Henk W Berendse

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Detection of preclinical Parkinson's disease along the olfactory trac(t)
    H W Berendse
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Neural Transm Suppl . 2006
  2. ncbi request reprint [Presymptomatic detection of Parkinson's disease]
    H W Berendse
    Research Institute Neurosciences Vrije Universiteit, Afdeling Neurologie, VU Medisch Centrum, De Boelelaan 1117, 1081 HV Amsterdam
    Tijdschr Gerontol Geriatr 33:70-7. 2002
  3. doi request reprint Diagnosing premotor Parkinson's disease using a two-step approach combining olfactory testing and DAT SPECT imaging
    Henk W Berendse
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Parkinsonism Relat Disord 15:S26-30. 2009
  4. doi request reprint Stage-dependent patterns of disturbed neural synchrony in Parkinson's disease
    Henk W Berendse
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    Parkinsonism Relat Disord 13:S440-5. 2007
  5. doi request reprint Motor and non-motor correlates of olfactory dysfunction in Parkinson's disease
    Henk W Berendse
    Dept of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Neurol Sci 310:21-4. 2011
  6. doi request reprint Disrupted brain network topology in Parkinson's disease: a longitudinal magnetoencephalography study
    Kim T E Olde Dubbelink
    1 Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 137:197-207. 2014
  7. doi request reprint Slowing of M1 activity in Parkinson's disease during rest and movement--an MEG study
    Alistair N Vardy
    Faculty of Human Movement Sciences, Research Institute MOVE, VU University Amsterdam, Amsterdam, The Netherlands
    Clin Neurophysiol 122:789-95. 2011
  8. doi request reprint Cognitive decline in Parkinson's disease is associated with slowing of resting-state brain activity: a longitudinal study
    Kim T E Olde Dubbelink
    Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:408-18. 2013
  9. doi request reprint Advanced time-series analysis of MEG data as a method to explore olfactory function in healthy controls and Parkinson's disease patients
    Sanne Boesveldt
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:3020-30. 2009
  10. doi request reprint Depressive symptoms in Parkinson's disease are related to reduced [123I]FP-CIT binding in the caudate nucleus
    Chris Vriend
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 85:159-64. 2014

Detail Information

Publications60

  1. ncbi request reprint Detection of preclinical Parkinson's disease along the olfactory trac(t)
    H W Berendse
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Neural Transm Suppl . 2006
    ....
  2. ncbi request reprint [Presymptomatic detection of Parkinson's disease]
    H W Berendse
    Research Institute Neurosciences Vrije Universiteit, Afdeling Neurologie, VU Medisch Centrum, De Boelelaan 1117, 1081 HV Amsterdam
    Tijdschr Gerontol Geriatr 33:70-7. 2002
    ..In parallel, an effort will be made to define disease-specific patterns of olfactory dysfunction in neurodegenerative disorders...
  3. doi request reprint Diagnosing premotor Parkinson's disease using a two-step approach combining olfactory testing and DAT SPECT imaging
    Henk W Berendse
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Parkinsonism Relat Disord 15:S26-30. 2009
    ....
  4. doi request reprint Stage-dependent patterns of disturbed neural synchrony in Parkinson's disease
    Henk W Berendse
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    Parkinsonism Relat Disord 13:S440-5. 2007
    ..Future longitudinal studies are required to fully understand the disturbances of functional brain networks in Parkinson's disease and how they evolve throughout the course of the disease...
  5. doi request reprint Motor and non-motor correlates of olfactory dysfunction in Parkinson's disease
    Henk W Berendse
    Dept of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Neurol Sci 310:21-4. 2011
    ..Hyposmia may therefore be useful as a marker of disease progression, at least in the early disease stages...
  6. doi request reprint Disrupted brain network topology in Parkinson's disease: a longitudinal magnetoencephalography study
    Kim T E Olde Dubbelink
    1 Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 137:197-207. 2014
    ..As these network changes appear to reflect clinically relevant phenomena, they hold promise as markers of disease progression. ..
  7. doi request reprint Slowing of M1 activity in Parkinson's disease during rest and movement--an MEG study
    Alistair N Vardy
    Faculty of Human Movement Sciences, Research Institute MOVE, VU University Amsterdam, Amsterdam, The Netherlands
    Clin Neurophysiol 122:789-95. 2011
    ..Parkinson's disease is characterized by motor and cognitive problems that are accompanied by slowing of neural activity. This study examined the relationship between neural slowing and disease severity during rest and motor performance...
  8. doi request reprint Cognitive decline in Parkinson's disease is associated with slowing of resting-state brain activity: a longitudinal study
    Kim T E Olde Dubbelink
    Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:408-18. 2013
    ..The slowing of oscillatory brain activity strongly correlated with cognitive decline and therefore holds promise as an early marker for the development of dementia in PD...
  9. doi request reprint Advanced time-series analysis of MEG data as a method to explore olfactory function in healthy controls and Parkinson's disease patients
    Sanne Boesveldt
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:3020-30. 2009
    ....
  10. doi request reprint Depressive symptoms in Parkinson's disease are related to reduced [123I]FP-CIT binding in the caudate nucleus
    Chris Vriend
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 85:159-64. 2014
    ..This suggests regional specificity of dopaminergic deficits in the striatum in motor and depressive symptoms in PD...
  11. doi request reprint Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study
    Mirthe M Ponsen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Mov Disord 24:1060-5. 2009
    ..Interestingly, impaired odor discrimination was the best predictor for future PD...
  12. doi request reprint Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease
    Mirthe M Ponsen
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 81:396-9. 2010
    ..The usefulness of this two-step approach needs to be confirmed in larger populations...
  13. doi request reprint Dopaminergic modulation of cortico-cortical functional connectivity in Parkinson's disease: an MEG study
    Diederick Stoffers
    Institute for Clinical and Experimental Neurosciences, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Exp Neurol 213:191-5. 2008
    ..However, a strong motor response appears to be associated with decreases in local beta-band coupling, which may constitute a risk factor for the development of motor response fluctuations or dyskinesias...
  14. doi request reprint Depression and impulse control disorders in Parkinson's disease: two sides of the same coin?
    Chris Vriend
    Department of Psychiatry, VU University Medical Center VUmc, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VUMC, Amsterdam, the Netherlands Neuroscience Campus Amsterdam, VU VUmc, Amsterdam, The Netherlands Electronic address
    Neurosci Biobehav Rev 38:60-71. 2014
    ....
  15. ncbi request reprint Idiopathic hyposmia as a preclinical sign of Parkinson's disease
    Mirthe M Ponsen
    Research Institute Neurosciences Vrije Universiteit, Department of Neurology, VU University Medical Center Amsterdam, The Netherlands
    Ann Neurol 56:173-81. 2004
    ..These results indicate that idiopathic olfactory dysfunction is associated with an increased risk of developing PD of at least 10%...
  16. doi request reprint A comparative study of odor identification and odor discrimination deficits in Parkinson's disease
    Sanne Boesveldt
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Mov Disord 23:1984-90. 2008
    ..Although an odor identification deficit is generally believed to be independent of disease progression, the impairment in odor discrimination appears to increase with disease duration...
  17. doi request reprint Reduced dopamine transporter binding predates impulse control disorders in Parkinson's disease
    Chris Vriend
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands Neuroscience Campus Amsterdam, VU VUmc, Amsterdam, The Netherlands
    Mov Disord 29:904-11. 2014
    ....
  18. doi request reprint Extended testing across, not within, tasks raises diagnostic accuracy of smell testing in Parkinson's disease
    Sanne Boesveldt
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Mov Disord 24:85-90. 2009
    ..A combination of an odor detection threshold task and a 16-item odor identification test had the highest sensitivity and specificity in distinguishing between PD patients and controls...
  19. ncbi request reprint Impairment of complex upper limb motor function in de novo Parkinson's disease
    Mirthe M Ponsen
    Department of Neurology, ICEN, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HVAmsterdam, The Netherlands
    Parkinsonism Relat Disord 14:199-204. 2008
    ..The results of this study extend previous observations of impaired complex upper limb movements to newly diagnosed, untreated PD patients...
  20. pmc A double-blind randomized controlled trial to assess the effect of bright light therapy on depression in patients with Parkinson's disease
    Sonja Rutten
    Department of Psychiatry, VU University Medical Center GGZ inGeest, A J Ernststraat 887, 1081 HL, Amsterdam, The Netherlands
    BMC Psychiatry 16:355. 2016
    ..The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT) might be a new treatment option for depression in PD patients...
  21. pmc Cortical Thickness, Surface Area and Subcortical Volume Differentially Contribute to Cognitive Heterogeneity in Parkinson's Disease
    Niels J H M Gerrits
    Department of Anatomy and Neurosciences, VU University Medical Center VUmc, Amsterdam, The Netherlands
    PLoS ONE 11:e0148852. 2016
    ..We argue that this discrepancy is due to technical differences and the subtlety of the PD-related structural changes. ..
