Gaynor Davies

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi Cell-cell adhesion molecules and their associated proteins in bladder cancer cells and their role in mitogen induced cell-cell dissociation and invasion
    G Davies
    University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, U K
    Anticancer Res 19:547-52. 1999
  2. ncbi The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer
    G Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Int J Oncol 18:843-7. 2001
  3. ncbi HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells
    G Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Int J Mol Med 7:385-8. 2001
  4. ncbi Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Prostate 60:317-24. 2004
  5. ncbi Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion
    G Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Clin Cancer Res 7:3289-97. 2001
  6. ncbi Levels of expression of endothelial markers specific to tumour-associated endothelial cells and their correlation with prognosis in patients with breast cancer
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Clin Exp Metastasis 21:31-7. 2004
  7. ncbi The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Int J Cancer 106:348-54. 2003
  8. ncbi Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Carcinogenesis 24:1317-23. 2003
  9. ncbi Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Clin Cancer Res 9:4274-81. 2003
  10. ncbi Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 11:6012-9. 2005

Detail Information

Publications29

  1. ncbi Cell-cell adhesion molecules and their associated proteins in bladder cancer cells and their role in mitogen induced cell-cell dissociation and invasion
    G Davies
    University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, U K
    Anticancer Res 19:547-52. 1999
    ..Activation of beta-catenin and subsequent dysfunction of E-cadherin may be a key mechanism in the induction of invasion by the motogen, HGF/SF...
  2. ncbi The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer
    G Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Int J Oncol 18:843-7. 2001
    ..Whereas, in the presence of E-cadherin, beta-catenin is stabilised by forming tight cell-cell contacts which may influence the invasive potential of cancer cells...
  3. ncbi HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells
    G Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Int J Mol Med 7:385-8. 2001
    ..In conclusion, the association between the E-cadherin/catenin complex with the HGF/SF receptor c-Met, may influence or regulate intercellular adhesion in prostate cancer following stimulation by HGF/SF...
  4. ncbi Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Prostate 60:317-24. 2004
    ..This study examined the effect of a ribozyme transgene, designed to inhibit human c-Met expression, and its impact on in vitro invasion and migration in prostate cancer...
  5. ncbi Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion
    G Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Clin Cancer Res 7:3289-97. 2001
    ....
  6. ncbi Levels of expression of endothelial markers specific to tumour-associated endothelial cells and their correlation with prognosis in patients with breast cancer
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Clin Exp Metastasis 21:31-7. 2004
    ..We conclude that elevated levels of TEM-1, TEM-7R and TEM-8 (but not TEM-2, 4, 5, 6 and 7) are associated with either nodal involvement, and/or disease progression, and may therefore, have a prognostic value in breast cancer...
  7. ncbi The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Int J Cancer 106:348-54. 2003
    ..Finally, our study provides evidence of the therapeutic potential of NK4 in prostate cancer development by antagonising HGF/SF-mediated events...
  8. ncbi Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Carcinogenesis 24:1317-23. 2003
    ..This may occur by decreasing angiogenesis. This gives a clear indication of the therapeutic worth of NK4...
  9. ncbi Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Clin Cancer Res 9:4274-81. 2003
    ..This study examined if inhibition of HGF/SF receptor expression by cancer cells and HGF/SF expression by stromal fibroblasts affects the growth of mammary cancer...
  10. ncbi Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 11:6012-9. 2005
    ..The current study examined if targeting matrilysin using retroviral ribozyme transgenes may have an impact on breast cancer cells and may have clinical implications...
  11. ncbi Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
    Christian Parr
    Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 13:3568-76. 2007
    ..The role of matriptase-2 and its cellular function in cancer is unknown. This study aimed to provide new insights into the significance of matriptase-2 in cancer...
  12. ncbi Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Exp Ther Oncol 6:39-48. 2006
    ..In the current study we assessed the efficacy of targeting matriptase-1 using ribozyme technology in vitro and in vivo...
  13. ncbi Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Int J Mol Med 17:583-90. 2006
    ..It is highly expressed in aggressive breast tumours and is associated with clinical outcome. The enzyme is a potential therapeutic target in breast cancer...
