Johannes Waltenberger

Summary

Country: The Netherlands

Publications

  1. doi VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus
    Johannes Waltenberger
    Department of Cardiology, University Hospital of Maastricht, and Cardiovascular Research Institute of Maastricht, 6202 AZ Maastricht, The Netherlands
    Biochem Soc Trans 37:1167-70. 2009
  2. doi Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE
    Alexander Hirsch
    Department of Cardiology, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Eur Heart J 32:1736-47. 2011
  3. doi Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention
    Pascalle S Monraats
    Leiden University Medical Center, Department of Cardiology, C5 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Expert Opin Ther Targets 14:243-51. 2010
  4. doi Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes
    Vadim Tchaikovski
    Department of Cardiology, Maastricht University Medical Center, Maastricht University, Maastricht, The Netherlands
    Circulation 120:150-9. 2009
  5. doi The relationships between cardiovascular magnetic resonance imaging variables of acute myocardial infarction and both left ventricular dysfunction and immediate postreperfusion ST segment recovery
    Sebastiaan C Bekkers
    Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Electrocardiol 44:561-7. 2011
  6. doi Long term outcome after mononuclear bone marrow or peripheral blood cells infusion after myocardial infarction
    Ronak Delewi
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    Heart 101:363-8. 2015
  7. ncbi -455G/A polymorphism and preprocedural plasma levels of fibrinogen show no association with the risk of clinical restenosis in patients with coronary stent placement
    Pascalle S Monraats
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 93:564-9. 2005
  8. doi VEGF-A-induced chemotaxis of CD16+ monocytes is decreased secondary to lower VEGFR-1 expression
    Frauke S Czepluch
    Department of Cardiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University Medical Center, Maastricht, The Netherlands
    Atherosclerosis 215:331-8. 2011
  9. pmc Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis
    Marina Dunaeva
    Department of Cardiology, University Hospital of Maastricht, Cardiovascular Research Institute of Maastricht CARIM, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Basic Res Cardiol 105:61-71. 2010
  10. doi Detection of coronary plaques using MR coronary vessel wall imaging: validation of findings with intravascular ultrasound
    Suzanne Gerretsen
    Department of Radiology, Maastricht University Medical Centre, P Debyelaan 25, 6229HX, Maastricht, The Netherlands
    Eur Radiol 23:115-24. 2013

