J Cohen

Summary

Affiliation: Brighton and Sussex Medical School
Country: UK

Publications

  1. pmc Containing the threat--don't forget Ebola
    Jonathan Cohen
    Brighton and Sussex Medical School, Brighton, United Kingdom
    PLoS Med 1:e59. 2004
  2. pmc Diagnosing sepsis: does the microbiology matter?
    Jonathan Cohen
    Division of Clinical Medicine, Brighton and Sussex Medical School, Brighton Falmer BN1 9PX, UK
    Crit Care 12:145. 2008
  3. doi request reprint Sepsis: a roadmap for future research
    Jonathan Cohen
    Brighton and Sussex Medical School, Brighton, UK Electronic address
    Lancet Infect Dis 15:581-614. 2015
  4. doi request reprint Confronting the threat of multidrug-resistant Gram-negative bacteria in critically ill patients
    Jonathan Cohen
    Brighton and Sussex Medical School, Brighton BN1 9PH, UK
    J Antimicrob Chemother 68:490-1. 2013
  5. doi request reprint How I manage haematology patients with septic shock
    Jon Cohen
    Department of Infectious Diseases, Brighton and Sussex Medical School, Brighton Consultant in Intensive Care, Brighton and Sussex University Hospitals NHS Trust, Royal Sussex County Hospital, Brighton, UK
    Br J Haematol 152:380-91. 2011
  6. doi request reprint Non-antibiotic strategies for sepsis
    J Cohen
    Division of Medicine, Brighton and Sussex Medical School, Brighton, UK
    Clin Microbiol Infect 15:302-7. 2009
  7. ncbi request reprint Stranger's fever in Charleston, South Carolina: a mistaken diagnosis?
    J Cohen
    Department of History, University of Pennsylvania, Philadelphia, USA
    J R Coll Physicians Edinb 37:273-6. 2007
  8. ncbi request reprint Development of a time-to-positivity assay as a tool in the antibiotic management of septic patients
    P Kaltsas
    Department of Microbiology and Infectious Diseases, Hammersmith Hospital, London, UK
    Clin Microbiol Infect 11:109-14. 2005
  9. ncbi request reprint Recent developments in the identification of novel therapeutic targets for the treatment of patients with sepsis and septic shock
    Jonathan Cohen
    Division of Medicine, Brighton and Sussex Medical School, Brighton, UK
    Scand J Infect Dis 35:690-6. 2003
  10. ncbi request reprint The immunopathogenesis of sepsis
    Jonathan Cohen
    Brighton and Sussex Medical School, Westlain House, Falmer, UK
    Nature 420:885-91. 2002

Collaborators

Detail Information

Publications60

  1. pmc Containing the threat--don't forget Ebola
    Jonathan Cohen
    Brighton and Sussex Medical School, Brighton, United Kingdom
    PLoS Med 1:e59. 2004
  2. pmc Diagnosing sepsis: does the microbiology matter?
    Jonathan Cohen
    Division of Clinical Medicine, Brighton and Sussex Medical School, Brighton Falmer BN1 9PX, UK
    Crit Care 12:145. 2008
    ..New drugs that target specific points in the activation pathway are starting to emerge, and these will require us to be much more accurate in how we diagnose sepsis...
  3. doi request reprint Sepsis: a roadmap for future research
    Jonathan Cohen
    Brighton and Sussex Medical School, Brighton, UK Electronic address
    Lancet Infect Dis 15:581-614. 2015
    ..In this Commission, we set out our understanding of the clinical epidemiology and management of sepsis and then ask how the present approaches might be challenged to develop a new roadmap for future research. ..
  4. doi request reprint Confronting the threat of multidrug-resistant Gram-negative bacteria in critically ill patients
    Jonathan Cohen
    Brighton and Sussex Medical School, Brighton BN1 9PH, UK
    J Antimicrob Chemother 68:490-1. 2013
    ..Newer and better antibiotics would be welcome, but are unlikely alone to make a major impact on clinical outcomes...
  5. doi request reprint How I manage haematology patients with septic shock
    Jon Cohen
    Department of Infectious Diseases, Brighton and Sussex Medical School, Brighton Consultant in Intensive Care, Brighton and Sussex University Hospitals NHS Trust, Royal Sussex County Hospital, Brighton, UK
    Br J Haematol 152:380-91. 2011
    ..The review is limited to the management and initial resuscitation of septic shock in adult haematology patients and will not address the detailed intensive care management of these patients or the management of severe sepsis in children...
  6. doi request reprint Non-antibiotic strategies for sepsis
    J Cohen
    Division of Medicine, Brighton and Sussex Medical School, Brighton, UK
    Clin Microbiol Infect 15:302-7. 2009
    ..This is not intended to be a comprehensive review, but rather to provide examples in each category to illustrate the general principles-and the hurdles-that have characterized these approaches to therapy...
  7. ncbi request reprint Stranger's fever in Charleston, South Carolina: a mistaken diagnosis?
    J Cohen
    Department of History, University of Pennsylvania, Philadelphia, USA
    J R Coll Physicians Edinb 37:273-6. 2007
    ..However, a re-examination of the evidence suggests that he may not in fact have died of yellow fever...
  8. ncbi request reprint Development of a time-to-positivity assay as a tool in the antibiotic management of septic patients
    P Kaltsas
    Department of Microbiology and Infectious Diseases, Hammersmith Hospital, London, UK
    Clin Microbiol Infect 11:109-14. 2005
    ..The T(pos) assay might offer a quick and convenient way to improve the efficacy of antibiotic therapy in septic patients, and further prospective large-scale studies are now warranted...
  9. ncbi request reprint Recent developments in the identification of novel therapeutic targets for the treatment of patients with sepsis and septic shock
    Jonathan Cohen
    Division of Medicine, Brighton and Sussex Medical School, Brighton, UK
    Scand J Infect Dis 35:690-6. 2003
    ..Nevertheless, the fact that sepsis has finally proved tractable as a target for new drug development lends support to those who believe that at least some of the compounds identified in this paper will prove to have clinical benefit...
  10. ncbi request reprint The immunopathogenesis of sepsis
    Jonathan Cohen
    Brighton and Sussex Medical School, Westlain House, Falmer, UK
    Nature 420:885-91. 2002
    ..As a result, much has been learnt of the basic principles governing bacterial-host interactions, and new opportunities for therapeutic intervention have been revealed...
  11. ncbi request reprint Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice
    S Sriskandan
    Department of Infectious Diseases, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Infect Dis 184:166-73. 2001
    ..Lymphoid activation was undetectable in HLA-DQ mice infected with an isogenic SPEA(-) strain, which proves that a single superantigen can play a role in sepsis pathogenesis...
  12. ncbi request reprint Mitogenic factor (MF) is the major DNase of serotype M89 Streptococcus pyogenes
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, London W12 0NN, UK
    Microbiology 146:2785-92. 2000
    ..Despite loss of DNase activity, the virulence of S. pyogenes in a mouse model of necrotizing fasciitis and myositis was unaffected...
  13. ncbi request reprint Kallikrein-kinin system activation in streptococcal toxic shock syndrome
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Clin Infect Dis 30:961-2. 2000
    ..We speculate that bradykinin release following activation of the kallikrein-kinin system in streptococcal toxic shock may underlie the features of pain, capillary leaking, and severe hypotension characteristic of this syndrome...
  14. ncbi request reprint Contact activation in shock caused by invasive group A Streptococcus pyogenes
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Crit Care Med 28:3684-91. 2000
    ....
  15. pmc Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria
    T J Evans
    Department of Infections Diseases and Bacteriology, Royal Postgraduate Medical School, London, United Kingdom
    Proc Natl Acad Sci U S A 93:9553-8. 1996
    ....
  16. ncbi request reprint Microbiologic findings and correlations with serum tumor necrosis factor-alpha in patients with severe sepsis and septic shock
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Infect Dis 180:116-21. 1999
    ..6, 64.0, and 52.8 pg/mL, respectively, P=.004). These results provide further support for the concept that patients with sepsis are a heterogeneous group that require more precise definition...
