Hans W M Niessen

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation
    Martin C J Kneyber
    Department of Pediatric Intensive Care, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Crit Care 13:R87. 2009
  2. ncbi request reprint Type II secretory phospholipase A2 in cardiovascular disease: a mediator in atherosclerosis and ischemic damage to cardiomyocytes?
    Hans W M Niessen
    ICaR VU, VU Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 60:68-77. 2003
  3. doi request reprint Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)
    Jessica A Sipkens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Mol Cell Biochem 358:229-39. 2011
  4. doi request reprint S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 221:48-54. 2012
  5. doi request reprint Low myocardial protein kinase G activity in heart failure with preserved ejection fraction
    Loek van Heerebeek
    Department of Physiology, Cardiology, Pathology, and Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 126:830-9. 2012
  6. doi request reprint Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Physiol Biochem 28:53-62. 2011
  7. doi request reprint Validation of ultrastructural analysis of mitochondrial deposits in cardiomyocytes as a method of detecting early acute myocardial infarction in humans
    Mark P V Begieneman
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Forensic Sci 55:988-92. 2010
  8. doi request reprint NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans
    Nynke E Hahn
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Pathol 180:2222-9. 2012
  9. doi request reprint Inhibition of type 2A secretory phospholipase A2 reduces death of cardiomyocytes in acute myocardial infarction
    Annemieke van Dijk
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Apoptosis 14:753-63. 2009
  10. doi request reprint Ventricular myocarditis coincides with atrial myocarditis in patients
    Mark P V Begieneman
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands ICaR VU, VU University Medical Center, Amsterdam, the Netherlands Dutch Forensic Institute, The Hague, The Netherlands
    Cardiovasc Pathol 25:141-8. 2016

Detail Information

Publications59

  1. pmc Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation
    Martin C J Kneyber
    Department of Pediatric Intensive Care, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Crit Care 13:R87. 2009
    ..We hypothesized that mechanical ventilation (MV) augmented sepsis-induced myocardial CML deposition and inflammation...
  2. ncbi request reprint Type II secretory phospholipase A2 in cardiovascular disease: a mediator in atherosclerosis and ischemic damage to cardiomyocytes?
    Hans W M Niessen
    ICaR VU, VU Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 60:68-77. 2003
    ..It was concluded that sPLA2-II appears to be an important inflammatory mediator of cardiovascular disease...
  3. doi request reprint Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)
    Jessica A Sipkens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Mol Cell Biochem 358:229-39. 2011
    ....
  4. doi request reprint S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 221:48-54. 2012
    ....
  5. doi request reprint Low myocardial protein kinase G activity in heart failure with preserved ejection fraction
    Loek van Heerebeek
    Department of Physiology, Cardiology, Pathology, and Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 126:830-9. 2012
    ..To discern altered control of myocardial remodeling by PKG, HFPEF was compared with aortic stenosis and HF with reduced EF (HFREF)...
  6. doi request reprint Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Physiol Biochem 28:53-62. 2011
    ..In the present study the mechanism(s) involved in Hcy-induced PS exposure were analyzed...
  7. doi request reprint Validation of ultrastructural analysis of mitochondrial deposits in cardiomyocytes as a method of detecting early acute myocardial infarction in humans
    Mark P V Begieneman
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Forensic Sci 55:988-92. 2010
    ....
  8. doi request reprint NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans
    Nynke E Hahn
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Pathol 180:2222-9. 2012
    ..For the first time to our knowledge, we demonstrate NOX5 expression in human intramyocardial blood vessels and cardiomyocytes, with significant increases in the affected myocardium after acute myocardial infarction...
  9. doi request reprint Inhibition of type 2A secretory phospholipase A2 reduces death of cardiomyocytes in acute myocardial infarction
    Annemieke van Dijk
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Apoptosis 14:753-63. 2009
    ..In conclusion, PX-18 is a potent therapeutic to reduce infarct size by inhibiting sPLA(2)-IIA, and possibly also by inhibiting apoptosis of cardiomyocytes in a sPLA(2)-IIA independent manner...
