Paul A M van Leeuwen

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT
    B S van der Meij
    Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Eur J Clin Nutr 66:399-404. 2012
  2. ncbi request reprint The role of a disturbed arginine/NO metabolism in the onset of cancer cachexia: a working hypothesis
    N Buijs
    Department of Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Curr Med Chem 19:5278-86. 2012
  3. pmc Non-radical diagnostic biopsies do not negatively influence melanoma patient survival
    Barbara G Molenkamp
    Department of Surgical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Surg Oncol 14:1424-30. 2007
  4. doi request reprint Enteral administration of alanyl-[2-(15)N]glutamine contributes more to the de novo synthesis of arginine than does intravenous infusion of the dipeptide in humans
    Gerdien C Ligthart-Melis
    Department of Surgery, VU University Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 90:95-105. 2009
  5. ncbi request reprint The role of Kupffer cells after major liver surgery
    Hubert A Prins
    Department of Surgery, VU Medical Center, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 29:48-55. 2005
  6. doi request reprint Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients
    Barbara G Molenkamp
    Department of Surgical Oncology, Medical Oncology, and Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 14:4532-42. 2008
  7. doi request reprint Antioxidant-enriched enteral nutrition and immuno-inflammatory response after major gastrointestinal tract surgery
    Mireille F M van Stijn
    Department of Surgery, VU University Medical Centre Amsterdam, Amsterdam, The Netherlands
    Br J Nutr 103:314-8. 2010
  8. ncbi request reprint Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients
    Barbara G Molenkamp
    Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 13:2961-9. 2007
  9. doi request reprint Imbalance of arginine and asymmetric dimethylarginine is associated with markers of circulatory failure, organ failure and mortality in shock patients
    Marlieke Visser
    Department of Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Br J Nutr 107:1458-65. 2012
  10. ncbi request reprint Sentinel lymph node tumor load: an independent predictor of additional lymph node involvement and survival in melanoma
    Ronald J C L M Vuylsteke
    Department of Surgical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Surg Oncol 12:440-8. 2005

Collaborators

Detail Information

Publications83

  1. pmc Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT
    B S van der Meij
    Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Eur J Clin Nutr 66:399-404. 2012
    ....
  2. ncbi request reprint The role of a disturbed arginine/NO metabolism in the onset of cancer cachexia: a working hypothesis
    N Buijs
    Department of Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Curr Med Chem 19:5278-86. 2012
    ..New studies are essential to ground this hypothesis and to develop interventions to break through the pathological mechanisms underlying cachexia...
  3. pmc Non-radical diagnostic biopsies do not negatively influence melanoma patient survival
    Barbara G Molenkamp
    Department of Surgical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Surg Oncol 14:1424-30. 2007
    ..This study investigates both the influence of diagnostic biopsy type and the presence of residual tumor cells in the re-excision specimen on disease free and overall survival...
  4. doi request reprint Enteral administration of alanyl-[2-(15)N]glutamine contributes more to the de novo synthesis of arginine than does intravenous infusion of the dipeptide in humans
    Gerdien C Ligthart-Melis
    Department of Surgery, VU University Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 90:95-105. 2009
    ..However, because glutamine is unstable, we tested this pathway with a stable dipeptide of glutamine...
  5. ncbi request reprint The role of Kupffer cells after major liver surgery
    Hubert A Prins
    Department of Surgery, VU Medical Center, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 29:48-55. 2005
    ..Endotoxins play an important role in the development of systemic complications after partial hepatectomy by activating KCs. The role of KCs and endotoxins after partial hepatectomy is investigated...
  6. doi request reprint Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients
    Barbara G Molenkamp
    Department of Surgical Oncology, Medical Oncology, and Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 14:4532-42. 2008
    ..Here, we set out to ascertain whether these PF-3512676-induced immunostimulatory effects translate into higher frequencies of melanoma-specific CD8(+) T cells...
  7. doi request reprint Antioxidant-enriched enteral nutrition and immuno-inflammatory response after major gastrointestinal tract surgery
    Mireille F M van Stijn
    Department of Surgery, VU University Medical Centre Amsterdam, Amsterdam, The Netherlands
    Br J Nutr 103:314-8. 2010
    ..The results of the present pilot study suggest that enteral nutrition enriched with glutamine and antioxidants possibly moderates the immuno-inflammatory response (CRP, TNF-R75) after surgery...
