H Raza Ali

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc Astronomical algorithms for automated analysis of tissue protein expression in breast cancer
    H R Ali
    Department of Oncology, University of Cambridge, Cambridge CB1 9RN, UK
    Br J Cancer 108:602-12. 2013
  2. pmc Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer
    H R Ali
    Department of Oncology, University of Cambridge, Cambridge CB1 9RN, UK
    Br J Cancer 106:1798-806. 2012
  3. doi A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer
    H Raza Ali
    Department of Oncology, University of Cambridge, Cambridge, CB1 9RN, UK
    J Pathol 226:97-107. 2012
  4. pmc Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance
    H Raza Ali
    Department of Oncology, University of Cambridge, Cambridge CB1 9RN, UK
    Breast Cancer Res 13:R118. 2011
  5. doi Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue
    John Le Quesne
    Cancer Research UK, Cambridge Research Institute and Department of Oncology, University of Cambridge, UK
    J Pathol 227:306-14. 2012
  6. pmc Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer
    Muhammed Murtaza
    Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK
    Nat Commun 6:8760. 2015
  7. pmc Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer
    H Raza Ali
    Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK
    Breast Cancer Res 18:21. 2016
  8. pmc ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
    Daniel G Holland
    Cancer Research UK, Cambridge Research Institute, Cambridge, UK
    EMBO Mol Med 3:167-80. 2011

Collaborators

Detail Information

Publications8

  1. pmc Astronomical algorithms for automated analysis of tissue protein expression in breast cancer
    H R Ali
    Department of Oncology, University of Cambridge, Cambridge CB1 9RN, UK
    Br J Cancer 108:602-12. 2013
    ..Although TMAs have the potential to facilitate protein expression profiling on a scale to rival experiments of tumour transcriptomes, the bottleneck and imprecision of manually scoring TMAs has impeded progress...
  2. pmc Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer
    H R Ali
    Department of Oncology, University of Cambridge, Cambridge CB1 9RN, UK
    Br J Cancer 106:1798-806. 2012
    ..Proliferation has emerged as a major prognostic factor in luminal breast cancer. The immunohistochemical (IHC) proliferation marker Ki67 has been most extensively investigated but has not gained widespread clinical acceptance...
  3. doi A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer
    H Raza Ali
    Department of Oncology, University of Cambridge, Cambridge, CB1 9RN, UK
    J Pathol 226:97-107. 2012
    ..0; 95% CI, 1.4-2.9; p < 0.001). Ki67 and BCL2 can be effectively combined to produce an index which is an independent predictor of BCSS in ER-positive breast cancer, enhancing their potential prognostic utility...
  4. pmc Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance
    H Raza Ali
    Department of Oncology, University of Cambridge, Cambridge CB1 9RN, UK
    Breast Cancer Res 13:R118. 2011
    ..We set out to establish the clinical relevance of breast CSC markers by profiling a large cohort of breast tumours in tissue microarrays (TMAs) using immunohistochemistry (IHC)...
  5. doi Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue
    John Le Quesne
    Cancer Research UK, Cambridge Research Institute and Department of Oncology, University of Cambridge, UK
    J Pathol 227:306-14. 2012
    ..miR-205 is associated with tumours of ductal morphology and is of significant positive prognostic value within these tumours. We propose that the expression of miR-205 may contribute to ductal tumour morphology...
  6. pmc Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer
    Muhammed Murtaza
    Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK
    Nat Commun 6:8760. 2015
    ..This comparison of biopsy and plasma samples in a single patient with metastatic breast cancer shows that circulating tumour DNA can allow real-time sampling of multifocal clonal evolution. ..
  7. pmc Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer
    H Raza Ali
    Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK
    Breast Cancer Res 18:21. 2016
    ..We investigated the association between quantitative image metrics derived from computational analysis of digital pathology slides and response to chemotherapy in women with breast cancer who received neoadjuvant chemotherapy...
  8. pmc ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
    Daniel G Holland
    Cancer Research UK, Cambridge Research Institute, Cambridge, UK
    EMBO Mol Med 3:167-80. 2011
    ..Taken together, these data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer...