Romain Paillot

Summary

Affiliation: Animal Health Trust
Country: UK

Publications

  1. ncbi request reprint Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vaccine 23:4541-51. 2005
  2. ncbi request reprint Frequency and phenotype of EHV-1 specific, IFN-gamma synthesising lymphocytes in ponies: the effects of age, pregnancy and infection
    Romain Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Dev Comp Immunol 31:202-14. 2007
  3. doi request reprint Protection, systemic IFNgamma, and antibody responses induced by an ISCOM-based vaccine against a recent equine influenza virus in its natural host
    Romain Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk, CB8 7UU, UK
    Vet Res 39:21. 2008
  4. pmc How to Meet the Last OIE Expert Surveillance Panel Recommendations on Equine Influenza (EI) Vaccine Composition: A Review of the Process Required for the Recombinant Canarypox-Based EI Vaccine
    Romain Paillot
    Animal Health Trust, Lanwades Park, Kentford Newmarket CB8 7UU, UK
    Pathogens 5:. 2016
  5. pmc The Use of a Recombinant Canarypox-Based Equine Influenza Vaccine during the 2007 Australian Outbreak: A Systematic Review and Summary
    Romain Paillot
    Animal Health Trust, Lanwades Park, Kentford Newmarket, CB8 7UU Suffolk, UK
    Pathogens 5:. 2016
  6. pmc A Systematic Review of Recent Advances in Equine Influenza Vaccination
    Romain Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vaccines (Basel) 2:797-831. 2014
  7. doi request reprint Duration of equine influenza virus shedding and infectivity in immunised horses after experimental infection with EIV A/eq2/Richmond/1/07
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Microbiol 166:22-34. 2013
  8. doi request reprint A systematic review of the immune-modulators Parapoxvirus ovis and Propionibacterium acnes for the prevention of respiratory disease and other infections in the horse
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Immunol Immunopathol 153:1-9. 2013
  9. doi request reprint Whole inactivated equine influenza vaccine: Efficacy against a representative clade 2 equine influenza virus, IFNgamma synthesis and duration of humoral immunity
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Microbiol 162:396-407. 2013
  10. doi request reprint ISCOM-matrix-based equine influenza (EIV) vaccine stimulates cell-mediated immunity in the horse
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Immunol Immunopathol 145:516-21. 2012

