Adriaan A Lammertsma

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Quantitative Issues in Response Measurement by PET
    Adriaan A Lammertsma
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    PET Clin 3:5-11. 2008
  2. pmc Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes
    Weena J Y Chen
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
    Cardiovasc Diabetol 12:150. 2013
  3. pmc Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis
    Yoony Yj Gent
    Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Arthritis Res Ther 15:R37. 2013
  4. pmc Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor
    Hans Jc Buiter
    Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, Amsterdam, MB, 1007, The Netherlands
    EJNMMI Res 3:24. 2013
  5. pmc [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors
    Hans Jc Buiter
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 3:19. 2013
  6. pmc Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner
    Marc C Huisman
    Diabetes Center Department of Internal Medicine, VU University Medical Center, Amsterdam, 1081, HV, The Netherlands
    EJNMMI Res 2:63. 2012
  7. pmc [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats
    Joost Verbeek
    Department of Nuclear Medicine and PET Research, Radionuclide Centre, VU University Medical Center, P, O, Box 7057, Amsterdam 1081, HV, The Netherlands
    EJNMMI Res 2:36. 2012
  8. pmc Assessment of tumour size in PET/CT lung cancer studies: PET- and CT-based methods compared to pathology
    Patsuree Cheebsumon
    Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, Amsterdam, 1007MB, The Netherlands
    EJNMMI Res 2:56. 2012
  9. pmc Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, VU University Medical Center, P, O, Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 2:57. 2012
  10. pmc Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies
    Floris Hp van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    EJNMMI Res 2:10. 2012

Detail Information

Publications154 found, 100 shown here

  1. doi request reprint Quantitative Issues in Response Measurement by PET
    Adriaan A Lammertsma
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    PET Clin 3:5-11. 2008
    ..Although the focus of this review is on FDG, most issues presented apply to all tracers (ie, to PET quantification in general). ..
  2. pmc Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes
    Weena J Y Chen
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
    Cardiovasc Diabetol 12:150. 2013
    ....
  3. pmc Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis
    Yoony Yj Gent
    Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Arthritis Res Ther 15:R37. 2013
    ..These results warrant further exploration of [18F]fluoro-PEG-folate as a putative PET tracer for imaging (sub)clinical arthritis in RA patients...
  4. pmc Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor
    Hans Jc Buiter
    Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, Amsterdam, MB, 1007, The Netherlands
    EJNMMI Res 3:24. 2013
    ..For this purpose prucalopride, a high-affinity selective 5-HT4-R agonist, was selected...
  5. pmc [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors
    Hans Jc Buiter
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 3:19. 2013
    ..The aim of this study was to evaluate [11C]AF150(S) as a putative M1ACh-R agonist PET ligand, which, owing to its agonist properties, could provide a tool to explore the active G protein-coupled receptor...
  6. pmc Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner
    Marc C Huisman
    Diabetes Center Department of Internal Medicine, VU University Medical Center, Amsterdam, 1081, HV, The Netherlands
    EJNMMI Res 2:63. 2012
    ..As a further step towards widespread clinical applicability, the use of an image-derived input function (IDIF) is investigated...
  7. pmc [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats
    Joost Verbeek
    Department of Nuclear Medicine and PET Research, Radionuclide Centre, VU University Medical Center, P, O, Box 7057, Amsterdam 1081, HV, The Netherlands
    EJNMMI Res 2:36. 2012
    ..This could facilitate assessment of P-gp function when P-gp is upregulated. The purpose of this study was to synthesize [11C]phenytoin and to characterize its properties as a P-gp tracer...
  8. pmc Assessment of tumour size in PET/CT lung cancer studies: PET- and CT-based methods compared to pathology
    Patsuree Cheebsumon
    Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, Amsterdam, 1007MB, The Netherlands
    EJNMMI Res 2:56. 2012
    ..The purpose of this study was to compare tumour sizes obtained from CT- and various more commonly available PET-based tumour delineation methods to pathology findings...
