Tjeerd Germans

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Extent of late gadolinium enhancement detected by cardiovascular magnetic resonance correlates with the inducibility of ventricular tachyarrhythmia in hypertrophic cardiomyopathy
    Stephan Fluechter
    1st Medical Department, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    J Cardiovasc Magn Reson 12:30. 2010
  2. pmc Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness
    Iris K Rüssel
    Department of Clinical Physics, HagaZiekenhuis, The Hague, The Netherlands
    J Cardiovasc Magn Reson 13:3. 2011
  3. pmc CMR findings in patients with hypertrophic cardiomyopathy and atrial fibrillation
    Theano Papavassiliu
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Mannheim, Germany
    J Cardiovasc Magn Reson 11:34. 2009
  4. ncbi request reprint Images in cardiovascular medicine. Prominent crypt formation in the inferoseptum of a hypertrophic cardiomyopathy mutation carrier mimics noncompaction cardiomyopathy
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Circulation 115:e610-1. 2007
  5. doi request reprint The use of cardiac magnetic resonance imaging to determine the aetiology of left ventricular disease and cardiomyopathy
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Heart 94:510-8. 2008
  6. ncbi request reprint Effects of aging on left atrioventricular coupling and left ventricular filling assessed using cardiac magnetic resonance imaging in healthy subjects
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 100:122-7. 2007
  7. ncbi request reprint Structural abnormalities of the inferoseptal left ventricular wall detected by cardiac magnetic resonance imaging in carriers of hypertrophic cardiomyopathy mutations
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 48:2518-23. 2006
  8. pmc How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 12:13. 2010
  9. doi request reprint Effects of alcohol septal ablation on coronary microvascular function and myocardial energetics in hypertrophic obstructive cardiomyopathy
    Stefan A J Timmer
    Dept of Cardiology, 5F, VU Univ Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 301:H129-37. 2011
  10. doi request reprint Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction
    Stefan A J Timmer
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur J Heart Fail 13:1283-9. 2011

Collaborators

Detail Information

Publications36

  1. pmc Extent of late gadolinium enhancement detected by cardiovascular magnetic resonance correlates with the inducibility of ventricular tachyarrhythmia in hypertrophic cardiomyopathy
    Stephan Fluechter
    1st Medical Department, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    J Cardiovasc Magn Reson 12:30. 2010
    ..We hypothesized that the extent of LGE might be associated with the inducibility of ventricular tachyarrhythmias (VT) during programmed ventricular stimulation (PVS)...
  2. pmc Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness
    Iris K Rüssel
    Department of Clinical Physics, HagaZiekenhuis, The Hague, The Netherlands
    J Cardiovasc Magn Reson 13:3. 2011
    ..We hypothesize that increased LV torsion is already present in healthy mutation carriers with normal wall thickness...
  3. pmc CMR findings in patients with hypertrophic cardiomyopathy and atrial fibrillation
    Theano Papavassiliu
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Mannheim, Germany
    J Cardiovasc Magn Reson 11:34. 2009
    ....
  4. ncbi request reprint Images in cardiovascular medicine. Prominent crypt formation in the inferoseptum of a hypertrophic cardiomyopathy mutation carrier mimics noncompaction cardiomyopathy
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Circulation 115:e610-1. 2007
  5. doi request reprint The use of cardiac magnetic resonance imaging to determine the aetiology of left ventricular disease and cardiomyopathy
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Heart 94:510-8. 2008
  6. ncbi request reprint Effects of aging on left atrioventricular coupling and left ventricular filling assessed using cardiac magnetic resonance imaging in healthy subjects
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 100:122-7. 2007
    ..Conduit volume contributed most to LV filling and decreased with age, suggesting it to be an indicator of diastolic function...
  7. ncbi request reprint Structural abnormalities of the inferoseptal left ventricular wall detected by cardiac magnetic resonance imaging in carriers of hypertrophic cardiomyopathy mutations
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 48:2518-23. 2006
    ....
  8. pmc How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 12:13. 2010
    ..We aimed to confirm the presence of functional abnormalities using cardiovascular magnetic resonance (CMR), and to investigate if sensitive functional assessment could be employed to identify carriers...
  9. doi request reprint Effects of alcohol septal ablation on coronary microvascular function and myocardial energetics in hypertrophic obstructive cardiomyopathy
    Stefan A J Timmer
    Dept of Cardiology, 5F, VU Univ Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 301:H129-37. 2011
    ..Furthermore, ASA has favorable effects on myocardial energetics...
  10. doi request reprint Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction
    Stefan A J Timmer
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur J Heart Fail 13:1283-9. 2011
    ..Therefore, the aim was to investigate myocardial perfusion and energetics in genotype-positive, phenotype-negative HCM subjects (carriers)...
  11. doi request reprint Determinants of myocardial energetics and efficiency in symptomatic hypertrophic cardiomyopathy
    Stefan A J Timmer
    Department of Cardiology, 5F, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:779-88. 2010
    ..The present study was conducted to identify determinants of MEE in patients with HCM by use of dynamic positron emission tomography (PET) and cardiovascular magnetic resonance imaging (CMR)...
  12. ncbi request reprint Mechanical dyssynchrony or myocardial shortening as MRI predictor of response to biventricular pacing?
    Iris K Rüssel
    Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
    J Magn Reson Imaging 26:1452-60. 2007
    ..To investigate whether mechanical dyssynchrony (regional timing differences) or heterogeneity (regional strain differences) in myocardial function should be used to predict the response to cardiac resynchronization therapy (CRT)...
  13. doi request reprint Relation of coronary microvascular dysfunction in hypertrophic cardiomyopathy to contractile dysfunction independent from myocardial injury
    Stefan A J Timmer
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 107:1522-8. 2011
    ..When present, DCE reflected a progressed disease state as characterized by an increased perfusion deficit and contractile dysfunction...
  14. doi request reprint Relation between three-dimensional echocardiography derived left ventricular volume and MRI derived circumferential strain in patients eligible for cardiac resynchronization therapy
    Iris K Rüssel
    Department of Physics and Medical Technology, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands
    Int J Cardiovasc Imaging 25:1-11. 2009
    ..To compare regional left ventricular (LV) volume curves obtained with real time three-dimensional echocardiography (RT3DE) with two-dimensional circumferential strain curves obtained by MRI in cardiac resynchronization therapy candidates...
  15. doi request reprint Right ventricular energetics in patients with hypertrophic cardiomyopathy and the effect of alcohol septal ablation
    S A J Timmer
    Department of Cardiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Card Fail 17:827-31. 2011
    ..The aim was to study right-to-left ventricular oxidative metabolism in HCM and the effects of alcohol septal ablation (ASA)...
  16. pmc Feasibility of subendocardial and subepicardial myocardial perfusion measurements in healthy normals with (15)O-labeled water and positron emission tomography
    Ilse A Vermeltfoort
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    J Nucl Cardiol 18:650-6. 2011
    ..The aim of this study is to determine the feasibility of subendocardial and subepicardial MBF in normal human hearts assessed with (15)O-labeled water PET...
  17. doi request reprint Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations
    E Rosalie Witjas-Paalberends
    Department of Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 103:248-57. 2014
    ..This study investigated if mutations in genes encoding myosin-binding protein C (MYBPC3) and myosin heavy chain (MYH7) underlie changes in the energetic cost of contraction in the development of human HCM disease...
  18. doi request reprint Multiple myocardial crypts on modified long-axis view are a specific finding in pre-hypertrophic HCM mutation carriers
    Wessel P Brouwer
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur Heart J Cardiovasc Imaging 13:292-7. 2012
    ..Finally, we evaluated the accuracy of crypts to identify carriers in HCM family screening...
  19. ncbi request reprint The effect of left bundle branch block on left ventricular remodeling, dyssynchrony and deformation of the mitral valve apparatus: an observational cardiovascular magnetic resonance imaging study
    Vroni van der Land
    Department of Cardiology, VU Univerisity Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Int J Cardiovasc Imaging 23:529-36. 2007
    ....
  20. pmc Arrhythmogenic right ventricular cardiomyopathy with evidence of biventricular involvement
    Robin Nijveldt
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    CMAJ 176:1819-21. 2007
  21. pmc Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations
    Vasco Sequeira
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circ Res 112:1491-505. 2013
    ..However, myofilament Ca(2+) sensitivity depends on protein phosphorylation and muscle length, and at present, data in humans are scarce...
  22. doi request reprint Stroke volume measurements with first-pass dynamic positron emission tomography: comparison with cardiovascular magnetic resonance
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Cardiol 15:218-24. 2008
    ..The aim of this study was to compare first-pass derived SV with cardiovascular magnetic resonance imaging (CMR)-obtained values in a larger population of subjects...
  23. ncbi request reprint Myocardial strain and torsion quantified by cardiovascular magnetic resonance tissue tagging: studies in normal and impaired left ventricular function
    Marco J W Götte
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 48:2002-11. 2006
    ..This review discusses the clinical use of cardiovascular magnetic resonance tissue tagging for quantitative assessment of regional myocardial function, thereby underlining the specific features and emerging role of this technique...
  24. ncbi request reprint Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H986-93. 2008
    ..These observations suggest that, in addition to reduced capillary density caused by hypertrophy, extravascular compressive forces contribute to microvascular dysfunction in HCM patients...
  25. pmc In-vivo T1 cardiovascular magnetic resonance study of diffuse myocardial fibrosis in hypertrophic cardiomyopathy
    Wessel P Brouwer
    Department of Cardiology, ICaR VU, VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
    J Cardiovasc Magn Reson 16:28. 2014
    ..We hypothesized that with T1 mapping, which is employed to determine the myocardial extracellular volume fraction (ECV), can detect diffuse interstitial fibrosis in HCM patients...
  26. pmc Feature tracking compared with tissue tagging measurements of segmental strain by cardiovascular magnetic resonance
    Lina Wu
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 16:10. 2014
    ....
  27. doi request reprint The development of familial hypertrophic cardiomyopathy: from mutation to bedside
    Wessel P Brouwer
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 41:568-78. 2011
    ..Additionally, present and future therapeutic options will be briefly discussed...
  28. doi request reprint Semi-quantitative assessment of right ventricular function in comparison to a 3D volumetric approach: a cardiovascular magnetic resonance study
    Robin Nijveldt
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur Radiol 18:2399-405. 2008
    ..The 3D volumetric approach is preferred to assess RV function for research purposes or to evaluate treatment response...
  29. ncbi request reprint Myocardial energetics and efficiency: current status of the noninvasive approach
    Paul Knaapen
    Department of Cardiology, 6D 120, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Circulation 115:918-27. 2007
  30. ncbi request reprint Images in cardiovascular medicine. Coronary collaterals in full effect
    Paul Knaapen
    Department of Cardiology, 6D 120, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Circulation 114:e501-2. 2006
  31. ncbi request reprint A corpulent heart. Lipomatous hypertrophy of the interatrial septum
    Constantin Marcu
    Department of Cardiology, VU Medical Centre, Amsterdam, The Netherlands
    N Z Med J 118:U1720. 2005
  32. ncbi request reprint Assessment of mitral annulus size and function by real-time 3-dimensional echocardiography in cardiomyopathy: comparison with magnetic resonance imaging
    Ashraf M Anwar
    Cardiology Department, Al Husein University Hospital, Al Azhar University, Cairo, Egypt
    J Am Soc Echocardiogr 20:941-8. 2007
    ..We sought to assess mitral annular (MA) size and function in hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) using real-time 3-dimensional (3D) echocardiography (RT3DE)...
  33. doi request reprint A more detailed view calls for more detailed definition: description of cardiac morphology with high-resolution CT and MRI
    Tjeerd Germans
    AJR Am J Roentgenol 190:W169. 2008
  34. ncbi request reprint Quantitative comparison of 2D and 3D circumferential strain using MRI tagging in normal and LBBB hearts
    Sandra R R Tecelão
    Institute of Biophysics and Biomedical Engineering, University of Lisbon, Lisbon, Portugal
    Magn Reson Med 57:485-93. 2007
    ..Thus, to measure dyssynchrony, 2D strain analysis will suffice. Since 2D analysis is easier to implement than 3D analysis, this finding brings the application of MRI tagging and strain analysis closer to the clinical routine...
  35. ncbi request reprint Non-compaction: a distinct cardiomyopathy or non-specific morphological trait?
    Tjeerd Germans
    Eur Heart J 29:949-50; author reply 950-1. 2008
  36. doi request reprint Role of magnetic resonance imaging in arrhythmogenic right ventricular cardiomyopathy
    Robin Nijveldt
    Am Heart J 155:e57. 2008