  10. doi request reprint Ventricular myocarditis coincides with atrial myocarditis in patients
    Mark P V Begieneman
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands ICaR VU, VU University Medical Center, Amsterdam, the Netherlands Dutch Forensic Institute, The Hague, The Netherlands
    Cardiovasc Pathol 25:141-8. 2016
    ..However, little is known about the occurrence of atrial inflammation in myocarditis patients. Here, we analyzed inflammatory cell numbers in the atria of myocarditis patients without symptomatic AF...
  11. pmc Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cell Biochem Biophys 67:341-52. 2013
    ..The data presented in this article reveal accumulation of nuclear NOX2 and peri-nuclear NOX4 accumulation as potential source of ROS production in Hcy-induced apoptosis in endothelial cells. ..
  12. doi request reprint C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure
    Paul A J Krijnen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Atherosclerosis 220:86-92. 2012
    ..Inflammation, including complement activation, is assumed to play a pivotal role herein. Here, we analyzed the effects of C1-esterase inhibitor (C1inh) on early vein graft remodeling...
  13. doi request reprint NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species
    Nynke E Hahn
    Department of Pathology, VU University Medical Centre, De Boelelaan 1117, Amsterdam, The Netherlands
    Cell Physiol Biochem 27:471-8. 2011
    ..g. under ischemia or high concentrations of homocysteine, is an important step in the induction of apoptosis in these cells. Here this ischemia-induced nuclear targeting and activation of NOX2 was specified in cardiomyocytes...
  14. doi request reprint Atrial fibrillation coincides with the advanced glycation end product N(ε)-(carboxymethyl)lysine in the atrium
    Mark P V Begieneman
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands Department of Pathology, The Netherlands Forensic Institute, The Hague, The Netherlands ICaR VU, Amsterdam, The Netherlands Electronic address
    Am J Pathol 185:2096-104. 2015
    ..Our results indicate that in AF the intramyocardial blood vessels of the left atrial appendage have an increased CML presence and proinflammatory status coinciding with a local increase in the number of inflammatory cells. ..
  15. ncbi request reprint Degeneration and atherosclerosis inducing increased deposition of type IIA secretory phospholipase A2, C-reactive protein and complement in aortic valves cause neutrophilic granulocyte influx
    Koba Kupreishvili
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Heart Valve Dis 20:29-36. 2011
    ..The study aim was to monitor the deposition of CRP, its activator sPLA2-IIA and its effector complement, and the subsequent influx of neutrophilic granulocytes in degenerative and atherosclerotic aortic valves...
  16. doi request reprint Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model
    Mark P V Begieneman
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Burn Care Res 33:544-51. 2012
    ..Therefore, C1inh might be a possible therapeutic intervention for burn wound patients...
  17. pmc Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients
    Paul A J Krijnen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Basic Res Cardiol 107:233. 2012
    ..Our data suggest that the loss of DPP4 activity affects the anti-thrombogenic nature of the endothelium...
  18. ncbi request reprint Inhibition of sPLA2-IIA, C-reactive protein or complement: new therapy for patients with acute myocardial infarction?
    Paul A J Krijnen
    VU Medical Center, Department of Pathology, Room nr 1B116, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Cardiovasc Hematol Disord Drug Targets 6:113-23. 2006
    ..This review will focus on the pathogenic effects of sPLA2-IIA, CRP and complement and on the putative therapeutic effects of inhibitors of these inflammatory mediators in acute myocardial infarction...
  19. ncbi request reprint N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels
    Alexi Baidoshvili
    Department of Cardiac Surgery, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Atherosclerosis 174:287-92. 2004
    ..Our data support the hypothesis that the process of degeneration of aortic valves resembles that of atherosclerosis in blood vessels. They suggest that CML also plays a role in the process of atherosclerosis in aortic valves...
  20. pmc Early NADPH oxidase-2 activation is crucial in phenylephrine-induced hypertrophy of H9c2 cells
    Nynke E Hahn
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands ICaR VU, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Cell Signal 26:1818-24. 2014
    ..These data show that early NOX2-mediated ROS production is crucial in PE-induced hypertrophy of H9c2 cells...
  21. doi request reprint The basement membrane of intramyocardial capillaries is thickened in patients with acute myocardial infarction
    Mark P V Begieneman
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Vasc Res 47:54-60. 2010
    ..Recently, we found that intramyocardial capillaries may also play a role in AMI induction. We have now evaluated intramyocardial capillaries using ultrastructural analysis in AMI patients...
