Yusuf Tutar

Summary

Affiliation: Cumhuriyet University
Country: Turkey

Publications

  1. doi Neglected role of cAMP receptor protein monomer
    Yusuf Tutar
    Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140, Sivas, Turkey
    Mol Biol Rep 39:4261-5. 2012
  2. ncbi Ydj1 but not Sis1 stabilizes Hsp70 protein under prolonged stress in vitro
    Lütfi Tutar
    Chemistry and Biochemistry Department, Faculty of Science, Cumhuriyet University, Sivas 58140, Turkey
    Biopolymers 89:171-4. 2008
  3. ncbi Hsp70 in oncology
    Yusuf Tutar
    Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
    Recent Pat DNA Gene Seq 5:214-8. 2011
  4. doi Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer
    Yusuf Tutar
    Cumhuriyet University, Faculty of Pharmacy, Department of Basic Sciences, Division of Biochemistry, Sivas, Turkey Electronic address
    Biomed Pharmacother 83:1182-1190. 2016
  5. ncbi Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications
    Aykut Ozgur
    Cumhuriyet University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, Sivas, Turkey
    Anticancer Agents Med Chem 16:280-90. 2016
  6. ncbi Regulation of Heat Shock Proteins by miRNAs in human breast cancer
    Aykut Ozgur
    Department of Basic Pharmaceutical Sciences, Division of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, 58140, Turkey
    Microrna 3:118-35. 2014
  7. ncbi MicroRNAs and cancer; an overview
    Lütfi Tutar
    Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey, 58140
    Curr Pharm Biotechnol 15:430-7. 2014
  8. ncbi miRNA and cancer; computational and experimental approaches
    Yusuf Tutar
    Cumhuriyet University Faculty of Pharmacy Division of Biochemistry 58140 Sivas, Turkey
    Curr Pharm Biotechnol 15:429. 2014
  9. pmc Pseudogenes
    Yusuf Tutar
    Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
    Comp Funct Genomics 2012:424526. 2012
  10. ncbi Therapeutic proteins: A to Z
    Aykut Ozgur
    Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey
    Protein Pept Lett 20:1365-72. 2013

Collaborators

  • Irfan Koca
  • Semra Ozcelik
  • Lütfi Tutar
  • Aykut Ozgur
  • Steven R Tomlinson
  • Mehmet Gumus
  • Kübra Açıkalın Coşkun
  • Kübra A Coskun
  • Youtao Song
  • James G Harman
  • Ali Dişli
  • Esen Tutar
  • Begüm Otag
  • Nazif Elaldi
  • Mesut Mungan
  • Evan Eisenberg
  • Daniel C Masison
  • Lois E Greene
  • Giman Jung
  • Yue Xuan Wu

