Genomes and Genes
J Louise Jones
Affiliation: Cancer Research UK
- Overdiagnosis and overtreatment of breast cancer: progression of ductal carcinoma in situ: the pathological perspectiveJ Louise Jones
Tumour Biology Laboratory, Institute of Cancer, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, UK
Breast Cancer Res 8:204. 2006....
- Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasionDeborah L Holliday
Centre for Tumour Biology, Institute of Cancer and CR UK Clinical Centre, Bart s and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
Breast Cancer Res 9:R67. 2007..This study directly examined the impact of MMP SNP genotype on the ability of host fibroblasts to promote tumor cell invasion...
- Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanismsRachael A Hancox
Department of Cancer Studies and Molecular Medicine, Infirmary Close, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
Breast Cancer Res 11:R24. 2009..The ECM protein tenascin-C (TNC) is frequently up-regulated in breast cancer and we have previously identified two novel isoforms - one containing exon 16 (TNC-16) and one containing exons 14 plus 16 (TNC-14/16)...
- The use of multiple displacement amplified DNA as a control for methylation specific PCR, pyrosequencing, bisulfite sequencing and methylation-sensitive restriction enzyme PCRSimon Hughes
Tumour Biology Laboratory, John Vane Science Centre, Cancer Research UK Clincial Centre, Queen Mary s School of Medicine and Dentistry, UK
BMC Mol Biol 8:91. 2007..However, although it is possible to utilise these methods to measure CpG methylation, optimisation of the assays can be complicated due to the absence of suitable control DNA samples...
- Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progressionDeborah L Holliday
Centre for Tumour Biology, Institute of Cancer and CR UK Clinical Centre, Bart s and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, UK
Breast Cancer Res 11:R3. 2009....
- Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasionMichael D Allen
Centre for Tumour Biology, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
J Pathol 223:646-58. 2011....
- αvβ6 Expression in myoepithelial cells: a novel marker for predicting DCIS progression with therapeutic potentialMichael D Allen
Barts Cancer Institute, a CR UK Centre of Excellence, Centre for Tumor Biology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, United Kingdom
Cancer Res 74:5942-7. 2014..As αvβ6 is not expressed on most normal adult tissues, this finding may also provide novel targets for therapy in this high-risk group...
- Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progressionSimon Hughes
Tumour Biology Laboratory and Cancer Research UK Centre for Epidemiology, Wolfson Institute of Preventive Medicine, Cancer Research UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
Clin Cancer Res 13:6673-80. 2007..We hypothesized that an individual's MMP genotype and haplotype will influence breast tumor progression and help predict prognosis...
- Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesisMitchel Germain
The Adhesion and Angiogenesis Laboratory, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK
J Pathol 220:370-81. 2010..By developing the first endothelial-specific alpha6-knockout mice, we show that the expression of the alpha6-integrin subunit in endothelial cells acts as a negative regulator of angiogenesis both in vivo and ex vivo...
- Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinomaSarah Porter
School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
Clin Cancer Res 10:2429-40. 2004..ADAMTS15 has emerged as being an independent predictor of survival, with RNA expression levels significantly lower (P = 0.007) in grade 3 breast carcinoma compared with grade 1 and 2 breast carcinoma...
- Differential expression of metallothionein 1 and 2 isoforms in breast cancer lines with different invasive potential: identification of a novel nonsilent metallothionein-1H mutant variantSiew Kian Tai
Department of Microbiology, Human Genome Laboratory, Faculty of Medicine, National University of Singapore, 4 Medical Drive, S 117 597 Singapore, Republic of Singapore
Am J Pathol 163:2009-19. 2003..The observations in this study are relevant to the development of novel approaches to metastatic breast cancer disease, and may herald the search for novel MT mutants and the elucidation of their biological roles...
- Breast cell invasive potential relates to the myoepithelial phenotypeLinda A Gordon
Department of Pathology, University of Leicester, Clinical Sciences, Glenfield Hospital, Leicester, United Kingdom
Int J Cancer 106:8-16. 2003..These results suggest that tumours that exhibit a myoepithelial phenotype may be clinically more aggressive because a high invasive capacity is intrinsic to the myoepithelial phenotype...
- Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancerDaniel E B Swinson
Departments of Oncology, Pathology, and Epidemiology, University Hospitals of Leicester NHS Trust, United Kingdom
J Clin Oncol 21:473-82. 2003..To evaluate carbonic anhydrase (CA) IX as a surrogate marker of hypoxia and investigate the prognostic significance of different patterns of expression in non-small-cell lung cancer (NSCLC)...
- Oestrogen receptors alpha and beta differ in normal human breast and breast carcinomasJacqueline A Shaw
Breast Cancer Research Unit, Department of Pathology, University of Leicester, Clinical Sciences, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
J Pathol 198:450-7. 2002..The findings indicate a need to understand the role and regulation of ERbeta in normal breast and the reason for its down-regulation in mammary carcinogenesis...
- Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variablesDaniel E B Swinson
Department of Oncology, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
Lung Cancer 37:235-40. 2002..Tumour necrosis (TN) is recognized to be a consequence of chronic cellular hypoxia. TN and hypoxia correlate with poor prognosis in solid tumours...
- Changes in tenascin-C isoform expression in invasive and preinvasive breast diseaseMatthew Adams
University of Leicester, Breast Cancer Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
Cancer Res 62:3289-97. 2002..Functional studies are now essential to establish the effect of these isoforms on tumor behavior and evaluate whether they will provide appropriate targets for therapeutic intervention...