  22. pmc More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease
    Nazha Hamdani
    Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Muscle Res Cell Motil 31:289-301. 2010
    ..Alterations in the βAR pathway are more pronounced in IDCM than in ISHD and may reflect sequential changes in cellular protein composition and function. Our data indicate that cellular dysfunction is more severe in IDCM than in ISHD...
  23. ncbi request reprint Long-term effects of 7-monohydroxyethylrutoside (monoHER) on DOX-induced cardiotoxicity in mice
    Anna M E Bruynzeel
    Department of Medical Oncology, VU University Medical Center, 1081 HV, CCA Building, room 1 38, De Boelelaan 1117, Amsterdam, The Netherlands
    Cancer Chemother Pharmacol 60:509-14. 2007
    ..It cannot be excluded that the dose and frequency of monoHER administration is crucial in obtaining an optimal antioxidant activity without a pro-oxidant activity of monoHER...
  24. doi request reprint Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction
    Reindert W Emmens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands Department of Immunopathology, Sanquin Research, Postbus 9892, 1006 AN, Amsterdam, The Netherlands Electronic address
    Cardiovasc Pathol 25:33-9. 2016
    ..In this study, we investigated whether endogenous C1-inhibitor, a well-known inhibitor of complement activation, is expressed in the heart after acute myocardial infarction...
  25. doi request reprint Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase
    Paul A J Krijnen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 49:781-90. 2010
    ..In this study, we show a regulatory role for a novel signaling route, Rho-ROCK-flippase signaling, in maintaining asymmetrical membrane phospholipid distribution in cardiomyocytes...
  26. pmc C-reactive protein activates complement in infarcted human myocardium
    Remco Nijmeijer
    Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 163:269-75. 2003
    ..Hence, CRP seems to enhance local inflammatory reactions ensuing in human myocardial infarcts of more than 12 hours duration...
  27. doi request reprint Intravenous clusterin administration reduces myocardial infarct size in rats
    Annemieke van Dijk
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 40:893-902. 2010
    ..We therefore hypothesized that intravenous clusterin administration would reduce myocardial infarction damage...
  28. doi request reprint Right ventricular oxygen supply parameters are decreased in human and experimental pulmonary hypertension
    Gerrina Ruiter
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Heart Lung Transplant 32:231-40. 2013
    ..Because autopsy tissue only reflects end-stage disease, rat models with stable and progressive pulmonary hypertension (PH) were studied as well...
  29. doi request reprint Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium
    Nicky M Boontje
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 50:487-99. 2011
    ..The increased myofilament responsiveness in MI may depend on the preserved cMyBP-C phosphorylation possibly resulting from increased CaMKII-δC activity and may help to maintain proper diastolic performance during exercise...
  30. ncbi request reprint Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 117:43-51. 2008
    ..The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF...
  31. doi request reprint Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage
    Lourens F H J Robbers
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur Heart J 34:2346-53. 2013
    ..However, the exact histopathological correlate of the contrast-devoid core and its relation to IMH is unknown...
  32. doi request reprint Early myocardial dysfunction is not caused by mitochondrial abnormalities in a rat model of peritonitis
    Lonneke Smeding
    Department of Pediatric Intensive Care, VU University Medical Center, Amsterdam, The Netherlands
    J Surg Res 176:178-84. 2012
    ..We hypothesized that early dysfunction during sepsis is associated with inflammation, mitochondrial injury, impaired mitochondrial function, and activation of mitochondrial biogenesis...
  33. pmc Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery by
    Marlieke Visser
    Department of Cardiothoracic Surgery, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Cardiothorac Surg 6:36. 2011
    ....
  34. doi request reprint H9c2 cardiomyoblasts produce thyroid hormone
    Christof Meischl
    VU University Medical Center, Department of Pathology, Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 294:C1227-33. 2008
    ..In conclusion, our findings demonstrate for the first time that cardiomyocytes produce thyroid hormone in a manner adapted to the cell's environment...
