Genomes and Genes
Affiliation: Cancer Research UK
- Pericytes: gatekeepers in tumour cell metastasis?Holger Gerhardt
Vascular Biology Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
J Mol Med (Berl) 86:135-44. 2008..In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis...
- Endothelial cells dynamically compete for the tip cell position during angiogenic sproutingLars Jakobsson
Vascular Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
Nat Cell Biol 12:943-53. 2010..The regular exchange of the leading tip cell raises novel implications for the concept of guided angiogenic sprouting...
- Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivoDenise Stenzel
Vascular Biology Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
EMBO Rep 12:1135-43. 2011..We conclude that appropriate laminin/integrin-induced signalling is necessary to induce physiologically functional levels of Dll4 expression and regulate branching frequency during sprouting angiogenesis in vivo...
- Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesisDenise Stenzel
Vascular Biology Laboratory, London Research Institute Cancer Research UK, London WC2A 3PX, UK
Development 138:4451-63. 2011..We propose that in vivo the VEGF-binding properties of FN and HS promote directional tip cell migration, whereas FN integrin-binding functions to support filopodia adhesion to the astrocytic migration template...
- VEGF and Notch in tip and stalk cell selectionRaquel Blanco
Vascular Biology Laboratory, London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3LY, UK
Cold Spring Harb Perspect Med 3:a006569. 2013..In this article, we summarize the current knowledge and implications of the tip/stalk cell concepts and the quantitative and dynamic integration of VEGF and Notch signaling in tip and stalk cell selection...
- Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodellingClaudio A Franco
Vascular Biology Laboratory, Lincoln s Inn Laboratories, London Research Institute, The Francis Crick Institute, London, United Kingdom
elife 5:e07727. 2016..Collectively our data suggest that non-canonical Wnt signalling stabilizes forming vascular networks by reducing endothelial shear sensitivity, thus keeping vessels open under low flow conditions that prevail in the primitive plexus...
- VEGFRs and Notch: a dynamic collaboration in vascular patterningLars Jakobsson
Vascular Biology Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Biochem Soc Trans 37:1233-6. 2009....
- Peripheral mural cell recruitment requires cell-autonomous heparan sulfateDenise Stenzel
Vascular Biology Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London, United Kingdom
Blood 114:915-24. 2009..Once MCs are in contact with the vessel, as during CNS vascularization, endothelial HS appears sufficient to facilitate PDGFR-beta activation in trans...
- Vascular morphogenesis: a Wnt for every vessel?Claudio Areias Franco
Vascular Biology Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, WC2A 3PX London, UK
Curr Opin Genet Dev 19:476-83. 2009..Here, we review the emerging concepts of the molecular actions of Wnt-signalling in regulating differential behaviour and/or cell functions during vascular development...
- Agent-based simulation of notch-mediated tip cell selection in angiogenic sprout initialisationKatie Bentley
Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
J Theor Biol 250:25-36. 2008....
- Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesisKatie Bentley
Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
PLoS Comput Biol 5:e1000549. 2009..Thus we suggest the use of migration inhibitors as therapeutic agents for vascular normalisation in cancer...
- Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivoVéronique Gebala
The Francis Crick Institute, Lincoln s Inn Fields Laboratory, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
Nat Cell Biol 18:443-50. 2016..We show that in the case of blood vessels such membrane dynamics can drive local cell shape changes required for global tissue morphogenesis, shedding light on a pressure-driven mechanism of lumen formation in vertebrates. ..
- Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of NotchIrene Maria Aspalter
Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY, UK
Nat Commun 6:7264. 2015....
- Imaging transient blood vessel fusion events in zebrafish by correlative volume electron microscopyHannah E J Armer
Electron Microscopy Unit, London Research Institute, Cancer Research UK, London, UK
PLoS ONE 4:e7716. 2009..The resulting data give unprecedented microanatomical detail of the zebrafish and, for the first time, allow visualization of the ultrastructure of a time-limited biological event within the context of a whole organism...
- Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesisLi Kun Phng
Vascular Biology Laboratory, London Research Institute Cancer Research UK, London, UK
Dev Cell 16:70-82. 2009..In vivo, loss of Nrarp, Lef1, or endothelial Ctnnb1 causes vessel regression. We suggest that the balance between Notch and Wnt signaling determines whether to make or break new vessel connections...
- Dynamic endothelial cell rearrangements drive developmental vessel regressionClaudio A Franco
Vascular Biology Laboratory, London Research Institute Cancer Research UK, Lincoln s Inn Laboratories, London, United Kingdom Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisboa, Portugal
PLoS Biol 13:e1002125. 2015..We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments. ..
- Growth factor gradients in vascular patterningAndrea Lundkvist
Vascular Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Novartis Found Symp 283:194-201; discussion 201-6, 238-41. 2007..Disruption of VEGF-A gradients provides a novel concept for the mechanism underlying pathological patterning in ocular disease...
- VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodiaHolger Gerhardt
Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
J Cell Biol 161:1163-77. 2003..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
- Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migrationMariona Graupera
Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Nature 453:662-6. 2008..These results provide the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis...
- Pericytes limit tumor cell metastasisXiaojie Xian
Stem Cell Center, Lund University, Lund, Sweden
J Clin Invest 116:642-51. 2006..These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions...
- Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wallPer Lindblom
Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
Genes Dev 17:1835-40. 2003..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
- Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivoTetyana Levchenko
Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institute, SE 17176, Stockholm, Sweden
FASEB J 22:880-9. 2008..These findings provide a rationale for using angiomotin antibodies for specifically targeting endothelial migration in angiogenesis-dependent diseases...
- Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous systemHolger Gerhardt
Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
Dev Dyn 231:503-9. 2004..These observations suggest that Nrp-1 plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain...
- Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular developmentAlexandra Abramsson
Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Genes Dev 21:316-31. 2007....
- Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivoAlan G F Worsley
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
Eur J Immunol 38:1043-9. 2008..These data suggest that, although involved in Th2 direction in vitro, jagged2 is not fundamentally required for Th2 induction by SEA-activated dendritic cells in vivo...
- Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrinsJoseph H McCarty
Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Cell Biol 22:7667-77. 2002..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
- Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesisChristiana Ruhrberg
Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
Genes Dev 16:2684-98. 2002..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
- Endothelial-pericyte interactions in angiogenesisHolger Gerhardt
Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, PO Box 440, SE 405 30, Goteborg, Sweden
Cell Tissue Res 314:15-23. 2003..Genetic data demonstrate the critical importance of pericytes for vascular morphogenesis and function, and imply specific roles for the cell type in various aspects of angiogenesis...
- Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signalingJody J Haigh
Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Canada
Dev Biol 262:225-41. 2003..VEGF-A dosage is therefore a critical parameter regulating the density of the vascular plexus in the developing CNS that is in turn a key determinant in the development and architectural organization of the nervous system...
- Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in miceChrister Betsholtz
Department of Medical Biochemistry, University of Goteborg, Sweden
Curr Opin Nephrol Hypertens 13:45-52. 2004....
- Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lensChristopher A Mitchell
Department of Obstetrics and Gynaecology, University of Nottingham, City Hospital, Hucknall Rd, Nottingham, NG5 1PB, UK
Angiogenesis 9:209-24. 2006..The results of this study indicate that individual isoforms of VEGFA induce distinct vascular phenotypes in the eye during embryonic development and that their relative doses provide instructive cues for vascular patterning...
- Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesisMats Hellstrom
AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
Nature 445:776-80. 2007....
- Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeabilityChristopher A Jones
Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
Nat Med 14:448-53. 2008....
- Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathyMaria Enge
Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
EMBO J 21:4307-16. 2002..Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy...