 acts as a putative tumour suppressor in prostate cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 18:981-6. 2006
    ..Com-1/p8 is a potential tumour suppressor in human prostate cancer...
  54. ncbi request reprint Does the PGC-1/PPARgamma pathway play a role in Com-1/p8 mediated cell growth inhibition in prostate cancer?
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 18:1169-75. 2006
    ..Com-1 may act as a tumour suppressor in human prostate cancer cells. The potential tumour suppressive effect of Com-1 is at least partly via its interaction with PGC-1, the PPAR-gamma coactivator...
  55. pmc Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Mol Cancer 7:71. 2008
    ..To investigate the expression of EPLIN-alpha, epithelial protein lost in neoplasm, in human breast cancer tissues/cells and investigate the cellular impact of EPLIN-alpha on breast cancer cells...
  56. doi request reprint The prostate transglutaminase (TGase-4, TGaseP) regulates the interaction of prostate cancer and vascular endothelial cells, a potential role for the ROCK pathway
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Microvasc Res 77:150-7. 2009
    ..It is therefore concluded, that TGase-4 plays a pivotal role in the interaction between endothelial cells and prostate cancer cells, an action which is independent of the ROCK pathway...
  57. ncbi request reprint The prostate transglutaminase, TGase-4, coordinates with the HGFL/MSP-RON system in stimulating the migration of prostate cancer cells
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int J Oncol 37:413-8. 2010
    ..It is concluded that TGase-4 expression is intrinsically linked to the activation of RON in prostate cancer cells and that this autoactivation of RON contributes to the increased cell motility in TGase-4 expressing cells...
  58. doi request reprint Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes
    Wen G Jiang
    Department of Surgery, Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    Wound Repair Regen 18:594-604. 2010
    ..The WAVE proteins have a significant predicative and therapeutic value in wound healing...
  59. ncbi request reprint Cancer metastasis, challenges, progress and the opportunities
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom
    Front Biosci (Elite Ed) 3:391-4. 2011
    ..This issue of the journal is directed toward consideration of some of the salient aspects of cancer metastasis, with a focus on recent progress of the molecular and cellular mechanisms of cancer invasion and metastasis...
  60. ncbi request reprint Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis
    Zhu Yuan
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Anticancer Res 31:303-10. 2011
    ..The role of human antigen R (HuR) and its prognostic value in breast cancer is currently only partially understood. This study aimed to determine the levels of expression of HuR in breast cancer and assess its prognostic value...
  61. ncbi request reprint The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells
    Mahir A A Al-Rawi
    Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 XN, UK
    Int J Oncol 27:721-30. 2005
    ..This might have a significant impact on the lymphatic spread of solid tumours. Furthermore, interruption of IL-7 signalling might provide an attractive therapeutic option in cancer lymphatic metastasis...
  62. doi request reprint Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Eur J Cancer 45:1673-83. 2009
    ..We conclude that MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells...
  63. ncbi request reprint Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
    Jun Cai
    School of Optometry and Vision Sciences, Cardiff University, UK
    J Biol Chem 281:3604-13. 2006
    ..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
  64. ncbi request reprint Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer
    Simon R Davies
    Metastasis and Angiogenesis Research Group, Department of Surgery, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, United Kingdom
    Ann Surg Oncol 14:1909-18. 2007
    ..The CCN family has three Wnt-inducted secreted proteins named WISP-1, WISP-2 and WISP-3. These molecules are known to play a diverse role in cells, but their role in cancer cells remains controversial...
  65. ncbi request reprint Genetic manipulation of stromal cell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells
    Hua Kang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, UK
    Int J Oncol 26:1429-34. 2005
    ..SDF-1, together with its receptor CXCR4 may provide important information for predicting the aggressive nature and constitute important therapeutic targets in human breast cancer...
  66. ncbi request reprint Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer
    Hua Kang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Oncol 35:205-11. 2009
    ..These SDFs thus have prognostic value and warrant further investigation in their biological functions and clinical value...
  67. ncbi request reprint Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications
    Simon R Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, CF14 4XN Cardiff, UK
    Int J Oncol 36:1129-36. 2010
    ..WISPs may play important but contrasting roles in colorectal cancer with WISP-1 appearing to act as a factor stimulating aggressiveness, WISP-2 as a tumour suppressor and WISP-3 having no definable beneficial or detrimental role...
  68. ncbi request reprint Elevated levels of tumour endothelial marker-8 in human breast cancer and its clinical significance
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Int J Oncol 29:1311-7. 2006
    ..We conclude that TEM-8 is a useful marker for identifying tumour associated micro-vessels and that elevated levels are associated with disease progression, which may have some bearing on the prognostic outcome in breast cancer...
  69. ncbi request reprint Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Exp Ther Oncol 6:39-48. 2006
    ..In the current study we assessed the efficacy of targeting matriptase-1 using ribozyme technology in vitro and in vivo...
  70. ncbi request reprint The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
    Mohammad K Zia
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 20:605-11. 2007
    ..Low levels of VHL occur in most aggressive breast tumours. Taken together, VHL is a powerful putative tumour suppressor gene in human breast cancer...