  9. pmc Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, VU University Medical Center, P, O, Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 2:57. 2012
    ..The purpose of this study was to assess the effects of C1236T, G2677T/A and C3435T single-nucleotide polymorphisms in ABCB1 on blood-brain barrier P-glycoprotein function in healthy subjects and patients with Alzheimer's disease...
  10. pmc Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies
    Floris Hp van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    EJNMMI Res 2:10. 2012
    ..The purpose of this study was to investigate the impact of various image registration strategies on standardized uptake value (SUV) and metabolic volume test-retest variability (TRT)...
  11. pmc Reproducibility of quantitative (R)-[11C]verapamil studies
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, PK 1Z035, VU University Medical Center, P, O, Box 7057, Amsterdam 1007 MB, The Netherlands
    EJNMMI Res 2:1. 2012
    ..The purpose of this study was to assess reproducibility of several tracer kinetic models used for analysis of (R)-[11C]verapamil data...
  12. pmc Measurement of metabolic tumor volume: static versus dynamic FDG scans
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P, O, Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 1:35. 2011
    ....
  13. pmc [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
    Femke E Froklage
    Division of Pharmacology, LACDR, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands
    EJNMMI Res 2:12. 2012
    ..The purpose of this study was to investigate whether [11C]flumazenil is a P-gp substrate...
  14. pmc Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
    Hedy Folkersma
    Neurosurgical Center Amsterdam, VU University Medical Center, De Boelelaan 1117, NL 1081 HV Amsterdam, The Netherlands
    J Neuroinflammation 8:67. 2011
    ..The aim of the present study was to investigate microglia activation over time following traumatic brain injury (TBI) and to relate these findings to glutamate release...
  15. pmc Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography
    Charissa E van den Brom
    Department of Endocrinology, Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Diabetol 8:39. 2009
    ..The purpose of the present study was to study in a rat model of early DCM, in vivo changes in myocardial substrate metabolism and their association with myocardial function...
  16. pmc (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, P, O, Box 9502, 2300 RA Leiden, The Netherlands
    BMC Med Imaging 11:1. 2011
    ..The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate...
  17. ncbi request reprint Myocardial perfusion in 3 dimensions
    Adriaan A Lammertsma
    Clinical PET Centre, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 43:1041-3. 2002
  18. ncbi request reprint How should we analyse FDG PET studies for monitoring tumour response?
    Adriaan A Lammertsma
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 33:16-21. 2006
    ..For a new drug, first a pilot study is performed to assess whether it affects this relationship. Based on this pilot, it is decided whether or not a simplified clinical method can be used in further studies...
  19. ncbi request reprint Radioligand studies: imaging and quantitative analysis
    Adriaan A Lammertsma
    PET Centre, VU University Medical Centre, P O Box 7057, 1022 MB, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 12:513-6. 2002
    ..For receptor studies, where binding potential is the parameter of interest, it might also be possible to avoid arterial sampling provided a tissue can be defined that is devoid of receptors...
  20. pmc Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
    Charissa E van den Brom
    Department of Internal Medicine Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Diabetol 9:25. 2010
    ..The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes...
  21. doi request reprint Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 135:2115-25. 2012
    ..As such, increased amyloid burden, together with metabolic dysfunction, in the parietal lobe of younger patients with Alzheimer's disease may contribute to the distinct cognitive profile in these patients...
  22. doi request reprint Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 80:359-65. 2013
    ..To examine the relationships between apolipoprotein E (APOE) ε4 dose and in vivo distributions of both fibrillary amyloid burden and glucose metabolism in the same Alzheimer disease dementia patients, selected for abnormal amyloid imaging...
  23. doi request reprint Absolute quantification of [(11)C]docetaxel kinetics in lung cancer patients using positron emission tomography
    Astrid A M van der Veldt
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 17:4814-24. 2011
    ..The secondary objective was to investigate whether [(11)C]docetaxel kinetics were associated with tumor perfusion, tumor size, and dexamethasone administration...