  22. doi request reprint Compensatory fronto-parietal hyperactivation during set-shifting in unmedicated patients with Parkinson's disease
    Niels J H M Gerrits
    Department of Anatomy and Neurosciences, VU University Medical Center VUmc, Amsterdam, The Netherlands Neuroscience Campus Amsterdam NCA, Amsterdam, The Netherlands Electronic address
    Neuropsychologia 68:107-16. 2015
    ....
  23. pmc Frequency-dependent functional connectivity within resting-state networks: an atlas-based MEG beamformer solution
    Arjan Hillebrand
    Department of Clinical Neurophysiology and Magnetoencephalography Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 59:3909-21. 2012
    ....
  24. ncbi request reprint Localization of slow wave activity in patients with tumor-associated epilepsy
    Johannes C Baayen
    Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
    Brain Topogr 16:85-93. 2003
    ..We studied the prevalence, characteristics and clinical correlates of ALFMA in 20 patients with brain tumors...
  25. ncbi request reprint Early-stage [123I]beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease
    Diederick Stoffers
    Department of Neurology, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, P O Box 7057, 1007, MB, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 32:689-95. 2005
    ..We hypothesized that distinguishing SPECT features might be most pronounced at an early disease stage, and the purpose of the present study was to investigate this hypothesis...
  26. doi request reprint Profiling cognitive and neuropsychiatric heterogeneity in Parkinson's disease
    Tim D van Balkom
    Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands Neuroscience Campus Amsterdam, VU University VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Parkinsonism Relat Disord 28:130-6. 2016
    ..The objective of this study was to assess subtypes of motor, cognitive and affective symptoms in PD...
  27. pmc Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity
    James P Trujillo
    Department of Emotion and Cognition, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Hum Brain Mapp 36:3703-15. 2015
    ..We used functional magnetic resonance imaging (fMRI) to identify accompanying neural dynamics...
  28. doi request reprint Anxiety in Parkinson's disease: Symptom dimensions and overlap with depression and autonomic failure
    Sonja Rutten
    Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Centre, Amsterdam, the Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Parkinsonism Relat Disord 21:189-93. 2015
    ..They nevertheless receive limited scientific attention. This study aimed to establish the symptom dimensions of anxiety in PD, and their relationship with depression, autonomic failure and motor symptoms...
  29. doi request reprint Cerebrospinal fluid and plasma clusterin levels in Parkinson's disease
    Karin D van Dijk
    Department of Anatomy and Neurosciences, Section Functional Neuroanatomy, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Parkinsonism Relat Disord 19:1079-83. 2013
    ..We elaborate on the identified correlations between levels of clusterin and AD related proteins and on possible explanations for the discrepant findings in clusterin studies in PD so far. ..
  30. doi request reprint Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrum
    Odile A van den Heuvel
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Sci 289:55-9. 2010
    ....
  31. doi request reprint Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: a pathogenetically based approach
    Karin D van Dijk
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Neurobiol Dis 39:229-41. 2010
    ..Furthermore, identified candidate biomarkers will have to be thoroughly validated before they can be implemented as diagnostic aids...
  32. pmc Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson's disease patients
    Corine C de Bondt
    Department of Anatomy and Neurosciences, VU University Medical Center VUmc, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    BMC Neurosci 17:20. 2016
    ....
  33. doi request reprint A smaller amygdala is associated with anxiety in Parkinson's disease: a combined FreeSurfer-VBM study
    Chris Vriend
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands Neuroscience Campus Amsterdam, VU VUmc, Amsterdam, The Netherlands Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 87:493-500. 2016
    ..This suggests that PD associated pathological alterations partly underlie these symptoms, although empirical evidence is limited...
  34. ncbi request reprint Distribution and Load of Amyloid-β Pathology in Parkinson Disease and Dementia with Lewy Bodies
    Dagmar H Hepp
    From the Department of Anatomy and Neurosciences, Section Quantitative Morphology DHH, DLEV, EH, WDJvdB, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands DHH, AWL, EMJF, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands NBB and Department of Pathology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands AJR
    J Neuropathol Exp Neurol 75:936-945. 2016
    ..Our findings suggest that the load and extent of Aβ pathology may contribute to cognitive dysfunction in PDD and the early-stage severe dementia in DLB...
  35. pmc The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects
    Nelleke Tolboom
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 40:472-9. 2015
    ....
  36. doi request reprint Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease
    Anke A Dijkstra
    Department of Anatomy and Neurosciences, Section of Functional Neuroanatomy, VU University Medical Center, Amsterdam, The Netherlands
    Mov Disord 29:1244-51. 2014
    ....
