Jesus Gil

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint Polycomb CBX7 has a unifying role in cellular lifespan
    Jesus Gil
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 6:67-72. 2004
  2. ncbi request reprint Role of polycomb group proteins in stem cell self-renewal and cancer
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    DNA Cell Biol 24:117-25. 2005
  3. ncbi request reprint Immortalization of primary human prostate epithelial cells by c-Myc
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, United Kingdom
    Cancer Res 65:2179-85. 2005
  4. pmc Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexes
    Nadine Martin
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Cell Cycle 12:2194-9. 2013
  5. pmc Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation
    Nadine Martin
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    EMBO J 32:982-95. 2013
  6. pmc Myc confers androgen-independent prostate cancer cell growth
    David Bernard
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kindom
    J Clin Invest 112:1724-31. 2003
  7. doi request reprint A role for CXCR2 in senescence, but what about in cancer?
    Juan C Acosta
    Cell Proliferation Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom
    Cancer Res 69:2167-70. 2009
  8. pmc CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a)
    Ana O'Loghlen
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, W12 0NN, UK
    Aging Cell 14:1113-21. 2015
  9. doi request reprint ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency
    Carlos F Pereira
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Stem Cell 6:547-56. 2010
  10. ncbi request reprint Glycolytic enzymes can modulate cellular life span
    Hiroshi Kondoh
    Wolfson Institute for Biomedical Research, University College London, London Research Institute, London, United Kingdom
    Cancer Res 65:177-85. 2005

Collaborators

  • Amancio Carnero
  • Alan Ashworth
  • Claudia Miranda
  • Marco A Pierotti
  • Shyam Prabhakar
  • David H Beach
  • Jing Wang
  • Vasso Episkopou
  • Veronique Azuara
  • Hiroshi Kondoh
  • Matthias Merkenschlager
  • Amanda G Fisher
  • Matilde E Lleonart
  • Nadine Martin
  • Ana O'Loghlen
  • Selina Raguz
  • Ana Banito
  • Juan C Acosta
  • Gordon Peters
  • Nikolay Popov
  • Maria Teresa Esposito
  • Ana Guerrero
  • Maria Grazia Vizioli
  • Chi Wai Eric So
  • Juan Carlos Acosta
  • Ambrosius P Snijders
  • Gopuraja Dharmalingam
  • Michelle Percharde
  • Joana Santos
  • Carlos F Pereira
  • Goedele N Maertens
  • David Bernard
  • Tsz Kan Fung
  • Anskar Y Leung
  • Valentina Rapisarda
  • Ebel Floridia
  • Lu Zhao
  • Juan Zalvide
  • Jayant K Rane
  • Cristina Iglesias
  • Sharon Brookes
  • Celia M Pombo
  • Amanda Wilson
  • Silvana Pilotti
  • Mara Mazzoni
  • Maria Chiara Anania
  • Angela Greco
  • Sonia Pagliardini
  • Bernd B Zeisig
  • Francesca Aguilo
  • SiDe Li
  • Martin J Walsh
  • Thomas Carroll
  • Efstathia Thymiakou
  • Malcolm G Parker
  • Jia Hui Ng
  • Fabrice Lavial
  • Jia Chi Yeo
  • Rute A Tomaz
  • Vibhor Kumar
  • Huck Hui Ng
  • Natalie K Ryan
  • Haruhiko Koseki
  • Tomomi Tsubouchi
  • Stephan Sauer
  • David Landeira
  • Francesco M Piccolo
  • Ludovica Bruno
  • Julie K Stock
  • Marc Rodriguez-Niedenführ
  • Tomas Racek
  • James Nicholls
  • Selma El Messaoudi-Aubert
  • Albin Pourtier-Manzanedo