Detail Information

Publications22

  1. ncbi request reprint Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vaccine 23:4541-51. 2005
    ..Measurement of equine IFN-gamma using these simple techniques can now be applied to future studies on protective cellular immune responses following virus infection and/or vaccination of horses...
  2. ncbi request reprint Frequency and phenotype of EHV-1 specific, IFN-gamma synthesising lymphocytes in ponies: the effects of age, pregnancy and infection
    Romain Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Dev Comp Immunol 31:202-14. 2007
    ..This study highlights the complexity of the relationship between EHV-1, a common pathogen in horses, and the virus-specific cellular immune response as measured using IFN-gamma synthesis...
  3. doi request reprint Protection, systemic IFNgamma, and antibody responses induced by an ISCOM-based vaccine against a recent equine influenza virus in its natural host
    Romain Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk, CB8 7UU, UK
    Vet Res 39:21. 2008
    ..In conclusion, evidence of type-1 immunity induced by an ISCOM-based vaccine is described for the first time in horses...
  4. pmc How to Meet the Last OIE Expert Surveillance Panel Recommendations on Equine Influenza (EI) Vaccine Composition: A Review of the Process Required for the Recombinant Canarypox-Based EI Vaccine
    Romain Paillot
    Animal Health Trust, Lanwades Park, Kentford Newmarket CB8 7UU, UK
    Pathogens 5:. 2016
    ..The recombinant canarypox-based EI vaccine was the first fully updated EI vaccine available in the EU, which will help to minimise the increasing risk of vaccine breakdown due to constant EIV evolution through antigenic drift...
  5. pmc The Use of a Recombinant Canarypox-Based Equine Influenza Vaccine during the 2007 Australian Outbreak: A Systematic Review and Summary
    Romain Paillot
    Animal Health Trust, Lanwades Park, Kentford Newmarket, CB8 7UU Suffolk, UK
    Pathogens 5:. 2016
    ..This systematic review reports and summarises information relating to the implementation of emergency vaccination during the 2007 Australian equine influenza outbreak, including the choice of vaccine and implementation strategies. ..
  6. pmc A Systematic Review of Recent Advances in Equine Influenza Vaccination
    Romain Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vaccines (Basel) 2:797-831. 2014
    ..This systematic review reports the advances of EI vaccines during the last few years as well as some of the mechanisms behind the inefficient or sub-optimal response of horses to vaccination. ..
  7. doi request reprint Duration of equine influenza virus shedding and infectivity in immunised horses after experimental infection with EIV A/eq2/Richmond/1/07
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Microbiol 166:22-34. 2013
    ..In infected sentinels EIV was detectable up to 12 days after commingling. Results also suggest that tests such as qRT-PCR may be a suitable substitute for time spent in pre-export quarantine...
  8. doi request reprint A systematic review of the immune-modulators Parapoxvirus ovis and Propionibacterium acnes for the prevention of respiratory disease and other infections in the horse
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Immunol Immunopathol 153:1-9. 2013
    ..This systematic review regroups articles published in peer-review journals, clinical trials reports, conference proceedings and other information made available in the last 2 decades...
  9. doi request reprint Whole inactivated equine influenza vaccine: Efficacy against a representative clade 2 equine influenza virus, IFNgamma synthesis and duration of humoral immunity
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Microbiol 162:396-407. 2013
    ..This study revealed that most immunised horses maintained significant levels of cross-reactive SRH antibody for a prolonged period of time, but individual monitoring may be beneficial to identify poor vaccine responders...
  10. doi request reprint ISCOM-matrix-based equine influenza (EIV) vaccine stimulates cell-mediated immunity in the horse
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Immunol Immunopathol 145:516-21. 2012
    ..In conclusion, EIV vaccine adjuvanted with ISCOM-matrix stimulates both antibody and a cellular immune response in the horse...
  11. pmc Contribution of each of four Superantigens to Streptococcus equi-induced mitogenicity, gamma interferon synthesis, and immunity
    Romain Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, United Kingdom
    Infect Immun 78:1728-39. 2010
    ..We propose that S. equi sAgs play an important role in S. equi pathogenicity by stimulating an overzealous and inappropriate Th1 response that may interfere with the development of an effective immune response...
  12. doi request reprint Efficacy of a whole inactivated EI vaccine against a recent EIV outbreak isolate and comparative detection of virus shedding
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Immunol Immunopathol 136:272-83. 2010
    ..Duvaxyn IE-T Plus therefore reduced clinical signs and virus shedding when ponies were challenged with A/eq2/Sydney/2888-8/07 (H3N8), 2 weeks after a second dose of vaccine...
  13. ncbi request reprint New assays to measure equine influenza virus-specific Type 1 immunity in horses
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vaccine 25:7385-98. 2007
    ..This study provides the tools to characterise the stimulation of CMI by the new generation of vaccines against equine influenza...
  14. ncbi request reprint Antibody and IFN-gamma responses induced by a recombinant canarypox vaccine and challenge infection with equine influenza virus
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vet Immunol Immunopathol 112:225-33. 2006
    ..This study also provided the first evidence for increased IFN-gamma protein synthesis in vaccinated ponies following challenge infection with EIV compared with control ponies...
  15. ncbi request reprint Vaccination against equine influenza: quid novi?
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vaccine 24:4047-61. 2006
    ..Finally it outlines progress in the development of a novel vaccination strategy against equine influenza using reverse genetics...
  16. ncbi request reprint Characterisation of CTL and IFN-gamma synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection
    R Paillot
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK
    Vaccine 24:1490-500. 2006
    ..However, the study does illustrate that vaccinia-based vaccines can stimulate CMI in the horse and may therefore contribute to protection against disease caused by EHV-1...
  17. pmc Comparison of two modern vaccines and previous influenza infection against challenge with an equine influenza virus from the Australian 2007 outbreak
    Neil A Bryant
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Kentford, Newmarket, CB8 7UU, United Kingdom
    Vet Res 41:19. 2010
    ..In summary, we demonstrate that vaccination with current EIV vaccines would partially protect against infection with A/eq/Sydney/2888-8/07-like strains and would help to limit the spread of disease in our vaccinated horse population...
  18. ncbi request reprint Equine herpesvirus-1-specific interferon gamma (IFNgamma) synthesis by peripheral blood mononuclear cells in thoroughbred horses
    R Luce
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    Equine Vet J 39:202-9. 2007
    ..The method requires validation in the field...
  19. pmc Identification of three novel superantigen-encoding genes in Streptococcus equi subsp. zooepidemicus, szeF, szeN, and szeP
    Romain Paillot
    Centre for Preventive Medicine, Animal Health Trust, Kentford, Newmarket, Suffolk, United Kingdom
    Infect Immun 78:4817-27. 2010
    ..000001, and P = 0.104, respectively). We conclude that horizontal transfer of these novel superantigens from and within the diverse S. equi subsp. zooepidemicus population is likely to have implications for veterinary and human disease...
  20. doi request reprint Streptococcus equi: a pathogen restricted to one host
    Andrew S Waller
    Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    J Med Microbiol 60:1231-40. 2011
    ..This review discusses the role of these genetic events on the evolution and emergence of this important host-restricted pathogen...
  21. doi request reprint Antigenic and genetic variations in European and North American equine influenza virus strains (H3N8) isolated from 2006 to 2007
    Neil A Bryant
    Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Kentford, Newmarket CB8 7UU, UK
    Vet Microbiol 138:41-52. 2009
    ..In conclusion, a variety of antigenically distinct EIVs continue to circulate worldwide. Florida sublineage clade 1 viruses appear to predominate in North America, clade 2 viruses in Europe...
  22. ncbi request reprint Australian equine influenza: vaccine protection in the UK
    Neil Bryant
    Vet Rec 162:491-2. 2008