Gert Storm

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. pmc Tumour-targeted nanomedicines: principles and practice
    T Lammers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, Utrecht 3584 CA, The Netherlands
    Br J Cancer 99:392-7. 2008
  2. doi request reprint Interview with gert storm
    Gert Storm
    Utrecht University, Department of Pharmaceutics, Utrecht, The Netherlands
    Ther Deliv 4:1493-7. 2013
  3. ncbi request reprint European Commission-supported development of targeted nanomedicines: did MediTrans make a difference?
    G Storm
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    Ther Deliv 2:861-4. 2011
  4. doi request reprint Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    J Steroid Biochem Mol Biol 111:101-10. 2008
  5. pmc Biodegradable poly(2-dimethylamino ethylamino)phosphazene for in vivo gene delivery to tumor cells. Effect of polymer molecular weight
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, 80082, 3508 TB, Utrecht, The Netherlands
    Pharm Res 24:1572-80. 2007
  6. pmc Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells
    M E M Dolman
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Int J Nanomedicine 7:417-33. 2012
  7. doi request reprint Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment
    Roy van der Meel
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    J Control Release 159:281-9. 2012
  8. pmc Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Pharm Res 25:1654-62. 2008
  9. doi request reprint Liposomes as carriers for colchicine-derived prodrugs: vascular disrupting nanomedicines with tailorable drug release kinetics
    Bart J Crielaard
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Eur J Pharm Sci 45:429-35. 2012
  10. doi request reprint Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting
    Marina Talelli
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, Utrecht, The Netherlands
    J Control Release 151:183-92. 2011

Detail Information

Publications75

  1. pmc Tumour-targeted nanomedicines: principles and practice
    T Lammers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, Utrecht 3584 CA, The Netherlands
    Br J Cancer 99:392-7. 2008
    ..Here, we briefly summarise the most important targeting systems and strategies, and discuss recent advances and future directions in the development of tumour-targeted nanomedicines...
  2. doi request reprint Interview with gert storm
    Gert Storm
    Utrecht University, Department of Pharmaceutics, Utrecht, The Netherlands
    Ther Deliv 4:1493-7. 2013
    b>Gert Storm studied biology at the Utrecht University, The Netherlands, and obtained his PhD degree in 1987 at the Department of Pharmaceutics of the same university...
  3. ncbi request reprint European Commission-supported development of targeted nanomedicines: did MediTrans make a difference?
    G Storm
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    Ther Deliv 2:861-4. 2011
    ..In this article, we will briefly address the research content, outcome and impact of the MediTrans project...
  4. doi request reprint Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    J Steroid Biochem Mol Biol 111:101-10. 2008
    ..F10 melanoma cells and the anti-proliferative effects of all LCL-GC towards angiogenic endothelial cells play a role in their antitumor activity...
  5. pmc Biodegradable poly(2-dimethylamino ethylamino)phosphazene for in vivo gene delivery to tumor cells. Effect of polymer molecular weight
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, 80082, 3508 TB, Utrecht, The Netherlands
    Pharm Res 24:1572-80. 2007
    ..In this study, we investigated the effect of p(DMAEA)-ppz molecular weight on both in vitro and in vivo tumor transfection, as well as on complex induced toxicity...
  6. pmc Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells
    M E M Dolman
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Int J Nanomedicine 7:417-33. 2012
    ..Activated proximal tubular cells play an important role in renal fibrosis. We investigated whether sunitinib and a kidney-targeted conjugate of sunitinib were capable of attenuating fibrogenic events in tubulointerstitial fibrosis...
  7. doi request reprint Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment
    Roy van der Meel
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    J Control Release 159:281-9. 2012
    ..Therefore, AG538-loaded nanobody-liposomes are a promising anti-cancer formulation due to efficient intracellular delivery of AG538 in combination with antagonistic and downregulating properties of the EGa1 nanobody-liposomes...
  8. pmc Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Pharm Res 25:1654-62. 2008
    ..The effect of CpG replacement on the levels of transgene expression was studied, after the i.v. administration of polyethylenimine (PEI) polyplexes...
  9. doi request reprint Liposomes as carriers for colchicine-derived prodrugs: vascular disrupting nanomedicines with tailorable drug release kinetics
    Bart J Crielaard
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Eur J Pharm Sci 45:429-35. 2012
    ....
  10. doi request reprint Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting
    Marina Talelli
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, Utrecht, The Netherlands
    J Control Release 151:183-92. 2011
    ..In conclusion, EGa1 decorated (mPEG/PDP-PEG)-b-(pHPMAm-Lac(n)) polymeric micelles are highly promising systems for active drug targeting...
