Arie Reijerkerk

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi The role of the fibrinolytic system in corneal angiogenesis
    J Mathijs Vogten
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Angiogenesis 6:311-6. 2003
  2. pmc Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis
    Fabiola Puentes
    Neuroimmunology Unit, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
    J Neuroinflammation 10:118. 2013
  3. doi Brain endothelial barrier passage by monocytes is controlled by the endothelin system
    Arie Reijerkerk
    Blood Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurochem 121:730-7. 2012
  4. ncbi Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier
    Arie Reijerkerk
    Neuroimmunology Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 181:3567-74. 2008
  5. doi The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier
    Arie Reijerkerk
    Blood Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Neurochem 113:447-53. 2010
  6. ncbi Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells
    Arie Reijerkerk
    Neuroimmunology Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    FASEB J 20:2550-2. 2006
  7. doi Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    Maarten E Witte
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:231-43. 2013
  8. doi Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol 124:397-410. 2012
  9. doi Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 134:555-70. 2011
  10. doi T lymphocytes impair P-glycoprotein function during neuroinflammation
    Gijs Kooij
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Autoimmun 34:416-25. 2010

Collaborators

Detail Information

Publications31

  1. ncbi The role of the fibrinolytic system in corneal angiogenesis
    J Mathijs Vogten
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Angiogenesis 6:311-6. 2003
    ..Our results corroborate earlier findings that angiogenesis in the mouse cornea is dependent on PAI-1 and plasminogen. The absence of tPA, uPA or TAFI did not affect the formation of new vessels in the cornea...
  2. pmc Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis
    Fabiola Puentes
    Neuroimmunology Unit, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
    J Neuroinflammation 10:118. 2013
    ..Similar to myelin autoimmunity, pathogenic immune response to neuroaxonal components such as neurofilaments may contribute to neurodegeneration in multiple sclerosis...
  3. doi Brain endothelial barrier passage by monocytes is controlled by the endothelin system
    Arie Reijerkerk
    Blood Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurochem 121:730-7. 2012
    ..Results from this study suggest that the endothelin system is a putative target within the brain for anti-inflammatory treatment in neurological diseases...
  4. ncbi Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier
    Arie Reijerkerk
    Neuroimmunology Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 181:3567-74. 2008
    ..These studies identify tPA as a novel and relevant pathological mediator of neuroinflammation and provide a potential mechanism for this...
  5. doi The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier
    Arie Reijerkerk
    Blood Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Neurochem 113:447-53. 2010
    ..Together, our results hold significant promise for the treatment of chronic inflammation in the brain...
  6. ncbi Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells
    Arie Reijerkerk
    Neuroimmunology Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    FASEB J 20:2550-2. 2006
    ..Our results provide a novel insight into the mechanism by which leukocytes traverse the BBB and illustrate that therapeutics aimed at the stabilization of the tight junction may be beneficial to resist a neuroinflammatory attack...
  7. doi Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    Maarten E Witte
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:231-43. 2013
    ..Taken together, our data indicate that reduced neuronal PGC-1α expression in MS cortex partly underlies mitochondrial dysfunction in MS grey matter and thereby contributes to neurodegeneration in MS cortex...
  8. doi Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol 124:397-410. 2012
    ....
  9. doi Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 134:555-70. 2011
    ....
  10. doi T lymphocytes impair P-glycoprotein function during neuroinflammation
    Gijs Kooij
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Autoimmun 34:416-25. 2010
    ..Loss of vascular P-gp function during neuroinflammation may disturb brain homeostasis and thereby aggravate disease progression via exposure of vulnerable CNS cells to detrimental compounds...
  11. doi MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis
    Arie Reijerkerk
    Blood Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Neurosci 33:6857-63. 2013
    ..In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS...
  12. doi Protective effects of peroxiredoxin-1 at the injured blood-brain barrier
    Gerty Schreibelt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 45:256-64. 2008
    ..On the other hand, it may function as an endogenous defense mechanism to inhibit leukocyte infiltration and counteract ROS-induced cellular injury...
  13. doi Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis
    Mark R Mizee
    Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 128:691-703. 2014
    ..A better understanding of RA signaling in MS pathophysiology may lead to the discovery of novel targets to halt disease progression. ..
  14. doi Roles for HB-EGF and CD9 in multiple sclerosis
    Geert J Schenk