  8. ncbi request reprint Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients
    Barbara G Molenkamp
    Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 13:2961-9. 2007
    ..CpG-activated PDC, in turn, release IFN alpha and may thus boost T-cell and natural killer cell responses as well as activate conventional myeloid dendritic cells (MDC)...
  9. doi request reprint Imbalance of arginine and asymmetric dimethylarginine is associated with markers of circulatory failure, organ failure and mortality in shock patients
    Marlieke Visser
    Department of Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Br J Nutr 107:1458-65. 2012
    ..We propose a pathophysiological mechanism in shock: the imbalance of arginine and ADMA contributes to endothelial and cardiac dysfunction resulting in poor organ perfusion and organ failure, thereby increasing the risk of death...
  10. ncbi request reprint Sentinel lymph node tumor load: an independent predictor of additional lymph node involvement and survival in melanoma
    Ronald J C L M Vuylsteke
    Department of Surgical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Surg Oncol 12:440-8. 2005
    ..The aim of this study was to predict the absence of ALN metastases in patients with a positive SLN by using features of the primary melanoma and SLN tumor load...
  11. doi request reprint Accuracy of quick and easy undernutrition screening tools--Short Nutritional Assessment Questionnaire, Malnutrition Universal Screening Tool, and modified Malnutrition Universal Screening Tool--in patients undergoing cardiac surgery
    Lenny M W van Venrooij
    Department of Cardio Thoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Diet Assoc 111:1924-30. 2011
    ..Further research to evaluate the modified version of the Malnutrition Universal Screening Tool, ie, the cardiac surgery-specific Malnutrition Universal Screening Tool, is needed prior to implementing...
  12. doi request reprint Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation
    Rieneke van de Ven
    Departments of Medical Oncology, VU University Medical Center Cancer Center Amsterdam, De Boelelaan, Amsterdam, The Netherlands
    Blood 118:2502-10. 2011
    ..These observations should be considered in the design of DC-targeting immunotherapies...
  13. ncbi request reprint Tumor-specific CD8+ T cell reactivity in the sentinel lymph node of GM-CSF-treated stage I melanoma patients is associated with high myeloid dendritic cell content
    Ronald J C L M Vuylsteke
    Department of Surgical Oncology, Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 12:2826-33. 2006
    ..Impaired immune functions in the sentinel lymph node (SLN) may facilitate early metastatic events during melanoma development. Local potentiation of tumor-specific T cell reactivity may be a valuable adjuvant treatment option...
  14. ncbi request reprint Specific amino acids in the critically ill patient--exogenous glutamine/arginine: a common denominator?
    Mechteld A R Vermeulen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Crit Care Med 35:S568-76. 2007
    ..Because glutamine can be given by the parenteral and enteral routes, possible different actions on the metabolic fate (e.g., generation of citrulline) with both routes are analyzed...
  15. doi request reprint Postoperative loss of skeletal muscle mass, complications and quality of life in patients undergoing cardiac surgery
    Lenny M W van Venrooij
    Department of Dietetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nutrition 28:40-5. 2012
    ....
  16. ncbi request reprint Glutamine is an important precursor for de novo synthesis of arginine in humans
    Gerdien C Ligthart-Melis
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Am J Clin Nutr 87:1282-9. 2008
    ..It is possible that glutamine exerts part of its beneficial effects by enhancing the availability of arginine...
  17. doi request reprint Carbohydrate supplementation before operation retains intestinal barrier function and lowers bacterial translocation in a rat model of major abdominal surgery
    Hetty Bouritius
    Numico Research BV, Wageningen, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 32:247-53. 2008
    ..The present study tested the hypothesis that one of the food constituents, namely carbohydrates, may be responsible for the protective effect of preoperative feeding on postoperative organ dysfunction...
  18. ncbi request reprint Local administration of granulocyte/macrophage colony-stimulating factor increases the number and activation state of dendritic cells in the sentinel lymph node of early-stage melanoma
    Ronald J C L M Vuylsteke
    Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Res 64:8456-60. 2004
    ....
  19. doi request reprint Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness
    Mariska Davids
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    Metabolism 61:482-90. 2012
    ....
  20. pmc Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery by
    Marlieke Visser
    Department of Cardiothoracic Surgery, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Cardiothorac Surg 6:36. 2011
    ....
