M Estee Torok

Summary

Affiliation: Addenbrooke's Hospital
Country: UK

Publications

  1. ncbi request reprint Outpatient parenteral antimicrobial therapy: Recent developments and future prospects
    M Estee Torok
    Cambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Curr Opin Investig Drugs 11:929-39. 2010
  2. pmc Use of Vitek 2 antimicrobial susceptibility profile to identify mecC in methicillin-resistant Staphylococcus aureus
    Edward J P Cartwright
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Clin Microbiol 51:2732-4. 2013
  3. pmc Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak
    M Estee Torok
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Clin Microbiol 51:611-4. 2013
  4. doi request reprint Rapid whole-genome sequencing of bacterial pathogens in the clinical microbiology laboratory--pipe dream or reality?
    M E Torok
    Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    J Antimicrob Chemother 67:2307-8. 2012
  5. pmc Bacterial gene loss as a mechanism for gain of antimicrobial resistance
    M E Torok
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Curr Opin Microbiol 15:583-7. 2012
  6. pmc Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)--associated tuberculous meningitis
    M Estee Torok
    Department of Infectious Diseases, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom
    Clin Infect Dis 52:1374-83. 2011
  7. pmc Dexamethasone and long-term outcome of tuberculous meningitis in Vietnamese adults and adolescents
    M Estee Torok
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e27821. 2011
  8. pmc Zero tolerance for healthcare-associated MRSA bacteraemia: is it realistic?
    M Estee Torok
    Department of Medicine, University of Cambridge, Cambridge, UK Department of Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, UK
    J Antimicrob Chemother 69:2238-45. 2014
  9. pmc Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland
    Sandra Reuter
    Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom
    Genome Res 26:263-70. 2016
  10. pmc Genome-based characterization of hospital-adapted Enterococcus faecalis lineages
    Kathy E Raven
    Department of Medicine, University of Cambridge, Box 157 Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Nat Microbiol 1:. 2016

