Michael D Coleman

Summary

Affiliation: Aston University
Country: UK

Publications

  1. ncbi request reprint Effects of lipoic acid and dihydrolipoic acid on total erythrocytic thiols under conditions of restricted glucose in vitro
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Basic Clin Pharmacol Toxicol 100:139-44. 2007
  2. ncbi request reprint Use of in vitro methaemoglobin generation to study antioxidant status in the diabetic erythrocyte
    M D Coleman
    Mechanisms of Drug Toxicity Group, Department of Pharmaceutical Sciences, Aston University, B4 7ET, Birmingham, UK
    Biochem Pharmacol 60:1409-16. 2000
  3. ncbi request reprint Dapsone-mediated agranulocytosis: risks, possible mechanisms and prevention
    M D Coleman
    Mechanisms of Drug Toxicity Group, Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
    Toxicology 162:53-60. 2001
  4. ncbi request reprint Effects of lipoic acid and dihydrolipoic acid on 4-aminophenol-mediated erythrocytic toxicity in vitro
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Basic Clin Pharmacol Toxicol 99:225-9. 2006
  5. ncbi request reprint A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Basic Clin Pharmacol Toxicol 102:25-9. 2008
  6. ncbi request reprint Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH
    Thomas R Zilz
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Toxicology 231:210-4. 2007
  7. pmc Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network
    Marta A Tarczyluk
    Aston Research Center for Healthy Ageing, Life and Health Sciences, Aston University, Birmingham, UK
    J Cereb Blood Flow Metab 33:1386-93. 2013
  8. pmc Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development
    Eric J Hill
    Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom
    PLoS ONE 8:e58822. 2013
  9. pmc A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
    PLoS ONE 7:e42768. 2012
  10. pmc A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems
    Elizabeth K Woehrling
    School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, United Kingdom
    PLoS ONE 10:e0118786. 2015

