Coen D A Stehouwer

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi Does homocysteine cause hypertension?
    Coen D A Stehouwer
    Department of Internal Medicine, Institute of Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Clin Chem Lab Med 41:1408-11. 2003
  2. ncbi Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death
    Coen D A Stehouwer
    Department of Internal Medicine and Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Diabetes 51:1157-65. 2002
  3. ncbi Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Hypertens 22:2339-47. 2004
  4. doi Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure
    Leonard P van der Zwan
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Hypertension 55:1366-72. 2010
  5. ncbi Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxid
    Prabath W B Nanayakkara
    Department of Internal Medicine, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, and Amphia Hospital, Breda, The Netherlands
    Arch Intern Med 167:1262-70. 2007
  6. doi Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels
    Katrien H J Gaens
    Department of Internal Medicine, Maastricht University Medical Center, Debeyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 94:5174-80. 2009
  7. ncbi Urinary cortisol is inversely associated with capillary recruitment in women: a potential explanation for the cortisol-blood pressure relationship
    Renate T de Jongh
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, De Boelelaan, Amsterdam, The Netherlands
    Clin Sci (Lond) 113:83-91. 2007
  8. ncbi Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the hoorn screening study
    Annemieke M W Spijkerman
    Institute for Research in Extramural Medicine, Vrije University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 26:2604-8. 2003
  9. doi Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD
    Prabath W B Nanayakkara
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Am J Kidney Dis 53:41-50. 2009
  10. doi Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease
    Prabath W B Nanayakkara
    Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Center, VU University, Amsterdam, The Netherlands
    Nephrol Dial Transplant 23:2586-92. 2008

Detail Information

Publications115 found, 100 shown here

  1. ncbi Does homocysteine cause hypertension?
    Coen D A Stehouwer
    Department of Internal Medicine, Institute of Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Clin Chem Lab Med 41:1408-11. 2003
    ....
  2. ncbi Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death
    Coen D A Stehouwer
    Department of Internal Medicine and Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Diabetes 51:1157-65. 2002
    ....
  3. ncbi Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Hypertens 22:2339-47. 2004
    ..To estimate the relation of precisely measured regional body composition with peripheral and central arterial stiffness in the elderly...
  4. doi Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure
    Leonard P van der Zwan
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Hypertension 55:1366-72. 2010
    ..These observations, together with emerging evidence that myeloperoxidase-derived oxidants contribute to the initiation and propagation of cardiovascular disease, identify myeloperoxidase as a promising target for drug development...
  5. ncbi Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxid
    Prabath W B Nanayakkara
    Department of Internal Medicine, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, and Amphia Hospital, Breda, The Netherlands
    Arch Intern Med 167:1262-70. 2007
    ..Patients with chronic kidney disease have an increased risk of cardiovascular disease. Oxidative stress has been proposed to play a role in the development of cardiovascular disease among these patients...
  6. doi Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels
    Katrien H J Gaens
    Department of Internal Medicine, Maastricht University Medical Center, Debeyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 94:5174-80. 2009
    ....
  7. ncbi Urinary cortisol is inversely associated with capillary recruitment in women: a potential explanation for the cortisol-blood pressure relationship
    Renate T de Jongh
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, De Boelelaan, Amsterdam, The Netherlands
    Clin Sci (Lond) 113:83-91. 2007
    ..These data suggest that, in women, impairment of capillary function mediates some of the adverse effects of cortisol and thus may provide a target to prevent such adverse effects...
  8. ncbi Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the hoorn screening study
    Annemieke M W Spijkerman
    Institute for Research in Extramural Medicine, Vrije University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 26:2604-8. 2003
    ..To investigate whether screening-detected diabetic patients differ from diabetic patients newly diagnosed in general practice with regard to the presence of microvascular complications...
  9. doi Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD
    Prabath W B Nanayakkara
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Am J Kidney Dis 53:41-50. 2009
    ..The aim of this study is to assess effects of the multistep intervention on plasma ADMA concentrations in the ATIC Study...
  10. doi Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease
    Prabath W B Nanayakkara
    Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Center, VU University, Amsterdam, The Netherlands
    Nephrol Dial Transplant 23:2586-92. 2008
    ....