  11. ncbi request reprint Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    J Control Release 113:1-8. 2006
    ....
  12. doi request reprint Inhibition of tumor growth by targeted anti-EGFR/IGF-1R nanobullets depends on efficient blocking of cell survival pathways
    Roy van der Meel
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    Mol Pharm 10:3717-27. 2013
    ..Combination therapy with kinase inhibitor-loaded Nb-liposomes is therefore an appealing strategy for inhibiting the proliferation of tumors that are highly dependent on EGFR and IGF-1R signaling. ..
  13. doi request reprint Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin
    Marina Talelli
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Biomaterials 31:7797-804. 2010
    ..The results presented in this paper show that mPEG-b-p(HPMAm-Lac(n)) polymeric micelles with covalently entrapped doxorubicin is a system highly promising for the targeted delivery of cytostatic agents...
  14. pmc Investigation into the role of tumor-associated macrophages in the antitumor activity of Doxil
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Room Z509, P O Box 80 082, 2508 TB, Utrecht, The Netherlands
    Pharm Res 25:1948-55. 2008
    ....
  15. ncbi request reprint Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 331:167-75. 2007
    ..Rather, the benefits are arising from carrier-induced changes in the intratumoral fate of the nucleic acids...
  16. ncbi request reprint Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis
    Gerben A Koning
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arthritis Rheum 54:1198-208. 2006
    ....
  17. ncbi request reprint Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA
    Sabrina Oliveira
    Department Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Biochim Biophys Acta 1768:1211-7. 2007
    ..In addition, local illumination of target tissue would only induce PCI in the desired cells, which can further increase the specificity of the treatment, supporting PCI as an attractive strategy to improve siRNA silencing efficiency...
  18. ncbi request reprint Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin
    Raymond M Schiffelers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O Box 80 082, 3508 TB, Utrecht, The Netherlands
    J Control Release 91:115-22. 2003
    ..Likely, these RGD-LCL-doxorubicin antitumor effects are brought about through direct effects on tumor endothelial cells...
  19. doi request reprint Erythrophagocytosis by angiogenic endothelial cells is enhanced by loss of erythrocyte deformability
    Marcel H A M Fens
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Exp Hematol 38:282-91. 2010
    ..In this study, we examined the interaction between lactadherin-opsonized erythrocytes with reduced deformability and angiogenic endothelium, as loss of deformability is characteristic for suicidal and aged erythrocytes...
  20. ncbi request reprint Pharmacokinetics of poly(hydroxyethyl-l-asparagine)-coated liposomes is superior over that of PEG-coated liposomes at low lipid dose and upon repeated administration
    Birgit Romberg
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Biochim Biophys Acta 1768:737-43. 2007
    ..Although the mechanisms behind these observations are still not clear yet, the use of PHEA-liposomes appears beneficial when single low lipid doses and/or repeated dosing schedules are being applied...
  21. doi request reprint Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation
    Maria Coimbra
    Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Dept of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    J Control Release 148:303-10. 2010
    ..The antitumor activity seems to result primarily from a local inhibition of tumor inflammation and stimulation of antitumor immune response...
  22. doi request reprint Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Mol Pharm 5:349-57. 2008
    ..pHPMA-DMAE-based polyplexes have potential for use in ovarian cancer therapy due to their considerable transfection activity, their low cytotoxicity, and their HA resistance...
  23. doi request reprint Gene silencing activity of siRNA polyplexes based on thiolated N,N,N-trimethylated chitosan
    Amir K Varkouhi
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Bioconjug Chem 21:2339-46. 2010
    ..Given the good extracellular stability and good silencing activity, it is concluded that polyplexes based on TMC-SH are attractive systems for further in vivo evaluations...
  24. doi request reprint Gene silencing activity of siRNA polyplexes based on biodegradable polymers
    Amir K Varkouhi
    Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands
    Eur J Pharm Biopharm 77:450-7. 2011
    ..Importantly, the polyplexes retained their silencing activity in the presence of serum, and they showed low cytotoxicity. These biodegradable vectors are therefore attractive systems for further in vivo evaluations...
  25. doi request reprint Enzyme-induced shedding of a poly(amino acid)-coating triggers contents release from dioleoyl phosphatidylethanolamine liposomes
    Birgit Romberg
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 355:108-13. 2008
    ..It was shown that PHEG-DODASuc is able to stabilize DOPE-based liposomes and that contents release can be triggered by shedding of the PHEG-coating...
