Pieter E Postmus

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi Bronchoscopy for lung cancer
    Pieter E Postmus
    Chest 128:16-8. 2005
  2. ncbi Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung
    Bart P H Wittgen
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 13:2414-21. 2007
  3. ncbi The IASLC Lung Cancer Staging Project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer
    Pieter E Postmus
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 2:686-93. 2007
  4. doi Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD
    Sebastiaan Holverda
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Pulm Pharmacol Ther 21:558-64. 2008
  5. pmc Spontaneous pneumothorax as indicator for Birt-Hogg-Dubé syndrome in paediatric patients
    Paul C Johannesma
    Department of Pulmonary Diseases, VU University Medical Center, PO Box 7057, 1007, MB Amsterdam, The Netherlands
    BMC Pediatr 14:171. 2014
  6. ncbi Consensus report IASLC workshop Bruges, September 2002: pretreatment minimal staging for non-small cell lung cancer
    Pieter E Postmus
    Department of Pulmonary Diseases, Vrije Universiteit Medical Cetner, Amsterdam, Netherlands
    Lung Cancer 42:S3-6. 2003
  7. ncbi Activity of pemetrexed (alimta), a new antifolate, against non-small cell lung cancer
    Pieter E Postmus
    Vrije Universiteit Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Lung Cancer 38:S3-7. 2002
  8. doi A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer
    Joline S W Lind
    Departments of Pulmonary Diseases, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Clin Cancer Res 16:3078-87. 2010
  9. ncbi The natural course of preneoplastic lesions in bronchial epithelium
    Roderick H Breuer
    Department of Pulmonology, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Clin Cancer Res 11:537-43. 2005
  10. ncbi Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients
    C Tji Joong Gan
    VU University Medical Center, De Boelelaan 1117 PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:11-7. 2007

Detail Information

Publications101 found, 100 shown here

  1. ncbi Bronchoscopy for lung cancer
    Pieter E Postmus
    Chest 128:16-8. 2005
  2. ncbi Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung
    Bart P H Wittgen
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 13:2414-21. 2007
    ..To investigate the safety and pharmacokinetics of aerosolized Sustained Release Lipid Inhalation Targeting (SLIT) Cisplatin in patients with lung carcinoma...
  3. ncbi The IASLC Lung Cancer Staging Project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer
    Pieter E Postmus
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 2:686-93. 2007
    ..To analyze all nonlymphatic metastatic components (T4 and M1) of the current TNM system of lung cancer, with the objective of providing suggestions for the next edition of the TNM classification for lung cancer...
  4. doi Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD
    Sebastiaan Holverda
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Pulm Pharmacol Ther 21:558-64. 2008
    ....
  5. pmc Spontaneous pneumothorax as indicator for Birt-Hogg-Dubé syndrome in paediatric patients
    Paul C Johannesma
    Department of Pulmonary Diseases, VU University Medical Center, PO Box 7057, 1007, MB Amsterdam, The Netherlands
    BMC Pediatr 14:171. 2014
    ..Clinical manifestations of BHD include skin fibrofolliculomas, renal cell cancer, lung cysts and (recurrent) spontaneous pneumothorax (SP). All clinical manifestations usually present in adults > 20 years of age...
  6. ncbi Consensus report IASLC workshop Bruges, September 2002: pretreatment minimal staging for non-small cell lung cancer
    Pieter E Postmus
    Department of Pulmonary Diseases, Vrije Universiteit Medical Cetner, Amsterdam, Netherlands
    Lung Cancer 42:S3-6. 2003
  7. ncbi Activity of pemetrexed (alimta), a new antifolate, against non-small cell lung cancer
    Pieter E Postmus
    Vrije Universiteit Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Lung Cancer 38:S3-7. 2002
    ..Toxicity is mainly hematologic and can be reduced by supportive measures. Overall, pemetrexed is an active agent that further improves the chemotherapeutic options of physicians involved in the treatment of NSCLC...
  8. doi A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer
    Joline S W Lind
    Departments of Pulmonary Diseases, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Clin Cancer Res 16:3078-87. 2010
    ....
  9. ncbi The natural course of preneoplastic lesions in bronchial epithelium
    Roderick H Breuer
    Department of Pulmonology, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Clin Cancer Res 11:537-43. 2005
    ..To study the natural history of preneoplastic lesions in the bronchial mucosa of the individuals at risk...
  10. ncbi Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients
    C Tji Joong Gan
    VU University Medical Center, De Boelelaan 1117 PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:11-7. 2007
    ..In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity...
  11. doi DNA copy number aberrations in endobronchial lesions: a validated predictor for cancer
    Robert A A van Boerdonk
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Thorax 69:451-7. 2014
    ..This classifier could assist in selecting subjects with endobronchial lesions who might benefit from more aggressive therapeutic intervention or surveillance. ..
  12. ncbi Cardiac function and position more than 5 years after pneumonectomy
    Sietske A Smulders
    Department of Pulmonary Diseases, Catharina Hospital, Eindhoven, The Netherlands
    Ann Thorac Surg 83:1986-92. 2007
    ..We investigated long-term effects of pneumonectomy on right ventricular (RV) and left ventricular (LV) function and whether this function is influenced by the side of pneumonectomy or the migration of the heart to its new position...
  13. pmc Non-invasive stroke volume assessment in patients with pulmonary arterial hypertension: left-sided data mandatory
    Gert Jan Mauritz
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 10:51. 2008
    ..Derivation of stroke volume (SV) from the pulmonary flow curves is considered as a standard in this respect. Our aim was to investigate the accuracy of pulmonary artery (PA) flow for measuring SV...
  14. doi Right ventricular oscillatory power is a constant fraction of total power irrespective of pulmonary artery pressure
    Nabil Saouti
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 182:1315-20. 2010
    ..Because mean power provides for net blood flow, the ratio of oscillatory to total power (oscillatory power fraction) preferably should be small. It is unknown whether this is the case in pulmonary arterial hypertension (PAH)...
  15. ncbi The natural history of carcinoma in situ involving bronchial resection margins
    Arifa Pasic
    Department of Pulmonology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Chest 128:1736-41. 2005
    ..We studied the natural history of patients with carcinoma in situ (CIS) at their bronchial resection margins to focus on the issue of stump recurrence...
  16. ncbi Ventilatory and cardiocirculatory exercise profiles in COPD: the role of pulmonary hypertension
    Bart G Boerrigter
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Chest 142:1166-74. 2012
    ..The impact of PH on exercise tolerance is largely unknown. We evaluated and compared the circulatory and ventilatory profiles during exercise in patients with COPD without PH, with moderate PH, and with severe PH...
  17. ncbi Right coronary artery flow impairment in patients with pulmonary hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Noord Holland, The Netherlands
    Eur Heart J 29:120-7. 2008
    ..This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion...
  18. pmc Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis
    Roderick H J Breuer
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Neoplasia 6:736-43. 2004
    ..Because PcG complexes are normally involved in the maintenance of cell characteristics, abnormal PcG expression may contribute to loss of cell identity...
  19. doi Exercise testing to estimate survival in pulmonary hypertension
    Herman Groepenhoff
    Institute for Cardiovascular Research and Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Med Sci Sports Exerc 40:1725-32. 2008
    ..The aims of our study were to compare prognostic values of different exercise parameters in PH and to assess whether CPET adds prognostic value to the information from the 6MWD...
  20. ncbi Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
    ..This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH)...
  21. ncbi Prognostic relevance of response evaluation using [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with locally advanced non-small-cell lung cancer
    Corneline J Hoekstra
    Department of Nuclear Medicine, Vrije University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 23:8362-70. 2005
    ....
  22. doi Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension
    Jan Willem Lankhaar
    Department of Physics and Medical Technology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur Heart J 29:1688-95. 2008
    ..We aimed at testing the hypothesis that R and C are coupled during treatment of PH and that substantial changes in both R and C would result in more haemodynamic improvement than changes in R alone...
  23. ncbi Initial bronchoscopic treatment for patients with intraluminal bronchial carcinoids
    Hes A P Brokx
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Cardiovasc Surg 133:973-8. 2007
    ..Carcinoid of the lung is considered low-grade malignancy, and less invasive treatment may therefore be considered. We analyzed the long-term outcome of initial bronchoscopic treatment in patients with intraluminal bronchial carcinoids...
