Øivind Torkildsen

Summary

Publications

  1. ncbi request reprint Ethnic variations of IL-10 polymorphisms in a Sami and Norwegian population
    O Torkildsen
    The Multiple Sclerosis National Competence Centre, Department of Clinical Medicine, Section for Neurology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Scand J Immunol 62:71-4. 2005
  2. doi request reprint The cuprizone model for demyelination
    O Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway
    Acta Neurol Scand Suppl 188:72-6. 2008
  3. doi request reprint Month of birth as a risk factor for multiple sclerosis: an update
    O Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Acta Neurol Scand Suppl . 2012
  4. doi request reprint ω-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial
    Oivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway
    Arch Neurol 69:1044-51. 2012
  5. doi request reprint Upregulation of immunoglobulin-related genes in cortical sections from multiple sclerosis patients
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Brain Pathol 20:720-9. 2010
  6. doi request reprint A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Clin Nutr 28:83-7. 2009
  7. doi request reprint Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
    Exp Neurol 215:160-6. 2009
  8. ncbi request reprint Immunomodulatory treatment of multiple sclerosis in Norway
    Ø Torkildsen
    The Multiple Sclerosis National Competence Center, Haukeland University Hospital, Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway
    Acta Neurol Scand Suppl 187:46-50. 2007
  9. ncbi request reprint FcgammaR and multiple sclerosis: an overview
    O Torkildsen
    The Multiple Sclerosis National Competence Centre, Department of Neurology, Haukeland University Hospital and Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway
    Acta Neurol Scand Suppl 183:61-3. 2006
  10. ncbi request reprint [Lars Hertervig and Carl Fredrik Hill--creativeness and mental illness]
    Øivind Torkildsen
    Senter for klinisk nevroforskning, Stavanger universitetssjukehus, 4068 Stavanger
    Tidsskr Nor Laegeforen 125:3450-3. 2005

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Ethnic variations of IL-10 polymorphisms in a Sami and Norwegian population
    O Torkildsen
    The Multiple Sclerosis National Competence Centre, Department of Clinical Medicine, Section for Neurology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Scand J Immunol 62:71-4. 2005
    ..There was a significant difference in haplotypes in the two populations with a P=0.0024. These findings may be important for the distribution and clinical outcome of various infectious and immune-related disorders in the two populations...
  2. doi request reprint The cuprizone model for demyelination
    O Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway
    Acta Neurol Scand Suppl 188:72-6. 2008
    ..In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone...
  3. doi request reprint Month of birth as a risk factor for multiple sclerosis: an update
    O Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Acta Neurol Scand Suppl . 2012
    ..Several studies have indicated month of birth as a risk factor for multiple sclerosis (MS) susceptibility and disease progression...
  4. doi request reprint ω-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial
    Oivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway
    Arch Neurol 69:1044-51. 2012
    ..To investigate whether ω-3 fatty acids reduce magnetic resonance imaging (MRI) and clinical disease activity in patients with multiple sclerosis, both as monotherapy and in combination with interferon beta-1a treatment...
  5. doi request reprint Upregulation of immunoglobulin-related genes in cortical sections from multiple sclerosis patients
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Brain Pathol 20:720-9. 2010
    ..The findings indicate that the Ig-producing B-cells found in the cerebrospinal fluid (CSF) of MS patients could have meningeal origin...
  6. doi request reprint A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Clin Nutr 28:83-7. 2009
    ..Cuprizone induced demyelination is a commonly used animal model for demyelination in the central nervous system...
  7. doi request reprint Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
    Exp Neurol 215:160-6. 2009
    ..This may be of importance related to the discrepant results in dietary intervention studies for demyelinating diseases...
  8. ncbi request reprint Immunomodulatory treatment of multiple sclerosis in Norway
    Ø Torkildsen
    The Multiple Sclerosis National Competence Center, Haukeland University Hospital, Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway
    Acta Neurol Scand Suppl 187:46-50. 2007
    ..To further calculate the treatment frequency, a nation-wide prevalence of MS in Norway was estimated, based on available prevalence studies...
  9. ncbi request reprint FcgammaR and multiple sclerosis: an overview
    O Torkildsen
    The Multiple Sclerosis National Competence Centre, Department of Neurology, Haukeland University Hospital and Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway
    Acta Neurol Scand Suppl 183:61-3. 2006
    ..Studies indicate however, that polymorphisms in some FcgammaR genes and treatment that induces FcgammaR on immune-competent cells could influence disease progression and treatment response...