  37. doi request reprint Failure of stop and go in de novo Parkinson's disease--a functional magnetic resonance imaging study
    Chris Vriend
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands Neuroscience Campus Amsterdam, VU VUmc, Amsterdam, The Netherlands Electronic address
    Neurobiol Aging 36:470-5. 2015
    ..This study provides insights into the neural underpinnings of impulse control deficits, relevant for the study of the neural vulnerability factors involved in the development of impulse control disorders in PD. ..
  38. doi request reprint Reduced neural connectivity but increased task-related activity during working memory in de novo Parkinson patients
    James P Trujillo
    Department of Anatomy and Neurosciences, VU University Medical Center VUmc, Amsterdam, The Netherlands Department of Psychiatry, VUMC, Amsterdam, The Netherlands Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Hum Brain Mapp 36:1554-66. 2015
    ..We investigated this hypothesis by studying task-related network activity and connectivity within a sample of de novo patients with PD, versus healthy controls, during a visuospatial working memory task...
  39. doi request reprint Beneficial effect of transcranial magnetic stimulation on sleep in Parkinson's disease
    Karin D van Dijk
    Department of Neurology, VU University Medical Center Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands
    Mov Disord 24:878-84. 2009
    ..0002) and reduced the average duration of nocturnal awakenings (P = 0.02). No change of motor symptoms or mood was observed. Disturbed sleep in PD patients may partly be reversed by parietal rTMS, without affecting motor symptoms or mood...
  40. ncbi request reprint Quantification of dopamine transporter binding using [18F]FP-beta-CIT and positron emission tomography
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1397-406. 2007
    ..SRTM is therefore the method of choice for quantitative [18F]FP-beta-CIT studies. SUVr might be an alternative for larger clinical trials...
  41. pmc Increased resting-state functional connectivity in obese adolescents; a magnetoencephalographic pilot study
    Kim T E Olde Dubbelink
    Department of Paediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 3:e2827. 2008
    ..The present pilot study was carried out to investigate functional connectivity in obese and non-obese adolescents using magnetoencephalography (MEG)...
  42. ncbi request reprint Pneumocephalus by Valsalva's maneuver
    Hans M Schrijver
    Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Neurology 60:345-6. 2003
  43. pmc BEWARE: Body awareness training in the treatment of wearing-off related anxiety in patients with Parkinson's disease: study protocol for a randomized controlled trial
    Ires Ghielen
    Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Trials 16:283. 2015
    ..This study will investigate whether this new intervention, named BEWARE, is more effective than treatment as usual in increasing self-efficacy...
  44. doi request reprint Functional connectivity and cognitive decline over 3 years in Parkinson disease
    Kim T E Olde Dubbelink
    From the Departments of Neurology K T E O D, H W B, Anatomy and Neurosciences M M S, Clinical Neuropsychology J B D, Clinical Epidemiology and Biostatistics J W R T, and Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam F B, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 83:2046-53. 2014
    ..To evaluate fMRI whole-brain resting-state functional connectivity changes in relation to cognitive decline in Parkinson disease (PD) over a 3-year period...
  45. doi request reprint Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease
    Karin D van Dijk
    Department of Anatomy and Neurosciences, Section of Functional Neuroanatomy, Neuroscience Campus Amsterdam, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Mov Disord 28:747-54. 2013
    ..The usefulness of CSF endolysosomal enzyme activity levels as PD biomarkers, either alone or in combination with other markers, remains to be established in future studies...
  46. doi request reprint Patterns of α-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease
    Wilma D J van de Berg
    Department of Anatomy and Neurostiences, Neurostience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Parkinsonism Relat Disord 18:S28-30. 2012
    ..Recognition of clinical subtypes in neuropathological studies is essential to identify selective vulnerability to protein accumulation that may determine the clinical phenotype in PD...
  47. pmc Abnormal susceptibility to distracters hinders perception in early stage Parkinson's disease: a controlled study
    Jan Berend Deijen
    Department of Clinical Neuropsychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
    BMC Neurol 6:43. 2006
    ..Impairment of substantia nigra function is thought to lead to this reduced ability to suppress reflexive saccades...
  48. pmc Genome-wide association study confirms extant PD risk loci among the Dutch
    Javier Simon-Sanchez
    Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Hum Genet 19:655-61. 2011
    ..22 × 10(-4), OR = 1.51; HLA, rs4248166: P = 4.39 × 10(-5), OR = 1.36; and MAPT, rs3785880: P = 1.9 × 10(-3), OR = 1.19)...
  49. doi request reprint CSF α-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease
    Fransje E Reesink
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 22:87-95. 2010
    ..05). Ultimately, CSF α-synuclein was not a useful diagnostic biomarker to differentiate DLB and/or PD (α-synucleinopathies) from AD or SC. In DLB patients maybe lower CSF α-synuclein levels are related to worse cognitive performance...
  50. ncbi request reprint The application of graph theoretical analysis to complex networks in the brain
    Jaap C Reijneveld
    Department of Neurology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Neurophysiol 118:2317-31. 2007
    ....
  51. ncbi request reprint Bimanual coordination dysfunction in early, untreated Parkinson's disease
    Mirthe M Ponsen
    ICEN, Department of Neurology, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Parkinsonism Relat Disord 12:246-52. 2006
    ..This study demonstrates that bimanual coordination dysfunction is a very early sign of PD. Bimanual coordination tasks, in particular those involving high frequency anti-phase movements, might prove useful in the early diagnosis of PD...
  52. pmc SERT-to-DAT ratios in early Parkinson's disease do not correlate with the development of dyskinesias
    Sven R Suwijn
    Department of Neurology, H2 225, Academic Medical Center, University of Amsterdam, PO Box 22660, Amsterdam 1100 DD, The Netherlands
    EJNMMI Res 3:44. 2013
    ..Based on this model, we hypothesized that dyskinesias will develop predominantly in PD patients with a relatively preserved serotonergic system...
  53. pmc Bright light therapy in Parkinson's disease: an overview of the background and evidence
    Sonja Rutten
    Department of Psychiatry, VU University Medical Center, 1007 MB Amsterdam, The Netherlands Department of Anatomy and Neuroscience, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Parkinsons Dis 2012:767105. 2012
    ..More research on the neurobiology and efficacy of BLT in PD is warranted...
  54. doi request reprint Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease
    Karlijn J Doorn
    University of Amsterdam, Swammerdam Institute for Life Sciences, Center for Neuroscience, Amsterdam, The Netherlands
    Prog Neurobiol 98:222-38. 2012
    ..Since neuroinflammatory responses are in principle modifiable, such approaches could help to identify new targets or adjunctive therapies for the full spectrum of PD-related symptoms...
  55. doi request reprint The ParkinsonNet trial: design and baseline characteristics
    Samyra H J Keus
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Mov Disord 25:830-7. 2010
    ..Baseline characteristics of participants in the ParkinsonNet and control clusters were comparable. With 699 participating patients, this is the largest allied health study in PD to date...
  56. ncbi request reprint Signal-to-noise ratio of chemosensory event-related potentials
    Sanne Boesveldt
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Neurophysiol 118:690-5. 2007
    ..We investigated the influence of the number of stimuli on signal-to-noise (S/N) ratio of CSERP...
  57. ncbi request reprint Generalized synchronization of MEG recordings in Alzheimer's Disease: evidence for involvement of the gamma band
    Cornelis J Stam
    Department of Clinical Neurophysiology, VU University Medical Centre, Amsterdam, The Netherlands
    J Clin Neurophysiol 19:562-74. 2002
    ..Synchronization likelihood may be more sensitive to detect such changes than the commonly used coherence analysis...
  58. doi request reprint Treatment of Fatigue in Parkinson Disease
    Roy G Elbers
    Department of Physiotherapy, University of Applied Sciences, Leiden, the Netherlands2Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands
    JAMA 315:2340-1. 2016
    ..Which pharmacological and nonpharmacological interventions are associated with improvement in general, physical, or mental fatigue and minimal adverse effects in patients with Parkinson disease (PD)?..
  59. ncbi request reprint [Hypersexuality and other impulse control disorders in Parkinson's disease]
    Elise A Nelis
    VU Medisch Centrum, Amsterdam
    Ned Tijdschr Geneeskd 160:A9359. 2016
    ..Although the research on effective treatment options has been limited so far, treatment alternatives from the addiction field seem promising. ..
  60. doi request reprint Depressive symptoms in Parkinson's disease are related to decreased hippocampus and amygdala volume
    Tom J van Mierlo
    Department of Neurology, VU University Medical Center VUmc, Amsterdam, The Netherlands
    Mov Disord 30:245-52. 2015
    ..We speculate that non-dopaminergic changes are essential in the pathophysiology of depressive symptoms in PD, because our findings suggest the involvement of extra-striatal brain regions...