  24. doi request reprint Impaired hyperemic myocardial blood flow is associated with inducibility of ventricular arrhythmia in ischemic cardiomyopathy
    Mischa T Rijnierse
    Department of Cardiology and Institute for Cardiovascular Research, Departments of Radiology and Nuclear Medicine, Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Circ Cardiovasc Imaging 7:20-30. 2014
    ..The aim of this pilot study was to assess whether hyperemic MBF impairment may be related with VA inducibility in patients with ischemic cardiomyopathy...
  25. doi request reprint Quantification of the neurokinin 1 receptor ligand [¹¹C]R116301
    Saskia P Wolfensberger
    Department of Nuclear Medicine, Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands
    Nucl Med Commun 32:896-902. 2011
    ..The purpose of this study was to evaluate various methods for quantifying specific [¹¹C]R116301 binding...
  26. doi request reprint Systolic pulmonary artery pressure and heart rate are main determinants of oxygen consumption in the right ventricular myocardium of patients with idiopathic pulmonary arterial hypertension
    Yeun Ying Wong
    Department of Pulmonology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur J Heart Fail 13:1290-5. 2011
    ..We hypothesize that systolic pulmonary artery pressure (PAP) and heart rate (HR) are the major determinants of RV MVO(2) in IPAH...
  27. doi request reprint Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:191-7. 2009
    ..The purpose of this study was to directly compare these tracers in patients with AD, patients with mild cognitive impairment (MCI), and healthy controls...
  28. doi request reprint Supine-exercise-induced oxygen supply to the right myocardium is attenuated in patients with severe idiopathic pulmonary arterial hypertension
    Yeun Ying Wong
    Department of Pulmonology, Institute of Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Heart 97:2069-74. 2011
    ..MBF and O(2) extraction from myocardial capillaries (O(2) extraction fraction (OEF)) influence myocardial O(2) supply...
  29. doi request reprint 11C-Acetate clearance as an index of oxygen consumption of the right myocardium in idiopathic pulmonary arterial hypertension: a validation study using 15O-labeled tracers and PET
    Yeun Ying Wong
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:1258-62. 2013
    ..The purpose of the present study was to assess whether MVO2 can also be determined in the right ventricle of IPAH patients from the clearance of (11)C-acetate, a simple method that is in use for MVO2 measurements of the left myocardium...
  30. doi request reprint Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study
    Alie Schuitemaker
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:128-36. 2013
    ..The purpose of this study was to assess whether increased (R)-[(11)C]PK11195 binding is present in AD and mild cognitive impairment (MCI), currently also known as "prodromal AD."..
  31. pmc Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 32:1600-8. 2012
    ..Incorporation of V(b) within RPM, together with SVCA4, appears to be the method of choice for analyzing cerebral (R)-[(11)C]PK11195 neurodegeneration studies...
  32. doi request reprint Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes
    Luuk J Rijzewijk
    Diabetes Center, Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Am Coll Cardiol 56:225-33. 2010
    ..The purpose of this study was to investigate the relationship between hepatic triglyceride content and both myocardial function and metabolism in type 2 diabetes mellitus (T2DM)...
  33. doi request reprint Image derived input functions for dynamic High Resolution Research Tomograph PET brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 43:676-86. 2008
    ..The results of this study indicate that the use of IDIFs, extracted from OP-OSEM or PVC OP-OSEM images, is feasible for dynamic HRRT data, thereby obviating the need for online arterial sampling...
  34. doi request reprint Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Phys Med Biol 53:99-118. 2008
    ..Using NEC-TR with segmentation or MAP-TR with an adjusted human brain prior showed less overestimation in both skull thickness and AC for these structures and are therefore the recommended methods for human brain studies...