Detail Information

Publications31

  1. doi Neglected role of cAMP receptor protein monomer
    Yusuf Tutar
    Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140, Sivas, Turkey
    Mol Biol Rep 39:4261-5. 2012
    ..The exchange behavior of CRP in the presence of different factors implies importance of monomer in transcription complex association and dissociation...
  2. ncbi Ydj1 but not Sis1 stabilizes Hsp70 protein under prolonged stress in vitro
    Lütfi Tutar
    Chemistry and Biochemistry Department, Faculty of Science, Cumhuriyet University, Sivas 58140, Turkey
    Biopolymers 89:171-4. 2008
    ..Stability experiments revealed that only Ydj1-protected Hsp70 proteins can hydrolyze ATP under prolonged stress...
  3. ncbi Hsp70 in oncology
    Yusuf Tutar
    Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
    Recent Pat DNA Gene Seq 5:214-8. 2011
    ..This review presents Hsp70s role for growth of transformed cells and the current state of Hsp70 as a drug target along with recent patents in humans in this particular area...
  4. doi Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer
    Yusuf Tutar
    Cumhuriyet University, Faculty of Pharmacy, Department of Basic Sciences, Division of Biochemistry, Sivas, Turkey Electronic address
    Biomed Pharmacother 83:1182-1190. 2016
    ....
  5. ncbi Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications
    Aykut Ozgur
    Cumhuriyet University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, Sivas, Turkey
    Anticancer Agents Med Chem 16:280-90. 2016
    ..In this paper, we emphasize on the key roles of Hsp90 and its co-chaperones in tumorigenesis and overview therapeutic strategies of Hsp90 inhibition in oncology. ..
  6. ncbi Regulation of Heat Shock Proteins by miRNAs in human breast cancer
    Aykut Ozgur
    Department of Basic Pharmaceutical Sciences, Division of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, 58140, Turkey
    Microrna 3:118-35. 2014
    ..Cancer cells use HSP network as an escape mechanism from apoptosis, therefore inhibition of associated HSPs by modulating miRNAs may provide a novel therapy for the tumorigenesis...
  7. ncbi MicroRNAs and cancer; an overview
    Lütfi Tutar
    Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey, 58140
    Curr Pharm Biotechnol 15:430-7. 2014
    ..This review emphasizes the latest discovery in the field of miRNA research involved in cancer, biomarkers, and therapeutics. ..
  8. ncbi miRNA and cancer; computational and experimental approaches
    Yusuf Tutar
    Cumhuriyet University Faculty of Pharmacy Division of Biochemistry 58140 Sivas, Turkey
    Curr Pharm Biotechnol 15:429. 2014
    ..These scientific studies and approaches are expected to improve current technologies for therapy and biomarker detection. ..
  9. pmc Pseudogenes
    Yusuf Tutar
    Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
    Comp Funct Genomics 2012:424526. 2012
    ..The paper reviews our current knowledge on pseudogenes and evaluates preliminary results of the chaperone data. Current efforts to understand pseudogenes interactions help to understand the functions of a genome...
  10. ncbi Therapeutic proteins: A to Z
    Aykut Ozgur
    Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey
    Protein Pept Lett 20:1365-72. 2013
    ..This paper will summarize the production processes, pharmaceuticals and physicochemical properties and important classes of therapeutic proteins with their potential use in clinical applications. ..
  11. ncbi Heat shock protein 40-Gok1 isolation from Toxoplasma gondii RH strain
    Kübra A Coskun
    Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey
    Protein Pept Lett 20:1294-301. 2013
    ..Hsp40-Gok1 functional and structural properties may facilitate drug design and protein targeting against toxoplasmosis. ..
  12. doi Hsp70 from Cyprinion macrostomus macrostomus and Garra rufa obtuse: stability and stability-dependent activity
    Y Tutar
    Department of Biochemistry, Faculty of Pharmacology, Cumhuriyet University, Sivas, 58140, Turkey
    Biochemistry (Mosc) 78:531-5. 2013
    ..The stability of the Hsp70 proteins maintains substrate proteins in the native state, which may aid in the adaptation of the fish species to the hot spring environment. ..
  13. ncbi Chemical linkage at allosteric activation of E. coli cAMP receptor protein
    Yusuf Tutar
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
    Protein J 27:21-9. 2008
    ..5) Deconvolution of DNA binding data leads us to propose a model for cAMP's role in transcription initiation process...
  14. doi Syn, anti, and finally both conformations of cyclic AMP are involved in the CRP-dependent transcription initiation mechanism in E. coli lac operon
    Yusuf Tutar
    Department of Chemistry, Cumhuriyet University, Sivas, Turkey
    Cell Biochem Funct 26:399-405. 2008
    ..Therefore, the aim of this review is to summarize recent works and developments on the cAMP-dependent CRP activation mechanism in E. coli...
  15. ncbi Therapeutic use of Heat Shock Protein 70
    Yusuf Tutar
    Department of Chemistry, Cumhuriyet University, Sivas, 58140, Turkey
    Recent Pat DNA Gene Seq 1:125-7. 2007
    ..Since altered functions of these proteins cause several diseases, a number of drug developments are underway to target Hsps. This review focuses on recent patents in this particular area...
  16. ncbi Heat shock proteins, substrate specificity and modulation of function
    Yusuf Tutar
    Chemistry Department, Faculty of Science, Cumhuriyet University, Sivas 58140, Turkey
    Protein Pept Lett 13:699-705. 2006