Collaborators

Detail Information

Publications28

  1. doi VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus
    Johannes Waltenberger
    Department of Cardiology, University Hospital of Maastricht, and Cardiovascular Research Institute of Maastricht, 6202 AZ Maastricht, The Netherlands
    Biochem Soc Trans 37:1167-70. 2009
    ..This unspecific pre-activation of intracellular pathways represents the molecular basis of VEGF resistance in diabetes mellitus...
  2. doi Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE
    Alexander Hirsch
    Department of Cardiology, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Eur Heart J 32:1736-47. 2011
    ..We designed a randomized controlled trial to determine the effect of intracoronary infusion of mononuclear cells from bone marrow (BM) or peripheral blood in patients with AMI...
  3. doi Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention
    Pascalle S Monraats
    Leiden University Medical Center, Department of Cardiology, C5 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Expert Opin Ther Targets 14:243-51. 2010
    ..Since the inflammatory response is implicated in restenosis, VDR-gene variants could therefore contribute to the risk of restenosis...
  4. doi Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes
    Vadim Tchaikovski
    Department of Cardiology, Maastricht University Medical Center, Maastricht University, Maastricht, The Netherlands
    Circulation 120:150-9. 2009
    ..This VEGF resistance correlates with impaired collateral growth. The aim of this study is to elucidate the molecular basis of VEGF resistance and impaired monocyte response in DM...
  5. doi The relationships between cardiovascular magnetic resonance imaging variables of acute myocardial infarction and both left ventricular dysfunction and immediate postreperfusion ST segment recovery
    Sebastiaan C Bekkers
    Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Electrocardiol 44:561-7. 2011
    ....
  6. doi Long term outcome after mononuclear bone marrow or peripheral blood cells infusion after myocardial infarction
    Ronak Delewi
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    Heart 101:363-8. 2015
    ....
  7. ncbi -455G/A polymorphism and preprocedural plasma levels of fibrinogen show no association with the risk of clinical restenosis in patients with coronary stent placement
    Pascalle S Monraats
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 93:564-9. 2005
    ..Therefore, these parameters are not worthwhile for stratifying patients at risk for restenosis pre-stenting...
  8. doi VEGF-A-induced chemotaxis of CD16+ monocytes is decreased secondary to lower VEGFR-1 expression
    Frauke S Czepluch
    Department of Cardiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University Medical Center, Maastricht, The Netherlands
    Atherosclerosis 215:331-8. 2011
    ..We investigated different functional properties of the two monocyte subsets...
  9. pmc Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis
    Marina Dunaeva
    Department of Cardiology, University Hospital of Maastricht, Cardiovascular Research Institute of Maastricht CARIM, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Basic Res Cardiol 105:61-71. 2010
    ..The Shh signaling was negatively affected by DM which might be involved in the pathogenesis of DM-related complications...
  10. doi Detection of coronary plaques using MR coronary vessel wall imaging: validation of findings with intravascular ultrasound
    Suzanne Gerretsen
    Department of Radiology, Maastricht University Medical Centre, P Debyelaan 25, 6229HX, Maastricht, The Netherlands
    Eur Radiol 23:115-24. 2013
    ..We compared MR-CVW with intravascular ultrasound (IVUS), the standard of reference for coronary vessel wall imaging, with regard to plaque detection and wall thickness measurements...
  11. doi TGF-β1/ALK5-induced monocyte migration involves PI3K and p38 pathways and is not negatively affected by diabetes mellitus
    Servé Olieslagers
    Department of Cardiology and the Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    Cardiovasc Res 91:510-8. 2011
    ..TGF-β1 signalling mechanisms mediating monocyte motility are unknown so far. Moreover, the influence of cardiovascular risk factor diabetes on TGF-β1-induced monocyte migration remains to be elucidated...
  12. doi Strenuous physical exercise adversely affects monocyte chemotaxis
    Frauke S Czepluch
    Department of Cardiology, Cardiovascular Research Institute Maastricht University Medical Center, Maastricht, Netherlands
    Thromb Haemost 105:122-30. 2011
    ..It remains to be established, whether this is a sound adaptation to increased stimuli or an untoward reaction to overtraining. Nevertheless, the effect remains for several weeks with no exercise...
  13. ncbi Enhanced functional response of CD133+ circulating progenitor cells in patients early after acute myocardial infarction
    Stefan Voo
    Department of Cardiology, University Hospital of Maastricht, P Debyelaan 25, PO Box 5800, 6202AZ Maastricht, The Netherlands
    Eur Heart J 29:241-50. 2008
    ..Growth factors including VEGF are produced during ischaemia and stimulate PC release and activation. In this study, we focused on the functional chemotactic response of PC to VEGF in subjects early after myocardial ischaemia...
  14. doi Chemotaxis analysis of circulating monocytes in patients with a recent acute coronary syndrome
    Frauke S Czepluch
    Department of Cardiology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
    Atherosclerosis 204:304-8. 2009
    ..We investigated whether ligand-induced monocyte chemotaxis can serve as biomarker in recent ACS and discriminate ACS from stable coronary artery disease (CAD)...