  17. ncbi request reprint High-throughput sequence typing of T-cell epitope polymorphisms in Plasmodium falciparum circumsporozoite protein
    A Alloueche
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Mol Biochem Parasitol 106:273-82. 2000
    ..PCR-SSOP could be used to determine the allelic frequencies of other parasite antigens and their geographical distribution...
  18. pmc Superantigen antagonist peptides
    M Llewelyn
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Crit Care 5:53-5. 2001
    ..In this article, we review the first published data to address one such strategy in the context of other recognised and experimental treatments...
  19. ncbi request reprint Complementation of a speA negative Streptococcus pyogenes with speA: effects on virulence and production of streptococcal pyrogenic exotoxin A
    M Unnikrishnan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, Du Can Road, London W12 0NN, UK
    Microb Pathog 31:109-14. 2001
    ..SPEA production was quantitated from muscle tissue of infected mice. However, H361 did not produce more SPEA than H305 in vivo. We conclude that SPEA does not play a key role in invasive murine streptococcal infection...
  20. ncbi request reprint The TCR Vbeta signature of bacterial superantigens spreads with stimulus strength
    Martin Llewelyn
    Department of Infectious Diseases, Faculty of Medicine, Imperial College, London W12 0NN, UK
    Int Immunol 18:1433-41. 2006
    ..These findings have important implications for heterogeneity in the response to Sags and the consequent differences in susceptibility to severe toxic shock...
  21. ncbi request reprint HLA class II polymorphisms determine responses to bacterial superantigens
    Martin Llewelyn
    Department of Infectious Diseases, Faculty of Medicine, Imperial College, Department of Immunology, Guy s, Kings and St Thomas School of Medicine, London, United Kingdom
    J Immunol 172:1719-26. 2004
    ..Our observations reveal a mechanism for the different outcomes seen following infection by toxigenic bacteria...
  22. ncbi request reprint Stimulation of cytokine release and adhesion molecule expression by products of Viridans streptococci
    W P Hanage
    Department of Infectious Diseases and Microbiology, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, United Kingdom w hanageic ac uk
    J Infect Dis 185:357-67. 2002
    ..This up-regulation was blocked by IL-1 receptor antagonist but not neutralizing antibody against TNF-alpha. These data may help explain the pathogenesis of the viridans streptococcal shock syndrome in neutropenic patients...
  23. ncbi request reprint Immunization against the murine malaria parasite Plasmodium yoelii using a recombinant protein with adjuvants developed for clinical use
    I T Ling
    National Institute for Medical Research, Mill Hill, London, UK
    Vaccine 15:1562-7. 1997
    ..Mice passively immunized with serum or purified IgG from vaccinated mice had delayed onset of parasitemia and were able to control the infection...
  24. ncbi request reprint New strategies for clinical trials in patients with sepsis and septic shock
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, London, England
    Crit Care Med 29:880-6. 2001
    ..The United Kingdom Medical Research Council convened an International Working Party to address these issues...
  25. ncbi request reprint Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation
    Shiranee Sriskandan
    Department of Infectious Diseases, Imperial College London, Hammersmith Hospital Du Cane Road, London W12 0NN, UK
    J Antimicrob Chemother 58:117-24. 2006
    ..The aim of this study was to assess IVIG therapeutic efficacy in an experimental model of streptococcal toxic shock...
  26. pmc Toll-like receptors: the key to the stable door?
    Philip Hopkins
    Clinical Research Fellow, Department of Infectious Diseases, Hammersmith Hospital, London, UK
    Crit Care 6:99-101. 2002
    ..The potential clinical difficulties that may result from intervention at this pattern-recognition receptor will also be explored...
  27. ncbi request reprint Observations on the role of tumor necrosis factor-alpha in a murine model of shock due to Streptococcus pyogenes
    J Wayte
    Department of Infectious Diseases and Bacteriology, Hammersmith Hospital, London, UK
    Crit Care Med 21:1207-12. 1993
    ..To examine the effect of a monoclonal antibody to tumor necrosis factor-alpha (TNF-alpha) in a murine model of shock due to Streptococcus pyogenes...