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Outpatient parenteral antimicrobial therapy: Recent developments and future prospects
    M Estee Torok
    Cambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Curr Opin Investig Drugs 11:929-39. 2010
    ..This review outlines recent developments in, and future prospects for, the antimicrobial agents used in OPAT...
  2. pmc Use of Vitek 2 antimicrobial susceptibility profile to identify mecC in methicillin-resistant Staphylococcus aureus
    Edward J P Cartwright
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Clin Microbiol 51:2732-4. 2013
    ..The presence of the mecC gene, determined by bacterial whole-genome sequencing, was used as the gold standard. This profile could provide a zero-cost screening method for identification of mecC-positive MRSA strains. ..
  3. pmc Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak
    M Estee Torok
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Clin Microbiol 51:611-4. 2013
    ..Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event...
  4. doi request reprint Rapid whole-genome sequencing of bacterial pathogens in the clinical microbiology laboratory--pipe dream or reality?
    M E Torok
    Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    J Antimicrob Chemother 67:2307-8. 2012
    ..This article reviews its potential applications in the clinical microbiology laboratory and discusses the current barriers to implementation...
  5. pmc Bacterial gene loss as a mechanism for gain of antimicrobial resistance
    M E Torok
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Curr Opin Microbiol 15:583-7. 2012
    ..This provides one explanation for ceftazidime treatment failure, and may be a frequent but undetected event in patients with melioidosis...
  6. pmc Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)--associated tuberculous meningitis
    M Estee Torok
    Department of Infectious Diseases, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom
    Clin Infect Dis 52:1374-83. 2011
    ..The optimal time to initiate antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-associated tuberculous meningitis is unknown...
  7. pmc Dexamethasone and long-term outcome of tuberculous meningitis in Vietnamese adults and adolescents
    M Estee Torok
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e27821. 2011
    ..Dexamethasone has been shown to reduce mortality in patients with tuberculous meningitis but the long-term outcome of the disease is unknown...
  8. pmc Zero tolerance for healthcare-associated MRSA bacteraemia: is it realistic?
    M Estee Torok
    Department of Medicine, University of Cambridge, Cambridge, UK Department of Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, UK
    J Antimicrob Chemother 69:2238-45. 2014
    ..This may not be the case for healthcare-associated infections such as methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia...
  9. pmc Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland
    Sandra Reuter
    Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom
    Genome Res 26:263-70. 2016
    ..We have generated a resource for the future surveillance and outbreak investigation of MRSA in the United Kingdom and Ireland and have shown the value of this during outbreak investigation and tracking of antimicrobial resistance. ..
  10. pmc Genome-based characterization of hospital-adapted Enterococcus faecalis lineages
    Kathy E Raven
    Department of Medicine, University of Cambridge, Box 157 Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Nat Microbiol 1:. 2016
    ..Each of the three main lineages contained a mixture of vancomycin-resistant and -susceptible E. faecalis (VSEfs), which has important implications for infection control and antibiotic stewardship...
  11. pmc Comparison of two chromogenic media for the detection of vancomycin-resistant enterococcal carriage by nursing home residents
    Theodore Gouliouris
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, United Kingdom Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom Electronic address
    Diagn Microbiol Infect Dis 85:409-12. 2016
    ..Brilliance VRE agar had higher selectivity at 48 hours, and after pre-enrichment. ..
  12. pmc Comparison of 2 chromogenic media for the detection of extended-spectrum β-lactamase producing Enterobacteriaceae stool carriage in nursing home residents
    Beth Blane
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom Electronic address
    Diagn Microbiol Infect Dis 84:181-3. 2016
    ..Pre-enrichment with cefpodoxime and extending incubation to 48 hours after direct plating both significantly increased sensitivity but reduced selectivity of both agars...
  13. pmc Whole-genome sequencing reveals transmission of vancomycin-resistant Enterococcus faecium in a healthcare network
    Hayley J Brodrick
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Box 157, Hills Road, Cambridge, CB2 0QQ, UK
    Genome Med 8:4. 2016
    ..We used WGS to define transmission of vancomycin-resistant enterococci (VRE) within a long-term care facility (LTCF), and between this and an acute hospital in the United Kingdom (UK)...
  14. pmc A decade of genomic history for healthcare-associated Enterococcus faecium in the United Kingdom and Ireland
    Kathy E Raven
    University of Cambridge, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Genome Res 26:1388-1396. 2016
    ..faecium Our findings reveal the evolution and dissemination of hospital-associated E. faecium in the UK&I and provide evidence for WGS as an instrument for infection control...
  15. doi request reprint Genome-based characterization of hospital-adapted Enterococcus faecalis lineages
    Kathy E Raven
    Department of Medicine, University of Cambridge, Box 157 Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Nat Microbiol 1:15033. 2016
    ..Each of the three main lineages contained a mixture of vancomycin-resistant and -susceptible E. faecalis (VSEfs), which has important implications for infection control and antibiotic stewardship. ..
  16. pmc Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus
    Matthew J Ellington
    Public Health England, Microbiology Services Division, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QW, UK Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK Electronic address
    Int J Antimicrob Agents 45:477-84. 2015
    ..The development of chimeric cassettes that confer dual resistance to β-lactams and fusidic acid demonstrates that the genetics underpinning resistance in community-associated MRSA are evolving. ..
  17. pmc Rapid single-colony whole-genome sequencing of bacterial pathogens
    Claudio U Köser
    Department of Medicine, University of Cambridge, Cambridge, UK
    J Antimicrob Chemother 69:1275-81. 2014
    ..We have eliminated this rate-limiting step by developing a protocol to generate DNA libraries for whole-genome sequencing directly from single bacterial colonies grown on primary culture plates...
  18. pmc Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks
    Ewan M Harrison
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Box 157, Hills Road, Cambridge, CB2 0QQ, UK
    Genome Med 8:102. 2016
    ..Whole-genome sequencing (WGS) has been used successfully to understand MRSA epidemiology and transmission in hospitals and has the potential to identify transmission between these and LTCF...
  19. pmc Incidence and characterisation of methicillin-resistant Staphylococcus aureus (MRSA) from nasal colonisation in participants attending a cattle veterinary conference in the UK
    Gavin K Paterson
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    PLoS ONE 8:e68463. 2013
    ..Contact with livestock, including dairy cattle, may still be a risk factor for human colonisation with mecC-MRSA but occurs at a rate below the lower limit of detection available in this study. ..
  20. pmc Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study
    Simon R Harris
    Wellcome Trust Sanger Institute, Cambridge, UK
    Lancet Infect Dis 13:130-6. 2013
    ..We assessed the use of whole-genome sequencing to enhance detection of MRSA transmission between these settings...
  21. pmc Impact of infectious diseases consultation on the management of Staphylococcus aureus bacteraemia in children
    Rebecca B Saunderson
    Department of Medicine, University of Cambridge, Cambridge, UK
    BMJ Open 4:e004659. 2014
    ..Infectious diseases consultation (IDC) in adults with Staphylococcus aureus bacteraemia (SAB) has been shown to improve management and outcome. The aim of this study was to evaluate the impact of IDC on the management of SAB in children...
  22. doi request reprint Public perceptions of bacterial whole-genome sequencing for tuberculosis
    Anna Davies
    Department of Medicine, University of Cambridge, Cambridge, UK
    Trends Genet 31:58-60. 2015
    ..We held an open public debate to explore public understanding and perceptions of bacterial whole-genome sequencing (WGS), which we describe here. ..