  24. doi Progressive dilatation of the main pulmonary artery is a characteristic of pulmonary arterial hypertension and is not related to changes in pressure
    Bart Boerrigter
    VU University Medical Center, Amsterdam, The Netherlands
    Chest 138:1395-401. 2010
    ..The aim of this study was to evaluate PA size during follow-up in treated patients with PAH and whether it reflects pulmonary vascular hemodynamics...
  25. ncbi Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension
    C Tji Joong Gan
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:1906-12. 2007
    ....
  26. ncbi Detection and staging of preinvasive lesions and occult lung cancer in the central airways with 18F-fluorodeoxyglucose positron emission tomography: a pilot study
    Arifa Pasic
    Department of Pulmonology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 11:6186-9. 2005
    ..To evaluate the role of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in radiologically occult preinvasive lesions and lung cancer in the central airways...
  27. ncbi Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients: the European Early Lung Cancer Project
    Remco M van den Berg
    Department of Pulmonary Diseases, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Int J Oncol 37:455-61. 2010
    ..hTERT mRNA level in tumour tissue has no prognostic value for patients with early stage lung cancer. However, detection of hTERT mRNA expression in tumour-distant normal lung tissue may indicate an increased risk of progressive disease...
  28. ncbi Early changes of cardiac structure and function in COPD patients with mild hypoxemia
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Chest 127:1898-903. 2005
    ..Although functional abnormalities of the right ventricle (RV) have been well described in COPD patients with severe hypoxemia, little is known about these changes in patients with normoxia and mild hypoxemia...
  29. doi Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy?
    Pyng Lee
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Lung Cancer 62:309-15. 2008
    ..As good locoregional tumor control can be achieved with current treatment strategies, patients who develop second primary tumors from field cancerization have poorer prognosis...
  30. ncbi CT detected indeterminate pulmonary nodules in a chemoprevention trial of fluticasone
    Remco M van den Berg
    Department of Pulmonology, VU University Medical Center, Boelelaan 1117, 1081HV Amsterdam, The Netherlands
    Lung Cancer 60:57-61. 2008
    ..We performed a secondary analysis of CT data of subjects at risk of lung cancer enrolled in a chemoprevention trial of fluticasone...
  31. ncbi The influence of fluticasone inhalation on markers of carcinogenesis in bronchial epithelium
    Remco M van den Berg
    Department of Pulmonology, VU Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Respir Crit Care Med 175:1061-5. 2007
    ..Bronchial epithelium exposed to cigarette smoke undergoes a series of histologic changes that may ultimately lead to invasive cancer. Inhaled corticosteroids reduce the number of lung tumors developing in rats exposed to cigarette smoke...
  32. ncbi Assessment of the pulmonary volume pulse in idiopathic pulmonary arterial hypertension by means of electrical impedance tomography
    Henk J Smit
    Department of Pulmonary Diseases, VU Medical Center, Amsterdam, The Netherlands
    Respiration 73:597-602. 2006
    ..Electrical impedance tomography (EIT) is a non-invasive imaging technique which can be used to measure the blood volume changes in the pulmonary vascular bed during the cardiac cycle...
  33. pmc Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ
    Pyng Lee
    Pulmonary Diseases and Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Cancer Res 15:4700-5. 2009
    ..The aim of the study was to determine if color fluorescence ratio (R/G ratio) added to autofluorescence bronchoscopy could provide an objective means to guide biopsy...
  34. doi Addition of prostanoids in pulmonary hypertension deteriorating on oral therapy
    Wouter Jacobs
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Heart Lung Transplant 28:280-4. 2009
    ..The aim of our study was to describe the efficacy of addition of intravenous or subscutaneous prostanoids in idiopathic pulmonary arterial hypertension (PAH) patients deteriorating on bosentan or on bosentan-sildenafil...
  35. doi Progressive changes in right ventricular geometric shortening and long-term survival in pulmonary arterial hypertension
    Gert Jan Mauritz
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Chest 141:935-43. 2012
    ..The aim of this study was to investigate time courses of RV geometric changes during the progression of RV failure...
  36. ncbi Stroke volume response during exercise measured by acetylene uptake and MRI
    Herman Groepenhoff
    Institute for Cardiovascular Research and Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Physiol Meas 28:1-11. 2007
    ....