  14. ncbi The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivo
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, UK
    Int J Mol Med 16:723-8. 2005
    ..Hepatocyte growth factor has potential lymphangiogenic activities, and this may have important implications in the nodal spread of cancer cells...
  15. doi Phospholipase-C gamma-1 (PLCgamma-1) is critical in hepatocyte growth factor induced in vitro invasion and migration without affecting the growth of prostate cancer cells
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Urol Oncol 26:386-91. 2008
    ..This study sought to determine the effect of HGF on the invasive and migratory potential of prostate cancer cells targeted by a ribozyme transgene to PLCgamma-1...
  16. ncbi Elevated levels of tumour endothelial marker-8 in human breast cancer and its clinical significance
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Int J Oncol 29:1311-7. 2006
    ..We conclude that TEM-8 is a useful marker for identifying tumour associated micro-vessels and that elevated levels are associated with disease progression, which may have some bearing on the prognostic outcome in breast cancer...
  17. ncbi The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant
    C Parr
    Department of Surgery, Department of Oncology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    Biochem Biophys Res Commun 285:1330-7. 2001
    ....
  18. ncbi Does the PGC-1/PPARgamma pathway play a role in Com-1/p8 mediated cell growth inhibition in prostate cancer?
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 18:1169-75. 2006
    ..Com-1 may act as a tumour suppressor in human prostate cancer cells. The potential tumour suppressive effect of Com-1 is at least partly via its interaction with PGC-1, the PPAR-gamma coactivator...
  19. ncbi Com-1/p8 acts as a putative tumour suppressor in prostate cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 18:981-6. 2006
    ..Com-1/p8 is a potential tumour suppressor in human prostate cancer...
  20. ncbi Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom
    J Exp Ther Oncol 6:257-64. 2007
    ....
  21. ncbi Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells
    Lin Ye
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Health Park, Cardiff, CF14 4XN, UK
    Int J Oncol 30:521-9. 2007
    ..This may have important implications in the development of bone metastasis in prostate cancer...
  22. ncbi Hepatocyte growth factor, its receptor, and their potential value in cancer therapies
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Crit Rev Oncol Hematol 53:35-69. 2005
    ..The current article discusses the potential value of HGF and its receptor as targets in cancer therapies, the current development in anti-HGF research, and the clinical value of HGF in prognosis and treatment...
  23. ncbi Rapid molecular and morphological responses of prostate cell lines to cell-cell contact
    Despina Bazou
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Cell Commun Adhes 13:279-94. 2006
    ..These results, discussed also in the context of earlier studies of cell adhesion in an ultrasound trap, characterize a reduced adhesiveness of DU-145 cells compared to PZ-HPV-7 cells...
  24. ncbi Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff CF4 4XN, UK
    Biochem Biophys Res Commun 330:253-62. 2005
    ..The current study investigated the impact of Com-1 on oestrogen regulated cell growth of breast cancer cells and explored the potential link between Com-1 and ER-beta...
  25. ncbi Distribution and expression of CD44 isoforms and Ezrin during prostate cancer-endothelium interaction
    Gregory M Harrison
    Metastasis Research Group, Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Int J Oncol 21:935-40. 2002
    ..The CD44/ezrin complex plays a pivotal role in the capture and invasion of endothelial cells by prostate cancer cells...
  26. ncbi The influence of CD44v3-v10 on adhesion, invasion and MMP-14 expression in prostate cancer cells
    G M Harrison
    Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Oncol Rep 15:199-206. 2006
    ....
  27. ncbi Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: design, synthesis and biological evaluation
    C Congiatu
    Welsh School of Pharmacy, Cardiff University, Cardiff, UK
    Nucleosides Nucleotides Nucleic Acids 24:485-9. 2005
    ..We report in this work a new series of derivatives containing naphthol as aryl masking group on the phosphate moiety, which has shown a significant increase in anticancer activity in preliminary biological evaluations...
  28. ncbi Cell adhesion molecules and adhesion abnormalities in prostate cancer
    Malcolm D Mason
    Department of Clinical Oncology, University of Wales College of Medicine, Health Park, Cardiff, UK
    Crit Rev Oncol Hematol 41:11-28. 2002
    ..The molecular and cellular function of cell adhesion molecules, their role in cancer and cancer progression, the clinical impact of these molecules, and therapeutic considerations are also discussed...
  29. ncbi Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin
    Christopher McGuigan
    Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
    Bioorg Med Chem 13:3219-27. 2005
    ..This derivative emerges as a low micromolar inhibitor of HT115 cells and a new lead for further optimisation...