  21. doi request reprint Hypothermic renal perfusion during aortic surgery reduces the presence of lipocalin-2 and preserves renal extraction of dimethylarginines in rats
    Kak K Yeung
    Depts of Surgery and Physiology, VU Univ Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Am J Physiol Renal Physiol 301:F1231-41. 2011
    ..Renal perfusion with saline per se during renal ischemia is effective in diminishing renal leukocyte accumulation and oxidative stress...
  22. ncbi request reprint The clinical significance of asymmetric dimethylarginine
    Michiel P C Siroen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Annu Rev Nutr 26:203-28. 2006
    ..To elucidate the clinical significance of ADMA in these conditions, the field of research must be enlarged...
  23. pmc Matched skin and sentinel lymph node samples of melanoma patients reveal exclusive migration of mature dendritic cells
    Barbara G Molenkamp
    Vrije Universiteit Medical Center, Department of Surgical Oncology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Pathol 167:1301-7. 2005
    ..These data are indicative of migration of small numbers of phenotypically mature DCs to lymph nodes under steady state conditions...
  24. doi request reprint Preservation of the gut by preoperative carbohydrate loading improves postoperative food intake
    Joanna Luttikhold
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Clin Nutr 32:556-61. 2013
    ..An intestinal ischaemia reperfusion (IR) animal model was used to investigate whether preoperative CHO loading increases spontaneous postoperative food intake, intestinal barrier function and the catabolic response...
  25. doi request reprint Accurate perioperative flow measurement of the portal vein and hepatic and renal artery: a role for preoperative MRI?
    Mechteld A R Vermeulen
    Department of Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Radiol 81:2042-8. 2012
    ..It is not clear whether Duplex Doppler Ultrasound during surgery or MRI before surgery is the tool to choose...
  26. ncbi request reprint The effects of surgery, with or without rhGM-CSF, on the angiogenic profile of patients treated for colorectal carcinoma
    Francis P K Wu
    Department of Surgery, VU Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cytokine 25:68-72. 2004
    ....
  27. ncbi request reprint The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients
    Gerdien C Melis
    Department of Surgery, VU University Medical Centre, Amsterdam, The Netherlands
    Br J Nutr 94:19-26. 2005
    ..Interestingly, in spite of the high availability of citrulline with enteral administration of the dipeptide, only parenteral infusion of Ala-Gln increased plasma arginine concentration...
  28. ncbi request reprint Hypertaurinemia in bile duct-ligated rats after surgery: the effect of gut endotoxin restriction on organ fluxes and oxidative status
    Alexander P J Houdijk
    Department of Surgery, Medical Center Alkmaar, Alkmaar, The Netherlands
    JPEN J Parenter Enteral Nutr 30:186-93. 2006
    ..This uptake may contribute to the improved antioxidant status in cholestyramine-treated BDL rats...
  29. doi request reprint Human taurine metabolism: fluxes and fractional extraction rates of the gut, liver, and kidneys
    Mireille F M van Stijn
    Department of Surgery, Medical Center Alkmaar, Wilhelminalaan 12, 1815 JD, Alkmaar, The Netherlands
    Metabolism 61:1036-40. 2012
    ..Future studies on human taurine metabolism are required to determine whether taurine is an essential aminosulfonic acid during pathological conditions and whether it should therefore be supplemented...
  30. pmc Intestinal and hepatic metabolism of glutamine and citrulline in humans
    Marcel C G van de Poll
    Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    J Physiol 581:819-27. 2007
    ..In conclusion, glutamine is an important precursor for the synthesis of arginine after intestinal conversion to citrulline in humans...
  31. doi request reprint The prominent role of the liver in the elimination of asymmetric dimethylarginine (ADMA) and the consequences of impaired hepatic function
    Milan C Richir
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 32:613-21. 2008
    ..The prominent role of the liver in the elimination of ADMA and the consequences of impaired hepatic function on ADMA levels will be discussed in this article...
  32. ncbi request reprint Pattern and incidence of first site recurrences following sentinel node procedure in melanoma patients
    Markwin G Statius Muller
    Department of Surgical Oncology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Surg 26:1405-11. 2002
    ..High Breslow thickness, lymphatic invasion, and ulceration of the primary melanoma are strong risk factors for recurrence...
  33. pmc Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery
    Mireille F M van Stijn
    Department of Surgery, VU University Medical Center Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Gastroenterol 14:6960-9. 2008
    ..To investigate the effects of an enteral supplement containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery...