  15. pmc Noninvasive diagnosis of ruptured peripheral atherosclerotic lesions and myocardial infarction by antibody profiling
    Kitty B J M Cleutjens
    Department of Pathology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
    J Clin Invest 118:2979-85. 2008
    ....
  16. ncbi Monocyte function is severely impaired by the fluorochrome calcein acetomethylester
    Frauke S Czepluch
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, Maastricht, The Netherlands
    Biochem Biophys Res Commun 361:410-3. 2007
    ..Therefore, use of the fluorochrome calcein AM cannot be recommended for functional testing of monocytes...
  17. doi Intravenous immunoglobulin therapy for patients with idiopathic cardiomyopathy and endomyocardial biopsy-proven high PVB19 viral load
    Robert Dennert
    Department of Cardiology, CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Antivir Ther 15:193-201. 2010
    ..Such therapy might improve cardiac function in patients with chronic dilated cardiomyopathy (DCM) and a significant PVB19 viral load in the heart...
  18. pmc Metabolic background determines the importance of NOS3 polymorphisms in restenosis after percutaneous coronary intervention: A study in patients with and without the metabolic syndrome
    Douwe Pons
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Dis Markers 26:75-83. 2009
    ..58 [95%CI: 1.04-2.40], HR: 1.95 [95%CI: 1.02-3.70] and HR: 1.67 [95%CI: 1.09-2.54], respectively). In the group without the metabolic syndrome we observed no association between the three polymorphisms and TVR...
  19. doi Intracoronary infusion of autologous mononuclear bone marrow cells in patients with acute myocardial infarction treated with primary PCI: Pilot study of the multicenter HEBE trial
    Alexander Hirsch
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Catheter Cardiovasc Interv 71:273-81. 2008
    ..This study was a pilot trial to determine safety and feasibility of intracoronary infusion of mononuclear bone marrow cells (MBMC) in patients with acute myocardial infarction (MI)...
  20. doi Vascular potency of Sus scrofa bone marrow-derived mesenchymal stem cells: a progenitor source of medial but not endothelial cells
    Nynke M S Van Den Akker
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht University, Maastricht, The Netherlands
    Tissue Eng Part A 18:828-39. 2012
    ..We conclude that bone marrow-derived MSCs can be used as a bona fide source of medial, but not EC in small-diameter vascular tissue engineering...
  21. ncbi The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes
    Vadim Tchaikovski
    Department of Cardiology, University Hospital of Maastricht, Cardiovascular Research Institute of Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 28:322-8. 2008
    ..Little is known about intracellular signaling pathways mediating the biological functions triggered by VEGFR-1 in primary monocytes...
  22. pmc Clinical implications of microvascular obstruction and intramyocardial haemorrhage in acute myocardial infarction using cardiovascular magnetic resonance imaging
    Sebastiaan C A M Bekkers
    Department of Cardiology, Maastricht University Medical Center, P Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Radiol 20:2572-8. 2010
    ..To investigate the clinical implications of microvascular obstruction (MVO) and intramyocardial haemorrhage (IMH) in acute myocardial infarction (AMI)...
  23. ncbi Stress testing at the cellular and molecular level to unravel cellular dysfunction and growth factor signal transduction defects: what Molecular Cell Biology can learn from Cardiology
    Johannes Waltenberger
    Department of Cardiology, University of Maastricht, Maastricht, The Netherlands
    Thromb Haemost 98:975-9. 2007
    ..Cellular stress testing is introduced as a novel and intriguing approach, which was developed as bedside-to-bench. Future prospective clinical trials will have to validate the predictive value of cellular stress testing...
  24. pmc Long-term protection and mechanism of pacing-induced postconditioning in the heart
    Fawzi A Babiker
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    Basic Res Cardiol 105:523-33. 2010
    ....
  25. pmc Impaired collateral recruitment and outward remodeling in experimental diabetes
    Jolanda M van Golde
    Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    Diabetes 57:2818-23. 2008
    ..In this study, the effect of chronic hyperglycemia on acute ligation-induced collateral vasodilation, on monocyte chemotaxis, and on structural outward remodeling of collaterals was investigated...
  26. ncbi Smoking-induced monocyte dysfunction is reversed by vitamin C supplementation in vivo
    Nadina Stadler
    Department of Cardiology, University of Maastricht, Cardiovascular Research Institute of Maastricht, P Debyelaan 25, NL 6202 AZ Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 27:120-6. 2007
    ..This study investigated the negative effects of smoking on monocyte migratory responsiveness to VEGF-A and the usefulness of vitamin C to prevent smoking-induced monocyte dysfunction...
  27. doi Microvascular obstruction: underlying pathophysiology and clinical diagnosis
    Sebastiaan C A M Bekkers
    Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Am Coll Cardiol 55:1649-60. 2010
    ..Currently there is no consensus as to how and when MVO should be evaluated after acute myocardial infarction...
  28. ncbi The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions
    Douwe Pons
    Leiden University Medical Center, Department of Cardiology, C5 P, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 98:1323-8. 2007
    ..41, 95% CI: 0.19-0.86). Our findings indicate that polymorphisms in the factorV and PAI-1 genes may play a role in the process of restenosis...