  35. doi request reprint Simplified parametric methods for [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Neuroimage 49:433-41. 2010
    ..Furthermore, in simulations, RPM2 and MRTM2 provided the most accurate and precise BP(ND) estimates. RPM2 and MRTM2 are the methods of choice for parametric analysis of [(18)F]FDDNP studies...
  36. doi request reprint Quantitative parametric perfusion images using 15O-labeled water and a clinical PET/CT scanner: test-retest variability in lung cancer
    Astrid A M van der Veldt
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 51:1684-90. 2010
    ..The purpose of the present study was to assess validity and reproducibility of dynamic H(2)(15)O PET/CT scans for measuring tumor perfusion and validate the quantitative accuracy of parametric perfusion images...
  37. ncbi request reprint Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1965-74. 2007
    ..Most anatomic regions outperformed cluster analysis in terms of absence of both scan rejection and bias. Total cerebellum is the optimal reference region in this patient category...
  38. pmc Liver fat content in type 2 diabetes: relationship with hepatic perfusion and substrate metabolism
    Luuk J Rijzewijk
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 59:2747-54. 2010
    ..The aim of the current study was to assess hepatic parenchymal perfusion, together with glucose and fatty acid metabolism, in relation to hepatic triglyceride content...
  39. doi request reprint Peripheral metabolism of [(18)F]FDDNP and cerebral uptake of its labelled metabolites
    Gert Luurtsema
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Nucl Med Biol 35:869-74. 2008
    ..These labelled metabolites were reproduced in vitro using human hepatocytes. PET studies in rats showed that these polar metabolites can penetrate the blood-brain barrier and result in uniform brain uptake...
  40. doi request reprint Longitudinal amyloid imaging using 11C-PiB: methodologic considerations
    Bart N M van Berckel
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:1570-6. 2013
    ..Several methods are in use for analyzing (11)C-Pittsburgh compound-B ((11)C-PiB) data. The objective of this study was to identify the method of choice for measuring longitudinal changes in specific (11)C-PiB binding...
  41. ncbi request reprint Does myocardial fibrosis hinder contractile function and perfusion in idiopathic dilated cardiomyopathy? PET and MR imaging study
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Room 6D 120, 1081 HV Amsterdam, The Netherlands
    Radiology 240:380-8. 2006
    ....
  42. pmc Parametric imaging of myocardial viability using ¹⁵O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR
    Stefan de Haan
    Department of Cardiology, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 39:1240-5. 2012
    ..Recent technological advances have made it possible to generate parametric PTI images from a single [(15)O]H(2)O PET/CT scan. The purpose of this study was to validate these parametric PTI images...
  43. pmc Quantitative relationship between coronary artery calcium score and hyperemic myocardial blood flow as assessed by hybrid 15O-water PET/CT imaging in patients evaluated for coronary artery disease
    Ibrahim Danad
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    J Nucl Cardiol 19:256-64. 2012
    ..The aim of this study was therefore to evaluate the relationship between CAC content, hyperemic MBF, and coronary flow reserve (CFR) in patients undergoing hybrid (15)O-water PET/CT imaging...
  44. ncbi request reprint Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H986-93. 2008
    ..These observations suggest that, in addition to reduced capillary density caused by hypertrophy, extravascular compressive forces contribute to microvascular dysfunction in HCM patients...
  45. ncbi request reprint SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1081 MB Amsterdam, The Netherlands
    Neuroimage 35:1473-9. 2007
    ..Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding)...
  46. doi request reprint Reproducibility of quantitative 18F-3'-deoxy-3'-fluorothymidine measurements using positron emission tomography
    Adrianus J de Langen
    Department of Respiratory Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:389-95. 2009
    ..For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [(18)F]FLT measurements...
  47. pmc Evaluation of tracer kinetic models for analysis of [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Mol Imaging Biol 11:322-33. 2009
    ..Different pharmacokinetic methods for [18F]FDDNP studies were evaluated using both simulations and clinical data...
