Louk J M J Vanderschuren

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi Sequential analysis of social play behavior in juvenile rats: effects of morphine
    L J Vanderschuren
    Department of Medical Pharmacology, Utrecht University, Netherlands
    Behav Brain Res 72:89-95. 1995
  2. ncbi A single exposure to morphine induces long-lasting behavioural and neurochemical sensitization in rats
    L J Vanderschuren
    Drug Abuse Program, Research Institute Neurosciences Vrije Universiteit, Department of Medical Pharmacology, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Eur J Neurosci 14:1533-8. 2001
  3. ncbi Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 151:99-120. 2000
  4. ncbi Dissociable effects of the kappa-opioid receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by amphetamine and cocaine
    L J Vanderschuren
    Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 150:35-44. 2000
  5. ncbi Dopaminergic mechanisms mediating the long-term expression of locomotor sensitization following pre-exposure to morphine or amphetamine
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 143:244-53. 1999
  6. ncbi Does dizocilpine (MK-801) inhibit the development of morphine-induced behavioural sensitization in rats?
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Faculty of Medicine, Amsterdam, The Netherlands
    Life Sci 61:PL 427-33. 1997
  7. ncbi Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Faculty of Medicine, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 131:115-22. 1997
  8. ncbi The neurobiology of social play behavior in rats
    L J Vanderschuren
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Faculty of Medicine, Utrecht University, The Netherlands
    Neurosci Biobehav Rev 21:309-26. 1997
  9. ncbi On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization
    Louk J M J Vanderschuren
    Drug Abuse Program, Department of Medical Pharmacology, Research Institute Neurosciences VU, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Psychopharmacology (Berl) 169:176-85. 2003
  10. ncbi Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation
    Anton N M Schoffelmeer
    Drug Abuse Program, Research Institute Neurosciences Vrije Universiteit, Department of Medical Pharmacology, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
    J Neurosci 22:3269-76. 2002