  71. doi request reprint Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    J Cell Physiol 216:780-9. 2008
    ..Furthermore, the data presented implies a possible connection between matriptase-2 and the paxillin and FAK adhesion molecules which may ultimately contribute to the reduced migration rates seen in this study...
  72. doi request reprint WAVE3 is associated with invasiveness in prostate cancer cells
    Herman S Fernando
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom
    Urol Oncol 28:320-7. 2010
    ..We investigated the expression pattern and the effects of manipulating endogenous WAVE3 expression in prostate cancer cells...
  73. ncbi request reprint ALCAM, activated leukocyte cell adhesion molecule, influences the aggressive nature of breast cancer cells, a potential connection to bone metastasis
    Simon Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Anticancer Res 30:1163-8. 2010
    ..The present study investigated the biological influence of ALCAM on breast cancer cells in connection with bone biological environment...
  74. pmc Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer
    Hua Kang
    Wales College of Medicine, Cardiff University, Cardiff, UK
    Breast Cancer Res 7:R402-10. 2005
    ....
  75. ncbi request reprint Decreased pigment epithelium-derived factor expression in human breast cancer progression
    Jun Cai
    Cell and Molecular Biology Group, School of Optometry and Vision Sciences, Wales College of Medicine, Cardiff University, United Kingdom
    Clin Cancer Res 12:3510-7. 2006
    ..The aim of this study was to correlate the expression of pigment epithelium-derived factor (PEDF), a potent endogenous antiangiogenic molecule, with severity and prognosis in breast cancer...
  76. doi request reprint Phospholipase-C gamma-1 (PLCgamma-1) is critical in hepatocyte growth factor induced in vitro invasion and migration without affecting the growth of prostate cancer cells
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Urol Oncol 26:386-91. 2008
    ..This study sought to determine the effect of HGF on the invasive and migratory potential of prostate cancer cells targeted by a ribozyme transgene to PLCgamma-1...
  77. doi request reprint Claudin-16 reduces the aggressive behavior of human breast cancer cells
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    J Cell Biochem 105:41-52. 2008
    ..Claudin-16 expression was reduced in human breast cancer, particularly in patients with aggressive tumors and high mortality. This suggests that Claudin-16 plays a role beyond that of an initial metastasis repressor in this cancer type...
  78. doi request reprint WAVE1 is associated with invasiveness and growth of prostate cancer cells
    Herman S Fernando
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    J Urol 180:1515-21. 2008
    ..We investigated the expression pattern and the effects of manipulating endogenous WAVE1 expression in prostate cancer cells...
  79. ncbi request reprint Bone morphogenetic proteins 1 to 7 in human breast cancer, expression pattern and clinical/prognostic relevance
    Simon R Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    J Exp Ther Oncol 7:327-38. 2008
    ..Recently, BMP molecules have further been shown to have an impact on the biological behaviour of breast cancer cells. In this study, we looked, for the first time, at the expression of a panel of BMPs in breast carcinomas...
  80. ncbi request reprint Effect of expressional alteration of KAI1 on breast cancer cell growth, adhesion, migration and invasion
    Faraz Arshad Malik
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, Wales, United Kingdom
    Cancer Genomics Proteomics 6:205-13. 2009
    ..KAI1 did not affect cell growth. It is concluded therefore that KAI1 plays an important role in cell adhesion, invasion and migration of breast cancer cells, in vitro, and is a potential metastasis suppressor gene in breast cancer...
  81. ncbi request reprint Expression of MLN64 influences cellular matrix adhesion of breast cancer cells, the role for focal adhesion kinase
    Wei Cai
    Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int J Mol Med 25:573-80. 2010
    ..MLN64 contributes to the development and progression of breast cancer through the regulation of cell proliferation and adhesive capacity...
  82. ncbi request reprint Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance
    Shan Cheng
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, U K
    Cancer Genomics Proteomics 7:67-73. 2010
    ..This suggests that TACC2 may mediate an oncogenic effect on breast cancer cells and indicates that TACC2 may be a potential therapeutic target...
  83. ncbi request reprint Biphasic effects of 17-beta-estradiol on expression of occludin and transendothelial resistance and paracellular permeability in human vascular endothelial cells
    Lin Ye
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    J Cell Physiol 196:362-9. 2003
    ....
  84. ncbi request reprint Transcriptional and translational modulation of KAI1 expression in ductal carcinoma of the breast and the prognostic significance
    Fraz A Malik
    Department of Surgery, Cardiff University School of Medicine, Cardiff, Wales, UK
    Int J Mol Med 23:273-8. 2009
    ..0136). KAI1 inverse correlation with tumour progression may be used as a strong prognostic marker...