  28. ncbi request reprint Mechanisms of tissue injury in sepsis: contrasts between gram positive and gram negative infection
    J Cohen
    Dept of Infectious Diseases and Microbiology, Imperial College School of Medicine, Hammersmith Hospital, London, England, UK
    J Chemother 13:153-8. 2001
    ..These differences will assume greater importance in developing targeted therapeutic interventions to severe sepsis...
  29. ncbi request reprint Complete genomic characterization and antigenic relatedness of genogroup III, genotype 2 bovine noroviruses
    S L Oliver
    Department of Pathology and Infectious Diseases, Royal Veterinary College, London, UK
    Arch Virol 152:257-72. 2007
    ..A close antigenic relationship was demonstrated by ELISA between the genotype 2 viruses, which will allow their serological diagnosis...
  30. ncbi request reprint The detection and interpretation of endotoxaemia
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Intensive Care Med 26:S51-6. 2000
    ..It may be that the LAL assay, or one of the newer developments, may be more useful in excluding Gram negative infection, but that remains to be shown...
  31. doi request reprint Endotoxin removal devices for the treatment of sepsis and septic shock
    B Davies
    Department of Clinical Microbiology and Infectious Diseases, Brighton and Sussex Medical School, Brighton and Sussex University Hospitals Trust, UK
    Lancet Infect Dis 11:65-71. 2011
    ..The available evidence is reviewed to assess the potential use of such devices in clinical practice...
  32. ncbi request reprint Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo
    S P Salcedo
    Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College School of Medicine, The Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Cell Microbiol 3:587-97. 2001
    ..These results confirm that SifA and SPI-2 are involved in maintenance of the vacuolar membrane and intracellular replication in vivo...
  33. ncbi request reprint Behaviour of DRG sensory neurites at the intact and injured adult rat dorsal root entry zone: postnatal neurites become paralysed, whilst injury improves the growth of embryonic neurites
    J P Golding
    Department of Developmental Neurobiology, KCL, London, United Kingdom
    Glia 26:309-23. 1999
    ....
  34. ncbi request reprint The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of Streptococcus pyogenes
    Meera Unnikrishnan
    Department of Infectious Diseases, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, London, United Kingdom
    J Immunol 169:2561-9. 2002
    ..Most strikingly, a clear rise in murine Vbeta4(+) cells was seen in mice infected with the smez(-) mutant S. pyogenes strain, indicating a potential role for SMEZ as a repressor of cognate anti-streptococcal responses...
  35. ncbi request reprint Application of a rat model of streptococcal shock to evaluate on-line hemoperfusion and removal of circulating superantigens
    Peter Fenwick
    Department of Infectious Diseases and Microbiology, Faculty of Medicine, Imperial College of Science Technology and Medicine, Hammersmith Hospital, London, UK
    Crit Care Med 31:171-8. 2003
    ..To evaluate the efficacy of on-line hemoperfusion for the removal of circulating superantigens in a rat model of streptococcal shock...
  36. ncbi request reprint New method of classifying infections in critically ill patients
    Jonathan Cohen
    Department of Medicine, Brighton and Sussex Medical School, Falmer, UK
    Crit Care Med 32:1510-26. 2004
    ..To develop a systematic classification describing the contribution made by infection to the outcome from sepsis...
  37. ncbi request reprint Diagnosis of infection in sepsis: an evidence-based review
    Jonathan Cohen
    Department of Medicine, Brighton and Sussex Medical School, Brighton, UK
    Crit Care Med 32:S466-94. 2004
    ....
  38. ncbi request reprint Tracking the microbes in sepsis: advancements in treatment bring challenges for microbial epidemiology
    Martin J Llewelyn
    Brighton and Sussex Medical School, Falmer, Sussex, United Kingdom
    Clin Infect Dis 44:1343-8. 2007
    ....
  39. ncbi request reprint Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Section of Critical Care Medicine, Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden, NJ 08103, USA
    Intensive Care Med 30:536-55. 2004
    ....
  40. ncbi request reprint A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 23:400-5. 2005
    ..Treatment using the PMX cartridge is safe and may improve cardiac and renal dysfunction due to sepsis or septic shock. Further studies are needed to prove this effectiveness...