  48. doi request reprint Impact of molecular imaging on the diagnostic process in a memory clinic
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:414-21. 2013
    ..We evaluated the impact of these tracers on the diagnostic process in a memory clinic population...
  49. doi request reprint Effect of type 2 diabetes mellitus on epicardial adipose tissue volume and coronary vasomotor function
    Weena J Y Chen
    Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Am J Cardiol 113:90-7. 2014
    ..In conclusion, these results suggest a role for EAT in myocardial microvascular dysfunction; however, once DM has developed, other factors might be more dominant in contributing to impaired myocardial microvascular dysfunction...
  50. ncbi request reprint Postinjection transmission scanning in myocardial 18F-FDG PET studies using both filtered backprojection and iterative reconstruction
    Arno P van der Weerdt
    Department of Cardiology, Room 6N120, Institute for Cardiovascular Research VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Nucl Med 45:169-75. 2004
    ..An additional aim of this study was to compare images reconstructed with both standard filtered backprojection (FBP) and an iterative reconstruction algorithm (ordered-subset maximization expectation [OSEM])...
  51. ncbi request reprint Impact of scar on water-perfusable tissue index in chronic ischemic heart disease: Evaluation with PET and contrast-enhanced MRI
    Paul Knaapen
    Department of Cardiology, 6D 120, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Mol Imaging Biol 8:245-51. 2006
    ..In addition, the optimal PTI threshold for detection of myocardial viability was defined when DCE-MRI was taken as a reference...
  52. doi request reprint Determinants of myocardial energetics and efficiency in symptomatic hypertrophic cardiomyopathy
    Stefan A J Timmer
    Department of Cardiology, 5F, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:779-88. 2010
    ..The present study was conducted to identify determinants of MEE in patients with HCM by use of dynamic positron emission tomography (PET) and cardiovascular magnetic resonance imaging (CMR)...
  53. pmc First evaluation of [11C]R116301 as an in vivo tracer of NK1 receptors in man
    Saskia P A Wolfensberger
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Mol Imaging Biol 11:241-5. 2009
    ..R116301 is a selective NK1 receptor antagonist. In this pilot study, [(11)C]R116301 was evaluated as a potential positron emission tomography (PET) ligand for the NK1 receptor...
  54. ncbi request reprint Prognostic relevance of response evaluation using [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with locally advanced non-small-cell lung cancer
    Corneline J Hoekstra
    Department of Nuclear Medicine, Vrije University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 23:8362-70. 2005
    ....
  55. doi request reprint Hybrid imaging using quantitative H215O PET and CT-based coronary angiography for the detection of coronary artery disease
    Ibrahim Danad
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:55-63. 2013
    ..In addition, this study aimed to evaluate and compare the accuracy of hyperemic MBF versus coronary flow reserve (CFR)...
  56. doi request reprint Carotid artery intima-media thickness, but not coronary artery calcium, predicts coronary vascular resistance in patients evaluated for coronary artery disease
    Ibrahim Danad
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur Heart J Cardiovasc Imaging 13:317-23. 2012
    ..An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal coronary vascular resistance (CVR)...
  57. pmc Coronary microvascular resistance: methods for its quantification in humans
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Basic Res Cardiol 104:485-98. 2009
    ..This review is intended to provide an update pertaining to the methodology of these different imaging techniques, including the discussion of their strengths and weaknesses...
  58. pmc Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients
    Astrid A M van der Veldt
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1950-8. 2010
    ..The purpose of the present study was to determine the biodistribution and radiation absorbed dose of [(11)C]docetaxel in humans...
  59. doi request reprint Gap filling strategies for 3-D-FBP reconstructions of High-Resolution Research Tomograph scans
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    IEEE Trans Med Imaging 27:934-42. 2008
    ..Therefore, use of confosp for filling sinogram gaps with both iterative and noniterative estimation of missing planes are recommended for quantitative 3-D-FBP of HRRT studies...
