Susan C Tilton

Summary

Publications

  1. pmc Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin
    Susan C Tilton
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Toxicol Appl Pharmacol 267:137-48. 2013
  2. pmc Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice
    Nicolas Tchitchek
    Department of Microbiology, University of Washington, Seattle, WA 98195 USA
    BMC Syst Biol 7:69. 2013
  3. pmc Bioinformatics Resource Manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools
    Susan C Tilton
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA
    BMC Bioinformatics 13:311. 2012
  4. pmc Impaired transcriptional response of the murine heart to cigarette smoke in the setting of high fat diet and obesity
    Susan C Tilton
    Pacific Northwest National Laboratory, Richland, Washington 99352, United States
    Chem Res Toxicol 26:1034-42. 2013
  5. pmc Dysregulation of macrophage activation profiles by engineered nanoparticles
    Vamsi Kodali
    Pacific Northwest National Laboratory, Center for Nanotoxicology, and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States
    ACS Nano 7:6997-7010. 2013
  6. doi request reprint Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: implications for medical exposures
    Claere von Neubeck
    Department of Systems Toxicology, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Environ Mol Mutagen 53:247-59. 2012
  7. doi request reprint Data integration reveals key homeostatic mechanisms following low dose radiation exposure
    Susan C Tilton
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA 99338, USA
    Toxicol Appl Pharmacol 285:1-11. 2015
  8. pmc A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses
    Hugh D Mitchell
    Computational Sciences and Mathematics Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
    PLoS ONE 8:e69374. 2013
  9. pmc Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns
    Susan C Tilton
    Environmental Molecular Sciences Laboratory, and Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA
    Nanotoxicology 8:533-48. 2014
  10. pmc Separating the drivers from the driven: Integrative network and pathway approaches aid identification of disease biomarkers from high-throughput data
    Jason E McDermott
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Dis Markers 28:253-66. 2010

Collaborators

Detail Information

Publications10

  1. pmc Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin
    Susan C Tilton
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Toxicol Appl Pharmacol 267:137-48. 2013
    ..These data show obesity may increase sensitivity to further insult and that co-occurrence of environmental stressors result in complex biosignatures that are not predicted from analysis of individual exposures...
  2. pmc Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice
    Nicolas Tchitchek
    Department of Microbiology, University of Washington, Seattle, WA 98195 USA
    BMC Syst Biol 7:69. 2013
    ..The complex interplay between virus-encoded and host-specific pathogenicity regulators - and the relative contributions of each toward viral pathogenicity - is not well-understood...
  3. pmc Bioinformatics Resource Manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools
    Susan C Tilton
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA
    BMC Bioinformatics 13:311. 2012
    ..3 is a software environment for data management, mining, integration and functional annotation of HTP biological data. In this study, we report recent updates to BRM for miRNA data analysis and cross-species comparisons across datasets...
  4. pmc Impaired transcriptional response of the murine heart to cigarette smoke in the setting of high fat diet and obesity
    Susan C Tilton
    Pacific Northwest National Laboratory, Richland, Washington 99352, United States
    Chem Res Toxicol 26:1034-42. 2013
    ..Together, these results underscore the sensitivity of the heart to SS smoke and reveal adaptive responses in healthy individuals that are absent in the setting of high fat diet and obesity...
  5. pmc Dysregulation of macrophage activation profiles by engineered nanoparticles
    Vamsi Kodali
    Pacific Northwest National Laboratory, Center for Nanotoxicology, and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States
    ACS Nano 7:6997-7010. 2013
    ..Nanotoxicology screening strategies should therefore consider how exposure to these materials alters susceptibility to other environmental exposures. ..
  6. doi request reprint Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: implications for medical exposures
    Claere von Neubeck
    Department of Systems Toxicology, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Environ Mol Mutagen 53:247-59. 2012
    ..We discuss in particular the role of proliferation, emphasizing how the disregulation of cellular signaling in normal tissue may impact progression toward radiation-induced secondary diseases...
  7. doi request reprint Data integration reveals key homeostatic mechanisms following low dose radiation exposure
    Susan C Tilton
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA 99338, USA
    Toxicol Appl Pharmacol 285:1-11. 2015
    ..Our results demonstrate the advantage of data integration to broadly define the pathways and networks that represent the mechanisms by which complex biological systems respond to perturbation...
  8. pmc A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses
    Hugh D Mitchell
    Computational Sciences and Mathematics Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
    PLoS ONE 8:e69374. 2013
    ..Our results demonstrate the utility of integrating diverse 'omic datasets to predict and prioritize regulatory features conserved across multiple pathogen infection models. ..
  9. pmc Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns
    Susan C Tilton
    Environmental Molecular Sciences Laboratory, and Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA
    Nanotoxicology 8:533-48. 2014
    ..These two distinct sets of biological pathways might, therefore, underlie cellular responses to high and low NP toxicity, respectively...
  10. pmc Separating the drivers from the driven: Integrative network and pathway approaches aid identification of disease biomarkers from high-throughput data
    Jason E McDermott
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Dis Markers 28:253-66. 2010
    ....