  37. doi Comprehensive CADM1 promoter methylation analysis in NSCLC and normal lung specimens
    Remco M van den Berg
    Department of Pulmonary Diseases, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Lung Cancer 72:316-21. 2011
    ..Hence, CADM1 methylation analysis is unlikely to have diagnostic value for the early detection of lung cancer in an unselected population. However, a diagnostic value for selected subjects, such as females, cannot be excluded...
  38. ncbi Traditional versus up-front [18F] fluorodeoxyglucose-positron emission tomography staging of non-small-cell lung cancer: a Dutch cooperative randomized study
    Gerarda J M Herder
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 24:1800-6. 2006
    ..We investigated whether application of positron emission tomography (PET) immediately after first presentation might simplify staging while maintaining accuracy, as compared with traditional strategy in routine clinical setting...
  39. doi Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer
    A Jasmijn Hubers
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Pathol 65:541-5. 2012
    ..The aim of this methodological study was to determine whether the hypermethylation detection rate of RASSF1A, adenomatous polyposis coli (APC) and cytoglobin (CYGB) is influenced by the duration of sputum collection...
  40. doi Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status
    Idris Bahce
    Departments of Pulmonary Diseases, VU University Medical Center, Amsterdam, Netherlands
    Clin Cancer Res 19:183-93. 2013
    ....
  41. doi Right ventricular oxygen supply parameters are decreased in human and experimental pulmonary hypertension
    Gerrina Ruiter
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Heart Lung Transplant 32:231-40. 2013
    ..Because autopsy tissue only reflects end-stage disease, rat models with stable and progressive pulmonary hypertension (PH) were studied as well...
  42. doi Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension
    Frances S de Man
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Circ Heart Fail 5:97-105. 2012
    ..We therefore investigated whether chronic low-dose treatment with bisoprolol (a cardioselective β-blocker) has beneficial effects on cardiac function in experimental PH...
  43. ncbi Cardiopulmonary exercise test characteristics in patients with chronic obstructive pulmonary disease and associated pulmonary hypertension
    Sebastiaan Holverda
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Respiration 76:160-7. 2008
    ..It remains unclear whether exercise parameters can be used to discriminate between COPD patients with associated PH (COPD-PH) and COPD patients without associated PH (COPD-nonPH)...
  44. doi Osteoblastic bone lesions developing during treatment with erlotinib indicate major response in patients with non-small cell lung cancer: a brief report
    Joline S W Lind
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 5:554-7. 2010
    ..Nevertheless, no reliable markers can differentiate an osteoblastic flare or response from disease progression. In non-small cell lung cancer (NSCLC) osteoblastic bone flare or response has been reported in only a few patients...
  45. doi Prolonged right ventricular post-systolic isovolumic period in pulmonary arterial hypertension is not a reflection of diastolic dysfunction
    Gert Jan Mauritz
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Heart 97:473-8. 2011
    ..This concept recently has been questioned, since it was shown that RV contraction continues after pulmonary valve closure causing a post-systolic contraction period...
  46. doi Predictors of mortality in inoperable chronic thromboembolic pulmonary hypertension
    Nabil Saouti
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Respir Med 103:1013-9. 2009
    ..However, only limited data are available concerning predictors of mortality in these patients. The aim of this study was to assess, and to identify, predictors of the long-term outcome of inoperable CTEPH patients...
  47. pmc Are lung cysts in renal cell cancer (RCC) patients an indication for FLCN mutation analysis?
    Paul C Johannesma
    Department of Pulmonary Diseases, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Fam Cancer 15:297-300. 2016
    ....
  48. doi A de novo FLCN mutation in a patient with spontaneous pneumothorax and renal cancer; a clinical and molecular evaluation
    Fred H Menko
    Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
    Fam Cancer 12:373-9. 2013
    ..The finding that mutant FLCN was expressed in the tumour might indicate residual functionality of mutant FLCN, a notion which will be explored in future studies. ..
  49. doi Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C]docetaxel and positron emission tomography
    Astrid A M van der Veldt
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 19:4163-73. 2013
    ..The objective of this study was to investigate whether a [(11)C]docetaxel PET microdosing study could predict tumor uptake of therapeutic doses of docetaxel...
  50. doi Clinically significant change in stroke volume in pulmonary hypertension
    Serge A van Wolferen
    VU University Medical Center, Department of Pulmonary Disease, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Chest 139:1003-9. 2011
    ..However, the extent of change in stroke volume that constitutes a clinically significant change is unknown. The aim of this study was to determine the minimal important difference (MID) in stroke volume in PH...
  51. doi Side-effects of long-term administration of erlotinib in patients with non-small cell lung cancer
    Annemarie Becker
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 5:1477-80. 2010
    ..Patients with a mutation or deletion in the epidermal growth factor receptor gene will benefit most and are likely to receive the drug for long periods and willing to accept side effects if responding...
  52. ncbi Dual digital video-autofluorescence imaging for detection of pre-neoplastic lesions
    Pyng Lee
    Department of Pulmonary Diseases, VU University Medical Centre, Amsterdam, The Netherlands
    Lung Cancer 58:44-9. 2007
    ....
  53. ncbi Multiple suspicious lesions detected by autofluorescence bronchoscopy predict malignant development in the bronchial mucosa in high risk patients
    Arifa Pasic
    Department of Pulmonology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Lung Cancer 41:295-301. 2003
    ..This finding is compatible with field carcinogenesis and warrants a more upfront use of AFB in a lung cancer screening to sift the different risk-cohorts in a population mainly at risk for developing metachronous lung cancer...
  54. doi Long-term outcomes in pulmonary arterial hypertension in the first-line epoprostenol or first-line bosentan era
    Wouter Jacobs
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Heart Lung Transplant 29:1150-8. 2010
    ..The aim of this study was to describe the long-term outcomes in idiopathic pulmonary arterial hypertension (IPAH) treated with first-line bosentan or intravenous (IV) epoprostenol, and additional therapy as needed...
  55. ncbi Determinants of pulmonary perfusion measured by electrical impedance tomography
    Henk J Smit
    Department of Pulmonary Medicine, VU Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Appl Physiol 92:45-9. 2004
    ..05). The EIT signal likely reflects the size of the pulmonary microvascular bed, since neither a low cardiac output nor a change in SV of the heart appear to influence EIT...
  56. ncbi Surgical mediastinal staging in daily practice
    Sietske A Smulders
    Department of Pulmonary Diseases, Catharina Hospital, Eindhoven, PO Box 1350, 5602 ZA Eindhoven, The Netherlands
    Lung Cancer 47:243-51. 2005
    ..An adequately staged mediastinum remains obligatory in patients with NSCLC prior to surgery. In this study, we investigated the accuracy of preoperative surgical mediastinal staging procedures in four hospitals...
  57. ncbi Smoking behavior does not influence the natural course of pre-invasive lesions in bronchial mucosa
    Arifa Pasic
    Department of Pulmonology, Vrije Universiteit Medical Center, P O Box 7057, MB Amsterdam 1007, The Netherlands
    Lung Cancer 45:153-4. 2004
  58. doi Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs
    Astrid A M van der Veldt
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Cell 21:82-91. 2012
    ..These findings highlight the importance of drug scheduling and advocate further studies to optimize scheduling of anti-angiogenic drugs...
  59. doi Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension
    Koen T B Mouchaers
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H200-7. 2009
    ..These data indicate that the combination of Bosentan and Sildenafil may beneficially contribute to RV adaptation in PAH, not only by reducing PVR but also by acting on the mitochondria in the heart...
  60. doi DNA copy number alterations in endobronchial squamous metaplastic lesions predict lung cancer
    Robert A A van Boerdonk
    VU University Medical Center, Department of Pathology, De Boelelaan 1117, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 184:948-56. 2011
    ..Autofluorescence bronchoscopy (AFB) is a valid strategy for detecting premalignant endobronchial lesions. However, no biomarker can reliably predict lung cancer risk of subjects with AFB-visualized premalignant lesions...
  61. ncbi A comparison of noninvasive MRI-based methods of estimating pulmonary artery pressure in pulmonary hypertension
    Roald J Roeleveld
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    J Magn Reson Imaging 22:67-72. 2005
    ..To assess the accuracy of several noninvasive MRI-based estimators of pulmonary artery pressure by comparing them with invasive pressure measurement...
  62. ncbi Cost-effectiveness of early intervention: comparison between intraluminal bronchoscopic treatment and surgical resection for T1N0 lung cancer patients
    Arifa Pasic
    Department of Pulmonology, Vrije Universiteit Medical Center Amsterdam, Amsterdam, The Netherlands
    Respiration 71:391-6. 2004
    ....
  63. ncbi Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension
    C Tji Joong Gan
    Dept of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 290:H1528-33. 2006
    ..In PAH patients, ventricular interaction mediated by the interventricular septum impairs left ventricular filling, contributing to decreased stroke volume...
  64. doi The finding of premalignant lesions is not associated with smoking cessation in chemoprevention study volunteers
    Romane M Schook
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 5:1240-5. 2010
    ..The aim of this study was to evaluate whether the participation on a chemoprevention study for premalignant lesions could influence smoking cessation...
  65. ncbi Surgical treatment for octogenarians with lung cancer: results from a population-based series of 124 patients
    Hes A P Brokx
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 2:1013-7. 2007
    ..Previous reports on the outcome of surgery for lung cancer in octogenarians were mainly derived from single institutions. In contrast, this study presents results for all hospitals in a region of 3 million inhabitants...
  66. doi Quantitative parametric perfusion images using 15O-labeled water and a clinical PET/CT scanner: test-retest variability in lung cancer
    Astrid A M van der Veldt
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 51:1684-90. 2010
    ..The purpose of the present study was to assess validity and reproducibility of dynamic H(2)(15)O PET/CT scans for measuring tumor perfusion and validate the quantitative accuracy of parametric perfusion images...
  67. doi Evaluation of a treatment strategy for optimising preoperative chemoradiotherapy in stage III non-small-cell lung cancer
    Erik C J Phernambucq
    Department of Pulmonary Diseases, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Cardiothorac Surg 36:1052-7. 2009
    ..We describe the outcome of a treatment strategy to limit the duration of treatment splits...
  68. ncbi Elevated hTERT mRNA levels: A potential determinant of bronchial squamous cell carcinoma (in situ)
    Peter J F Snijders
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Int J Cancer 109:412-7. 2004
    ..03). These data indicate that elevated hTERT mRNA is associated with an increased relative risk of prevalent and incident bronchial squamous cell carcinoma (in situ)...
  69. ncbi Where is the heart after left-sided pneumonectomy?
    Sietske A Smulders
    Department of Pulmonary Diseases, Catharina Hospital, Eindhoven, The Netherlands
    J Thorac Oncol 1:69-70. 2006
  70. doi Usefulness of serial N-terminal pro-B-type natriuretic peptide measurements for determining prognosis in patients with pulmonary arterial hypertension
    Gert Jan Mauritz
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 108:1645-50. 2011
    ..In conclusion, a serum NT-pro-BNP level ≥1,256 pg/ml at time of diagnosis identifies poor outcome in patients with PAH. In addition, a decrease in NT-pro-BNP of >15%/year is associated with survival in PAH...
  71. ncbi Combined use of autofluorescence bronchoscopy and argon plasma coagulation enables less extensive resection of radiographically occult lung cancer
    Bart Schuurman
    Department of Pulmonary Medicine, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands
    Respiration 71:410-1. 2004
  72. doi Time for reappraisal of extracranial treatment options? Synchronous brain metastases from nonsmall cell lung cancer
    Joline S W Lind
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, Netherlands
    Cancer 117:597-605. 2011
    ..The authors aimed to identify patient groups with synchronous BM for whom radical treatment of the primary site may be appropriate...
  73. pmc Dynamic contrast-enhanced CT in patients treated with sorafenib and erlotinib for non-small cell lung cancer: a new method of monitoring treatment?
    Joline S W Lind
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Eur Radiol 20:2890-8. 2010
    ....
  74. ncbi The performance of( 18)F-fluorodeoxyglucose positron emission tomography in small solitary pulmonary nodules
    Gerarda J Herder
    Department of Pulmonary Diseases, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 31:1231-6. 2004
    ..Such results may help in the design of larger prospective trials with structured clinical work-up...
  75. ncbi What is early lung cancer? A review of the literature
    Arifa Pasic
    Department of Pulmonary Medicine, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Lung Cancer 45:267-77. 2004
    ..Caution is necessary, however, as clinical staging remains inferior to pathological staging which is based on tissue samples collected after complete tumor removal and mediastinal lymph nodes dissection have been performed...