  41. ncbi request reprint 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  42. ncbi request reprint The international sepsis forum consensus conference on definitions of infection in the intensive care unit
    Thierry Calandra
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Crit Care Med 33:1538-48. 2005
    ..To develop definitions of infection that can be used in clinical trials in patients with sepsis...
  43. ncbi request reprint 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  44. ncbi request reprint The less they know, the better: abstinence-only HIV/AIDS programs in Uganda
    Jonathan Cohen
    Reprod Health Matters 14:174-8. 2006
    ..9 percent, with rates of 6.5 percent in major towns and 4.1 percent in rural areas. This is the summary and excerpts from the recommendations of this publication...
  45. doi request reprint Sepsis: time to reconsider the concept
    Jean Carlet
    Intensive Care Unit, Infectious Diseases Department, Groupe Hospitalier Paris Saint Joseph, Paris, France
    Crit Care Med 36:964-6. 2008
    ..To discuss the difficulty in using the concept of sepsis for clinical trials and propose new ways for designing future trials for severe infections...
  46. ncbi request reprint Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study
    Heide Stirnadel
    World Wide Epidemiology, GlaxoSmithKline, Harlow, UK
    Atherosclerosis 197:868-76. 2008
    ....
  47. pmc Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection
    Joanna Warren
    Rheumatology Section, Division of Medicine, Department of Biochemistry, Imperial College School of Medicine London, University of Cambridge, Cambridge, United Kingdom
    Infect Immun 70:551-7. 2002
    ..The data presented here suggest the possibility of novel pathways by which C1q may modulate the pathogenesis of infectious diseases caused by intracellular pathogens...
  48. ncbi request reprint AIDS in Uganda: the human-rights dimension
    Jonathan Cohen
    HIV AIDS and Human Rights Programme and Children s Rights Division of Human Rights Watch, New York, NY 10118, USA
    Lancet 365:2075-6. 2005
  49. ncbi request reprint Successful organ transplantation from donors with Acinetobacter baumannii septic shock
    Jonathan Cohen
    Department of General Intensive Care, Rabin Medical Center, Campus Beilinson, Petah Tikva 49100, Israel
    Transplantation 81:853-5. 2006
    ..Two recipients developed postoperative infections, none with Acinetobacter sp. (one Pseudomonas sp. urinary tract infection, one Klebsiella sp. central venous catheter sepsis)...
  50. ncbi request reprint ABC in Uganda: success or subterfuge?
    Jonathan Cohen
    HIV AIDS Policy Law Rev 10:23-4. 2005
    ....
  51. ncbi request reprint Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
    ....
  52. ncbi request reprint Clusters of cases of invasive aspergillosis in transplant units: nosocomial spread or enhanced virulence?
    Jonathan Cohen
    Clin Infect Dis 35:776. 2002
  53. ncbi request reprint Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project)
    Diego F Wyszynski
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 95:194-8. 2005
    ..In subjects aged <35 years, atherogenic dyslipidemia frequently occurs in the absence of other metabolic syndrome risk factors...
  54. ncbi request reprint Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  55. ncbi request reprint Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Crit Care Med 32:858-73. 2004
    ....
  56. ncbi request reprint Shock factor shed by microbe
    Jonathan Cohen
    Nat Med 10:342-3. 2004
  57. ncbi request reprint Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerp, Belgium manu malbrain skynet be
    Intensive Care Med 30:822-9. 2004
    ..This study assessed the prevalence of IAH and its risk factors in a mixed population of intensive care patients...
  58. ncbi request reprint Readmission to the intensive care unit after "fast-track" cardiac surgery: risk factors and outcomes
    Alexander Kogan
    Cardiothoracic Surgery, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Petah Tiqva, Israel
    Ann Thorac Surg 76:503-7. 2003
    ..Readmission to the ICU, traditionally used as a quality index, has not been investigated in these patients. The aim of this study was to assess the causes, risk factors, and outcomes associated with readmission to the ICU...
  59. pmc The PIRO concept: I is for infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 7:252-5. 2003
  60. pmc Management of bacterial meningitis in adults
    Jonathan Cohen
    BMJ 326:996-7. 2003