Collaborators

Detail Information

Publications34

  1. ncbi Sequential analysis of social play behavior in juvenile rats: effects of morphine
    L J Vanderschuren
    Department of Medical Pharmacology, Utrecht University, Netherlands
    Behav Brain Res 72:89-95. 1995
    ....
  2. ncbi A single exposure to morphine induces long-lasting behavioural and neurochemical sensitization in rats
    L J Vanderschuren
    Drug Abuse Program, Research Institute Neurosciences Vrije Universiteit, Department of Medical Pharmacology, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Eur J Neurosci 14:1533-8. 2001
    ..We therefore conclude that a single exposure to morphine induces long-lasting behavioural sensitization and associated neuroadaptations...
  3. ncbi Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 151:99-120. 2000
    ....
  4. ncbi Dissociable effects of the kappa-opioid receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by amphetamine and cocaine
    L J Vanderschuren
    Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 150:35-44. 2000
    ..By influencing dopaminergic neurotransmission, opioid drugs can alter the behavioral effects of psychostimulants...
  5. ncbi Dopaminergic mechanisms mediating the long-term expression of locomotor sensitization following pre-exposure to morphine or amphetamine
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 143:244-53. 1999
    ..Taken together, these data suggest a marked relationship between drug-seeking behaviour and drug sensitization...
  6. ncbi Does dizocilpine (MK-801) inhibit the development of morphine-induced behavioural sensitization in rats?
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Faculty of Medicine, Amsterdam, The Netherlands
    Life Sci 61:PL 427-33. 1997
    ..These findings seriously question whether MK-801 can be used to study the development of morphine-induced behavioural sensitization...
  7. ncbi Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Faculty of Medicine, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 131:115-22. 1997
    ..It is concluded that intermittent morphine pretreatment is far more effective in inducing long-term behavioural sensitization than chronic morphine pretreatment...
  8. ncbi The neurobiology of social play behavior in rats
    L J Vanderschuren
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Faculty of Medicine, Utrecht University, The Netherlands
    Neurosci Biobehav Rev 21:309-26. 1997
    ..It is concluded that there is not only behavioral, but also neurobiological evidence to suggest that social play behavior represents a separate category of behavior, instead of a precursor for adult social, sexual or aggressive behavior...
  9. ncbi On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization
    Louk J M J Vanderschuren
    Drug Abuse Program, Department of Medical Pharmacology, Research Institute Neurosciences VU, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Psychopharmacology (Berl) 169:176-85. 2003
    ....
  10. ncbi Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation
    Anton N M Schoffelmeer
    Drug Abuse Program, Research Institute Neurosciences Vrije Universiteit, Department of Medical Pharmacology, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
    J Neurosci 22:3269-76. 2002
    ..These data indicate that nicotinic receptor activation (by endogenously released acetylcholine) is a common denominator initiating neuroplasticity involved in the development of amphetamine, as well as cocaine-induced sensitization...
  11. ncbi Behavioral disinhibition requires dopamine receptor activation
    Marcel M van Gaalen
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research CNCR, VU Medical Center, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 187:73-85. 2006
    ..Behavioral disinhibition can be investigated by measuring premature responding in the 5-choice serial reaction time task (5-CSRTT) in which attentional parameters can be measured as well...
  12. ncbi Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 191:587-98. 2007
    ..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect...
  13. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
    ..Commonly prescribed for this condition, amphetamine (Adderall), reduces impulsive decision making; however, the neuropharmacologic mechanism of this effect of amphetamine is unclear...
  14. ncbi Compartment-specific changes in striatal neuronal activity during expression of amphetamine sensitization are the result of drug hypersensitivity
    Louk J M J Vanderschuren
    Drug Abuse Program, Research Institute Neurosciences, Vrije Universiteit, at Department of Medical Pharmacology, VU Medical Center, Amsterdam, The Netherlands
    Eur J Neurosci 16:2462-8. 2002
    ....
  15. ncbi Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization
    Taco J de Vries
    Research Institute Neurosciences Vrije Universiteit, Drug Abuse Program, Department of Medical Pharmacology, VU Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 26:18-26. 2002
    ..Thus, it appears that dopamine D2 receptors have a time-dependent role in relapse to cocaine and heroin seeking which is strongly associated with a behaviorally sensitized state...
  16. doi The neuropharmacology of impulsive behaviour
    Tommy Pattij
    Department of Anatomy and Neurosciences, Center for Neurogenomics and Cognitive Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Trends Pharmacol Sci 29:192-9. 2008
    ..However, recent findings also implicate glutamate and cannabinoid neurotransmission in impulsivity. In this review, we will discuss some of the recent developments in the neuropharmacological manipulation of impulsive behaviour...
  17. pmc Dissociating the role of endocannabinoids in the pleasurable and motivational properties of social play behaviour in rats
    E J Marijke Achterberg
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Netherlands
    Pharmacol Res 110:151-8. 2016
    ..Thus, endocannabinoids likely drive the expression of social play behaviour as a whole, without differentially affecting its motivational or pleasurable properties. ..
  18. pmc Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats
    E J Marijke Achterberg
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Neuropsychopharmacology 41:858-68. 2016
    ....
  19. doi What the laboratory rat has taught us about social play behavior: role in behavioral development and neural mechanisms
    Louk J M J Vanderschuren
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Curr Top Behav Neurosci 16:189-212. 2014
    ..Last, we will discuss the neural substrates of social play behavior in rats, with emphasis on the limbic corticostriatal circuits that underlie emotions and their influence on behavior. ..
  20. pmc Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms
    E J Marijke Achterberg
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Psychopharmacology (Berl) 231:1503-15. 2014
    ..Interestingly, psychostimulant drugs, such as amphetamine and cocaine, profoundly suppress social play, but the neural mechanisms underlying these effects remain to be elucidated...
  21. pmc Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats
    E J Marijke Achterberg
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands
    J Neurosci 35:161-9. 2015
    ..These findings increase our understanding of the neural underpinnings of this developmentally important social behavior, as well as the mechanism of action of two widely used treatments for ADHD. ..
  22. pmc Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, the Netherlands Department of Neuropharmacology, Brain Research Institute, University of Bremen, Germany Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Addict Biol 18:908-11. 2013
    ..Thus, up-regulation of striatal DRD2 by chronic rimonabant administration may be an underlying mechanism of action and confirms the interactions of the endocannabinoid and dopaminergic systems. ..
  23. ncbi Putting a spin on the dorsal-ventral divide of the striatum
    Pieter Voorn
    Department of Anatomy, Research Institute Neurosciences, VU University Medical Center, MF G 102, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Trends Neurosci 27:468-74. 2004
    ..Therefore, this review presents a synthesis between the dorsal-ventral distinction and the more mediolateral-oriented functional striatal gradient...
  24. doi Stable immediate early gene expression patterns in medial prefrontal cortex and striatum after long-term cocaine self-administration
    Ping Gao
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Addict Biol . 2015
    ..Thus, sustained impulses to IEG regulation during prolonged cocaine self-administration may evoke neuroplastic changes underlying compulsive drug use...
  25. doi Modeling autism-relevant behavioral phenotypes in rats and mice: Do 'autistic' rodents exist?
    Michela Servadio
    aDepartment of Science, Section of Biomedical Sciences and Technologies, University Roma Tre, Rome, Italy bDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht cDepartment of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Behav Pharmacol 26:522-40. 2015
    ..This approach has greatly contributed to our understanding of this disease, and is useful in identifying new therapeutic targets. ..
  26. pmc Animal studies of addictive behavior
    Louk J M J Vanderschuren
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, 3584 CG Utrecht, The Netherlands
    Cold Spring Harb Perspect Med 3:a011932. 2013
    ....
  27. pmc β-Adrenoreceptor stimulation mediates reconsolidation of social reward-related memories
    E J Marijke Achterberg
    Division of Behavioural Neuroscience, Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e39639. 2012
    ....
  28. ncbi Bidirectional cannabinoid modulation of social behavior in adolescent rats
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Psychopharmacology (Berl) 197:217-27. 2008
    ..Marijuana use in adolescents is a highly social activity, and interacting endocannabinoid and opioid systems may modulate social reward. However, cannabinoid exposure has been reported to reduce social behavior...
  29. ncbi Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
    ....
  30. doi Cannabis and the developing brain: insights from behavior
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Pharmacol 585:441-52. 2008
    ....
  31. ncbi Involvement of the dorsal striatum in cue-controlled cocaine seeking
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:8665-70. 2005
    ..In addition, given the importance of the dorsal striatum in stimulus-response habit learning, these data suggest that the habitual or compulsive quality of persistent drug seeking depends on dorsal striatal mechanisms...
  32. pmc Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats
    Judith R Homberg
    Hubrecht Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Psychopharmacology (Berl) 195:175-82. 2007
    ....
  33. doi Anti-obesity drugs and neural circuits of feeding
    Roger A H Adan
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Trends Pharmacol Sci 29:208-17. 2008
    ..Several potential drug targets are expressed in different neural circuits, implying that current and future obesity drugs act on partially overlapping systems that control food intake...
  34. pmc Cannabinoid and opioid modulation of social play behavior in adolescent rats: differential behavioral mechanisms
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:519-30. 2008
    ....