  11. ncbi Mild renal insufficiency is associated with increased left ventricular mass in men, but not in women: an arterial stiffness-related phenomenon--the Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands
    Kidney Int 68:673-9. 2005
    ..We therefore investigated, in a cross-sectional population-based study, the influence of increased arterial stiffness on the association between renal function and LVM...
  12. ncbi Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure
    Prabath W B Nanayakkara
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Kidney Int 68:2230-6. 2005
    ....
  13. ncbi Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinase
    Etto C Eringa
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:274-80. 2006
    ..To investigate whether TNF-alpha directly impairs insulin-mediated vasoreactivity in skeletal muscle resistance arteries and the role of c-Jun N-terminal kinase (JNK) in this interference...
  14. ncbi Are retinal microvascular abnormalities associated with large artery endothelial dysfunction and intima-media thickness? The Hoorn Study
    Manon V Van Hecke
    Department of Ophthalmology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Sci (Lond) 110:597-604. 2006
    ..Therefore our data provide evidence that retinal microvascular disease is of limited value in risk stratification for future cardiovascular events...
  15. ncbi Sagittal abdominal diameter: no advantage compared with other anthropometric measures as a correlate of components of the metabolic syndrome in elderly from the Hoorn Study
    Janine Mukuddem-Petersen
    Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije University Amsterdam, Amsterdam, The Netherlands
    Am J Clin Nutr 84:995-1002. 2006
    ..The sagittal abdominal diameter has been proposed as a useful measure by which to estimate abdominal obesity and as being more strongly related to components of the metabolic syndrome than are other anthropometric measures...
  16. ncbi Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 107:2089-95. 2003
    ..In nondiabetic individuals, increased arterial stiffness is an important cause of cardiovascular disease. Associations between DM-2 and IGM and arterial stiffness have not been systematically investigated...
  17. ncbi Current and adolescent body fatness and fat distribution: relationships with carotid intima-media thickness and large artery stiffness at the age of 36 years
    Isabel Ferreira
    Institute for Research in Extramural Medicine, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Hypertens 22:145-55. 2004
    ....
  18. ncbi Carotid arterial remodeling: a maladaptive phenomenon in type 2 diabetes but not in impaired glucose metabolism: the Hoorn study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 35:671-6. 2004
    ..Arterial remodeling has not been studied in relation to glucose tolerance...
  19. ncbi Type 2 diabetes is associated with impaired endothelium-dependent, flow-mediated dilation, but impaired glucose metabolism is not; The Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 174:49-56. 2004
    ..It is controversial whether or not FMD is impaired in DM2 and IGM. We investigated this issue in a population-based setting...
  20. doi A prospective study of dairy consumption in relation to changes in metabolic risk factors: the Hoorn Study
    Marieke B Snijder
    Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Obesity (Silver Spring) 16:706-9. 2008
    ..The aim of our study was to investigate the prospective association between dairy consumption and changes in weight and metabolic disturbances...
  21. doi S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 221:48-54. 2012
    ....
  22. ncbi Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance
    Renate T de Jongh
    Department of Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 109:2529-35. 2004
    ..We hypothesized that obesity is a primary cause of microvascular dysfunction, which may contribute to the development of these obesity-related disorders...
  23. ncbi TNF-alpha levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-alpha and insulin resistance
    Richard G Ijzerman
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Clin Sci (Lond) 110:361-8. 2006
    ..Our data suggest that these relationships are initiated during growth from childhood to adulthood...
  24. pmc Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study
    Johanna W M Nin
    Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:2027-32. 2010
    ....
  25. ncbi Endothelial dysfunction contributes to renal function-associated cardiovascular mortality in a population with mild renal insufficiency: the Hoorn study
    Frank Stam
    Department of Internal Medicine, Academic Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Am Soc Nephrol 17:537-45. 2006
    ..In conclusion, endothelial dysfunction was related to renal function and contributed to the excess in cardiovascular mortality in this population-based cohort with mild renal insufficiency...