  10. ncbi request reprint [Lars Hertervig and Carl Fredrik Hill--creativeness and mental illness]
    Øivind Torkildsen
    Senter for klinisk nevroforskning, Stavanger universitetssjukehus, 4068 Stavanger
    Tidsskr Nor Laegeforen 125:3450-3. 2005
    ..This paper describes the artistic development of the two painters and discusses this in relation to how brain diseases may influence creativity and artistic expression...
  11. doi request reprint Vitamin D-dependent rickets as a possible risk factor for multiple sclerosis
    Øivind Torkildsen
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Arch Neurol 65:809-11. 2008
    ..Vitamin D is emerging as an important risk factor for susceptibility to multiple sclerosis (MS), but there have been no studies on the possible association between hereditary rickets and this disease...
  12. ncbi request reprint High dose methylprednisolone induces FcgammaRI on granulocytes in MS-patients
    O Torkildsen
    The Multiple Sclerosis National Competence Centre, Department of Clinical Medicine, Section for Neurology, Haukeland University Hospital, University of Bergen, N 5021 Bergen, Norway
    J Neuroimmunol 167:138-42. 2005
    ..There was no change in FcgammaRII and FcgammaRIII expression. The effect of IVMP on FcgammaRI expression could be important for the clearance of immune complexes in MS...
  13. doi request reprint The cuprizone model: regional heterogeneity of pathology
    Stig Wergeland
    Department of Neurology, Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
    APMIS 120:648-57. 2012
    ..Cuprizone-induced demyelination is a relevant model for the study of regional heterogeneity of demyelination and lesion pathology in multiple sclerosis...
  14. doi request reprint Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis
    Kristin I Løken-Amsrud
    Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway
    Mult Scler 19:451-7. 2013
    ..Vitamin A has immunomodulatory properties and may regulate the transcription of genes involved in remyelination...
  15. doi request reprint Label-free analysis of human cerebrospinal fluid addressing various normalization strategies and revealing protein groups affected by multiple sclerosis
    Jill A Opsahl
    Proteomics Unit PROBE, Department of Biomedicine, University of Bergen, Bergen, Norway
    Proteomics 16:1154-65. 2016
    ..Our data indicate that the preferable way to quantify proteins in CSF is to first match the samples on total protein amount and then normalize the data based on the median intensities, preferably from the CNS-enriched proteins. ..
  16. pmc No association of tobacco use and disease activity in multiple sclerosis
    Silje Kvistad
    Department of Immunology and Transfusion Medicine S K, Norwegian Multiple Sclerosis Competence Centre, Department of Neurology S K, S W, Ø T, and Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology K M M, S W, Ø T, Haukeland University Hospital, Bergen KG Jebsen MS Research Centre S K, K M M, Ø T, Department of Clinical Medicine, University of Bergen Department of Neurology T H, and HØKH, Research Centre J Š B, Akershus University Hospital, Lørenskog Institute of Clinical Medicine T H, J S B, University of Oslo Department of Neurology K I L A, Innlandet Hospital Trust, Lillehammer Multiple Sclerosis Centre Hakadal A G B Clinic of Laboratory Medicine K S B and Department of Neurology H H, St Olavs Hospital, Trondheim University Hospital Department of Laboratory Medicine K S B, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim Curato Oslo F L Department of Neurology R M, Molde Hospital Unit for Applied Clinical Research R M, Norwegian University of Science and Technology, Trondheim Unilabs Drammen T P, Drammen and Department of Neuroradiology S J B, Oslo University Hospital Rikshospitalet, Norway
    Neurol Neuroimmunol Neuroinflamm 3:e260. 2016
    ..To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS)...
  17. doi request reprint Body mass index influence interferon-beta treatment response in multiple sclerosis
    Silje Stokke Kvistad
    Hormone Laboratory, Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway Electronic address
    J Neuroimmunol 288:92-7. 2015
    ..Among normal-weight patients 26% obtained NEDA-status compared to only 13% of patients with BMI >25 (p=0.05). This may indicate that BMI affects interferon-beta treatment response. ..
  18. pmc Dietary vitamin D3 supplements reduce demyelination in the cuprizone model
    Stig Wergeland
    Department of Neurology, Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
    PLoS ONE 6:e26262. 2011
    ..In conclusion, high dietary doses of vitamin D3 reduce the extent of demyelination, and attenuate microglia activation and macrophage infiltration in a toxic model of demyelination, independent of lymphocyte infiltration...
  19. pmc Alpha-tocopherol and MRI outcomes in multiple sclerosis--association and prediction
    Kristin I Løken-Amsrud
    Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway
    PLoS ONE 8:e54417. 2013
    ..The aim of this study was to study alpha-tocopherol concentrations and their relationship to disease activity in Norwegian multiple sclerosis (MS) patients...