  34. ncbi request reprint Elevation of asymmetric dimethylarginine (ADMA) in patients developing hepatic failure after major hepatectomy
    Robert J Nijveldt
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 28:382-7. 2004
    ..Therefore, we aimed to confirm the role of the liver in humans and hypothesized elevated ADMA levels after major liver resection by a reduction of functional liver mass and injury to the remnant liver...
  35. doi request reprint Nutrition during trimodality treatment in stage III non-small cell lung cancer: not only important for underweight patients
    Barbara S van der Meij
    Department of Nutrition and Dietetics, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 6:1563-8. 2011
    ..The aim of this retrospective study was to investigate the predictive value of nutritional parameters on postoperative morbidity, mortality, and survival...
  36. ncbi request reprint The route of administration (enteral or parenteral) affects the conversion of isotopically labeled L-[2-15N]glutamine into citrulline and arginine in humans
    Gerdien C Ligthart-Melis
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 31:343-48; discussion 349-50. 2007
    ....
  37. ncbi request reprint Gut and liver handling of asymmetric and symmetric dimethylarginine in the rat under basal conditions and during endotoxemia
    Robert J Nijveldt
    Department of Surgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Liver Int 24:510-8. 2004
    ..In previous studies, evidence was found for the liver in the metabolism of dimethylarginines. We aimed to investigate dimethylarginine handling of the gut and the liver in detail under basal conditions and during endotoxemia...
  38. doi request reprint Asymmetric dimethylarginine and critical illness
    Saskia J H Brinkmann
    aDepartment of Plastic and Reconstructive Surgery bDepartment of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Curr Opin Clin Nutr Metab Care 17:90-7. 2014
    ..The aim of this review is to describe new insights into the role of ADMA in critical illness and its clinical relevance...
  39. doi request reprint Gastric emptying, glucose metabolism and gut hormones: evaluation of a common preoperative carbohydrate beverage
    Mechteld A R Vermeulen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Nutrition 27:897-903. 2011
    ..Because gut hormones link carbohydrate metabolism and gastric emptying, hormonal responses were studied...
  40. doi request reprint Infrarenal aortic-clamping after renal ischaemia aggravates acute renal failure
    Kak K Yeung
    Department of Surgery, VU University Medical Center VUmc, Amsterdam, The Netherlands
    Eur J Clin Invest 41:605-15. 2011
    ..We hypothesized that infrarenal aortic-clamping, despite restoring renal perfusion provokes additional renal damage...
  41. doi request reprint The impact of low preoperative fat-free body mass on infections and length of stay after cardiac surgery: a prospective cohort study
    Lenny M W van Venrooij
    Department of Dietetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thorac Cardiovasc Surg 142:1263-9. 2011
    ..The main aim of this study was to assess the still unknown association between preoperative low fat-free mass index and adverse cardiac surgical outcomes...
  42. doi request reprint Plasma ADMA concentrations at birth and mechanical ventilation in preterm infants: a prospective pilot study
    Milan C Richir
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Pediatr Pulmonol 43:1161-6. 2008
    ....
  43. ncbi request reprint Kupffer cell-depleted rats have a diminished acute-phase response following major liver resection
    Hubert A Prins
    Department of Surgery, VU University Medical Centre, Amsterdam, The Netherlands
    Shock 21:561-5. 2004
    ..We conclude that after PH, KC function in the remnant liver is important for the acute-phase reaction and reduces endotoxin-induced hepatocyte damage...
  44. ncbi request reprint Clinical relevance of parasternal uptake in sentinel node procedure for breast cancer
    Hans F J Fabry
    Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Surg Oncol 87:13-8. 2004
    ..e., whether any internal mammary lymph node uptake should be surgically biopsied. An analysis of all sentinel node procedures with parasternal uptake was performed...
  45. ncbi request reprint Low plasma concentrations of arginine and asymmetric dimethylarginine in premature infants with necrotizing enterocolitis
    Milan C Richir
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Br J Nutr 97:906-11. 2007
    ..Overall, these data suggest that a diminished nitric oxide production may be involved in the pathophysiology of NEC, but this needs further investigation...
  46. ncbi request reprint The transplanted liver graft is capable of clearing asymmetric dimethylarginine
    Michiel P C Siroen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Liver Transpl 10:1524-30. 2004
    ..In addition, increased ADMA concentrations in the posttransplantation period reflect serious dysfunction of the liver graft during acute rejection...
