Genomes and Genes
Gillian C Barnett
- A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicityGillian C Barnett
Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, UK University of Cambridge, Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, UK Electronic address
Radiother Oncol 111:178-85. 2014..This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity 2years after radiotherapy...
- Genetics and genomics of radiotherapy toxicity: towards predictionCatharine M West
School of Cancer and enabling Sciences, The University of Manchester, Manchester Academic Health Science Centre, The Christie, Wilmslow Road, Manchester M20 4BX, UK
Genome Med 3:52. 2011..In this review, we highlight recent advances in radiotherapy and discuss results from four genome-wide studies of radiotoxicity...
- Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicityGillian C Barnett
Cambridge University Hospital NHS Foundation Trust, UK
Radiother Oncol 105:289-95. 2012..To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies...
- Standardized Total Average Toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studiesGillian C Barnett
University of Cambridge Department of Oncology, Oncology Centre, Cambridge, UK
Int J Radiat Oncol Biol Phys 82:1065-74. 2012..We propose a novel metric, the Standardized Total Average Toxicity (STAT) score, to try to overcome these difficulties...
- Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis studyGillian C Barnett
University of Cambridge, Department of Oncology, Cambridge, UK
Lancet Oncol 13:65-77. 2012..Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset...
- Information given to patients about adverse effects of radiotherapy: a survey of patients' viewsG C Barnett
Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
Clin Oncol (R Coll Radiol) 16:479-84. 2004..We present a study to evaluate the amount of information patients feel that they should be given...
- The impact of clinical factors on the development of late radiation toxicity: results from the Medical Research Council RT01 trial (ISRCTN47772397)G C Barnett
University of Cambridge, Department of Oncology, Oncology Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
Clin Oncol (R Coll Radiol) 23:613-24. 2011..The effect of other treatment- and patient-related factors is less well established. The aim of this study was to elucidate the influence of such factors in the development of late symptoms after radical radiotherapy to the prostate...
- No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER studyGillian C Barnett
Department of Oncology, University of Cambridge, Cambridge, UK
Radiother Oncol 97:9-14. 2010....
- Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotypeGillian C Barnett
Department of Oncology, University of Cambridge, Oncology Centre, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Nat Rev Cancer 9:134-42. 2009..Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy...
- Risk factors for the incidence of breast cancer: do they affect survival from the disease?Gillian C Barnett
Oncology Centre, Box 193, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2QQ, United Kingdom
J Clin Oncol 26:3310-6. 2008..Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis...
- Randomized controlled trial of forward-planned intensity modulated radiotherapy for early breast cancer: interim results at 2 yearsGillian C Barnett
Department of Oncology, University of Cambridge, Cambridge University Hospitals, National Health Service Foundation Trust, Cambridge, United Kingdom
Int J Radiat Oncol Biol Phys 82:715-23. 2012..This single-center randomized trial was designed to investigate whether intensity-modulated radiotherapy (IMRT) reduces late toxicity in patients with early-stage breast cancer...
- Randomized controlled trial of intensity-modulated radiotherapy for early breast cancer: 5-year results confirm superior overall cosmesisMukesh B Mukesh
Mukesh B Mukesh, Gillian C Barnett, Jennifer S Wilkinson, Anne M Moody, Charles Wilson, Wendi Qian, Nicola Twyman, Neil G Burnet, and Charlotte E Coles, Cambridge University Hospitals National Health Service Foundation Trust Gillian C Barnett, Charleen Chan Wah Hak, and Neil G Burnet, University of Cambridge and Gordon C Wishart, Anglia Ruskin University, Cambridge, United Kingdom
J Clin Oncol 31:4488-95. 2013..The Cambridge Breast IMRT trial investigated this hypothesis, and the 5-year results are reported...
- Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: results from the Cambridge Breast IMRT trialMukesh B Mukesh
Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, UK Department of Oncology, Colchester Hospital University NHS Foundation Trust, Essex, UK Electronic address
Radiother Oncol 111:270-5. 2014....
- Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy ToxicityLeila Dorling
Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom
Clin Cancer Res 22:1413-20. 2016..This study investigated the relationship between common breast cancer risk variants and radiotherapy toxicity...
- A randomised controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: baseline characteristics and dosimetry resultsGillian C Barnett
Department of Oncology, University of Cambridge, Cambridge, UK
Radiother Oncol 92:34-41. 2009..This paper reports baseline characteristics of trial participants and dosimetry results...