  35. ncbi request reprint C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion
    Niubel Diaz Padilla
    Department of Immunopathology, Sanquin Research, Plesmalaan 125, Amsterdam, The Netherlands
    Surgery 142:722-33. 2007
    ..The effect of C1-esterase inhibitor (C1-Inh) on this complement activation along with other inflammatory mediators was also studied...
  36. ncbi request reprint Increased accumulation of the glycoxidation product Nepsilon-(carboxymethyl)lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti-CML antibody
    Casper G Schalkwijk
    Department of Clinical Chemistry, Vrije Universiteit Medical Center, Amsterdam 1007 MB, The Netherlands
    Biochim Biophys Acta 1636:82-9. 2004
    ..The accumulation of CML in diabetic hearts may contribute to the increased risk of heart failure in hyperglycaemia...
  37. ncbi request reprint Neonatal porencephaly and adult stroke related to mutations in collagen IV A1
    Marjo S van der Knaap
    Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 59:504-11. 2006
    ..The objective of this study was to describe leukoencephalopathy, lacunar infarcts, microbleeds and macrobleeds in the context of a collagen IV A1 mutation...
  38. doi request reprint Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction
    Constantijn Franssen
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    JACC Heart Fail 4:312-24. 2016
    ....
  39. pmc Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Apoptosis 12:1407-18. 2007
    ..While numerous studies have analyzed the role of homocysteine (Hcy) in the vasculature, only a few studies investigated the role of Hcy in the heart. Therefore we have analyzed the effects of Hcy on isolated cardiomyocytes...
  40. ncbi request reprint Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis
    Jeroen W J van Heijst
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Lett 241:309-19. 2006
    ..These findings suggest that a high level of argpyrimidine-modified Hsp27 is a mechanism of cancer cells for evasion of apoptosis...
  41. doi request reprint Acute inflammation is persistent locally in burn wounds: a pivotal role for complement and C-reactive protein
    Franklin van de Goot
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Burn Care Res 30:274-80. 2009
    ....
  42. pmc Insulin-induced changes in skeletal muscle microvascular perfusion are dependent upon perivascular adipose tissue in women
    Rick I Meijer
    Department of Internal Medicine, VU University Medical Center and Institute for Cardiovascular Research, VU University Medical Center, Room 4A72, Postbus 7057, 1007 MB, Amsterdam, The Netherlands
    Diabetologia 58:1907-15. 2015
    ..We studied whether perivascular adipose tissue (PVAT) controls insulin-induced vasodilation in human muscle, and whether altered properties of PVAT relate to reduced insulin-induced vasodilation in obesity...
  43. doi request reprint Diagnosis of myocarditis: Current state and future perspectives
    P Stefan Biesbroek
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands Interuniversity Cardiology Institute of the Netherlands ICIN, Utrecht, The Netherlands Institute for Cardiovascular Research of the Vrije Universiteit of Amsterdam ICaR VU, Amsterdam, The Netherlands Electronic address
    Int J Cardiol 191:211-9. 2015
    ..In this review, we give a comprehensive overview of the current diagnostic strategies for patients with suspected myocarditis, and demonstrate several new techniques that may help to improve the diagnostic work-up. ..
  44. doi request reprint Lymphocytes infiltrate the quadriceps muscle in lymphocytic myocarditis patients: a potential new diagnostic tool
    Reindert W Emmens
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands ICaR VU, Institute of Cardiovascular Research, VU Medical Center, Amsterdam, The Netherlands Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands Electronic address
    Can J Cardiol 30:1547-54. 2014
    ..The objective of this study was to analyze infiltration of inflammatory cells in quadriceps skeletal muscle of LM patients and investigate the potential diagnostic value of assaying infiltrating inflammatory cells...
  45. ncbi request reprint Intercellular adhesion molecule-1 in the heart
    Hans W M Niessen
    Department of Pathology, ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    Ann N Y Acad Sci 973:573-85. 2002
    ..Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction...
  46. pmc Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir
    Anja M van der Laan
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Eur Heart J 35:376-85. 2014
    ..The purpose of this study was a gain of insight into the source and recruitment of monocytes following AMI in humans...