    ..In this work, nucleotide and peptide binding domain communication of Hsp70 proteins during their interaction with nucleotides and peptide substrates were investigated in vitro by using hybrid constructs...
  17. doi Heat, pH induced aggregation and surface hydrophobicity of S. cerevesiae Ssa1 protein
    Yusuf Tutar
    Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140, Sivas, Turkey
    Protein J 29:501-8. 2010
    ..Ssa1 secondary structure alterations and hydrophobic properties in aqueous solutions with differing ionic strengths and temperature were also studied...
  18. ncbi Key residues involved in Hsp70 regulatory activity and affect of co-chaperones on mechanism of action
    Yusuf Tutar
    Chemistry Department, Faculty of Science, Cumhuriyet University, Sivas 58140, Turkey
    Protein Pept Lett 13:693-8. 2006
    ..To elucidate function of key residues and affect of other factors involved in this allosteric mechanism, a biochemical study was undertaken...
  19. ncbi Effect of salt bridge on transcription activation of CRP-dependent lactose operon in Escherichia coli
    Yusuf Tutar
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
    Arch Biochem Biophys 453:217-23. 2006
    ....
  20. ncbi Target peptide recognition by S100P protein and role of central linker region and dimer interface
    Yusuf Tutar
    Cumhuriyet Universitesi Kimya Bölümü Biyokimya A B D Sivas Turkey
    Protein Pept Lett 13:307-11. 2006
    ..Since little is known about the recognition sequence, mellitin interaction form a model for S100P. Interaction between mellitin and protein examined to identify key regions required for the protein-protein interaction...
  21. ncbi Dimerization and ion binding properties of S100P protein
    Yusuf Tutar
    Cumhuriyet Universitesi Kimya Bölümü Biyokimya A B D Sivas Turkey
    Protein Pept Lett 13:301-6. 2006
    ..producing a pair of sites for target protein binding or ii. modulation of cation binding affinity. The extent of exposed protein hydrophobicity was related to dimer formation...
  22. ncbi CRP subunit association and hinge conformation changes in response to cAMP binding: analysis of C-helix cysteine-substituted CRP
    Steven R Tomlinson
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, USA
    Biochemistry 45:13438-46. 2006
    ..cAMP complex...
  23. ncbi Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
    Mehmet Gumus
    Department of Chemistry, Faculty of Arts and Sciences, Bozok University, Yozgat, Turkey
    Curr Pharm Biotechnol 17:1231-1245. 2016
    ..Therefore, new therapeutic approaches are being developed and Hsp90 is an important target for drug design. For this purpose, a series of benzodiazepine derivatives were designed and synthesized as novel Hsp90 inhibitor...
  24. ncbi Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery
    Steven R Tomlinson
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409 1061, USA
    Biochemistry 42:3759-65. 2003
    ....
  25. doi Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
    Irfan Koca
    Bozok University, Faculty of Arts and Sciences, Department of Chemistry, Yozgat, Turkey
    Bioorg Med Chem 21:3859-65. 2013
    ..These results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment. Furthermore, these compounds have a great potential and significance for further investigations...
  26. doi Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis
    Irfan Koca
    Bozok University, Faculty of Arts and Sciences, Department of Chemistry, Yozgat, Turkey Electronic address
    Eur J Med Chem 122:280-90. 2016
    ..Pyrimidinyl acyl thiourea derivatives may provide a drug template for effective treatment of invasive ductal breast carcinoma and its bone metastasis as well as new therapeutic perspective for drug design. ..
  27. ncbi A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
    Irfan Koca
    Bozok University, Faculty of Arts and Sciences, Department of Chemistry, Yozgat, Turkey
    Anticancer Agents Med Chem 15:916-30. 2015
    ..Thiazolyl coumarine compounds are found to be significant and useful for the treatment of human colon and liver cancer as evidenced by in vitro and in silico results. ..
  28. pmc Isolation and identification of free-living amoebae from tap water in Sivas, Turkey
    Kübra Açıkalın Coşkun
    Department of Parasitology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
    Biomed Res Int 2013:675145. 2013
    ..Furthermore, the presence of temperature tolerant Acanthamoeba genotype T4 in tap water in the region must be taken into account for health risks. ..
  29. ncbi Heat shock proteins; an overview
    Lütfi Tutar
    Department of Biology, Science Faculty, Selcuk University, Konya, Turkey
    Curr Pharm Biotechnol 11:216-22. 2010
    ..This first review of the theme issue will discuss general properties of Hsps concisely along with their potential use in pharmaceutical and biotechnological applications...
  30. pmc Primate chaperones Hsc70 (constitutive) and Hsp70 (induced) differ functionally in supporting growth and prion propagation in Saccharomyces cerevisiae
    Yusuf Tutar
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 172:851-61. 2006
    ..Our data support a view that intrinsic activities of Hsp70 isoforms are comparable, and functional differences in vivo lie mainly in complex interactions of Hsp70 with cochaperones...
  31. pmc Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication
    Youtao Song
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Eukaryot Cell 4:289-97. 2005
    ..Our data suggest that Ssa1-21p interferes with disruption of large Sup35p aggregates, which lack or have limited capacity to function as seed, into polymers that function more efficiently as [PSI+] seeds...