  47. ncbi request reprint The human liver clears both asymmetric and symmetric dimethylarginine
    Michiel P C Siroen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Hepatology 41:559-65. 2005
    ....
  48. ncbi request reprint Immunomodulation of the melanoma sentinel lymph node: a novel adjuvant therapeutic option
    Barbara G Molenkamp
    Department of Surgical Oncology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunobiology 211:651-61. 2006
    ....
  49. doi request reprint Role of the human erythrocyte in generation and storage of asymmetric dimethylarginine
    Mariska Davids
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 302:H1762-70. 2012
    ....
  50. doi request reprint The role of asymmetric dimethylarginine and arginine in the failing heart and its vasculature
    Marlieke Visser
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Heart Fail 12:1274-81. 2010
    ..This review discusses the roles of ADMA and arginine in the failing heart and its vasculature. Furthermore, it proposes nutritional therapies to improve NO availability...
  51. doi request reprint n-3 PUFAs in cancer, surgery, and critical care: a systematic review on clinical effects, incorporation, and washout of oral or enteral compared with parenteral supplementation
    Barbara S van der Meij
    Department of Nutrition and Dietetics, VU University Medical Center Amsterdam, Netherlands
    Am J Clin Nutr 94:1248-65. 2011
    ..n-3 (omega-3) Fatty acids (FAs) may have beneficial effects in patients with cancer or in patients who undergo surgery or critical care...
  52. ncbi request reprint Elimination of asymmetric dimethylarginine by the kidney and the liver: a link to the development of multiple organ failure?
    Robert J Nijveldt
    Department of Surgery, VU Univerity Medical Center, Amstredam, The Netherlands
    J Nutr 134:2848S-2852S; discussion 2853S. 2004
    ..We here summarize the role of both the kidney and the liver in the regulation of ADMA levels. In addition, the potential central role of ADMA as a causative factor in the development of multiple organ failure is discussed...
  53. doi request reprint Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival
    Nikki Buijs
    Department of Surgery, VU University Medical Center, MB Amsterdam, Netherlands
    Am J Clin Nutr 92:1151-6. 2010
    ..Furthermore, the prognosis of patients with head and neck cancer remains disappointing. Insufficient intake frequently leads to malnutrition, which contributes to high morbidity and mortality rates...
  54. pmc Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients
    Michiel P C Siroen
    VU University Medical Center, Department of Surgery, PO Box 7057, Amsterdam 1007 MB, The Netherlands
    World J Gastroenterol 14:7214-9. 2008
    ..To analyze the change of dimethylarginine plasma levels in cirrhotic patients receiving transjugular intrahepatic portosystemic shunt (TIPS)...
  55. ncbi request reprint Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia
    Robert J Nijveldt
    Department of Surgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Nephrol Dial Transplant 18:2542-50. 2003
    ..The kidney probably plays a crucial role in the metabolism of ADMA by both urinary excretion and degradation by DDAH. We aimed to further elucidate the role of the kidney in a rat model under basal conditions and during endotoxaemia...
  56. doi request reprint Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model
    Milan C Richir
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Crit Care Med 37:2010-7. 2009
    ..The aim of this study was to evaluate the effects of low arginine plasma concentrations in combination with high ADMA plasma concentrations on hemodynamics and organ blood flow...
  57. ncbi request reprint Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: a possible explanation of reduced morbidity and mortality?
    Michiel P C Siroen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Crit Care Med 33:504-10. 2005
    ..Therefore, we aimed to investigate whether modulation of asymmetric dimethylarginine concentrations by intensive insulin therapy is involved in these effects...
  58. ncbi request reprint Poor diagnostic accuracy of a single fasting plasma citrulline concentration to assess intestinal energy absorption capacity
    Job H C Peters
    Department of Gastroenterology, Small Bowel Unit, VU University Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 102:2814-9. 2007
    ..Decreased intestinal energy absorption is regarded a marker of intestinal failure...
  59. ncbi request reprint No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia
    Michiel P C Siroen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Gynecol Obstet Invest 62:7-13. 2006
    ..Our primary aim was to investigate the role of the placenta in the metabolism of ADMA during normal pregnancy and PE...