  47. ncbi request reprint Secretory type II phospholipase A(2) binds to ischemic myocardium during myocardial infarction in humans
    Remco Nijmeijer
    Department of Pathology, VU Medical Center Amsterdam, Room No PA002, De Boelelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Cardiovasc Res 53:138-46. 2002
    ..Therefore, we studied the course of circulating sPLA(2), in patients with acute myocardial infarction (AMI) or unstable angina pectoris (UAP), and investigated the presence of sPLA(2) in infarcted myocardial tissue...
  48. doi request reprint Production of endothelin-1 and reduced blood flow in the rat kidney during lung-injurious mechanical ventilation
    Jan Willem Kuiper
    VU Medical Center, Department of Pediatric Intensive Care, P O Box 7057, 1007, Ambsterdam, The Netherlands
    Anesth Analg 107:1276-83. 2008
    ....
  49. doi request reprint Left ventricular outflow tract gradient is associated with reduced capillary density in hypertrophic cardiomyopathy irrespective of genotype
    Ahmet Güçlü
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 45:1252-9. 2015
    ..CMD may be caused by reduced capillary density. Here, we investigated whether a reduction in capillary density is related to genetic status or LVOT gradient severity in an in vitro study of HCM cardiac samples...
  50. ncbi request reprint Pressure-diameter relationship in the human greater saphenous vein
    Wim Stooker
    Department of Cardiothoracic Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Ann Thorac Surg 76:1533-8. 2003
    ..Furthermore, the effect of perivenous application of fibrin glue on mechanical vein wall properties was studied to evaluate its possible use as perivenous graft support...
  51. ncbi request reprint The influence of the time interval between monoHER and doxorubicin administration on the protection against doxorubicin-induced cardiotoxicity in mice
    Anna M E Bruynzeel
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cancer Chemother Pharmacol 58:699-702. 2006
    ..Therefore, the aim of the present study was to investigate this possible effect...
  52. ncbi request reprint Extent of MRI delayed enhancement of myocardial mass is related to right ventricular dysfunction in pulmonary artery hypertension
    Gerry P McCann
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    AJR Am J Roentgenol 188:349-55. 2007
    ..The purpose of our study was to assess the presence and extent of delayed contrast enhancement of ventricular myocardium in pulmonary artery hypertension...
  53. ncbi request reprint Myocardial structure and function differ in systolic and diastolic heart failure
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU Medical Center, Amsterdam, The Netherlands
    Circulation 113:1966-73. 2006
    ....
  54. ncbi request reprint Expression of Leu-7 in myocardial sleeves around human pulmonary veins
    Ivana Kholova
    Department of Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, Room OE16, 1007 MB, Amsterdam, The Netherlands
    Cardiovasc Pathol 12:263-6. 2003
    ..Myocardial sleeves onto pulmonary veins (PVs) have been recognized as a frequent site of origin of focal triggers for this arrhythmia. Expression of Leu-7 has been hypothesized to correspond with abnormal atrial automaticity...
  55. ncbi request reprint Activated human PMN synthesize and release a strongly fucosylated glycoform of alpha1-acid glycoprotein, which is transiently deposited in human myocardial infarction
    Dennis C W Poland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Leukoc Biol 78:453-61. 2005
    ..We suggest that AGP glycoforms in PMN provide an endogenous feedback-inhibitory response to excessive inflammation...
  56. ncbi request reprint Cardiovascular secrets of secretory phospholipase A(2)
    C Erik Hack
    Sanquin Research at CLB, Department of Immunopathology, Amsterdam
    Eur J Clin Invest 32:381-2. 2002
  57. ncbi request reprint Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine
    Jeroen W J van Heijst
    Department of Internal Medicine, University Hospital Maastricht, Debeyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Ann N Y Acad Sci 1043:725-33. 2005
    ..Because AGEs have been associated with the etiology of a variety of different diseases, these results suggest that CML and argpyrimidine could be implicated in the biology of human cancer...
  58. ncbi request reprint The antiapoptotic protein clusterin protects cardiomyocytes against ischemia-induced cell death
    Paul A J Krijnen
    Am J Physiol Heart Circ Physiol 293:H3223; author reply H3224. 2007
  59. ncbi request reprint C-reactive protein and the risk of cardiovascular mortality
    Hans W M Niessen
    Am J Med 114:241-2. 2003