  85. ncbi request reprint PGF isoforms, PLGF-1 and PGF-2 and the PGF receptor, neuropilin, in human breast cancer: prognostic significance
    Astrid Escudero-Esparza
    Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff, UK
    Oncol Rep 23:537-44. 2010
    ..Our study shows that PLGF isoforms PLGF-1 and PGF-2 and indeed their receptor neuopilin, have an aberrant pattern of expression and that high levels of the PLGF-1 and neuropilin are linked to a poor prognosis...
  86. ncbi request reprint Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer
    Jane Lane
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Int J Mol Med 12:253-7. 2003
    ..It is concluded that aggressive breast tumours have a reduced level of delta-6-desaturase. This aberrant expression has clinical bearings to the outcome in patients with breast cancer...
  87. ncbi request reprint The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer
    Hua Kang
    University Department of Surgery, Wales College of Medicine, Metastasis and Angiogenesis Research Group, Cardiff University, Heath Park, Cardiff CF4 4XN, UK
    Breast 14:360-7. 2005
    ..The elevated levels of CXCR4 suggest that the patient has high possibility of lymph node metastasis. CXCR4 may be a useful prognostic indicator and a potential therapeutic target in cancer therapies in patients with breast cancer...
  88. ncbi request reprint Rapid molecular and morphological responses of prostate cell lines to cell-cell contact
    Despina Bazou
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Cell Commun Adhes 13:279-94. 2006
    ..These results, discussed also in the context of earlier studies of cell adhesion in an ultrasound trap, characterize a reduced adhesiveness of DU-145 cells compared to PZ-HPV-7 cells...
  89. ncbi request reprint Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 20:613-9. 2007
    ..This implies that therapies inducing the overexpression of HAI-1 or delivering an exogenous source of HAI-1 protein may hold potential as a treatment to slow the progression of prostate cancer...
  90. ncbi request reprint Expression of transcription factor CREB1 in human breast cancer and its correlation with prognosis
    Alok Chhabra
    Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Oncol Rep 18:953-8. 2007
    ..We conclude that the level of CREB1 expression is aberrant in human breast cancer and is associated with disease progression in breast cancer patients...
  91. ncbi request reprint Hepatocyte growth factor regulation: an integral part of why wounds become chronic
    Kevin Conway
    Wound Healing Research Unit, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Wound Repair Regen 15:683-92. 2007
    ..This aberrant expression may have a value in predicting the process of healing and nonhealing wounds and constitute important targets of future therapies...
  92. pmc Lymphangiogenesis and lymph node metastasis in breast cancer
    Giles H Cunnick
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, CF14 4XN, Wales, UK
    Mol Cancer 7:23. 2008
    ..The cDNA from 153 frozen archived breast samples were analysed with Q-PCR for all seven lymphangiogenic markers. This was correlated with various prognostic factors as well as patient survival...
  93. ncbi request reprint Vascular endothelial growth inhibitor, expression in human prostate cancer tissue and the impact on adhesion and migration of prostate cancer cells in vitro
    Ning Zhang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Oncol 35:1473-80. 2009
    ..Together with its inhibitory effect on cellular motility and adhesion, this suggests that VEGI functions as a negative regulator for aggressiveness during the development and progression of prostate cancer...
  94. ncbi request reprint Growth and differentiation factor-9 promotes adhesive and motile capacity of prostate cancer cells by up-regulating FAK and Paxillin via Smad dependent pathway
    Sivan M Bokobza
    Department of Surgery, Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Oncol Rep 24:1653-9. 2010
    ....
  95. ncbi request reprint Upregulation of tumour endothelial marker-8 by interleukin-1beta and its impact in IL-1beta induced angiogenesis
    Khaled A Rmali
    Metastasis and Angiogenesis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Int J Mol Med 14:75-80. 2004
    ..It is concluded that IL-1beta is a powerful regulator of the expression of TEM-8 in vascular endothelial cells. Our results suggest an important pathway through which IL-1beta regulates tumour-associated angiogenesis...
  96. ncbi request reprint Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    J Cell Biochem 101:155-66. 2007
    ..This combination also completely reversed the effect of 17-beta-estradiol in these cells...
  97. ncbi request reprint N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Clin Exp Metastasis 25:97-108. 2008
    ..It is concluded that N-WASP, a member of the N-WASP family may act as a tumour progression suppressor in human breast cancer and may therefore have significant clinical value in this condition...
  98. ncbi request reprint Antagonistic effect of NK4 on HGF/SF induced changes in the transendothelial resistance (TER) and paracellular permeability of human vascular endothelial cells
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    J Cell Physiol 192:268-75. 2002
    ..NK4 was able to prevent the decrease in levels of ZO-1 protein by HGF/SF...
  99. ncbi request reprint The role of the CD44/ezrin complex in cancer metastasis
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, S Wales CF14 4XN, UK
    Crit Rev Oncol Hematol 46:165-86. 2003
    ..This article reviews the role of CD44, ezrin family and the CD44/ezrin complex in cancer cells and their clinical impact in patients with cancer...
  100. ncbi request reprint Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Carcinogenesis 24:1317-23. 2003
    ..This may occur by decreasing angiogenesis. This gives a clear indication of the therapeutic worth of NK4...