Detail Information

Publications19

  1. ncbi request reprint Polycomb CBX7 has a unifying role in cellular lifespan
    Jesus Gil
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 6:67-72. 2004
    ..Taken together, these data show that CBX7 controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 pathways...
  2. ncbi request reprint Role of polycomb group proteins in stem cell self-renewal and cancer
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    DNA Cell Biol 24:117-25. 2005
    ..In this review, we will briefly summarize current views on PcG function and the evidence linking specific PcG proteins with the behavior of stem cells and cancer cells...
  3. ncbi request reprint Immortalization of primary human prostate epithelial cells by c-Myc
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, United Kingdom
    Cancer Res 65:2179-85. 2005
    ..These results give a partial explanation for the physiologic role of c-Myc overexpression in prostate cancer...
  4. pmc Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexes
    Nadine Martin
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Cell Cycle 12:2194-9. 2013
    ..As both HLX1 and HOXA9 are oncogenes implicated in leukemogenesis, we discuss the implications that the collaboration between Homeobox proteins and PRCs has for senescence and cancer...
  5. pmc Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation
    Nadine Martin
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    EMBO J 32:982-95. 2013
    ..Our results reveal an unexpected and conserved interplay between homeodomain-containing proteins and PRCs with implications in senescence, development and cancer...
  6. pmc Myc confers androgen-independent prostate cancer cell growth
    David Bernard
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kindom
    J Clin Invest 112:1724-31. 2003
    ..Furthermore, we showed that c-myc-overexpressing cells retain a functional p53 pathway and thus respond to etoposide...
  7. doi request reprint A role for CXCR2 in senescence, but what about in cancer?
    Juan C Acosta
    Cell Proliferation Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom
    Cancer Res 69:2167-70. 2009
    ..The challenge remains in how to integrate this with the well-known tumor promoting effects of IL-8 and GROalpha...
  8. pmc CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a)
    Ana O'Loghlen
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, W12 0NN, UK
    Aging Cell 14:1113-21. 2015
    ..The ability of the miR-9 family to regulate senescence could have implications for understanding the role of miR-9 in cancer and aging...
  9. doi request reprint ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency
    Carlos F Pereira
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Stem Cell 6:547-56. 2010
    ....
  10. ncbi request reprint Glycolytic enzymes can modulate cellular life span
    Hiroshi Kondoh
    Wolfson Institute for Biomedical Research, University College London, London Research Institute, London, United Kingdom
    Cancer Res 65:177-85. 2005
    ..Because wild-type p53 down-regulates PGM, mutation of p53 can facilitate immortalization via effects on PGM levels and glycolysis...
  11. pmc Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus
    Goedele N Maertens
    Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 4:e6380. 2009
    ..Our findings provide the first evidence that a single gene can be regulated by several distinct PRC1 complexes and raise important questions about their configuration and relative functions...
  12. pmc Induced pluripotent stem cells and senescence: learning the biology to improve the technology
    Ana Banito
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    EMBO Rep 11:353-9. 2010
    ....
  13. doi request reprint Unbiased characterization of the senescence-associated secretome using SILAC-based quantitative proteomics
    Juan Carlos Acosta
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College, London, UK
    Methods Mol Biol 965:175-84. 2013
    ..This approach could be used to analyze the effect of diverse molecules on the senescence secretome or to catalogue unrelated secretomes...
  14. doi request reprint Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors
    Maria Teresa Esposito
    Leukemia and Stem Cell Biology Group, Department of Haematological Medicine, Division of Cancer Studies, King s College London, London, UK
    Nat Med 21:1481-90. 2015
    ..Together, these studies describe a potential utility of PARPi-induced synthetic lethality for leukemia treatment and reveal a novel molecular mechanism governing PARPi sensitivity in AML. ..
  15. pmc Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved
    Maria Grazia Vizioli
    Molecular Mechanism Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK
    Oncotarget 5:8270-83. 2014
    ..Importantly, we observed that CXCR2 expression coexists with OIS markers in thyroid tumour samples, suggesting that CXCR2 contributes to senescence, thus limiting thyroid tumour progression. ..
  16. pmc The cerebral cavernous malformation 3 gene is necessary for senescence induction
    Ana Guerrero
    Department of Physiology, CIMUS, Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, Santiago de Compostela, A Coruna, 15703, Spain Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, W12 0NN, UK
    Aging Cell 14:274-83. 2015
    ..These results broaden our knowledge on the mechanisms by which CCM3 deficiency results in disease and open new avenues of research into both CCM3 and senescence biology. ..
  17. pmc Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming
    Michelle Percharde
    Institute of Reproductive and Developmental Biology, Imperial College, London, United Kingdom
    Genes Dev 26:2286-98. 2012
    ..We propose an integrated model of transcriptional and coactivator control, mediated by Ncoa3, for the maintenance of ESC self-renewal and somatic cell reprogramming...
  18. pmc Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health
    Nikolay Popov
    Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Epigenetics 5:685-90. 2010
    ..In view of the intimate involvement of the INK4b-ARF-INK4a locus on disease, to understand its regulation is the first step for manipulate it to therapeutic benefit...
  19. ncbi request reprint Control of senescence by CXCR2 and its ligands
    Juan C Acosta
    Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    Cell Cycle 7:2956-9. 2008
    ..Here, we discuss our findings in the context of the emerging role for secreted factors in regulating senescence through paracrine and/or autocrine mechanisms...