Martin R Tremblay

Summary

Publications

  1. doi request reprint Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Med Chem 52:4400-18. 2009
  2. doi request reprint Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 51:6646-9. 2008
  3. doi request reprint Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Expert Opin Ther Pat 19:1039-56. 2009
  4. doi request reprint New developments in the discovery of small molecule Hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 14:428-35. 2010
  5. doi request reprint Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors
    Tao Liu
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 55:8859-78. 2012
  6. pmc Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate
    Catherine A Evans
    Infinity Pharmaceuticals, Inc, 784 Memorial Drive, Cambridge, Massachusetts 02139, United States
    ACS Med Chem Lett 7:862-7. 2016

Collaborators

  • Julian Adams
  • Bonnie Tillotson
  • James R Porter
  • Tao Liu
  • Catherine A Evans
  • Somarajan J Nair
  • André Lescarbeau
  • Alfredo C Castro
  • Patrick O'Hearn
  • Vito J Palombella
  • Thomas Tibbitts
  • Stanley I Goldstein
  • Jennifer L Proctor
  • Johan A Pradeilles
  • Jonathan P DiNitto
  • John R Soglia
  • Erin E Brophy
  • Janid A Ali
  • Christian M Martin
  • David G Winkler
  • Erin L O'Hearn
  • Melissa M Pink
  • Culver Cheung
  • Ann M Rowley
  • Louis Grenier
  • Quentin Glenadel
  • Jennifer G Hoyt
  • Kelly Slocum
  • Kip West
  • Adilah Bahadoor
  • Andrew Wylie
  • Stephane Peluso
  • Joseph Helble
  • Jitendra Belani
  • Sherri Smith
  • James Conley
  • Christian Fritz
  • Karen McGovern
  • Mark Douglas
  • JANID ALI

Detail Information

Publications6

  1. doi request reprint Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Med Chem 52:4400-18. 2009
    ..As a result, complete tumor regression was observed in a Hh-dependent medulloblastoma allograft model after daily oral administration of 40 mg/kg of compound 28...
  2. doi request reprint Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 51:6646-9. 2008
    ..Further modification of the A/B-ring homoallylic alcohol to the conjugated ketone led to the discovery of new cyclopamine analogues with improved pharmaceutical properties and in vitro potency (EC 50) ranging from 10 to 1000 nM...
  3. doi request reprint Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Expert Opin Ther Pat 19:1039-56. 2009
    ..During the past decade, efforts from academic and industrial groups have led to the discovery of a variety of Hh pathway inhibitors...
  4. doi request reprint New developments in the discovery of small molecule Hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 14:428-35. 2010
    ..While most of the small molecule modulators of the Hh pathway were discovered through screening and subsequent medicinal chemistry, a number of them originated from rational design or natural products...
  5. doi request reprint Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors
    Tao Liu
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 55:8859-78. 2012
    ..Simplified analogues of silvestrol such as compounds 74 and 76 were shown to have similar cytotoxic potency and better ADME characteristics relative to those of silvestrol...
  6. pmc Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate
    Catherine A Evans
    Infinity Pharmaceuticals, Inc, 784 Memorial Drive, Cambridge, Massachusetts 02139, United States
    ACS Med Chem Lett 7:862-7. 2016
    ..IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo and is currently in Phase 1 clinical evaluation in subjects with advanced solid tumors. ..