Niels D Prins

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Predictors of progression from mild cognitive impairment to dementia in the placebo-arm of a clinical trial population
    Niels D Prins
    Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 36:79-85. 2013
  2. pmc Amyloid imaging in prodromal Alzheimer's disease
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, 1007 MB Amsterdam, The Netherlands
    Alzheimers Res Ther 3:26. 2011
  3. pmc Can novel therapeutics halt the amyloid cascade?
    Niels D Prins
    Alzheimer Center, VU University Medical Center, Boelelaan 1118, Amsterdam, The Netherlands
    Alzheimers Res Ther 2:5. 2010
  4. doi request reprint Alzheimer disease: MRI and CSF biomarkers in AD--accuracy and temporal change
    Niels D Prins
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Boelelaan 1117, Amsterdam, The Netherlands
    Nat Rev Neurol 6:650-1. 2010
  5. doi request reprint Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome
    Everard G B Vijverberg
    Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 41:210-9. 2016
  6. doi request reprint Formal Psychiatric Disorders are not Overrepresented in Behavioral Variant Frontotemporal Dementia
    Flora T Gossink
    Department of Old Age Psychiatry, GGZinGeest VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 51:1249-56. 2016
  7. doi request reprint Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort
    Welmoed A Krudop
    Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 41:16-26. 2016
  8. pmc Cerebral perfusion in the predementia stages of Alzheimer's disease
    Maja A A Binnewijzend
    Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, Alzheimercenter Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 26:506-14. 2016
  9. doi request reprint Identifying bvFTD Within the Wide Spectrum of Late Onset Frontal Lobe Syndrome: A Clinical Approach
    Welmoed A Krudop
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Am J Geriatr Psychiatry 23:1056-66. 2015
  10. doi request reprint Distinct perfusion patterns in Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies
    Maja A A Binnewijzend
    Department of Radiology and Nuclear Medicine, VU University Medical Center and Neuroscience Campus Amsterdam, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 24:2326-33. 2014

Collaborators

Detail Information

Publications26

  1. doi request reprint Predictors of progression from mild cognitive impairment to dementia in the placebo-arm of a clinical trial population
    Niels D Prins
    Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 36:79-85. 2013
    ..We conclude that global cognitive function, episodic memory performance, and MTA on MRI independently predict progression to dementia in patients with MCI...
  2. pmc Amyloid imaging in prodromal Alzheimer's disease
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, 1007 MB Amsterdam, The Netherlands
    Alzheimers Res Ther 3:26. 2011
    ..These findings may have important implications for the design of future clinical trials aimed at preventing progression to Alzheimer's disease by lowering the brain amyloid-beta burden in patients with mild cognitive impairment...
  3. pmc Can novel therapeutics halt the amyloid cascade?
    Niels D Prins
    Alzheimer Center, VU University Medical Center, Boelelaan 1118, Amsterdam, The Netherlands
    Alzheimers Res Ther 2:5. 2010
    ..However, it may also be that these negative findings reflect our still incomplete understanding of, at least part of, the pathogenesis of Alzheimer's disease...
  4. doi request reprint Alzheimer disease: MRI and CSF biomarkers in AD--accuracy and temporal change
    Niels D Prins
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Boelelaan 1117, Amsterdam, The Netherlands
    Nat Rev Neurol 6:650-1. 2010
    ..Thus, a thorough understanding of the diagnostic accuracy of and longitudinal change in cerebrospinal fluid and MrI AD biomarkers is important...
  5. doi request reprint Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome
    Everard G B Vijverberg
    Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 41:210-9. 2016
    ..We aimed to prospectively assess the diagnostic accuracy of the revised criteria for behavioural variant frontotemporal dementia (bvFTD) among subjects presenting with a frontal lobe syndrome in middle-late adulthood...
  6. doi request reprint Formal Psychiatric Disorders are not Overrepresented in Behavioral Variant Frontotemporal Dementia
    Flora T Gossink
    Department of Old Age Psychiatry, GGZinGeest VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 51:1249-56. 2016
    ..In suspected bvFTD close collaboration between neurologists and psychiatrists will advance diagnostics and subsequent treatment. ..
  7. doi request reprint Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort
    Welmoed A Krudop
    Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 41:16-26. 2016
    ..The criteria for behavioral variant frontotemporal dementia (bvFTD) incorporate MRI and [18F]-FDG-PET. Cerebrospinal fluid (CSF) analysis is merely advised for excluding Alzheimer's disease...
  8. pmc Cerebral perfusion in the predementia stages of Alzheimer's disease
    Maja A A Binnewijzend
    Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, Alzheimercenter Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 26:506-14. 2016
    ..To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer's disease (AD)...
  9. doi request reprint Identifying bvFTD Within the Wide Spectrum of Late Onset Frontal Lobe Syndrome: A Clinical Approach
    Welmoed A Krudop
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Am J Geriatr Psychiatry 23:1056-66. 2015
    ..We aimed to identify the diagnostic spectrum causing a late onset frontal lobe syndrome and examine the quality of commonly used instruments to distinguish between bvFTD and non-bvFTD patients, within this syndrome...
  10. doi request reprint Distinct perfusion patterns in Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies
    Maja A A Binnewijzend
    Department of Radiology and Nuclear Medicine, VU University Medical Center and Neuroscience Campus Amsterdam, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 24:2326-33. 2014
    ....
  11. pmc Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease
    Marije R Benedictus
    Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol . 2016
    ..To determine whether lower cerebral blood flow (CBF) is associated with faster cognitive decline in patients with Alzheimer's disease (AD)...
  12. doi request reprint Brain volume and white matter hyperintensities as determinants of cerebral blood flow in Alzheimer's disease
    Marije R Benedictus
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Neurobiol Aging 35:2665-70. 2014
    ..Our results indicate that in AD, lower CBF as measured using pseudocontinuous arterial spin labeling, reflects the combined disease burden of both neurodegeneration and small vessel disease. ..
  13. doi request reprint Diagnostic Accuracy of MRI and Additional [18F]FDG-PET for Behavioral Variant Frontotemporal Dementia in Patients with Late Onset Behavioral Changes
    Everard G B Vijverberg
    Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 53:1287-97. 2016
    ....
  14. doi request reprint Schizophrenia as a mimic of behavioral variant frontotemporal dementia
    Cora J Kerssens
    a Department of Old Age Psychiatry, GGZ inGeest, Amsterdam, The Netherlands
    Neurocase 22:285-8. 2016
    ..Further clinicopathological validation of these criteria is needed to determine their exact specificity. ..
  15. doi request reprint Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease
    Anna E Leeuwis
    Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Alzheimers Dement . 2016
    ..We examined the association between decreased cerebral blood flow (CBF) and cognitive impairment in Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD)...
  16. doi request reprint Prevalence of cortical superficial siderosis in a memory clinic population
    Hazel I Zonneveld
    From the Alzheimer Center and the Neuroscience Campus Amsterdam, and Departments of Radiology and Nuclear Medicine H I Z, M P W, F B, Neurology J D C G, N D P, P S, W M v d F, Epidemiology and Biostatistics W M v d F, Physics and Medical Technology J P A K, and Internal Medicine M M, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 82:698-704. 2014
    ....
  17. doi request reprint Diagnostic impact of CSF biomarkers for Alzheimer's disease in a tertiary memory clinic
    Flora H Duits
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Alzheimers Dement 11:523-32. 2015
    ..We aimed to assess the impact of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease on decision making and patient management in a tertiary memory clinic...
  18. doi request reprint Microbleeds, Mortality, and Stroke in Alzheimer Disease: The MISTRAL Study
    Marije R Benedictus
    Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    JAMA Neurol 72:539-45. 2015
    ..Microbleeds are more prevalent in patients with Alzheimer disease (AD) compared with the general elderly population. In addition, microbleeds have been found to predict mortality in AD...
  19. doi request reprint White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline
    Marije R Benedictus
    From the Alzheimer Center and Department of Neurology M R B, A C v H, A E L, P S, N D P, W M v d F, Department of Radiology and Nuclear Medicine F B, Department of Medical Psychology T K, and Department of Epidemiology and Biostatistics W M v d F, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 46:2661-4. 2015
    ..In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline...
  20. doi request reprint Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease
    Marije R Benedictus
    Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2488-94. 2013
    ..Our results suggest that, unlike WMH, microbleeds in AD are particularly associated with additional amyloid burden, and as such, may relate to cerebral amyloid angiopathy. ..
  21. doi request reprint Associations between magnetic resonance imaging measures and neuropsychological impairment in early and late onset alzheimer's disease
    Annelies E van der Vlies
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 35:169-78. 2013
    ..To assess the associations of global atrophy and white matter hyperintensities (WMH) with neuropsychological function in early and late onset Alzheimer's disease (AD)...
  22. doi request reprint Impact of molecular imaging on the diagnostic process in a memory clinic
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:414-21. 2013
    ..We evaluated the impact of these tracers on the diagnostic process in a memory clinic population...
  23. ncbi request reprint Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Stroke 34:1907-12. 2003
    ..The purposes of our study were to operationalize the radiological part of the NINDS-AIREN criteria and to assess the effect of this operationalization on interobserver agreement...
  24. doi request reprint Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests
    Lisa D Van Mierlo
    Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 56:249-259. 2017
    ..Early cognitive screening in an anonymous and easily accessible manner may reassure older people who are unnecessarily worried about normal cognitive aging while it may also expedite help seeking in case of suspicious cognitive decline...
  25. doi request reprint Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study
    Welmoed A Krudop
    Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands Electronic address
    Am J Geriatr Psychiatry 22:735-40. 2014
    ....
  26. doi request reprint White matter hyperintensities, cognitive impairment and dementia: an update
    Niels D Prins
    Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands
    Nat Rev Neurol 11:157-65. 2015
    ..Here, we provide a timely Review on WMHs, including their relationship with cognitive decline and dementia. ..