Philip Scheltens

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi request reprint Effects of transcutaneous electrical nerve stimulation (TENS) on non-pain related cognitive and behavioural functioning
    Koene R A van Dijk
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Rev Neurosci 13:257-70. 2002
  2. ncbi request reprint Peripheral electrical stimulation in Alzheimer's disease
    Koene R A van Dijk
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 19:361-8. 2005
  3. doi request reprint CSF biomarker levels in early and late onset Alzheimer's disease
    Femke H Bouwman
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 30:1895-901. 2009
  4. doi request reprint Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease
    Ineke A van Rossum
    Department of Neurology Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 29:319-27. 2012
  5. doi request reprint MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population
    Wouter J P Henneman
    Department of Radiology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 40:492-8. 2009
  6. doi request reprint Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:191-7. 2009
  7. doi request reprint Progression to dementia in memory clinic patients without dementia: a latent profile analysis
    Sebastian Kohler
    From the Alzheimer Center Limburg S K, R H, P J V, P A, F R J V, I R, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht and Alzheimer Center and Department of Neurology N S, Y A L P, W M v d F, P S, P J V, Department of Medical Psychology T K, Neuroscience Campus Amsterdam, and Department Epidemiology and Biostatistics W M v d F, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 81:1342-9. 2013
  8. doi request reprint Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study
    Alie Schuitemaker
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:128-36. 2013
  9. doi request reprint Early onset Alzheimer's disease is associated with a distinct neuropsychological profile
    Lieke L Smits
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 30:101-8. 2012
  10. doi request reprint Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: a longitudinal study
    Jasper D Sluimer
    Alzheimer Centre and Department of Diagnostic Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 31:758-64. 2010

Detail Information

Publications149 found, 100 shown here

  1. ncbi request reprint Effects of transcutaneous electrical nerve stimulation (TENS) on non-pain related cognitive and behavioural functioning
    Koene R A van Dijk
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Rev Neurosci 13:257-70. 2002
    ..It is argued that arousal may underlie the beneficial influence of TENS in various conditions. Finally, suggestions are offered for future research...
  2. ncbi request reprint Peripheral electrical stimulation in Alzheimer's disease
    Koene R A van Dijk
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 19:361-8. 2005
    ..The lack of treatment effects calls for reconsideration of electrical stimulation as a symptomatic treatment in AD...
  3. doi request reprint CSF biomarker levels in early and late onset Alzheimer's disease
    Femke H Bouwman
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 30:1895-901. 2009
    ..To compare CSF levels of beta-amyloid 1-42 (Abeta(1-42)), total tau (tau) and tau phosphorylated at threonine 181 (ptau-181) between AD patients and controls according to age...
  4. doi request reprint Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease
    Ineke A van Rossum
    Department of Neurology Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 29:319-27. 2012
    ..Our findings implicate a different role for biomarkers in diagnosis and prognosis of MCI-AD. While amyloid markers can be used to identify MCI-AD, injury markers may predict rapid progression to dementia...
  5. doi request reprint MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population
    Wouter J P Henneman
    Department of Radiology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 40:492-8. 2009
    ..MRI biomarkers play an important role in the diagnostic work-up of dementia, but their prognostic value is less well-understood. We investigated if simple MRI rating scales predict mortality in a memory clinic population...
  6. doi request reprint Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:191-7. 2009
    ..The purpose of this study was to directly compare these tracers in patients with AD, patients with mild cognitive impairment (MCI), and healthy controls...
  7. doi request reprint Progression to dementia in memory clinic patients without dementia: a latent profile analysis
    Sebastian Kohler
    From the Alzheimer Center Limburg S K, R H, P J V, P A, F R J V, I R, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht and Alzheimer Center and Department of Neurology N S, Y A L P, W M v d F, P S, P J V, Department of Medical Psychology T K, Neuroscience Campus Amsterdam, and Department Epidemiology and Biostatistics W M v d F, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 81:1342-9. 2013
    ..To identify the existence of discrete cognitive subtypes among memory clinic patients without dementia and test their prognostic values...
  8. doi request reprint Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study
    Alie Schuitemaker
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:128-36. 2013
    ..The purpose of this study was to assess whether increased (R)-[(11)C]PK11195 binding is present in AD and mild cognitive impairment (MCI), currently also known as "prodromal AD."..