  26. ncbi Advanced glycation end-product peptides are associated with impaired renal function, but not with biochemical markers of endothelial dysfunction and inflammation, in non-diabetic individuals
    Frank Stam
    Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Nephrol Dial Transplant 21:677-82. 2006
    ..It has been suggested that advanced glycation end-products (AGEs) are involved in atherogenesis, possibly through induction of endothelial dysfunction and low-grade inflammation...
  27. doi Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians
    Steven J R Meex
    University of Maastricht, Cardiovascular Research Institute Maastricht CARIM, Department of Internal Medicine, Maastricht, The Netherlands
    Mol Genet Metab 94:352-5. 2008
    ..5%. In conclusion, the major allele of rs2073658 in the USF1 gene is associated with a modestly increased risk to develop type 2 diabetes in Dutch Caucasians, with considerable impact at the population level...
  28. doi Circulating PCSK9 is a strong determinant of plasma triacylglycerols and total cholesterol in homozygous carriers of apolipoprotein ε2
    Martijn C G J Brouwers
    Department of Internal Medicine, Divisions of General Internal Medicine and Endocrinology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maasctricht, The Netherlands
    Clin Sci (Lond) 126:679-84. 2014
    ..Furthermore, these results suggest that patients with type III hyperlipidaemia may benefit from PCSK9-antagonizing therapy. ..
  29. ncbi Microvascular dysfunction: a potential pathophysiological role in the metabolic syndrome
    Erik H Serne
    Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands
    Hypertension 50:204-11. 2007
  30. ncbi The association between birth weight and capillary recruitment is independent of blood pressure and insulin sensitivity: a study in prepubertal children
    Richard G Ijzerman
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit VU University Medical Center Amsterdam, The Netherlands
    J Hypertens 20:1957-63. 2002
    ..However, these variables are closely associated, so that it has been difficult to establish whether microvascular dysfunction is a cause or a consequence of increased blood pressure or insulin resistance...
  31. ncbi Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 27:372-7. 2004
    ..The main goal was to determine which tissue in the trunk and legs, fat or lean tissue, is associated with measures of glucose metabolism...
  32. ncbi Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy
    Renate T de Jongh
    Department of Internal Medicine, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Diabetes 53:2873-82. 2004
    ..In conclusion, FFA levels modulate microvascular function and may contribute to obesity-associated insulin resistance, hypertension, and microangiopathy...
  33. ncbi Plasma levels of AGE peptides in type 1 diabetic patients are associated with serum creatinine and not with albumin excretion rate: possible role of AGE peptide-associated endothelial dysfunction
    Casper G Schalkwijk
    Department of Clinical Chemistry, University Medical Center, Amsterdam, The Netherlands
    Ann N Y Acad Sci 1043:662-70. 2005
    ..AGE peptides are associated with some markers of endothelial activation, which may suggest an involvement of AGE peptides in the acceleration of cardiovascular complications in type 1 diabetic patients with renal impairment...
  34. ncbi Cigarette smoking is associated with an acute impairment of microvascular function in humans
    Richard G Ijzerman
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, Academic Hospital Vrije Universiteit, De Boelelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Sci (Lond) 104:247-52. 2003
    ..These findings may explain the increased blood pressure and decreased insulin sensitivity that have been observed after acute smoking...
  35. doi Activated complement factor 3 is associated with liver fat and liver enzymes: the CODAM study
    Nick Wlazlo
    Department of Internal Medicine, Catharina Hospital, Eindhoven, The Netherlands
    Eur J Clin Invest 43:679-88. 2013
    ..For this reason, we investigated whether circulating levels of activated complement factor 3 (C3a) were associated with hepatic steatosis and hepatocellular damage...
  36. doi Low-grade inflammation and insulin resistance independently explain substantial parts of the association between body fat and serum C3: the CODAM study
    Nick Wlazlo
    Department of Internal Medicine, Catharina Hospital, Eindhoven, The Netherlands
    Metabolism 61:1787-96. 2012
    ..Although C3 has been linked to type 2 diabetes and cardiovascular diseases, and C3 levels are closely related to body fat, the underlying mechanisms explaining this association are still unknown...
  37. doi Older individuals with diabetes have an increased risk of recurrent falls: analysis of potential mediating factors: the Longitudinal Ageing Study Amsterdam
    Evelien Pijpers
    Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Age Ageing 41:358-65. 2012
    ..to compare the incidence of recurrent falls in older people with and without diabetes, and to examine diabetes- and fall-related risk factors explaining the increased risk of recurrent falls associated with diabetes...
  38. doi Incorporation of the fasting free fatty acid concentration into quantitative insulin sensitivity check index improves its association with insulin sensitivity in adults, but not in children
    Richard G Ijzerman
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 160:59-64. 2009
    ..We investigated the association of clamp-derived insulin sensitivity with indices of insulin sensitivity derived from fasting blood in prepubertal children and adults, with and without incorporation of FFAs...
  39. ncbi The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study
    Isabel Ferreira
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Arch Intern Med 165:875-82. 2005
    ..We therefore examined whether the metabolic syndrome was associated with arterial stiffness and whether any such associations were independent of cardiopulmonary fitness and subcutaneous trunk fat...
  40. ncbi Endothelial dysfunction and low-grade inflammation explain much of the excess cardiovascular mortality in individuals with type 2 diabetes: the Hoorn Study
    Jolien de Jager
    Department of Internal Medicine, Bethesda General Hospital, Hoogeveen, The Netherlands
    Arterioscler Thromb Vasc Biol 26:1086-93. 2006
    ..However, there is no direct evidence for this contention...
  41. ncbi Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity
    Frank Stam
    Department of Internal Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Nephrol Dial Transplant 18:892-8. 2003
    ..At present, it is unclear whether endothelial dysfunction and chronic inflammatory activity are related to renal function in the pre-dialysis stage...
  42. ncbi Effect of folic acid on methionine and homocysteine metabolism in end-stage renal disease
    Frank Stam
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Kidney Int 67:259-64. 2005
    ..Folic acid lowers, but does not normalize, the plasma homocysteine level in patients with ESRD, but its effect on whole body metabolism of homocysteine is unknown...
  43. ncbi Larger thigh and hip circumferences are associated with better glucose tolerance: the Hoorn study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Obes Res 11:104-11. 2003
    ..Muscle mass might be better reflected by thigh circumference. The aim of this study was to investigate the contributions of thigh and hip circumferences, independent of waist circumference, to measures of glucose metabolism...
  44. ncbi Birthweight and arterial stiffness and blood pressure in adulthood--results from the Amsterdam Growth and Health Longitudinal Study
    Saskia J te Velde
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Int J Epidemiol 33:154-61. 2004
    ..Increased arterial stiffness may be an underlying mechanism for this phenomenon. This study investigated whether birthweight was related to blood pressure and local and regional arterial stiffness...
  45. ncbi Left ventricular mass increases with deteriorating glucose tolerance, especially in women: independence of increased arterial stiffness or decreased flow-mediated dilation: the Hoorn study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 27:522-9. 2004
    ....
  46. pmc Multiple inflammatory biomarker detection in a prospective cohort study: a cross-validation between well-established single-biomarker techniques and an electrochemiluminescense-based multi-array platform
    Bas C T van Bussel
    Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 8:e58576. 2013
    ..In terms of time, effort and quality, multiplex technology is an attractive alternative for well-established single-biomarker measurements in clinical studies. However, limited data comparing these methods are available...
  47. ncbi The relationship of lipoprotein lipase activity and LDL size is dependent on glucose metabolism in an elderly population: the Hoorn Study
    Griët Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 27:796-8. 2004
  48. ncbi Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility in patients with mild-to-moderate chronic kidney disease
    Susanna J E Veringa
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Clin Nephrol 78:263-72. 2012
    ..We therefore investigated the effect of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility coefficients in mild-to-moderate CKD...
  49. doi HbA1c is an independent predictor of non-fatal cardiovascular disease in a Caucasian population without diabetes: a 10-year follow-up of the Hoorn Study
    Esther van 't Riet
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Prev Cardiol 19:23-31. 2012
    ....
  50. doi Systemic inflammation is linked to low arginine and high ADMA plasma levels resulting in an unfavourable NOS substrate-to-inhibitor ratio: the Hoorn Study
    Leonard P van der Zwan
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Clin Sci (Lond) 121:71-8. 2011
    ..In contrast, the relationship between CRP and arginine was not modified by levels of oxLDL. In conclusion, an unfavourable NOS substrate/inhibitor ratio may contribute to the reduced NO bioavailability associated with inflammation...
  51. doi Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Physiol Biochem 28:53-62. 2011
    ..In the present study the mechanism(s) involved in Hcy-induced PS exposure were analyzed...
  52. ncbi Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium
    Etto C Eringa
    Laboratory for Physiology, Vrije Universiteit Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 287:H2043-8. 2004
    ..These findings provide a novel mechanism by which insulin may determine blood flow and glucose disposal in skeletal muscle...
  53. ncbi Opposite contributions of trunk and leg fat mass with plasma lipase activities: the Hoorn study
    Griët Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Obes Res 13:1817-23. 2005
    ..LPL activity is negatively, whereas HL activity is positively, associated with total body fat. We determined the associations of trunk and leg fat mass with plasma LPL and HL activities in a cross-sectional study...
  54. doi Angiotensin II enhances insulin-stimulated whole-body glucose disposal but impairs insulin-induced capillary recruitment in healthy volunteers
    Amy M Jonk
    Department of Internal Medicine, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 95:3901-8. 2010
    ..The underlying mechanisms are undefined. AngII may increase glucose uptake through a direct effect on muscle cell insulin signaling or through increasing insulin delivery to muscle cells through effects on the microvasculature...
  55. ncbi Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study
    Miranda T Schram
    Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Hypertension 43:176-81. 2004
    ..Deteriorating glucose tolerance is associated with increased central and peripheral arterial stiffness, which may partly explain why both DM-2 and IGM are associated with increased cardiovascular risk...
  56. doi Increased plasma apolipoprotein C-III concentration independently predicts cardiovascular mortality: the Hoorn Study
    Peter G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Clin Chem 54:1325-30. 2008
    ..The aim of this study was to investigate the prognostic value of plasma apoC-III concentrations for cardiovascular mortality...
  57. ncbi Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats
    Etto C Eringa
    Laboratory for Physiology, Institute for Cardiovascular Research ICaR VU VU University Medical Center, 1081 BT, Amsterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E1134-9. 2007
    ..Insulin exerts both vasodilator and vasoconstrictor effects on muscle resistance arteries, which may be differentially impaired in obesity...
  58. ncbi Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women
    Marinka S Post
    Project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 23:1116-21. 2003
    ....
  59. ncbi Low birth weight is associated with increased sympathetic activity: dependence on genetic factors
    Richard G Ijzerman
    Department of Internal Medicine and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 108:566-71. 2003
    ....
  60. ncbi Visceral and truncal subcutaneous adipose tissue are associated with impaired capillary recruitment in healthy individuals
    Renate T de Jongh
    Department of Internal Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 91:5100-6. 2006
    ..Microvascular dysfunction is thought to contribute to obesity-associated insulin resistance and hypertension and may thus link central adiposity with cardiovascular risk...
  61. doi Microvascular function has no menstrual-cycle-dependent variation in healthy ovulatory women
    Iris J G Ketel
    Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Microcirculation 16:714-24. 2009
    ..Hyper- and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle)...
  62. ncbi Diabetic patients detected by population-based stepwise screening already have a diabetic cardiovascular risk profile
    Annemieke M W Spijkerman
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 25:1784-9. 2002
    ..To describe a population-based two-step screening procedure for type 2 diabetes and to study the cardiovascular risk profile of the patients identified by the screening...
  63. ncbi Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study
    Roger K Schindhelm
    Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 191:391-6. 2007
    ..Further studies should confirm these findings and elucidate the pathophysiological mechanisms...
  64. doi Birth weight relates to salt sensitivity of blood pressure in healthy adults
    Michiel P de Boer
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, University Medical Center Amsterdam, The Netherlands
    Hypertension 51:928-32. 2008
    ..Birth weight is associated with salt sensitivity of blood pressure, and this may play a role in the maintenance of elevated blood pressure in individuals with a low birth weight...
  65. doi Albuminuria, but not estimated glomerular filtration rate, is associated with maladaptive arterial remodeling: the Hoorn Study
    Marc M H Hermans
    Division of Nephrology and General Internal Medicine, Department of Internal Medicine, Academic Hospital Maastricht, Maastricht, The Netherlands
    J Hypertens 26:791-7. 2008
    ..Arterial remodeling aims to maintain a constant circumferential wall stress (sigmac). A failing remodeling process is associated with stroke. Data on the relationship between chronic kidney disease and arterial remodeling are scarce...
  66. doi Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus
    Martijn C G J Brouwers
    Laboratory of Vascular Medicine and Metabolism, Department of Internal Medicine, Divisions of General Internal Medicine and Endocrinology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Curr Opin Lipidol 21:530-8. 2010
    ..Recent findings suggest that FCHL and T2DM are less distinct than initially anticipated, which could offer new insights for their therapeutic approach...
  67. doi Carotid intima-media thickness and arterial stiffness in HIV-infected patients: the role of HIV, antiretroviral therapy, and lipodystrophy
    Marit G A van Vonderen
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Acquir Immune Defic Syndr 50:153-61. 2009
    ..We aimed to identify the effects of HIV, ART, and lipodystrophy (LD) on carotid artery intima-media thickness (C-IMT), a surrogate measure of atherosclerosis, and arterial stiffness, a marker of cardiovascular risk...
  68. ncbi C-reactive protein and soluble vascular cell adhesion molecule-1 are associated with elevated urinary albumin excretion but do not explain its link with cardiovascular risk
    Agnes Jager
    Institute for Research in Extramural Medicine, the Institute for Cardiovascular, Vrije Universiteit, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 22:593-8. 2002
    ..Leukocyte adhesion (sVCAM-1) and low-grade inflammation (CRP) are determinants of the development of elevated UAER. However, these determinants do not explain the association between elevated UAER and cardiovascular mortality...
  69. ncbi Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia
    Erik H Serne
    Department of Medicine, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes 51:1515-22. 2002
    ..In addition, locally administered insulin 4) induces a rapid increase in total skin blood flow, independent of systemic effects...
  70. ncbi Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension
    Amy M Jonk
    Department of Internal Medicine, University Hospital Maastricht, and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    Physiology (Bethesda) 22:252-60. 2007
    ..Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension...
  71. doi Circulating oxidized LDL: determinants and association with brachial flow-mediated dilation
    Leonard P van der Zwan
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    J Lipid Res 50:342-9. 2009
    ..Therefore correction of oxLDL for LDL particle number may improve the clinical usefulness of oxLDL measurement...
  72. ncbi Regulation of vascular function and insulin sensitivity by adipose tissue: focus on perivascular adipose tissue
    Etto C Eringa
    Laboratory for Physiology, UV University Medical Center, Amsterdam, The Netherlands
    Microcirculation 14:389-402. 2007
    ....
  73. ncbi Increased levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine in type 1 diabetic patients with impaired renal function: correlation with markers of endothelial dysfunction
    Mariska L M Lieuw-A-Fa
    Department of Physiology, and Institute of Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Nephrol Dial Transplant 19:631-6. 2004
    ....
  74. ncbi Vascular complications in diabetes mellitus: the role of endothelial dysfunction
    Casper G Schalkwijk
    Department of Internal Medicine, Academic Hospital Maastricht, The Netherlands
    Clin Sci (Lond) 109:143-59. 2005
    ..Finally, the components of the metabolic syndrome can impair endothelial function...
  75. ncbi Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles
    Etto C Eringa
    Laboratory for Physiology, VU Medical Centre, Van der Boechorststraat 7, Amsterdam, The Netherlands
    Cardiovasc Res 56:464-71. 2002
    ..To determine the roles of nitric oxide, endothelin-1 and phosphatidylinositol 3-kinase (PI3-kinase) in acute responses of isolated rat skeletal muscle arterioles to insulin...
  76. ncbi Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study
    Miranda T Schram
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 46:232-7. 2005
    ..These findings suggest that the formation of advanced glycation end products is an important pathway in the development of arterial stiffness in young type 1 diabetic individuals...
  77. ncbi Moderate alcohol consumption is associated with lower risk for incident diabetes and mortality: the Hoorn Study
    Femmie de Vegt
    Institute for Research in Extramural Medicine EMGO, Vrije Universiteit Medical Centre, Van der Boechorststraat 7, Amsterdam, The Netherlands
    Diabetes Res Clin Pract 57:53-60. 2002
    ..Adjustment for classical cardiovascular risk factors and other lifestyle variables did not materially affect the estimates. In conclusion, moderate alcohol consumption was associated with a lower risk for mortality and diabetes...
  78. ncbi Combination of insulin and metformin in the treatment of type 2 diabetes
    Michiel G Wulffelé
    Department of Internal Medicine, Bethesda Hospital Hoogeveen, Drenthe, The Netherlands
    Diabetes Care 25:2133-40. 2002
    ..To investigate the metabolic effects of metformin, as compared with placebo, in type 2 diabetic patients intensively treated with insulin...
  79. ncbi Homocysteine and methionine metabolism in renal failure
    Coen van Guldener
    Department of Internal Medicine, Amphia Hospital, Breda, Maastricht, The Netherlands
    Semin Vasc Med 5:201-8. 2005
    ..According to the currently available data, effective normalization of plasma homocysteine can only be obtained when its metabolic clearance through transsulfuration is restored...
  80. ncbi In vivo stable isotope measurements of methyl metabolism: applications in pathophysiology and interventions
    Kees de Meer
    Institute for Cardiovascular Research ICaR VU, Vrije Universiteit Medical Center, Amsterdam, Netherlands
    Food Nutr Bull 23:113-9. 2002
    ..Methods to quantitate one-carbon acceptor metabolism pathways and folate metabolism have recently become available...
  81. ncbi Vitamin E inhibits lipid peroxidation-induced adhesion molecule expression in endothelial cells and decreases soluble cell adhesion molecules in healthy subjects
    Bastiaan van Dam
    Department of Internal Medicine and Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Res 57:563-71. 2003
    ..In a combination of in vivo and in vitro studies, we investigated mechanisms via which alpha-tocopherol, a lipid soluble form of vitamin E, can directly affect endothelial activation as induced by H(2)O(2) and TNFalpha...
  82. ncbi 17 beta-Estradiol induces a rapid, endothelium-dependent, sex-specific vasodilatation in spontaneous constricted rat arterioles
    Ramon G V Smolders
    Project Aging Women, and the Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Obstet Gynecol 187:375-81. 2002
    ..Our purpose was to resolve the apparent contradiction between the endothelium-dependent and endothelium-independent vasodilator effects of 17 beta-estradiol reported in different studies...
  83. ncbi Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians
    Steven J R Meex
    Cardiovascular Research Institute Maastricht, Department of Internal Medicine, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 92:2720-5. 2007
    ..Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians...
  84. ncbi Homocysteine and large arteries
    Coen van Guldener
    Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands
    Adv Cardiol 44:278-301. 2007
    ..Studies that have examined the relationship between plasma homocysteine and arterial stiffness parameters have shown heterogenous results...
  85. ncbi Determinants of brachial artery mean 24 h pulse pressure in individuals with Type II diabetes mellitus and untreated mild hypertension
    Robert A J M van Dijk
    Institute for Cardiovascular Research, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Sci (Lond) 102:177-86. 2002
    ..Approx. 60% of the variance in brachial artery pulse pressure could be explained by potentially modifiable determinants...
  86. ncbi Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study
    Jacqueline M Dekker
    The Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 112:666-73. 2005
    ....
  87. ncbi Folate metabolism and cardiovascular disease
    Yvo M Smulders
    Department of Internal Medicine, VU University Medical Center, Amsterdam
    Semin Vasc Med 5:87-97. 2005
    ..As cardiovascular researchers, we should try to develop a more integrative view on folate metabolism, rather than focusing merely on hyperhomocysteinemia...
  88. doi Increase in carotid artery intima-media thickness and arterial stiffness but improvement in several markers of endothelial function after initiation of antiretroviral therapy
    Marit G A van Vonderen
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Infect Dis 199:1186-94. 2009
    ..We studied the changes in vascular properties after the initiation of combination antiretroviral therapy (cART) as well as the contribution of different drug classes...
  89. ncbi Net renal extraction of asymmetrical (ADMA) and symmetrical (SDMA) dimethylarginine in fasting humans
    Robert J Nijveldt
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Nephrol Dial Transplant 17:1999-2002. 2002
    ..Thus, our aim was to investigate the renal extraction of dimethylarginines...
  90. doi Prognostic value of adiponectin for cardiovascular disease and mortality
    Jacqueline M Dekker
    EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Clin Endocrinol Metab 93:1489-96. 2008
    ..Low adiponectin concentrations are associated with the presence of an adverse cardiovascular disease (CVD) risk profile...
  91. ncbi Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status
    Yvo M Smulders
    Department of Internal Medicine and Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
    J Nutr Biochem 18:693-9. 2007
    ..In contrast to plasma, RBC folate can appear in different biochemical isoforms. So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC folate vitamer distribution...
  92. ncbi Differences in heart rate variability between depressed and non-depressed elderly
    Koen G van der Kooy
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 21:147-50. 2006
    ..To determine whether older primary care patients with a Major Depressive Disorder (MDD) have lower heart rate variability (HRV) compared to non-depressed patients. HRV is a measure of cardiac autonomic functioning...
  93. ncbi Homocysteine impairs estrogen-induced vasodilation in isolated rat arterioles
    Raimond G V Smolders
    Aging Women Project, Institute for Cardiovascular Research, Vrije University, Amsterdam, The Netherland
    Menopause 11:98-103. 2004
    ..Moreover, homocysteine has also been shown to influence vasoreactivity. We investigated the influence of homocysteine on the rapid vasodilatory effects of estradiol in an isolated vessel setup...
  94. ncbi Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, Department of Clinical Epidemiology and Biostatistics, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Kidney Int 62:1402-7. 2002
    ..We investigated the association of renal function with all-cause and cardiovascular mortality in a population-based cohort and explored potential mechanisms underlying any such relationship...
  95. ncbi The effect of calcium dobesilate on vascular endothelial function, blood pressure, and markers of oxidation in obese male smokers: a placebo-controlled randomised clinical trial
    Miranda T Schram
    Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, Netherlands
    Atherosclerosis 170:59-72. 2003
    ..Thus, our data provide no evidence of an effect on vascular function of calcium dobesilate in humans...
  96. ncbi C-reactive protein in type 1 diabetes and its relationship to coronary artery calcification
    Helen M Colhoun
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
    Diabetes Care 25:1813-7. 2002
    ..In 196 type 1 diabetic subjects and 195 nondiabetic subjects aged 30-55 years, we examined whether C-reactive protein (CRP) is elevated in diabetes and whether CRP is associated with coronary artery calcification (CAC)...
  97. ncbi Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian
    Jonathan Krakoff
    Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes Care 26:1745-51. 2003
    ....
  98. ncbi Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 77:1192-7. 2003
    ..However, smaller hip or thigh circumference may also explain the predictive value of the WHR or WTR for type 2 diabetes...
  99. ncbi Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications study
    Nish Chaturvedi
    Department of Epidemiology and Public Health, Imperial College of Medicine at St Mary s, London, UK
    Diabetes Care 25:2320-7. 2002
    ..We sought to examine the role of both urinary and circulating TGF-beta1 and its promoter Amadori albumin in the vascular complications of type 1 diabetes...
  100. ncbi Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes
    Lise Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 27:765-9. 2004
    ..This study investigated the relation between ADMA and diabetic micro- and macrovascular complications in a large cohort of type 1 diabetic patients with and without early diabetic nephropathy...
  101. ncbi Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c
    Qing Qiao
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Clin Epidemiol 57:590-6. 2004
    ..To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality...