Jessica A Sipkens

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Apoptosis 12:1407-18. 2007
  2. doi Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)
    Jessica A Sipkens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Mol Cell Biochem 358:229-39. 2011
  3. doi S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 221:48-54. 2012
  4. pmc Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cell Biochem Biophys 67:341-52. 2013
  5. doi Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Physiol Biochem 28:53-62. 2011
  6. pmc Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients
    Paul A J Krijnen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Basic Res Cardiol 107:233. 2012
  7. doi Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase
    Paul A J Krijnen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 49:781-90. 2010

Detail Information

Publications7

  1. pmc Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Apoptosis 12:1407-18. 2007
    ..While numerous studies have analyzed the role of homocysteine (Hcy) in the vasculature, only a few studies investigated the role of Hcy in the heart. Therefore we have analyzed the effects of Hcy on isolated cardiomyocytes...
  2. doi Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)
    Jessica A Sipkens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Mol Cell Biochem 358:229-39. 2011
    ....
  3. doi S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 221:48-54. 2012
    ....
  4. pmc Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cell Biochem Biophys 67:341-52. 2013
    ..The data presented in this article reveal accumulation of nuclear NOX2 and peri-nuclear NOX4 accumulation as potential source of ROS production in Hcy-induced apoptosis in endothelial cells. ..
  5. doi Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Physiol Biochem 28:53-62. 2011
    ..In the present study the mechanism(s) involved in Hcy-induced PS exposure were analyzed...
  6. pmc Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients
    Paul A J Krijnen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Basic Res Cardiol 107:233. 2012
    ..Our data suggest that the loss of DPP4 activity affects the anti-thrombogenic nature of the endothelium...
  7. doi Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase
    Paul A J Krijnen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 49:781-90. 2010
    ..In this study, we show a regulatory role for a novel signaling route, Rho-ROCK-flippase signaling, in maintaining asymmetrical membrane phospholipid distribution in cardiomyocytes...