  9. doi request reprint Early onset Alzheimer's disease is associated with a distinct neuropsychological profile
    Lieke L Smits
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 30:101-8. 2012
    ..In conclusion, early onset AD presents with a different cognitive profile and the disease course seems different. Relative sparing of memory function in early stages stresses the need to adequately test other cognitive domains...
  10. doi request reprint Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: a longitudinal study
    Jasper D Sluimer
    Alzheimer Centre and Department of Diagnostic Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 31:758-64. 2010
    ..To assess associations between cerebrospinal fluid (CSF) biomarker levels and MRI-based whole-brain atrophy rate in mild cognitive impairment (MCI) and Alzheimer's disease (AD)...
  11. doi request reprint Impact of molecular imaging on the diagnostic process in a memory clinic
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:414-21. 2013
    ..We evaluated the impact of these tracers on the diagnostic process in a memory clinic population...
  12. doi request reprint Cognitive correlates of cerebrospinal fluid biomarkers in frontotemporal dementia
    Esther L G E Koedam
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:269-75. 2013
    ..In this study we investigated the relationships between cerebrospinal fluid (CSF) biomarkers (tau and amyloid-β1-42 [Aβ1-42]) and cognition or behavior in patients with frontotemporal dementia (the behavioral variant, bvFTD)...
  13. doi request reprint Microbleeds do not affect rate of cognitive decline in Alzheimer disease
    Annelies E van der Vlies
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:763-9. 2012
    ..To investigate the relationship between brain microbleeds (MBs) and the rate of cognitive decline in Alzheimer disease (AD)...
  14. doi request reprint Dementia mimicking Alzheimer's disease Owing to a tau mutation: CSF and PET findings
    Nelleke Tolboom
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 24:303-7. 2010
    ..This, in combination with elevated levels of CSF t-tau and p-tau, has potential value in differential diagnosis of frontotemporal dementia from AD...
  15. doi request reprint Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease
    Cees Mulder
    Department of Clinical Chemistry, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Clin Chem 56:248-53. 2010
    ..We have used these markers and evaluated their performance...
  16. ncbi request reprint Model-free group analysis shows altered BOLD FMRI networks in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:256-66. 2009
    ..The technique is more sensitive than the commonly applied model-based method. Consistent with other research, we show that networks of activation and deactivation show decreased reactivity in dementia...
  17. doi request reprint Serum amyloid p component as a biomarker in mild cognitive impairment and Alzheimer's disease
    Nicolaas A Verwey
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 26:522-7. 2008
    ..The aim was to investigate if SAP levels in cerebrospinal fluid (CSF) and serum can be used to discriminate controls, AD and mild cognitive impairment (MCI) patients, and to identify incipient AD among MCI patients...
  18. doi request reprint Discriminatory and predictive capabilities of enzyme-linked immunosorbent assay and multiplex platforms in a longitudinal Alzheimer's disease study
    Wesley Jongbloed
    Department of Clinical Chemistry, Neurological laboratory, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:276-83. 2013
    ....
  19. doi request reprint Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 80:359-65. 2013
    ..To examine the relationships between apolipoprotein E (APOE) ε4 dose and in vivo distributions of both fibrillary amyloid burden and glucose metabolism in the same Alzheimer disease dementia patients, selected for abnormal amyloid imaging...
  20. doi request reprint Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:1464-70. 2009
    ....
  21. ncbi request reprint Profile of cognitive impairment in chronic heart failure
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    J Am Geriatr Soc 55:1764-70. 2007
    ..To determine the frequency and pattern of cognitive dysfunction in outpatients with chronic congestive heart failure (CHF) and to identify the corresponding demographic and clinical correlates...
  22. ncbi request reprint Behavioural and psychological symptoms are not related to white matter hyperintensities and medial temporal lobe atrophy in Alzheimer's disease
    Salka S Staekenborg
    Alzheimer Centre and Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 23:387-92. 2008
    ..On MRI, medial temporal lobe atrophy (MTA) is presumed to reflect Alzheimer- type pathology. White matter hyperintensities (WMH) are considered markers of vascular pathology...
  23. ncbi request reprint Cognitive impairment in Alzheimer's disease is modified by APOE genotype
    Annelies E van der Vlies
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 24:98-103. 2007
    ..We examined whether impairment in specific cognitive domains in Alzheimer's disease (AD) differed according to APOE genotype and age at onset...