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Effects of lipoic acid and dihydrolipoic acid on total erythrocytic thiols under conditions of restricted glucose in vitro
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Basic Clin Pharmacol Toxicol 100:139-44. 2007
    ..5 +/- 2.4% and 8.4 +/- 1.4%, respectively). These studies suggest that in certain circumstances such as hypoglycaemia, lipoic acid administration may actually be detrimental to cellular oxidant protection status...
  2. ncbi request reprint Use of in vitro methaemoglobin generation to study antioxidant status in the diabetic erythrocyte
    M D Coleman
    Mechanisms of Drug Toxicity Group, Department of Pharmaceutical Sciences, Aston University, B4 7ET, Birmingham, UK
    Biochem Pharmacol 60:1409-16. 2000
    ..Equalization in vitro of diabetic methaemoglobin generation with that of age/sex-matched non-diabetic subjects might provide an early indication of diabetic antioxidant status improvement in these studies...
  3. ncbi request reprint Dapsone-mediated agranulocytosis: risks, possible mechanisms and prevention
    M D Coleman
    Mechanisms of Drug Toxicity Group, Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
    Toxicology 162:53-60. 2001
    ....
  4. ncbi request reprint Effects of lipoic acid and dihydrolipoic acid on 4-aminophenol-mediated erythrocytic toxicity in vitro
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Basic Clin Pharmacol Toxicol 99:225-9. 2006
    ..Lipoic acid, and to a lesser extent its reduced derivative DHLA, acted as a prooxidant in the presence of 4-aminophenol, enhancing the oxidative stress effects of the amine in human erythrocytes...
  5. ncbi request reprint A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Basic Clin Pharmacol Toxicol 102:25-9. 2008
    ..These alpha-diketones also display a degree of toxic selectivity towards neuroblastoma cells, which may have therapeutic implications...
  6. ncbi request reprint Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH
    Thomas R Zilz
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Toxicology 231:210-4. 2007
    ....
  7. pmc Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network
    Marta A Tarczyluk
    Aston Research Center for Healthy Ageing, Life and Health Sciences, Aston University, Birmingham, UK
    J Cereb Blood Flow Metab 33:1386-93. 2013
    ..Similar results were also shown after treatment with glutamate, potassium, isoproterenol, and dbcAMP. Together, these results demonstrate for the first time a functional ANLS in a human stem cell-derived co-culture. ..
  8. pmc Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development
    Eric J Hill
    Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom
    PLoS ONE 8:e58822. 2013
    ..This neurosphere model might provide the basis of a human-based cellular approach for the regulatory exploration of developmental impact of potential toxic chemicals...
  9. pmc A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
    PLoS ONE 7:e42768. 2012
    ..This report suggests that the impact of some pesticides, both individually and in combinations, merits further study in terms of their impact on human cellular health...
  10. pmc A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems
    Elizabeth K Woehrling
    School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, United Kingdom
    PLoS ONE 10:e0118786. 2015
    ..Overall, this NT2.N/A model may be appropriate for further investigation of adverse anticholinergic effects of multiple medications, in order to inform clinical choices of suitable drug use in the elderly. ..
  11. ncbi request reprint Discovery of a potent phenolic N1-benzylidene-pyridinecarboxamidrazone selective against Gram-positive bacteria
    Daniel L Rathbone
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Bioorg Med Chem Lett 16:879-83. 2006
    ..In addition, this compound is active against various drug-resistant Gram-positive bacteria...
  12. doi request reprint Single-cell ELISA and flow cytometry as methods for highlighting potential neuronal and astrocytic toxicant specificity
    E K Woehrling
    School of Life and Health Sciences, Aston University, Aston Street, Birmingham, UK
    Neurotox Res 19:472-83. 2011
    ..Further work using the NT2.N/A model and a broader array of toxicants is appropriate in order to confirm the applicability of these methods...
  13. doi request reprint Evaluation of the importance of astrocytes when screening for acute toxicity in neuronal cell systems
    E K Woehrling
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Neurotox Res 17:103-13. 2010
    ..In conclusion, the suitability of NT2 neurons and astrocytes as cell systems for acute toxicity screening deserves further investigation...
  14. doi request reprint Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing
    E J Hill
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Toxicology 249:243-50. 2008
    ..Acrylamide reduced neurosphere viability but did not affect neuronal protein marker expression. Overall, this NT2/D1-based neurosphere model of neurogenesis, may provide the basis for a model of developmental neurotoxicity in vitro...
  15. ncbi request reprint Development of a neurotoxicity test-system, using human post-mitotic, astrocytic and neuronal cell lines in co-culture
    E K Woehrling
    School of Life and Health Sciences, Aston University, Aston Street, Birmingham, B4 7ET, UK
    Toxicol In Vitro 21:1241-6. 2007
    ..Thus, it appears the use of astrocytes in an in vitro predictive neurotoxicity test-system may be more relevant to human CNS structure and function than neuronal cells alone...
  16. ncbi request reprint The effect of acetylation and deacetylation on the disposition of dapsone and monoacetyl dapsone hydroxylamines in human erythrocytes in-vitro
    M D Coleman
    Department of Pharmaceutical Sciences, Aston University, Birmingham, UK
    J Pharm Pharmacol 48:401-6. 1996
    ..It is possible that the hydroxylamines undergo erythrocytic processes of acetylation and deacetylation before methaemoglobin-mediated reduction to their respective amines...
  17. doi request reprint The effects of the fungicides fenhexamid and myclobutanil on SH-SY5Y and U-251 MG human cell lines
    David A Nagel
    School of Life and Health Sciences, Aston University, Aston Triangle, B4 7ET Birmingham, UK
    Environ Toxicol Pharmacol 38:968-76. 2014
    ....
  18. ncbi request reprint Brain-derived neurotrophic factor as an indicator of chemical neurotoxicity: an animal-free CNS cell culture model
    Elizabeth K Woehrling
    Mechanisms of Toxicity Group, School of Life and Health Sciences, Aston University, Birmingham, UK
    Altern Lab Anim 41:503-11. 2013
    ..In addition, the production of NT2.N/A cells without the use of animal products, such as fetal bovine serum, is being explored, to produce a fully-humanised cellular model. ..
  19. ncbi request reprint Assessment of the astrogliotic responses of three human astrocytoma cell lines to ethanol, trimethyltin chloride and acrylamide
    Lindsay J Holden
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Toxicology 241:75-83. 2007
    ..This study underlines the significance of period of exposure, as well as toxin concentration in astrocytoma cellular response to toxic pressure...
  20. pmc NT2 derived neuronal and astrocytic network signalling
    Eric J Hill
    Aston Research Centre into Healthy Ageing ARCHA, Aston University, Birmingham, West Midlands, United Kingdom
    PLoS ONE 7:e36098. 2012
    ..Indeed, this also supports the intriguing possibility of selective therapeutic replacement of astrocytes in diseases where these cells are either lost or lose functionality...
  21. ncbi request reprint Further preliminary assessment of three human glioma cell lines as models of human astrocytic toxicity in vitro
    Lindsay J Holden
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Environ Toxicol Pharmacol 26:290-6. 2008
    ..It is possible that batteries of astrocytic human glioma cell lines may be applicable to the sensitive evaluation of toxicants on astrogliotic expression markers such as GFAP and IL-6...
  22. ncbi request reprint Improvement of patient tolerance to dapsone: current and future developments
    Michael D Coleman
    Dermatol Online J 13:18. 2007