  76. ncbi Pemetrexed as a single agent in the therapy of advanced lung cancer
    Pieter E Postmus
    Department of Pulmonary Diseases, Vrije Universiteit, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Semin Oncol 29:17-22. 2002
    ..Toxicity in both situations is mild; myelotoxicity is primarily seen. This review describes phase I and II studies performed before folic acid and vitamin B(12) supplementation...
  77. ncbi Effects of epoprostenol on right ventricular hypertrophy and dilatation in pulmonary hypertension
    Roald J Roeleveld
    Department of Pulmonology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Chest 125:572-9. 2004
    ..To gain more knowledge of changes in main pulmonary artery flow and right ventricular mass and volumes in patients with pulmonary hypertension during epoprostenol therapy...
  78. pmc Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology and Lu
    Berend J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 27:78-84. 2009
    ..Detailed effects of PCI on health-related quality of life (HRQOL) are reported here...
  79. ncbi A 31-year-old man with hemoptysis at high altitude and abnormal hepatic biochemistry tests
    Harm J Bogaard
    Department of Pulmonary Medicine, VU Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Chest 132:1088-92. 2007
  80. ncbi Interventricular septal configuration at mr imaging and pulmonary arterial pressure in pulmonary hypertension
    Roald J Roeleveld
    Departments of Pulmonology and Physics and Medical Technology, VU University Medical Center Institute of Cardiovascular Research ICaR VU, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 234:710-7. 2005
    ..To investigate whether a relationship exists between septum shape and systolic pulmonary arterial pressure (PAP) in patients with pulmonary hypertension...
  81. ncbi Interventricular mechanical asynchrony due to right ventricular pressure overload in pulmonary hypertension plays an important role in impaired left ventricular filling
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Chest 128:628S-630S. 2005
  82. ncbi Pulmonary vascular responses to hypoxia and hyperoxia in healthy volunteers and COPD patients measured by electrical impedance tomography
    Henk J Smit
    Department of Pulmonary Medicine, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Chest 123:1803-9. 2003
    ..Electrical impedance tomography (EIT) is a noninvasive imaging technique using impedance to visualize and measure blood volume changes...
  83. doi Dramatic response to low-dose erlotinib of epidermal growth factor receptor mutation-positive recurrent non-small cell lung cancer after severe cutaneous toxicity
    Joline S W Lind
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 4:1585-6. 2009
    ..Our case suggests that in the presence of rash, dose reductions to "subtherapeutic" levels remain effective and may prevent unnecessary early treatment termination...
  84. ncbi Suprabasal p53 immunostaining in premalignant endobronchial lesions in combination with histology is associated with bronchial cancer
    Roderick H J Breuer
    Department of Pulmonology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Lung Cancer 40:165-72. 2003
    ....
  85. ncbi Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial
    Harm Van Tinteren
    Comprehensive Cancer Centre Amsterdam, Amsterdam, Netherlands
    Lancet 359:1388-93. 2002
    ..We did a randomised controlled trial in patients with suspected non-small-cell lung cancer, who were scheduled for surgery after conventional workup, to test whether PET with 18FDG reduces number of futile thoracotomies...
  86. ncbi Bronchoscopic treatment of patients with intraluminal microinvasive radiographically occult lung cancer not eligible for surgical resection: a follow-up study
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Lung Cancer 39:49-53. 2003
    ..Sixteen patients are still alive without any tumor recurrence. These data showed that BT is an effective treatment modality for high-risk patients with ROLC, who are not eligible for surgical resection...
  87. ncbi Paclitaxel triggers cell death primarily via caspase-independent routes in the non-small cell lung cancer cell line NCI-H460
    Cynthia Huisman
    Department of Medical Oncology, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Cancer Res 8:596-606. 2002
    ..Here we report on the role of mitochondria, death receptors (DRs), and caspases in exerting the cytotoxic effect of clinically relevant concentrations of paclitaxel in the non-small cell lung cancer cell line NCI-H460...
  88. ncbi Unusual pulmonary lesions: case 2. Endobronchial carcinoid of the lung
    Henk Codrington
    Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Clin Oncol 20:2747-8. 2002
  89. ncbi The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer
    Frances A Shepherd
    Department of Medicine, Division of Medical Oncology and Hematology of the University Health Network, Princess Margaret Hospital and the University of Toronto, Ontario, Canada
    J Thorac Oncol 2:1067-77. 2007
    ..The current analysis looks to the impact of the TNM system on the clinical staging of SCLC and of the new International Association for the study of Lung Cancer (IASLC) proposals...