  24. doi request reprint Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints
    Argonde C van Harten
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:481-7. 2013
    ....
  25. doi request reprint Alzheimer's disease patients not carrying the apolipoprotein E ε4 allele show more severe slowing of oscillatory brain activity
    Hanneke De Waal
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2158-63. 2013
    ..In conclusion, the most pronounced effect of genotype was seen in AD patients, and APOE ε4 noncarriers showed slower activity, especially in parieto-occipital regions...
  26. doi request reprint Increase in cerebrospinal fluid F2-isoprostanes is related to cognitive decline in APOE ε4 carriers
    Flora H Duits
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 36:563-70. 2013
    ..Our results reiterate the importance of oxidative stress in neurodegeneration, especially in APOE ε4 carrying patients. Future studies should focus on the possibility of increased vulnerability to oxidative damage in APOE ε4 carriers. ..
  27. doi request reprint Predictors of progression from mild cognitive impairment to dementia in the placebo-arm of a clinical trial population
    Niels D Prins
    Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 36:79-85. 2013
    ..We conclude that global cognitive function, episodic memory performance, and MTA on MRI independently predict progression to dementia in patients with MCI...
  28. doi request reprint Longitudinal amyloid imaging using 11C-PiB: methodologic considerations
    Bart N M van Berckel
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:1570-6. 2013
    ..Several methods are in use for analyzing (11)C-Pittsburgh compound-B ((11)C-PiB) data. The objective of this study was to identify the method of choice for measuring longitudinal changes in specific (11)C-PiB binding...
  29. pmc Injury markers predict time to dementia in subjects with MCI and amyloid pathology
    Ineke A van Rossum
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:1809-16. 2012
    ..However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology...
  30. doi request reprint CSF biomarkers in Alzheimer's disease and controls: associations with APOE genotype are modified by age
    Maartje I Kester
    Alzheimer Center and Department of Neurology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Alzheimers Dis 16:601-7. 2009
    ..This suggests that cognitively healthy APOE epsilon4 carriers are more prone to develop AD pathology with aging. For AD patients, this provides support for the existence of subtypes within the disease...
  31. doi request reprint Diagnostic impact of CSF biomarkers in a local hospital memory clinic
    Maartje I Kester
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 29:491-7. 2010
    ..We examined the impact of these biomarkers in the diagnostic process in a non-academic memory clinic...
  32. ncbi request reprint Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 26:231-9. 2005
    ..These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology...
  33. doi request reprint Early-onset dementia is associated with higher mortality
    Esther L G E Koedam
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 26:147-52. 2008
    ..Our objective was to compare the mortality risks of patients with early- and late-onset dementia with non-demented controls of the same age range and to analyse the mortality risks in subtypes of dementia...
  34. doi request reprint CSF levels of PSA and PSA-ACT complexes in Alzheimer's disease
    Sandra D Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Ann Clin Biochem 46:477-83. 2009
    ..Therefore, we aimed to determine whether PSA is produced in the brain and whether PSA and PSA-ACT complex levels in CSF can be used as a biomarker for AD...
  35. ncbi request reprint Transcranial Doppler blood flow assessment in patients with mild heart failure: correlates with neuroimaging and cognitive performance
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital and the Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands
    Congest Heart Fail 14:61-5. 2008
    ....
  36. ncbi request reprint Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1965-74. 2007
    ..Most anatomic regions outperformed cluster analysis in terms of absence of both scan rejection and bias. Total cerebellum is the optimal reference region in this patient category...
  37. doi request reprint Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease
    Salka S Staekenborg
    Department of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 81:547-51. 2010
    ....
  38. doi request reprint Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions
    Rik Ossenkoppele
    From the Department of Radiology and Nuclear Medicine R O, S C J V, H V, A V, R A v S, S M A, M D Z, R B, A D W, F B, A A L, B N M v B, Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam R O, W M v d F, S A S, S M A, M D Z, P S, and Department of Epidemiology and Biostatistics W M v d F, S A S, J T, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 82:1768-75. 2014
    ..To assess how amyloid deposition, glucose hypometabolism, and cerebral atrophy affect neuropsychological performance in patients with Alzheimer disease (AD) dementia, patients with mild cognitive impairment (MCI), and controls over time...
  39. doi request reprint Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease
    Christiane Möller
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2014-22. 2013
    ..Our results suggest that patterns of atrophy might vary in the spectrum of AD...
  40. doi request reprint Microglial activation in healthy aging
    Alie Schuitemaker
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Neurobiol Aging 33:1067-72. 2012
    ..This indicates that activated microglia appear in several cortical and subcortical areas during healthy aging, suggesting widespread neuronal loss...
  41. doi request reprint Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment
    Maja A A Binnewijzend
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:2018-28. 2012
    ..Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD...
  42. pmc No evidence for additional blood-brain barrier P-glycoprotein dysfunction in Alzheimer's disease patients with microbleeds
    Daniëlle M E van Assema
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 32:1468-71. 2012
    ..No differences were found in binding potential and nonspecific volume of distribution of (R)-[(11)C]verapamil between patient groups. These results provide no evidence for additional Pgp dysfunction in AD patients with MBs...
  43. pmc Evaluation of tracer kinetic models for analysis of [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Mol Imaging Biol 11:322-33. 2009
    ..Different pharmacokinetic methods for [18F]FDDNP studies were evaluated using both simulations and clinical data...
  44. doi request reprint Simplified parametric methods for [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Neuroimage 49:433-41. 2010
    ..Furthermore, in simulations, RPM2 and MRTM2 provided the most accurate and precise BP(ND) estimates. RPM2 and MRTM2 are the methods of choice for parametric analysis of [(18)F]FDDNP studies...
  45. doi request reprint White matter tract integrity in aging and Alzheimer's disease
    Jessica S Damoiseaux
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:1051-9. 2009
    ..This different pattern of decreased anatomical connectivity in normal aging and AD suggests that AD is not merely accelerated aging...
  46. pmc Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:1629-38. 2009
    ....
  47. doi request reprint On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...
  48. doi request reprint BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology
    Sandra D Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 20:253-60. 2010
    ..38, r=0.63, and r=0.65; all p< 0.05), but not with Abeta(42). These data suggest that increased BACE1 activity in CSF relates to AD pathology in the brain...
  49. doi request reprint Incidence of depression and anxiety in the spouses of patients with dementia: a naturalistic cohort study of recorded morbidity with a 6-year follow-up
    Karlijn J Joling
    Department of General Practice, Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 18:146-53. 2010
    ..In this study, the authors assess the long-term incidence of depression and anxiety in the spouses of patients with dementia as recorded by general practitioners...
  50. doi request reprint How useful is the IQCODE for discriminating between Alzheimer's disease, mild cognitive impairment and subjective memory complaints?
    Sietske A M Sikkes
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 30:411-6. 2010
    ....
  51. ncbi request reprint Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Stroke 37:836-40. 2006
    ..Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms...
  52. doi request reprint Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers
    Maartje I Kester
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    JAMA Neurol 71:855-62. 2014
    ..It remains unclear if and how associations between cerebral small-vessel disease and Alzheimer disease (AD) pathology lead to cognitive decline and dementia...
  53. doi request reprint Assessment of instrumental activities of daily living in dementia: diagnostic value of the Amsterdam Instrumental Activities of Daily Living Questionnaire
    Sietske A M Sikkes
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    J Geriatr Psychiatry Neurol 26:244-50. 2013
    ..We recently developed the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q; note 1). We aim to investigate the diagnostic accuracy of the A-IADL-Q for dementia in a memory clinic setting...
  54. doi request reprint Prevalence of cortical superficial siderosis in a memory clinic population
    Hazel I Zonneveld
    From the Alzheimer Center and the Neuroscience Campus Amsterdam, and Departments of Radiology and Nuclear Medicine H I Z, M P W, F B, Neurology J D C G, N D P, P S, W M v d F, Epidemiology and Biostatistics W M v d F, Physics and Medical Technology J P A K, and Internal Medicine M M, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 82:698-704. 2014
    ....
  55. pmc Single-subject grey matter graphs in Alzheimer's disease
    Betty M Tijms
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e58921. 2013
    ..These findings contribute to a better understanding of structural alterations and cognitive dysfunction in AD...
  56. doi request reprint Disruption of functional brain networks in Alzheimer's disease: what can we learn from graph spectral analysis of resting-state magnetoencephalography?
    Willem de Haan
    Department of Clinical Neurophysiology and Magnetoencephalography, VU University Medical Center, Amsterdam, The Netherlands
    Brain Connect 2:45-55. 2012
    ..Our findings imply that GSA is valuable for the purpose of studying altered brain network topology and dynamics in AD...
  57. pmc Does a family meetings intervention prevent depression and anxiety in family caregivers of dementia patients? A randomized trial
    Karlijn J Joling
    Department of General Practice and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e30936. 2012
    ..This study examines the preventive effects of family meetings for primary caregivers of community-dwelling dementia patients...
  58. ncbi request reprint Neurological signs in relation to type of cerebrovascular disease in vascular dementia
    Salka S Staekenborg
    Department of Neurology and Alzheimer Centre, Vrije University Medical Centre, Amsterdam, The Netherlands
    Stroke 39:317-22. 2008
    ....
  59. ncbi request reprint The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia
    Antonio J Bastos-Leite
    Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 38:3182-5. 2007
    ..Therefore, our purpose was to investigate the relative contribution of cerebrovascular disease and MTA to cognitive impairment in patients fulfilling diagnostic criteria for VaD...
  60. doi request reprint Whole-brain atrophy rate and cognitive decline: longitudinal MR study of memory clinic patients
    Jasper D Sluimer
    Department of Diagnostic Radiology, Alzheimer Centre, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Radiology 248:590-8. 2008
    ....
  61. doi request reprint Progression of mild cognitive impairment to dementia: contribution of cerebrovascular disease compared with medial temporal lobe atrophy
    Salka S Staekenborg
    Department of Neurology, Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 40:1269-74. 2009
    ....
  62. ncbi request reprint Neuroimaging and correlates of cognitive function among patients with heart failure
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 24:418-23. 2007
    ..We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF)...
  63. doi request reprint EEG abnormalities are associated with different cognitive profiles in Alzheimer's disease
    Lieke L Smits
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 31:1-6. 2011
    ..Our purpose was to investigate associations between different cognitive profiles and their underlying functional brain changes as measured by electroencephalogram (EEG) in Alzheimer's disease (AD)...
  64. pmc Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia
    Elisabeth C W van Straaten
    Dept of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, 7057, 1007 MB, Amsterdam, The Netherlands
    J Neurol 255:1302-8. 2008
    ..The influence of WMH on progression of aMCI to Alzheimer's disease (AD) is less clear...
  65. doi request reprint Alzheimer's disease: connecting findings from graph theoretical studies of brain networks
    Betty M Tijms
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2023-36. 2013
    ..We highlight confounding factors such as differences in graph construction methods and provide recommendations for future research...
  66. doi request reprint Microbleeds relate to altered amyloid-β metabolism in Alzheimer's disease
    Jeroen D C Goos
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:1011.e1-9. 2012
    ..MB distribution related to different amyloid profiles, supporting distinct etiologies. Our results suggest that Aβ42 is retained in cerebrovasculature of AD patients with MBs, while in contrast, VaD patients may possibly drain amyloid...
  67. doi request reprint Young Alzheimer patients show distinct regional changes of oscillatory brain dynamics
    Hanneke De Waal
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:1008.e25-31. 2012
    ..This finding supports the hypothesis that early onset AD presents with a distinct endophenotype...
  68. doi request reprint Serial CSF sampling in Alzheimer's disease: specific versus non-specific markers
    Maartje I Kester
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:1591-8. 2012
    ..Contrary to AD-specific markers, nonspecific CSF biomarkers, most notably isoprostane, showed change over time. These markers could potentially be used to monitor disease progression in AD...
  69. pmc Identifying target groups for the prevention of depression among caregivers of dementia patients
    Karlijn J Joling
    Department of General Practice, EMGO Institute for Health and Health Care Research, VU University Medical Centre, Amsterdam, The Netherlands
    Int Psychogeriatr 24:298-306. 2012
    ..However, it is not yet clear which caregivers are at increased risk of developing depression. With this knowledge preventive strategies could focus on these groups to maximize health gain and minimize effort...
  70. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
    ..To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer's disease (AD) and other dementias...
  71. ncbi request reprint Whole brain analysis of T2* weighted baseline FMRI signal in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 28:1313-7. 2007
    ..We conclude that in FMRI studies of dementia, not only the dynamic BOLD signal (activation and deactivation) but also the average baseline signal is diminished in certain regions. The method we applied may also be used in task-rel..
  72. doi request reprint EEG abnormalities in early and late onset Alzheimer's disease: understanding heterogeneity
    Hanneke De Waal
    Alzheimer Center, Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:67-71. 2011
    ..EEG) abnormalities between early and late onset Alzheimer's disease (AD) and to assess the influence of APOE genotype on this association, in order to understand the biological differences in AD according to age at onset..
  73. doi request reprint Early-versus late-onset Alzheimer's disease: more than age alone
    Esther L G E Koedam
    Department of Neurology, VU University Medical Centre, Alzheimer Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 19:1401-8. 2010
    ..Atypical presentations of AD should be considered in the clinical differential diagnosis of early-onset dementia...
  74. doi request reprint Evaluation of intrathecal serum amyloid P (SAP) and C-reactive protein (CRP) synthesis in Alzheimer's disease with the use of index values
    Sandra D Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 22:1073-9. 2010
    ..Interestingly, the SAP index value was much lower than expected, based on its molecular size. In conclusion, these data suggest that local production of SAP and CRP in the AD brain does not substantially contribute to the CSF levels...
  75. doi request reprint Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population
    Yolande A L Pijnenburg
    Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 25:157-64. 2008
    ..The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population...
  76. pmc Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity
    Ernesto J Sanz-Arigita
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 5:e13788. 2010
    ..The form and role of functional connectivity changes thus remains ambiguous. The current study shows more conclusive data on connectivity changes in early AD using graph analysis on resting-state condition fMRI data...
  77. pmc Accelerating regional atrophy rates in the progression from normal aging to Alzheimer's disease
    Jasper D Sluimer
    Department of Diagnostic Radiology, VU University Medical Centre, Amsterdam, The Netherlands
    Eur Radiol 19:2826-33. 2009
    ..Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD...
  78. ncbi request reprint Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
    ..We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease...
  79. pmc Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory
    Willem de Haan
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    BMC Neurosci 10:101. 2009
    ..All results were normalized for network size and compared with random control networks...
  80. doi request reprint Tau and p-tau as CSF biomarkers in dementia: a meta-analysis
    Argonde C van Harten
    Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Chem Lab Med 49:353-66. 2011
    ....
  81. pmc Prevention of depression and sleep disturbances in elderly with memory-problems by activation of the biological clock with light--a randomized clinical trial
    Els I S Most
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Trials 11:19. 2010
    ....
  82. ncbi request reprint Precuneus atrophy in early-onset Alzheimer's disease: a morphometric structural MRI study
    Giorgos Karas
    Department of Diagnostic Radiology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Neuroradiology 49:967-76. 2007
    ..In this study we set out to investigate whether age at onset in patients with AD determines the pattern of atrophy on cerebral MRI scans...
  83. doi request reprint Clinical characteristics of patients with frontotemporal dementia with and without lobar atrophy on MRI
    Esther L G E Koedam
    Alzheimer Centre and Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 24:242-7. 2010
    ..We compared clinical characteristics of bvFTD patients with frontotemporal lobar atrophy on MRI to those lacking the typical pattern at presentation...
  84. doi request reprint Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial
    Philip Scheltens
    VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 6:1-10.e1. 2010
    ..To investigate the effect of a medical food on cognitive function in people with mild Alzheimer's disease (AD)...
  85. doi request reprint Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease
    Eric van Exel
    Department of Psychiatry, VU University Medical Center GGZ inGeest, Osdorpplein 880, 1068 TD, Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:1263-70. 2009
    ..Alzheimer disease (AD) is a complex disorder with a strong heritable component. Amyloid pathology, vascular factors, and inflammation are postulated to be involved in its pathogenesis, but causality has not been established unequivocally...
  86. ncbi request reprint Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 23:1450-9. 2004
    ..This should encourage further functional imaging studies to examine the status of neurotransmitter systems in disease...
  87. ncbi request reprint Attention modulates hemispheric differences in functional connectivity: evidence from MEG recordings
    Liselotte Gootjes
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Neuroimage 30:245-53. 2006
    ..This supports the idea of a supervisory role for the frontal cortex in attention processes...
  88. ncbi request reprint Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Brain 129:141-57. 2006
    ....
  89. doi request reprint Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition
    Jeroen D C Goos
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 40:3455-60. 2009
    ..A minority of patients has multiple MBs. We aimed to investigate associations of multiple MBs in Alzheimer disease with clinical and MRI characteristics and cerebrospinal fluid biomarkers...
  90. doi request reprint Variability in longitudinal cerebrospinal fluid tau and phosphorylated tau measurements
    Nicolaas A Verwey
    Neurology Department, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Clin Chem Lab Med 46:1300-4. 2008
    ..The influence of assay variation and duration of storage on changes in cerebrospinal fluid (CSF) levels of tau and phosphorylated (P)-tau with time was evaluated in 112 patients with various neurological disorders...
  91. ncbi request reprint CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer's disease and controls
    Yolande A L Pijnenburg
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands, and Chelsea and Westminster, Brompton and Charing Cross Hospitals, London, UK
    Dement Geriatr Cogn Disord 23:225-30. 2007
    ....
  92. ncbi request reprint Infratentorial abnormalities in vascular dementia
    Antonio J Bastos Leite
    Department of Radiology and Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 37:105-10. 2006
    ..Our purposes were to determine the prevalence of infratentorial abnormalities in VaD, their relation with supratentorial abnormalities, and whether they are relevant to cognition...
  93. pmc Imaging in Alzheimer's disease
    Philip Scheltens
    Dept Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dialogues Clin Neurosci 11:191-9. 2009
    ..In this review, the various imaging techniques will be highlighted, with an emphasis on their ability to diagnose Alzheimer's disease and separate it from other entities...
  94. ncbi request reprint Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males
    Rutger Goekoop
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 31:1508-18. 2006
    ..Behaviorally, such neurofunctional effects may actively block decreased memory performance as a result of context-dependency. The validity of these predictions can be tested in large-scale clinical trials...
  95. ncbi request reprint Pain intensity and pain affect in relation to white matter changes
    Joukje M Oosterman
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Pain 125:74-81. 2006
    ..These results suggest that pain experience may change as a result of aging and that white matter changes might be indicative for these alterations...
  96. doi request reprint Understanding higher level gait disturbances in mild dementia in order to improve rehabilitation: 'last in-first out'
    Erik Scherder
    Department of Clinical Neuropsychology, VU University, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Neurosci Biobehav Rev 35:699-714. 2011
    ..These new strategies emerge from five neural networks: the superior longitudinal fasciculus, the uncinate fasciculus, the fronto-cerebellar and fronto-striatal connections, and the cingulum...
  97. ncbi request reprint Generalized synchronization of MEG recordings in Alzheimer's Disease: evidence for involvement of the gamma band
    Cornelis J Stam
    Department of Clinical Neurophysiology, VU University Medical Centre, Amsterdam, The Netherlands
    J Clin Neurophysiol 19:562-74. 2002
    ..Synchronization likelihood may be more sensitive to detect such changes than the commonly used coherence analysis...
  98. ncbi request reprint An fMRI study of planning-related brain activity in patients with moderately advanced multiple sclerosis
    Richard H C Lazeron
    Department of Radiology and the MS MRI Centre, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Mult Scler 10:549-55. 2004
    ..We used functional magnetic resonance imaging (fMRI) to study planning, an executive function, in moderately impaired MS patients...
  99. ncbi request reprint Pathological aging of the brain: an overview
    Antonio J Bastos Leite
    Department of Radiology, Vrije Universiteit VU Medical Center, Amsterdam, The Netherlands
    Top Magn Reson Imaging 15:369-89. 2004
    ....
  100. ncbi request reprint Apolipoprotein E genotype influences presence and severity of delusions and aggressive behavior in Alzheimer disease
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 23:42-6. 2007
    ..We investigated differences in the prevalence and severity of 10 neuropsychiatric and behavioral symptoms according to apolipoprotein E (APOE) genotype and dementia severity in Alzheimer disease (AD)...
  101. ncbi request reprint Validation of the HIV Dementia Scale in an elderly cohort of patients with subcortical cognitive impairment caused by subcortical ischaemic vascular disease or a normal pressure hydrocephalus
    Barbera van Harten
    Department of Neurology, Sint Lucas Andreas Hospital, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 18:109-14. 2004
    ....