    Department of Anatomy and Neurosciences, Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, The Netherlands Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Glia 61:1890-905. 2013
    ..Together, we demonstrate that these molecules are likely implicated in processes that are highly relevant for MS lesion formation, and therefore, HB-EGF and TSPs are promising therapeutic targets...
  15. doi Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 58:1465-76. 2010
    ..Results from this study indicate that astrocytes may act as a yet-unknown target within the CNS for the anti-inflammatory effects observed after FTY720P administration in the treatment of MS...
  16. doi Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions
    Philip G Nijland
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 62:1125-41. 2014
    ....
  17. pmc Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    J Neuroinflammation 9:133. 2012
    ..Here we demonstrate that the brain endothelial receptor S1P5 largely contributes to the maintenance of brain endothelial barrier function...
  18. doi Retinoic acid induces blood-brain barrier development
    Mark R Mizee
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Neurosci 33:1660-71. 2013
    ..Together, our results point to an important role for RA in the induction of the BBB during human and mouse development...
  19. doi Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma
    Michiel Smits
    Neuro oncology Research Group, Department of Neurosurgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    FASEB J 26:2639-47. 2012
    ..This loop is functionally impeded by the VEGF receptor inhibitor vandetanib, and our results may contribute to the further development of inhibitors of tumor-angiogenesis...
  20. ncbi Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity
    Gerty Schreibelt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Immunol 177:2630-7. 2006
    ..In conclusion, we show that LA has a protective effect on EAE development not only by affecting the migratory capacity of monocytes, but also by stabilization of the BBB, making LA an attractive therapeutic agent for the treatment of MS...
  21. doi Ultrasound and microbubble-induced intra- and intercellular bioeffects in primary endothelial cells
    Lynda J M Juffermans
    Department of Physiology, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Ultrasound Med Biol 35:1917-27. 2009
    ..In conclusion, these data provide more insight in the interactions between US, microbubbles and endothelial cells, which is important for understanding the mechanisms behind US and microbubble-enhanced uptake of drugs or genes...
  22. pmc P-glycoprotein acts as an immunomodulator during neuroinflammation
    Gijs Kooij
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8212. 2009
    ..P-gp generally drives cellular efflux of a variety of compounds and is thought to be involved in excretion of inflammatory agents from immune cells, like DCs. So far, the immunomodulatory role of these ABC transporters is unknown...
  23. doi P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol 127:699-711. 2014
    ....
  24. ncbi Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling
    Gerty Schreibelt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    FASEB J 21:3666-76. 2007
    ..Our study reveals new insights into molecular mechanisms underlying BBB regulation and provides novel opportunities for the treatment of neuroinflammatory diseases...
  25. doi Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation
    Gijs Kooij
    Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol 128:267-77. 2014
    ..Together, this study highlights a profound role for the choroid plexus in the pathogenesis of multiple sclerosis, and implies that CLDN3 may be regarded as a crucial and novel determinant of BCSFB integrity. ..
  26. doi Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4
    Lydia van der Steen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Gastroenterology 137:2018-29.e1-3. 2009
    ..Interestingly, the IgA Fc receptor (Fc(alpha)RI) potently activates neutrophils. As such, we investigated whether IgA-Fc(alpha)RI interaction contributes to tissue damage in UC...
  27. doi Glutathione conjugation dose-dependently increases brain-specific liposomal drug delivery in vitro and in vivo
    David Maussang
    to BBB technologies BV now 2 BBB Medicines BV, J H Oortweg 19, 2333 CH, Leiden, The Netherlands Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Drug Discov Today Technol 20:59-69. 2016
    ....
  28. ncbi SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function
    Ruud D Fontijn
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H891-900. 2008
    ....
  29. ncbi Do antiangiogenic protein fragments have amyloid properties?
    Martijn F B G Gebbink
    Labortory of Thrombosis and Hemostasis, Department of Hematology, G03 647, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 104:1601-5. 2004
    ..The hypothesis provides new insights in the potential mechanisms of these angiogenesis inhibitors and offers opportunities to improve their use...
  30. ncbi Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system
    Arie Reijerkerk
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Cancer Res 1:561-8. 2003
    ..Our results suggest that amyloid endostatin may inhibit angiogenesis and tumor growth by stimulating the fibrinolytic system...
  31. ncbi Tissue-type plasminogen activator is a multiligand cross-beta structure receptor
    Onno Kranenburg
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Curr Biol 12:1833-9. 2002
    ..Our results classify tPA as a multiligand receptor and show that cross-beta structure is the common denominator in tPA binding ligands...