  90. ncbi Impaired stroke volume response to exercise in pulmonary arterial hypertension
    Sebastiaan Holverda
    J Am Coll Cardiol 47:1732-3. 2006
  91. ncbi The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours
    Peter Goldstraw
    Royal Brompton Hospital, Imperial College, London, United Kingdom
    J Thorac Oncol 2:706-14. 2007
    ..The recommendations of this committee for changes to the T, N, and M descriptors have been published. This report contains the proposals for the new stage groupings...
  92. ncbi Cost-effectiveness of FDG-PET in staging non-small cell lung cancer: the PLUS study
    Paul Verboom
    Institute for Medical Technology Assessment, Erasmus Medical Centre Erasmus University Rotterdam, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 30:1444-9. 2003
    ..The additional use of PET in the staging of patients with NSCLC is feasible, safe and cost saving from a clinical and from an economic perspective...
  93. ncbi Lung density measurements in spontaneous pneumothorax demonstrate airtrapping
    Hans J M Smit
    Department of Pulmonary Medicine, Rijnstate Hospital, Arnhem, The Netherlands
    Chest 125:2083-90. 2004
    ..We hypothesize that rather peripheral airway inflammation leads to obstruction with check valve phenomena and by that to airtrapping in the lung parenchyma, which precedes spontaneous pneumothorax...
  94. ncbi CT screening for lung cancer
    Pyng Lee
    N Engl J Med 356:745; author reply 746-7. 2007
  95. ncbi Standard versus intensified chemotherapy with granulocyte colony-stimulating factor support in small-cell lung cancer: a prospective European Organization for Research and Treatment of Cancer-Lung Cancer Group Phase III Trial-08923
    Andrea Ardizzoni
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    J Clin Oncol 20:3947-55. 2002
    ..To assess the impact on survival of increasing dose-intensity (DI) of cyclophosphamide, doxorubicin, and etoposide (CDE) in small-cell lung cancer (SCLC)...
  96. ncbi Effects on smoking cessation: naltrexone combined with a cognitive behavioral treatment based on the community reinforcement approach
    Hendrik G Roozen
    Department of Clinical Psychology, Research Institute of Psychology and Health, Vrije Universiteit, Amsterdam, The Netherlands
    Subst Use Misuse 41:45-60. 2006
    ..The abstinence rate in the CRA group was nearly double that in the non-psychosocial therapy group (46% vs. 25%; NS) at 3 months follow-up after treatment...
  97. ncbi Comparison of observer variability and accuracy of different criteria for lung scan interpretation
    Petronella J Hagen
    Department of Pulmonary Medicine, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Nucl Med 44:739-44. 2003
    ..The purpose of this study was to evaluate interobserver variability and accuracy of 3 sets of criteria: the Hull and PIOPED (Prospective Investigation of Pulmonary Embolism Diagnosis) criteria and the Gestalt interpretation...
  98. ncbi Lung attenuation measurements in healthy young adults
    Hans J M Smit
    Department of Pulmonary Medicine, Rijnstate Hospital, Arnhem, The Netherlands
    Respiration 70:143-8. 2003
    ..High-resolution computed tomography (HRCT) attenuation measurements may be more sensitive in finding early emphysematous changes in relatively young subjects than lung function measurements...
  99. ncbi Second-line for small cell lung cancer: how-to-do-it?
    Pieter E Postmus
    Lung Cancer 48:263-5. 2005
  100. ncbi Bronchial typical carcinoid tumors: histological study of intra- versus extraluminal growth pattern
    Hes A P Brokx
    Department of Pulmonology, Vrije Universiteit Medical Center, PO Box 7057, Amsterdam 1007 MB, The Netherlands
    Lung Cancer 44:129-30. 2004
  101. ncbi Actual and predicted postoperative changes in lung function after pneumonectomy: a retrospective analysis
    Sietske A Smulders
    Department of Pulmonary Diseases, Catharina Hospital Eindhoven, The Netherlands
    Chest 125:1735-41. 2004
    ..We evaluated the long-term validity of two formulas frequently used to predict postoperative lung function, as well as trends in postoperative lung function and late postoperative exercise capacity...