Johannes M A Daniels
Affiliation: VU University Medical Center
Country: The Netherlands
- Sputum colour reported by patients is not a reliable marker of the presence of bacteria in acute exacerbations of chronic obstructive pulmonary diseaseJ M A Daniels
Department of Pulmonary Diseases, Medical Centre Alkmaar, Alkmaar, The Netherlands
Clin Microbiol Infect 16:583-8. 2010..Assessed sputum colour is clearly superior and is also related to bacterial load and systemic inflammation...
- Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary diseaseJohannes M A Daniels
Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Am J Respir Crit Care Med 181:150-7. 2010..The role of antibiotics in acute exacerbations is controversial and their efficacy when added to systemic corticosteroids is unknown...
- Procalcitonin vs C-reactive protein as predictive markers of response to antibiotic therapy in acute exacerbations of COPDJohannes M A Daniels
Department of Pulmonary Diseases, Medical Centre Alkmaar, The Netherlands
Chest 138:1108-15. 2010..Rational prescription of antibiotics in acute exacerbations of COPD (AECOPD) requires predictive markers. We aimed to analyze whether markers of systemic inflammation can predict response to antibiotics in AECOPD...
- Efficacy of corticosteroids in community-acquired pneumonia: a randomized double-blinded clinical trialDominic Snijders
Department of Pulmonary Diseases, Medical Centre Alkmaar, Wilhelminalaan 15, 1812 JD Alkmaar, The Netherlands
Am J Respir Crit Care Med 181:975-82. 2010..Some studies have shown a beneficial effect of corticosteroids in patients with community-acquired pneumonia (CAP), possibly by diminishing local and systemic antiinflammatory host response...
- Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trialHendrik J Prins
Department Pulmonary Diseases, Medical Centre Alkmaar, Alkmaar, The Netherlands
Respir Med 110:46-52. 2016..The tetracycline analogue doxycycline has been shown to inhibit neutrophil-mediated inflammation. It was thus reasoned that doxycycline may attenuate neutrophil-mediated inflammation in COPD...