Jean G F Bronzwaer

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Endomyocardial nitric oxide synthase and the hemodynamic phenotypes of human dilated cardiomyopathy and of athlete's heart
    Jean G F Bronzwaer
    Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cardiovasc Res 55:270-8; discussion 225-8. 2002
  2. ncbi request reprint Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy
    Jean G F Bronzwaer
    VU University Medical Center and Institute for Cardiovascular Research VU, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H10-6. 2003
  3. ncbi request reprint Right coronary artery flow impairment in patients with pulmonary hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Noord Holland, The Netherlands
    Eur Heart J 29:120-7. 2008
  4. ncbi request reprint Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients
    C Tji Joong Gan
    VU University Medical Center, De Boelelaan 1117 PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:11-7. 2007
  5. doi request reprint Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction
    Nazha Hamdani
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Eur Heart J 30:1863-72. 2009
  6. doi request reprint Low myocardial protein kinase G activity in heart failure with preserved ejection fraction
    Loek van Heerebeek
    Department of Physiology, Cardiology, Pathology, and Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 126:830-9. 2012
  7. ncbi request reprint Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium
    Jolanda van der Velden
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 69:876-87. 2006
  8. ncbi request reprint Myocardial structure and function differ in systolic and diastolic heart failure
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU Medical Center, Amsterdam, The Netherlands
    Circulation 113:1966-73. 2006
  9. ncbi request reprint Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 117:43-51. 2008
  10. ncbi request reprint Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Endomyocardial nitric oxide synthase and the hemodynamic phenotypes of human dilated cardiomyopathy and of athlete's heart
    Jean G F Bronzwaer
    Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cardiovasc Res 55:270-8; discussion 225-8. 2002
    ....
  2. ncbi request reprint Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy
    Jean G F Bronzwaer
    VU University Medical Center and Institute for Cardiovascular Research VU, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H10-6. 2003
    ..In DCM, myocardial fibrosis is unrelated to the intensity of myocardial gene expression of NOS, antioxidative enzymes (HO-1), or cytokines (TNF-alpha) and blunts NOS2-related recruitment of LV preload reserve...
  3. ncbi request reprint Right coronary artery flow impairment in patients with pulmonary hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Noord Holland, The Netherlands
    Eur Heart J 29:120-7. 2008
    ..This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion...
  4. ncbi request reprint Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients
    C Tji Joong Gan
    VU University Medical Center, De Boelelaan 1117 PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:11-7. 2007
    ..In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity...
  5. doi request reprint Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction
    Nazha Hamdani
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Eur Heart J 30:1863-72. 2009
    ....
  6. doi request reprint Low myocardial protein kinase G activity in heart failure with preserved ejection fraction
    Loek van Heerebeek
    Department of Physiology, Cardiology, Pathology, and Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 126:830-9. 2012
    ..To discern altered control of myocardial remodeling by PKG, HFPEF was compared with aortic stenosis and HF with reduced EF (HFREF)...
  7. ncbi request reprint Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium
    Jolanda van der Velden
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 69:876-87. 2006
    ..This study was designed to reveal the effects of PKC on myofilament function in human myocardium under basal conditions and upon modulation of protein phosphorylation by PKA and phosphatases...
  8. ncbi request reprint Myocardial structure and function differ in systolic and diastolic heart failure
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU Medical Center, Amsterdam, The Netherlands
    Circulation 113:1966-73. 2006
    ....
  9. ncbi request reprint Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 117:43-51. 2008
    ..The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF...
  10. ncbi request reprint Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
    ..This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH)...
  11. doi request reprint Clinically significant change in stroke volume in pulmonary hypertension
    Serge A van Wolferen
    VU University Medical Center, Department of Pulmonary Disease, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Chest 139:1003-9. 2011
    ..However, the extent of change in stroke volume that constitutes a clinically significant change is unknown. The aim of this study was to determine the minimal important difference (MID) in stroke volume in PH...
  12. doi request reprint Effects of QRS duration and pacing location on pressure-volume loop evaluation of cardiac resynchronization therapy in end-stage heart failure
    Gerben J de Roest
    Department of Cardiology and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 108:1581-8. 2011
    ..The temporary biventricular stimulation protocol might aid in individual patient selection and in research aiming at a reduction of nonresponders and improvement in lead positioning...
  13. doi request reprint Prediction of long-term outcome of cardiac resynchronization therapy by acute pressure-volume loop measurements
    Gerben J de Roest
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Heart Fail 15:299-307. 2013
    ..However, the long-term results of this approach have been poorly studied. The present study relates acute haemodynamic effects of CRT to long-term outcome...
  14. ncbi request reprint Effects of aging on left atrioventricular coupling and left ventricular filling assessed using cardiac magnetic resonance imaging in healthy subjects
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 100:122-7. 2007
    ..Conduit volume contributed most to LV filling and decreased with age, suggesting it to be an indicator of diastolic function...
  15. ncbi request reprint Cardiomyocyte stiffness in diastolic heart failure
    Attila Borbely
    Laboratory for Physiology, Institute for Cardiovascular Research, VUMC, Amsterdam, The Netherlands
    Circulation 111:774-81. 2005
    ..Single cardiomyocytes were isolated from these biopsy samples to assess cellular contractile performance...
  16. ncbi request reprint Diastolic and systolic heart failure: different stages or distinct phenotypes of the heart failure syndrome?
    Jean G F Bronzwaer
    Department of Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Curr Heart Fail Rep 6:281-6. 2009
    ..This review analyzes arguments supporting DHF and SHF as successive stages or distinct phenotypes of the HF syndrome...
  17. ncbi request reprint Assessment of coronary artery bypass graft disease using cardiovascular magnetic resonance determination of flow reserve
    Willemijn L F Bedaux
    Department of Cardiology, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Am Coll Cardiol 40:1848-55. 2002
    ..The purpose of this study was to assess the value of cardiovascular magnetic resonance (CMR)-determined graft flow and flow reserve in differentiating significant from non-significant vein graft disease...
  18. pmc Improved clinical outcome after invasive management of patients with recent myocardial infarction and proven myocardial viability: primary results of a randomized controlled trial (VIAMI-trial)
    Ramon B van Loon
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Trials 13:1. 2012
    ..Therefore, an invasive strategy with PCI of the infarct-related coronary artery in patients with viability would reduce the occurrence of a composite end point of death, reinfarction, or unstable angina (UA)...
  19. ncbi request reprint Nitric oxide's role in the heart: control of beating or breathing?
    Walter J Paulus
    Institute for Cardiovascular Research, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 287:H8-13. 2004
    ..A drop in these concerted actions of NO on diastolic LV distensibility and on myocardial energetics could well be instrumental for the relentless deterioration of failing myocardium...
  20. doi request reprint Recurrent ventricular fibrillation caused by coronary artery spasm leading to implantable cardioverter defibrillator implantation
    Matthijs L Hendriks
    Department of Cardiology, VU University Medical Centre, Amsterdam, The Netherlands
    Europace 10:1456-7. 2008
    ..During an intra-coronary acetylcholine provocation test, severe coronary spasm could be induced. The patient was treated with a hybrid approach of medication and an implantable defibrillator...
  21. ncbi request reprint Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension
    C Tji Joong Gan
    Dept of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 290:H1528-33. 2006
    ..In PAH patients, ventricular interaction mediated by the interventricular septum impairs left ventricular filling, contributing to decreased stroke volume...
  22. ncbi request reprint Effects of epoprostenol on right ventricular hypertrophy and dilatation in pulmonary hypertension
    Roald J Roeleveld
    Department of Pulmonology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Chest 125:572-9. 2004
    ..To gain more knowledge of changes in main pulmonary artery flow and right ventricular mass and volumes in patients with pulmonary hypertension during epoprostenol therapy...
  23. pmc Myofilament degradation and dysfunction of human cardiomyocytes in Fabry disease
    Cristina Chimenti
    Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele La Pisana, Rome, Italy
    Am J Pathol 172:1482-90. 2008
    ..Partial reversal of high resting tension after pharmacological PKA treatment of cardiomyocytes suggests potential benefits from enzyme replacement therapy and/or energy-releasing agents...
  24. ncbi request reprint What mechanisms underlie diastolic dysfunction in heart failure?
    David A Kass
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circ Res 94:1533-42. 2004
    ..This review puts these developments into perspective with the major aim of highlighting current knowledge gaps and controversies...
  25. ncbi request reprint Matrix, cytoskeleton, or myofilaments: which one to blame for diastolic left ventricular dysfunction?
    Jean G F Bronzwaer
    Department of Physiology and Cardiology, Institute for Cardiovascular Research ICaR VU, Vrije Universitrit Amsterdam, The Netherlands
    Prog Cardiovasc Dis 47:276-84. 2005
    ....
  26. ncbi request reprint Myocardial contractile effects of nitric oxide
    Walter J Paulus
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Heart Fail Rev 7:371-83. 2002
    ..Finally, shifts in isoforms or in concentrations of myofilaments can affect NO-mediated myofilamentary desensitization and alter the myocardial contractile effects of NO in hypertrophied or failing myocardium...
  27. ncbi request reprint High dose adenosine for suboptimal myocardial reperfusion after primary PCI: A randomized placebo-controlled pilot study
    Martin G Stoel
    Department of Cardiology, Medisch Spectrum Twente, Enschede, The Netherlands
    Catheter Cardiovasc Interv 71:283-9. 2008
    ..This study was designed to investigate the influence of high dose intracoronary adenosine on persistent ST-segment elevation after primary percutaneous coronary intervention (PCI)...