  60. pmc Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis
    Mechteld A R Vermeulen
    Department of Internal Medicine, VU University Medical Center, 1081 HV Amsterdam, Netherlands Department of Surgery, VU University Medical Center, 1081 HV Amsterdam, Netherlands
    J Nutr Metab 2016:1373060. 2016
    ..This suggests that for arginine synthesis enhancement there is no need for an additional dose of glutamine when this population is adequately fed. This trial is registered with NTR2285. ..
  61. doi request reprint Pre-cachexia and cachexia at diagnosis of stage III non-small-cell lung carcinoma: an exploratory study comparing two consensus-based frameworks
    Barbara S van der Meij
    Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Br J Nutr 109:2231-9. 2013
    ..Further studies are warranted to more extensively explore the validity and prognostic value of these new frameworks in cancer patients...
  62. doi request reprint The effect of fibers on coagulation of casein-based enteral nutrition in an artificial gastric digestion model
    Joanna Luttikhold
    Department of Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Food Funct 5:1866-71. 2014
    ..The suggestion that insoluble fibers increase the risk of gastrointestinal obstruction in critically ill patients is not supported by these data. ..
  63. doi request reprint Taurine Concentrations Decrease in Critically Ill Patients With Shock Given Enteral Nutrition
    Mechteld A R Vermeulen
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 40:264-72. 2016
    ..We hypothesized that plasma concentrations, when deficit, increase during EN and that persistent deficiency is associated with poor outcome...
  64. ncbi request reprint Preoperative granulocyte/macrophage colony-stimulating factor (GM-CSF) increases hepatic dendritic cell numbers and clustering with lymphocytes in colorectal cancer patients
    Steven J Oosterling
    Department of Surgical Oncology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Immunobiology 211:641-9. 2006
    ..Both increases in DC numbers and DC interaction with CD8+ T cells suggest enhanced immunological activation, which may reduce liver metastases formation and ultimately improve survival after initial colorectal surgery...
  65. doi request reprint Open surgical repair of ruptured juxtarenal aortic aneurysms with and without renal cooling: observations regarding morbidity and mortality
    Kak K Yeung
    Department of Surgery, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Vasc Surg 51:551-8. 2010
    ..As endovascular alternatives rarely exist in this situation, open repair continues to be the gold standard. We analyzed our results of open RJAA repair during an 11-year period...
  66. doi request reprint Perioperative glutamine supplementation restores disturbed renal arginine synthesis after open aortic surgery: a randomized controlled clinical trial
    Saskia J H Brinkmann
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Renal Physiol 311:F567-75. 2016
    ..This study shows that an intravenous supplement of glutamine increases the production of citrulline and arginine and compensates for the inhibitory effect of ischemia-reperfusion injury. ..
  67. doi request reprint Novel nutritional substrates in surgery
    Nikki Buijs
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Proc Nutr Soc 72:277-87. 2013
    ..In conclusion, there are various nutritional substrates that may be of great value in improving the condition of the surgical patient, which may be beneficial for post-operative recovery. ..
  68. doi request reprint Preoperative and postoperative agreement in fat free mass (FFM) between bioelectrical impedance spectroscopy (BIS) and dual-energy X-ray absorptiometry (DXA) in patients undergoing cardiac surgery
    Lenny M W van Venrooij
    Departments of Dietetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Nutr 29:789-94. 2010
    ....
  69. doi request reprint Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats
    Nikki Buijs
    a Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands and Department of Surgery, Medical Center Alkmaar, Trial Center Holland Health, Alkmaar, The Netherlands
    Nutr Cancer 67:713-20. 2015
    ..The adaptations found in the cachectic, tumor-bearing rat do not depend on glutamine availability. ..
  70. pmc The Arginine/ADMA Ratio Is Related to the Prevention of Atherosclerotic Plaques in Hypercholesterolemic Rabbits When Giving a Combined Therapy with Atorvastatine and Arginine
    Saskia J H Brinkmann
    Department of Surgery, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Int J Mol Sci 16:12230-42. 2015
    ....
  71. doi request reprint Arming the Melanoma Sentinel Lymph Node through Local Administration of CpG-B and GM-CSF: Recruitment and Activation of BDCA3/CD141(+) Dendritic Cells and Enhanced Cross-Presentation
    Berbel J R Sluijter
    Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Immunol Res 3:495-505. 2015
    ..Combined local CpG/GM-CSF delivery thus supports protective antimelanoma immunity through concerted activation of pDC and cDC subsets and recruitment of BDCA3(+) cDC subsets with T cell-stimulatory and cross-priming abilities...
  72. doi request reprint Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment
    Barbara S van der Meij
    Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Nutr 140:1774-80. 2010
    ..03 and B = 25.0 g, P = 0.01, respectively). In conclusion, a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids beneficially affects nutritional status during multimodality treatment in patients with NSCLC...
  73. ncbi request reprint Intestinal renal metabolism of L-citrulline and L-arginine following enteral or parenteral infusion of L-alanyl-L-[2,15N]glutamine or L-[2,15N]glutamine in mice
    Petra G Boelens
    Dept of Surgery, Vrije Universiteit University Medical Center, 1007 MB Amsterdam, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 289:G679-85. 2005
    ..In this model, the feeding route and form of GLN did not influence de novo renal ARG production derived from GLN...
  74. doi request reprint The bioelectrical impedance phase angle as an indicator of undernutrition and adverse clinical outcome in cardiac surgical patients
    Marlieke Visser
    Department of Cardiothoracic Surgery, Academic Medical Center University of Amsterdam, The Netherlands
    Clin Nutr 31:981-6. 2012
    ..In cardiac surgical patients, undernutrition increases the risk of adverse clinical outcome. We investigated whether the bioelectrical impedance phase angle is an indicator of undernutrition and clinical outcome in cardiac surgery...
  75. ncbi request reprint Glutamine-enriched enteral nutrition increases in vitro interferon-gamma production but does not influence the in vivo specific antibody response to KLH after severe trauma. A prospective, double blind, randomized clinical study
    Petra G Boelens
    Department of Surgery, VU University Medical Center, PO Box 7057, Amsterdam 1007 MB, The Netherlands
    Clin Nutr 23:391-400. 2004
    ....
  76. ncbi request reprint Glutamine: recent developments in research on the clinical significance of glutamine
    Gerdien C Melis
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Curr Opin Clin Nutr Metab Care 7:59-70. 2004
    ..The aim of this review is to describe the clinical relevance of supplementation of glutamine from the recent literature. First, new basic research is examined and subsequently recent clinical trials and a metaanalysis are illustrated...
  77. ncbi request reprint A minimum of 5 days of feeding
    Paul A M van Leeuwen
    Department of Surgery, Free University Hospital, Amsterdam, The Netherlands
    Nutrition 18:715. 2002
  78. pmc Sampling tumor-draining lymph nodes for phenotypic and functional analysis of dendritic cells and T cells
    Ronald J C L M Vuylsteke
    Department of Surgical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 161:19-26. 2002
    ..Scraping may even be applied to small LNs that a pathologist will submit entirely for histological examination and may thus prove useful in the monitoring of immune responses in SNs...
  79. ncbi request reprint Unpredictability of lymphatic drainage patterns in melanoma patients
    Markwin G Statius Muller
    Department of Surgical Oncology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 29:255-61. 2002
    ..In total, 34% of the patients had a cutaneous lymphatic drainage that was unpredictable, either totally or partially. We therefore conclude that an SN procedure is indispensable if the drainage site(s) are to be accurately identified...
  80. ncbi request reprint A carbohydrate-rich beverage prior to surgery prevents surgery-induced immunodepression: a randomized, controlled, clinical trial
    Gerdien C Melis
    Department of Nutrition Science and Dietetics and Nutritional Team, VU University Medical Center, Amsterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 30:21-6. 2006
    ..The aim of this study was to investigate whether preoperative intake of carbohydrate-rich beverages could postoperatively influence the immune system...
  81. ncbi request reprint Net renal extraction of asymmetrical (ADMA) and symmetrical (SDMA) dimethylarginine in fasting humans
    Robert J Nijveldt
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Nephrol Dial Transplant 17:1999-2002. 2002
    ..Thus, our aim was to investigate the renal extraction of dimethylarginines...
  82. ncbi request reprint Effects of major liver resection, with or without recombinant bactericidal/permeability-increasing protein (rBPI21), on the angiogenic profile of patients with metastatic colorectal carcinoma
    Francis P K Wu
    Department of Surgery, VU Medical Center, Amsterdam, The Netherlands
    J Surg Oncol 84:137-42. 2003
    ..This may reduce postoperative infectious complications. In addition, BPI has been shown to be an inhibitor of angiogenesis...