  26. pmc Effect of liposome characteristics and dose on the pharmacokinetics of liposomes coated with poly(amino acid)s
    Birgit Romberg
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Pharm Res 24:2394-401. 2007
    ..However, the use of relatively high amounts of strongly charge-inducing lipids and a too large mean size is to be avoided. In conclusion, PAA-liposomes represent a versatile drug carrier system for a wide variety of applications...
  27. doi request reprint Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy
    Marina Talelli
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Biomaterials 34:1255-60. 2013
    ....
  28. doi request reprint Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharm Sci 45:330-5. 2012
    ....
  29. doi request reprint Polyplexes based on cationic polymers with strong nucleic acid binding properties
    Amir K Varkouhi
    Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands
    Eur J Pharm Sci 45:459-66. 2012
    ..Based on the results of this study, it is concluded that formation of strong siRNA complexes with polymers containing double charges per monomer is advantageous...
  30. ncbi request reprint In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, The Netherlands
    J Control Release 109:275-87. 2005
    ..The observed preferential tumor gene expression mediated by the p(DMAEA)-ppz polyplexes enables the application of this polymer to deliver therapeutic genes to tumors...
  31. doi request reprint Antitumor activity and tumor localization of liposomal glucocorticoids in B16 melanoma-bearing mice
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    J Control Release 127:131-6. 2008
    ..The high potency of LCL-BUP confers the risk for occurrence of strong side effects. However, at the dose of 3 mg/kg, LCL-BUP was highly efficacious without the occurrence of adverse effects...
  32. ncbi request reprint Application of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes for gene transfer into human ovarian carcinoma cells
    Ferry J Verbaan
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Int J Pharm 304:185-92. 2005
    ..It was further demonstrated that active targeting of polyplexes to OVCAR-3 cells growing in the peritoneal cavity of mice is a realistic possibility to avoid transfection of non-target cells...
  33. ncbi request reprint A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity
    Josbert M Metselaar
    Department of Pharmaceutics, Utrecht University, The Netherlands
    Bioconjug Chem 14:1156-64. 2003
    ..PHEA and PHEG are attractive alternative polymers for the design of LCL: their performance is similar to that of PEG-liposomes but they have the advantage of being biodegradable...
  34. pmc Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Neoplasia 10:108-17. 2008
    ..One of the major inhibitory actions of LCL-PLP on tumor growth is the reduction of the TAM-mediated production of pro-angiogenic factors, whereas production of anti-angiogenic factors by these cells is hardly affected...
  35. doi request reprint Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 416:448-52. 2011
    ..For C2, the release was rapid in both HBS and BSA at 37°C. In conclusion, the formulation of NTDE inhibitors C1 and C2 in liposomes has been demonstrated and holds promise to deliver NTDE inhibitors in vivo...
  36. pmc Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis
    Bart J Crielaard
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    Angew Chem Int Ed Engl 51:7254-8. 2012
    ..By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models...
  37. doi request reprint Critical factors in the development of tumor-targeted anti-inflammatory nanomedicines
    Maria Coimbra
    Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Dept of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    J Control Release 160:232-8. 2012
    ....
  38. ncbi request reprint Cytosolic delivery of liposomally targeted proteins induced by photochemical internalization
    Marjan M Fretz
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Pharm Res 24:2040-7. 2007
    ..PCI makes use of photosensitising agents which localize in endocytic vesicles, inducing endosomal release upon light exposure...
  39. ncbi request reprint Utility of targeted glucocorticoids in cancer therapy
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Liposome Res 18:47-57. 2008
    ..We also present an overview of the current status of tumor-targeted glucocorticoid delivery. It appears that long-circulating liposomes are the only targeting system currently being explored for this purpose...
  40. doi request reprint Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells
    Marcel H A M Fens
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Blood 111:4542-50. 2008
    ..Implications of our findings for diagnostic and therapy of angiogenesis-driven diseases are discussed...
  41. ncbi request reprint Poly(amino acid)s: promising enzymatically degradable stealth coatings for liposomes
    Birgit Romberg
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 331:186-9. 2007
    ..Like other liposome types, they appear to activate the complement system. However, a role of endotoxin contamination of the PAA-liposome formulations used cannot be excluded in our complement activation studies...
  42. ncbi request reprint Transporting silence: design of carriers for siRNA to angiogenic endothelium
    Raymond M Schiffelers
    Department Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    J Control Release 109:5-14. 2005
    ..In this presentation, we discuss design strategies for development of self-assembling nanoscale carriers for neovasculature targeted delivery of siRNA inhibiting tumor or ocular angiogenesis...
  43. ncbi request reprint Strategies for cytosolic delivery of liposomal macromolecules
    Marjan M Fretz
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 298:305-9. 2005
    ....
  44. doi request reprint Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery
    Marina Talelli
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Langmuir 25:2060-7. 2009
    ..This, together with their ease of preparation and their size of approximately 200 nm, makes these systems highly suitable for image-guided drug delivery...
  45. pmc Sheddable coatings for long-circulating nanoparticles
    Birgit Romberg
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, Utrecht, The Netherlands
    Pharm Res 25:55-71. 2008
    ..Detach mechanisms and stimuli that have been used are described...
  46. doi request reprint New insights into the HIFU-triggered release from polymeric micelles
    Roel Deckers
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Langmuir 29:9483-90. 2013
    ..We therefore hypothesize that the polymeric micelles are temporally destabilized upon HIFU exposure due to radiation force induced shear forces, leading to NR release on demand...
  47. ncbi request reprint Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    Josbert M Metselaar
    Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    Arthritis Rheum 48:2059-66. 2003
    ....
  48. ncbi request reprint Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery
    Osamu Soga
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Pharmaceutical Sciences, Utrecht University, P O Box 80 082, 3508 TB Utrecht, The Netherlands
    J Control Release 103:341-53. 2005
    ..The present results suggest that pHPMAmDL-b-PEG block copolymer micelles are a promising delivery system for the parenteral administration of PTX...
  49. doi request reprint Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes
    Maria Coimbra
    Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Dept of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Int J Pharm 416:433-42. 2011
    ....
  50. pmc Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice
    Raymond M Schiffelers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht, The Netherlands
    Neoplasia 7:118-27. 2005
    ..In conclusion, the present study shows potent antitumor effects of liposomal formulations of glucocorticoids in a low dose and low-frequency schedule, offering promise for liposomal glucocorticoids as novel antitumor agents...
  51. pmc Identification of peptide ligands for targeting to the blood-brain barrier
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Pharm Res 27:673-82. 2010
    ..Transport of drugs to the brain is limited by the blood-brain barrier. New, specific brain endothelium ligands can facilitate brain-specific delivery of drugs...
  52. ncbi request reprint Synthetic delivery systems for intravenous administration of nucleic acids
    Raymond M Schiffelers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Nanomedicine (Lond) 2:169-81. 2007
    ....
  53. doi request reprint The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy
    Roy van der Meel
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    Drug Discov Today 16:219-28. 2011
    ..Recent findings describe the development of innovative Rho GTPase inhibitors. Positive clinical effects of Rho GTPase targeting in combination with conventional anticancer therapy is of increasing interest...
  54. doi request reprint Endosomal escape pathways for delivery of biologicals
    Amir K Varkouhi
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, University of Utrecht, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Control Release 151:220-8. 2011
    ..In this review, several mechanisms and agents which are involved in endosomal escape are introduced...
  55. pmc Physicochemical and biological evaluation of siRNA polyplexes based on PEGylated Poly(amido amine)s
    Pieter Vader
    Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508, TB, Utrecht, The Netherlands
    Pharm Res 29:352-61. 2012
    ..Cationic polymers have been thoroughly investigated for this purpose but often display unfavorable characteristics for systemic administration, such as interactions with serum and/or toxicity...
  56. doi request reprint Dendrimer-based macromolecular conjugate for the kidney-directed delivery of a multitargeted sunitinib analogue
    M E Emmy M Dolman
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, Utrecht, The Netherlands
    Macromol Biosci 12:93-103. 2012
    ..These results are encouraging for future studies focusing on the development of novel therapeutics for the treatment of renal diseases...
  57. ncbi request reprint Liposomal targeting of angiogenic vasculature
    Raymond M Schiffelers
    Dept Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB, Utrecht, The Netherlands
    Curr Drug Deliv 2:363-8. 2005
    ..In particular, attention has been focused on inhibition of tumor growth. In this review, the recent progress in targeting liposomes to angiogenic endothelial cells is discussed...
  58. doi request reprint Macromolecular nanotheranostics for multimodal anticancer therapy
    Ruben Huis In 't Veld
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    Nanoscale 3:4022-34. 2011
    ....
  59. pmc A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy
    Bart J Crielaard
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Int J Nanomedicine 6:2697-703. 2011
    ..These findings demonstrate that the polymeric colchicinoid prodrug has a substantially improved efficacy/toxicity ratio compared with that of colchicine, making it a promising VDA for cancer therapy...
  60. doi request reprint Downregulation of EGFR by a novel multivalent nanobody-liposome platform
    Sabrina Oliveira
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Control Release 145:165-75. 2010
    ..Also in vivo, EGFR downregulation was observed in tumors of mice intravenously injected with EGa1-L, indicating that this multivalent platform blocks ligand binding to the receptor and simultaneously induces the downregulation of EGFR...
