Almut Schulze

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
    Susana Ros
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Cancer Metab 1:8. 2013
  2. pmc Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
    Beatrice Griffiths
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Cancer Metab 1:3. 2013
  3. pmc Antagonism between FOXO and MYC Regulates Cellular Powerhouse
    Barrie Peck
    Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute London, UK
    Front Oncol 3:96. 2013
  4. doi How cancer metabolism is tuned for proliferation and vulnerable to disruption
    Almut Schulze
    Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Nature 491:364-73. 2012
  5. doi Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells
    Almut Schulze
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK
    Mol Cell 44:846-8. 2011
  6. pmc A fresh look at cancer metabolism in a historical setting
    Almut Schulze
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, UK
    EMBO Rep 12:289-91. 2011
  7. pmc The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component
    Almut Schulze
    Gene Expression Analysis, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Mol Biol Cell 15:3450-63. 2004
  8. pmc Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression
    Oona Delpuech
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell Biol 27:4917-30. 2007
  9. pmc SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    Thomas Porstmann
    Gene Expression Analysis Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cell Metab 8:224-36. 2008
  10. doi Genetic ablation of S6-kinase does not prevent processing of SREBP1
    Caroline A Lewis
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, UK
    Adv Enzyme Regul 51:280-90. 2011

Collaborators

Detail Information

Publications25

  1. pmc Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
    Susana Ros
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Cancer Metab 1:8. 2013
    ..This article will review our current understanding of the role of PFKFB proteins in the control of cancer metabolism and discuss the emerging interest in these enzymes as potential targets for the development of antineoplastic agents. ..
  2. pmc Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
    Beatrice Griffiths
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Cancer Metab 1:3. 2013
    ....
  3. pmc Antagonism between FOXO and MYC Regulates Cellular Powerhouse
    Barrie Peck
    Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute London, UK
    Front Oncol 3:96. 2013
    ..This review will focus on the antagonism between FOXO3a and MYC and discuss their role in cellular bioenergetics, reactive oxygen metabolism, and adaptation to hypoxia, raising questions about the role of FOXO proteins in cancer...
  4. doi How cancer metabolism is tuned for proliferation and vulnerable to disruption
    Almut Schulze
    Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Nature 491:364-73. 2012
    ..The identification of metabolic weaknesses of cancer cells has been used to create strategies for treating cancer, but there are still challenges to be faced in bringing the drugs that target cancer metabolism to the clinic...
  5. doi Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells
    Almut Schulze
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK
    Mol Cell 44:846-8. 2011
    ..In this issue of Molecular Cell, Hitosugi et al. (2011) show that the switch from oxidative phosphorylation to glycolysis in cancer cells is regulated by tyrosine phosphorylation of PDHK1...
  6. pmc A fresh look at cancer metabolism in a historical setting
    Almut Schulze
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, UK
    EMBO Rep 12:289-91. 2011
    ..It was organized with the support of the Banco Bilbao Vizcaya Argentaria Foundation and offered an outstanding line-up of acclaimed speakers within an intimate setting that allowed plenty of opportunity for informal interactions...
  7. pmc The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component
    Almut Schulze
    Gene Expression Analysis, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Mol Biol Cell 15:3450-63. 2004
    ..The use of transcriptional profiling in this way allows detailed analysis of the architecture of signaling pathways to be undertaken...
  8. pmc Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression
    Oona Delpuech
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell Biol 27:4917-30. 2007
    ..Our results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function...
  9. pmc SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    Thomas Porstmann
    Gene Expression Analysis Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cell Metab 8:224-36. 2008
    ..Our results suggest that the PI3K/Akt/TOR pathway regulates protein and lipid biosynthesis in an orchestrated manner and that both processes are required for cell growth...
  10. doi Genetic ablation of S6-kinase does not prevent processing of SREBP1
    Caroline A Lewis
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, UK
    Adv Enzyme Regul 51:280-90. 2011
    ..Taken together, these results suggest that S6-kinases 1 and 2 are dispensable for the induction of SREBP processing in the experimental systems used here...
  11. pmc Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
    Barrie Peck
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY UK Present address The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB UK
    Cancer Metab 4:6. 2016
    ..Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be suitable therapeutic targets...
  12. doi Regulation of the SREBP transcription factors by mTORC1
    Caroline A Lewis
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Biochem Soc Trans 39:495-9. 2011
    ..In the present paper, we discuss the increasing amount of data supporting the potential mechanisms of mTORC1-dependent activation of SREBP as well as the implications of this signalling pathway in cancer...
  13. pmc Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
    Franziska Baenke
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Dis Model Mech 6:1353-63. 2013
    ..These processes are crucial for the dissemination of tumour cells and formation of metastases, which constitute the main cause of cancer mortality. ..
  14. ncbi Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells
    Barbara Nicke
    Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell 20:673-85. 2005
    ..MINK is thus a distal target of Ras signaling in the induction of a growth-arrested, senescent-like phenotype that may act to oppose oncogenic transformation in HOSE cells...
  15. doi A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size
    Thomas Porstmann
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Biochem Soc Trans 37:278-83. 2009
    ....
  16. doi Lipid metabolism in cancer
    Claudio R Santos
    Translational Cancer Therapeutics, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, UK
    FEBS J 279:2610-23. 2012
    ..This review will examine some of the alterations in lipid metabolism that have been reported in cancer, at both cellular and organismal levels, and discuss how they contribute to different aspects of tumourigenesis...
  17. ncbi PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    Thomas Porstmann
    Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Oncogene 24:6465-81. 2005
    ..Our data indicate that activation of SREBP by Akt leads to the induction of key enzymes of the cholesterol and fatty acid biosynthesis pathways, and thus membrane lipid biosynthesis...
  18. doi Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
    Susana Ros
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
    Cancer Discov 2:328-43. 2012
    ..PFKFB4 mRNA expression was also found to be greater in metastatic prostate cancer compared with primary tumors. Taken together, these results indicate that PFKFB4 is a potential target for the development of antineoplastic agents...
  19. doi Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth
    Susana Ros
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
    Cancer Discov 3:1105-7. 2013
    ..The authors also show that HK2 can be systemically deleted without adverse physiologic consequences. These findings provide attractive insights into HK2 deletion as a potential therapeutic intervention for cancer...
  20. pmc Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
    Zachary T Schug
    Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Cancer Cell 27:57-71. 2015
    ..These results signify a critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment. ..
  21. doi Lipid desaturation - the next step in targeting lipogenesis in cancer?
    Barrie Peck
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    FEBS J 283:2767-78. 2016
    ..This review will summarise some key findings that implicate altered lipid metabolism in cancer and investigate the molecular interactions between lipid desaturation and cancer cell survival. ..
  22. doi Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival
    Franziska Baenke
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, UK
    J Pathol 237:152-65. 2015
    ..These results suggest that MCT4 is a potential therapeutic target in defined breast cancer subtypes and reveal novel avenues for combination treatment...
  23. doi Cholesteryl esters: fueling the fury of prostate cancer
    Barrie Peck
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Cell Metab 19:350-2. 2014
    ..2014) report that aberrant cholesteryl ester accumulation is found in advanced prostate cancers with PTEN loss and PI3K/AKT activation. Importantly, inhibition of cholesterol esterification impaired cancer aggressiveness...
  24. doi Linking glycogen and senescence in cancer cells
    Susana Ros
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Cell Metab 16:687-8. 2012
    ..Favaro et al. (2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo...
  25. pmc Direct control of caveolin-1 expression by FOXO transcription factors
    A Pieter J van den Heuvel
    Laboratory of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 385:795-802. 2005
    ..Biol. Chem. 275, 20847-20852]. These findings suggest a novel mechanism by which FOXO factors can exert their cellular effects via transcriptional activation of caveolin-1...