  60. ncbi request reprint Evaluation of methods for generating parametric (R-[11C]PK11195 binding images
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1603-15. 2007
    ..In pathological conditions with reduced flow rates or large variations in blood volume, the basis function method is preferred because it produces less bias and is more precise...
  61. doi request reprint Widespread and prolonged increase in (R)-(11)C-PK11195 binding after traumatic brain injury
    Hedy Folkersma
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 52:1235-9. 2011
    ..Our objective was to measure (R)-(11)C-PK11195 binding as an indirect marker of neuronal damage after traumatic brain injury (TBI)...
  62. ncbi request reprint Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET
    Mark Lubberink
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:424-33. 2007
    ....
  63. doi request reprint Right ventricular failure in idiopathic pulmonary arterial hypertension is associated with inefficient myocardial oxygen utilization
    Yeun Ying Wong
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circ Heart Fail 4:700-6. 2011
    ..We related RV mechanical efficiency to clinical and hemodynamic parameters of RV function in patients with IPAH and associated it with glucose metabolism...
  64. pmc In vivo validation of reconstruction-based resolution recovery for human brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 30:381-9. 2010
    ....
  65. ncbi request reprint Quantitative 89Zr immuno-PET for in vivo scouting of 90Y-labeled monoclonal antibodies in xenograft-bearing nude mice
    Iris Verel
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 44:1663-70. 2003
    ..In this study, the biodistribution of (89)Zr-labeled and (88)Y-labeled mAb ((88)Y as substitute for (90)Y) was compared and the quantitative imaging performance of (89)Zr immuno-PET was evaluated...
  66. doi request reprint Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C]docetaxel and positron emission tomography
    Astrid A M van der Veldt
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 19:4163-73. 2013
    ..The objective of this study was to investigate whether a [(11)C]docetaxel PET microdosing study could predict tumor uptake of therapeutic doses of docetaxel...
  67. doi request reprint Radiation dose of the P-glycoprotein tracer 11C-laniquidar
    Andrey Postnov
    Departments of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:2101-3. 2013
    ..Given potential interspecies differences in biodistribution, the purpose of this study was to ensure safe use of (11)C-laniquidar by determining the dosimetry of (11)C-laniquidar using whole-body PET studies...
  68. doi request reprint Microglial activation in healthy aging
    Alie Schuitemaker
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Neurobiol Aging 33:1067-72. 2012
    ..This indicates that activated microglia appear in several cortical and subcortical areas during healthy aging, suggesting widespread neuronal loss...
  69. doi request reprint Image-derived input functions for PET brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:463-71. 2009
    ..To assess the robustness of a previously introduced method to obtain accurate image-derived input functions (IDIF) for three other tracers...
  70. ncbi request reprint Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial
    Nanda C Krak
    Clinical PET Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 32:294-301. 2005
    ..The main purpose of this study was to determine the effects of different ROI methods on quantitative outcome, using two reconstruction methods and the standard uptake value (SUV) as a simple quantitative measure of FDG uptake...
  71. ncbi request reprint 18F-2-fluoro-2-deoxy-d-glucose positron emission tomography in staging of locally advanced breast cancer
    Jacobus J M van Der Hoeven
    Departments of Nuclear Medicine and PET Research, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 22:1253-9. 2004
    ..To prospectively evaluate the effect of adding whole-body (18)F-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) to conventional screening for distant metastases in patients with locally advanced breast cancer (LABC)...
  72. ncbi request reprint Effects of attenuation correction and reconstruction method on PET activation studies
    Catalina T Mesina
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 20:898-908. 2003
    ..It is concluded that OSEM is a good alternative for FBP reconstructions providing SPM results with less noise...
  73. ncbi request reprint Performance of immuno-positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients
    Pontus K E Börjesson
    Department of Otolaryngology Head and Neck Surgery, Nuclear Medicine and Positron Emission Tomography Research, Radiology, Amsterdam, The Netherlands
    Clin Cancer Res 12:2133-40. 2006
    ....
  74. pmc Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:1629-38. 2009
    ....
  75. doi request reprint Relation of coronary microvascular dysfunction in hypertrophic cardiomyopathy to contractile dysfunction independent from myocardial injury
    Stefan A J Timmer
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 107:1522-8. 2011
    ..When present, DCE reflected a progressed disease state as characterized by an increased perfusion deficit and contractile dysfunction...
  76. ncbi request reprint Accuracy of 3D acquisition mode for myocardial FDG PET studies using a BGO-based scanner
    Arno P van der Weerdt
    Department of Cardiology, Institute for Cardiovascular Research VU, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 34:1439-46. 2007
    ..The aim of the present study was to evaluate the quantitative and qualitative accuracy of 3D PET acquisitions for myocardial FDG studies...
  77. doi request reprint Accuracy of 3-dimensional reconstruction algorithms for the high-resolution research tomograph
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:72-80. 2009
    ..The goal of this study was to evaluate quantitative accuracy of these iterative reconstruction algorithms, compared with 3-dimensional filtered backprojection (3D-FBP)...
  78. doi request reprint Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:1464-70. 2009
    ....
  79. ncbi request reprint Hyperaemic microvascular resistance is not increased in viable myocardium after chronic myocardial infarction
    Koen M Marques
    Department of Cardiology, VU University Medical Centre, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur Heart J 28:2320-5. 2007
    ..The present study compared microvascular resistance (MR) of viable myocardium in infarct areas with those in reference areas in patients with chronic myocardial infarction (MI)...
  80. doi request reprint Pharmacokinetic analysis of [18F]FAZA in non-small cell lung cancer patients
    Eline E Verwer
    Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 40:1523-31. 2013
    ..The aims of this study were to determine the optimal kinetic model along with validation of using alternatives to arterial blood sampling for analysing [(18)F]FAZA studies and to assess the validity of simplified analytical methods...
  81. ncbi request reprint Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography
    Rolf Toornvliet
    Department of Clinical Pharmacology and Pharmacy, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Pharmacol Ther 79:540-8. 2006
    ..Furthermore, the relationship between BBB P-gp activity and peripheral P-gp activity in CD3-positive leukocytes was investigated. Finally, plasma pharmacokinetics of carbon 11-labeled (R)-verapamil was evaluated...
  82. pmc No evidence for additional blood-brain barrier P-glycoprotein dysfunction in Alzheimer's disease patients with microbleeds
    Daniëlle M E van Assema
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 32:1468-71. 2012
    ..No differences were found in binding potential and nonspecific volume of distribution of (R)-[(11)C]verapamil between patient groups. These results provide no evidence for additional Pgp dysfunction in AD patients with MBs...
  83. doi request reprint Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction
    Stefan A J Timmer
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur J Heart Fail 13:1283-9. 2011
    ..Therefore, the aim was to investigate myocardial perfusion and energetics in genotype-positive, phenotype-negative HCM subjects (carriers)...
  84. doi request reprint Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: findings of a prospective pilot study
    Yoony Y J Gent
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 64:62-6. 2012
    ....
  85. ncbi request reprint Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat
    Gert Luurtsema
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Nucl Med Biol 32:87-93. 2005
    ..Sixty minutes after injection, unmetabolized (R)-[11C] verapamil was 27% and 48% in the plasma and the brain, respectively...
  86. pmc Association of plasma osteoprotegerin and adiponectin with arterial function, cardiac function and metabolism in asymptomatic type 2 diabetic men
    Weena J Y Chen
    Diabetes Center Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Cardiovasc Diabetol 10:67. 2011
    ..We assessed the relationship of plasma OPG and ADPN and arterial function, cardiac function and myocardial glucose metabolism in T2DM...
  87. ncbi request reprint Microvascular function in viable myocardium after chronic infarction does not influence fractional flow reserve measurements
    Koen M Marques
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 48:1987-92. 2007
    ..Therefore, the correlation between FFR and RFR using H(2)(15)O PET was studied...
  88. pmc Feasibility of subendocardial and subepicardial myocardial perfusion measurements in healthy normals with (15)O-labeled water and positron emission tomography
    Ilse A Vermeltfoort
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    J Nucl Cardiol 18:650-6. 2011
    ..The aim of this study is to determine the feasibility of subendocardial and subepicardial MBF in normal human hearts assessed with (15)O-labeled water PET...
  89. pmc Measuring response to therapy using FDG PET: semi-quantitative and full kinetic analysis
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:832-42. 2011
    ..The goal of this study was to analyse and compare various semi-quantitative measures for response assessment with full kinetic analysis, specifically in assessment of novel therapies...
  90. doi request reprint Reference tissue models and blood-brain barrier disruption: lessons from (R)-[11C]PK11195 in traumatic brain injury
    Hedy Folkersma
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:1975-9. 2009
    ..The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[(11)C]PK11195 studies in traumatic brain injury (TBI), where blood-brain barrier disruptions are likely...
  91. doi request reprint Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results
    Ursula M H Klumpers
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:565-74. 2010
    ..Although GABA has been suggested to inhibit HPA axis activity, their relationship has never been studied at the level of the central GABA(A)-benzodiazepine receptor in depressed patients or in relation to antidepressant treatment...
  92. doi request reprint Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging
    Luuk J Rijzewijk
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 54:1524-32. 2009
    ....
  93. doi request reprint Effects of image characteristics on performance of tumor delineation methods: a test-retest assessment
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 52:1550-8. 2011
    ..The purpose of this study was to assess test-retest variability of tumor delineation methods, with emphasis on the effects of several image characteristics (e.g., resolution and contrast)...
  94. doi request reprint Reproducibility of tumor perfusion measurements using 15O-labeled water and PET
    Adrianus J de Langen
    Department of Respiratory Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 49:1763-8. 2008
    ..However, to use the technique for serial imaging of individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative H215O measurements...
  95. doi request reprint Simplified parametric methods for [11C]PIB studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 42:76-86. 2008
    ..RPM2 and MRTM2 also provided best accuracy and precision in the simulation studies and are therefore the methods of choice for parametric analysis of clinical [11C]PIB studies...
  96. pmc Partial volume correction strategies for quantitative FDG PET in oncology
    Nikie J Hoetjes
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1679-87. 2010
    ..The purpose of the present study was to assess accuracy and precision of different partial volume correction (PVC) methods...
  97. doi request reprint Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats
    Gert Luurtsema
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Nucl Med Biol 36:643-9. 2009
    ..Valspodar did not have any effect on cerebral uptake of [11C]laniquidar. In vivo rate of metabolism was relatively low. Further kinetic studies are needed to investigate the antagonistic behaviour of [11C]laniquidar at tracer level...
  98. doi request reprint Dementia mimicking Alzheimer's disease Owing to a tau mutation: CSF and PET findings
    Nelleke Tolboom
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 24:303-7. 2010
    ..This, in combination with elevated levels of CSF t-tau and p-tau, has potential value in differential diagnosis of frontotemporal dementia from AD...
  99. pmc Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studies
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:1636-47. 2011
    ..The purpose of this study was therefore to implement and characterize a method that enables quantification of heterogeneity in tumour FDG uptake...
  100. ncbi request reprint FDG PET as a predictor of response to resynchronisation therapy in patients with ischaemic cardiomyopathy
    C M C van Campen
    Department of Cardiology, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 34:309-15. 2007
    ....
  101. pmc Impact of [¹⁸F]FDG PET imaging parameters on automatic tumour delineation: need for improved tumour delineation methodology
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:2136-44. 2011
    ..e. reconstruction parameters, noise levels and tumour characteristics, and thereby the need for standardization or inter-institute calibration...