  61. doi request reprint MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent
    Lisette H Deddens
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Mol Imaging Biol 15:411-22. 2013
    ..Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after stroke and to establish a most efficient imaging procedure...
  62. ncbi request reprint Nanomedicines as cancer therapeutics: current status
    Sohail Akhter
    Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands
    Curr Cancer Drug Targets 13:362-78. 2013
    ..It also discusses the effects of nano-sized materials on tissues/organ functions, the possibility of overcoming multi-drug resistance by using nanomedicines and their current clinical status...
  63. doi request reprint Evidence for a new mechanism behind HIFU-triggered release from liposomes
    Chris Oerlemans
    Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    J Control Release 168:327-33. 2013
    ....
  64. ncbi request reprint Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release
    Lauri Paasonen
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Bioconjug Chem 18:2131-6. 2007
    ..This study demonstrates that liposomes surface-modified with HPMA mono/dilactate copolymer are attractive systems for achieving temperature-triggered contents release...
  65. ncbi request reprint 1H NMR spectroscopy as a tool for determining the composition of poly(hydroxyethyl-L-asparagine)-coated liposomes
    Birgit Romberg
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Bioconjug Chem 17:860-4. 2006
    ..In this study, a 1H NMR method to establish the composition of liposomes coated with PHEA was developed and validated...
  66. doi request reprint SiRNA delivery with functionalized carbon nanotubes
    Amir Khashayar Varkouhi
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Int J Pharm 416:419-25. 2011
    ..Nevertheless, in view of the present results and importantly also of the non-degradability of CNTs, preference should currently be given to designing biodegradable carriers which mimic the needle structure of CNTs...
  67. ncbi request reprint Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
    Sabrina Oliveira
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 331:211-4. 2007
    ..For both targets, strong enhancement of gene silencing activity was noted after addition of diINF-7 fusogenic peptide, identifying endosomal escape as a limiting factor for siRNA silencing efficiency...
  68. ncbi request reprint Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134
    Esther N M Nolte-'t Hoen
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584CM Utrecht, The Netherlands
    J Leukoc Biol 83:112-21. 2008
    ..Analysis of the function, phenotype, and amount of the CD4+ T cell subsets in different lymph node stations revealed spatiotemporal differences in effector cell and Treg compartments during experimental arthritis...
  69. ncbi request reprint Reprint of "Nanobody--shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting"
    Marina Talelli
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    J Control Release 153:93-102. 2011
    ..In conclusion, EGa1 decorated (mPEG/PDP-PEG)-b-(pHPMAm-Lac(n)) polymeric micelles are highly promising systems for active drug targeting...
  70. ncbi request reprint ICS-283: a system for targeted intravenous delivery of siRNA
    Raymond M Schiffelers
    Department of Pharmaceutics, Room Z735A, Utrecht Institute for Pharmaceutical Sciences, PO Box 80082, 3508 TB, Utrecht, The Netherlands
    Expert Opin Drug Deliv 3:445-54. 2006
    ..At present, ICS-283 is the only antiangiogenic siRNA delivery system that is designed for intravenous administration to treat angiogenesis-driven diseases...
  71. pmc In vivo methods to study uptake of nanoparticles into the brain
    Inge van Rooy
    Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Pharm Res 28:456-71. 2011
    ..Here we discuss the techniques generally used to measure nanoparticle uptake in addition to the techniques used for CNS compounds. Techniques include visualization methods, behavioral tests, and quantitative methods...
  72. doi request reprint Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors
    Marjan M Fretz
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    J Control Release 132:200-7. 2008
    ..Future in vivo studies should show their potential for the treatment of renal diseases...
  73. doi request reprint Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    J Control Release 150:30-6. 2011
    ..3 times higher. Additionally, these results show that many targeting ligands that have been described for brain targeting, do not target to the brain in vivo when coupled to a liposomal delivery vehicle...
  74. doi request reprint A method for quantifying cellular uptake of fluorescently labeled siRNA
    Pieter Vader
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    J Control Release 148:106-9. 2010
    ..This method offers a simple approach for quantifying cellular uptake of siRNA, which might help in the development of more efficient delivery systems...
  75. pmc CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis
    Elmieke P J Boot
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arthritis Res Ther 7:R604-15. 2005
    ..Thus, CD134 can be used as a marker for auto-aggressive CD4+ T cells early in arthritis, and specific liposomal targeting of drugs to these cells via CD134 can be employed to downregulate disease development...