  20. pmc The Brain Proteome of the Ubiquitin Ligase Peli1 Knock-Out Mouse during Experimental Autoimmune Encephalomyelitis
    Ragnhild Reehorst Lereim
    Proteomics Unit, Department of Biomedicine, University of Bergen, Norway Kristian Gerhard Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen Norway
    J Proteomics Bioinform 9:209-219. 2016
    ..The proteomics data is available in PRIDE with accession PXD003710...
  21. ncbi request reprint Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein-Barr virus in relapsing-remitting multiple sclerosis
    Egil Røsjø
    Department of Neurology, Akershus University Hospital, Lørenskog, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Mult Scler . 2016
    ..Elevated antibody levels against Epstein-Barr virus (EBV) and a poor vitamin D status are environmental factors that may interact in relapsing-remitting multiple sclerosis (RRMS) aetiology...
  22. pmc Level of education and multiple sclerosis risk over a 50-year period: Registry-based sibling study
    Kjetil Bjørnevik
    Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway The Norwegian Multiple Sclerosis Competence Center, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Mult Scler . 2016
    ..The conflicting results from studies on socioeconomic status (SES) and multiple sclerosis (MS) risk might be due to a change in the distribution of environmental exposures over time or to methodological limitations in previous research...
  23. doi request reprint In-Depth Cerebrospinal Fluid Quantitative Proteome and Deglycoproteome Analysis: Presenting a Comprehensive Picture of Pathways and Processes Affected by Multiple Sclerosis
    Ann Cathrine Kroksveen
    Proteomics Unit PROBE, Department of Biomedicine, The KG Jebsen Centre for MS research, Department of Clinical Medicine, KG Jebsen Center for Diabetes Research, Department of Clinical Science, and Computational Biology Unit, Department of Informatics, University of Bergen, Bergen N 5009, Norway
    J Proteome Res 16:179-194. 2017
    ....
  24. doi request reprint Fingolimod does not enhance cerebellar remyelination in the cuprizone model
    Maria Nordheim Alme
    Department of Clinical Medicine, University of Bergen, PB 7804, 5020 Bergen, Norway Electronic address
    J Neuroimmunol 285:180-6. 2015
    ..We found that fingolimod did not have any effect on cerebellar remyelination, number of mature oligodendrocytes, microglia or astrocytes when fed after cuprizone exposure. ..
  25. doi request reprint Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model
    Sveinung Fjær
    KG Jebsen Centre for MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway The Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway Electronic address
    Neurochem Int 83:28-40. 2015
    ....
  26. doi request reprint Month of birth as a latitude-dependent risk factor for multiple sclerosis in Norway
    Nina Grytten
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Mult Scler 19:1028-34. 2013
    ..We aimed to determine if the risk of Multiple Sclerosis (MS) is associated with month of birth in Norway and to explore a possible latitudinal gradient...
  27. doi request reprint Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis
    Ann C Kroksveen
    The KG Jebsen Centre for MS research, Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Proteomics 15:3361-9. 2015
    ..Sg1 should be included in further studies to elucidate its role in the early phases of MS pathogenesis and its potential as a biomarker for this disease. ..
  28. pmc Detection of varicella-zoster virus DNA during medullary and brainstem relapses in multiple sclerosis
    Øivind Torkildsen
    Department of Neurology, Haukeland Universitetssjukehus, Bergen, Norway
    BMJ Case Rep 2016:. 2016
    ..As this can have diagnostic and therapeutic consequences, further studies are warranted to evaluate the clinical relevance of these findings...
  29. doi request reprint Botulinum Toxin as Monotherapy in Symptomatic Trigeminal Neuralgia
    Hanne Marie Bøe Lunde
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Headache 56:1035-9. 2016
    ..We aimed to investigate the efficiency and safety of BTX-A treatment in a 60-year-old male with diabetes mellitus who in March 2013 presented with TN caused by an exostosis in Meckel's cave...
  30. doi request reprint Vitamin D supplementation and systemic inflammation in relapsing-remitting multiple sclerosis
    Egil Røsjø
    Department of Neurology, Akershus University Hospital, Lørenskog, Norway
    J Neurol 262:2713-21. 2015
    ....
  31. doi request reprint Cerebrospinal fluid proteomics in multiple sclerosis
    Ann C Kroksveen
    Proteomics Unit PROBE, Department of Biomedicine, University of Bergen, Postbox 7804, N 5009 Bergen, Norway The KG Jebsen Centre for MS research, Department of Clinical Medicine, University of Bergen, Postbox 7804, N 5021 Bergen, Norway
    Biochim Biophys Acta 1854:746-56. 2015
    ..This article is part of a Special Issue entitled: Neuroproteomics: Applications in Neuroscience and Neurology. ..